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Searching for up to 100 curated homologs for Ga0059261_4138 FitnessBrowser__Korea:Ga0059261_4138 (292 a.a.)

Found high-coverage hits (≥70%) to 39 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

6xycA Truncated form of carbohydrate esterase from gut microbiota (see paper)
    30% identity, 87% coverage of query (121 bits)

6nkfA / Q65FG3 Crystal structure of the lipase lip_vut4 from goat rumen metagenome.
    32% identity, 83% coverage of query (107 bits)

Build an alignment

Build an alignment for Ga0059261_4138 and 2 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

5aocA The structure of a novel thermophilic esterase from the planctomycetes species, thermogutta terrifontis, est2-valerate bound
    29% identity, 82% coverage of query (81.6 bits)

LIPC_MYCTU / P96402 Esterase LipC; EC 3.1.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    29% identity, 71% coverage of query (80.1 bits)

LIPQ_MYCTU / I6Y9F7 Esterase LipQ; EC 3.1.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    31% identity, 76% coverage of query (79.3 bits)

5aobA / A0A0X1KHD1 The structure of a novel thermophilic esterase from the planctomycetes species, thermogutta terrifontis, est2-butyrate bound (see paper)
    29% identity, 82% coverage of query (77.8 bits)

7bfrA Thermogutta terrifontis esterase 2 phosphorylated by paraoxon
    29% identity, 83% coverage of query (76.6 bits)

LIPM_MYCTU / Q50681 Probable carboxylic ester hydrolase LipM; EC 3.1.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    28% identity, 72% coverage of query (75.5 bits)

Q5V5N6 carboxylesterase (EC 3.1.1.1) from Haloarcula marismortui (see 2 papers)
    27% identity, 77% coverage of query (72.8 bits)

AUSA_EMENI / Q5ATJ7 Non-reducing polyketide synthase ausA; Austinoid biosynthesis clusters protein A; Methylorcinaldehyde synthase ausA; EC 2.3.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 6 papers)
    24% identity, 90% coverage of query (70.5 bits)

PCME / Q94AS5 prenylcysteine methylesterase from Arabidopsis thaliana (see paper)
ICME_ARATH / Q94AS5 Isoprenylcysteine alpha-carbonyl methylesterase ICME; Isoprenylcysteine methylesterase; Prenylcysteine methylesterase; AtPCME; EC 3.1.1.n2 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    25% identity, 92% coverage of query (69.3 bits)

AUSA_ASPCI / A0A0U5GFS8 Non-reducing polyketide synthase ausA; Austinoid biosynthesis cluster protein A; EC 2.3.1.- from Aspergillus calidoustus (see 2 papers)
    26% identity, 95% coverage of query (68.2 bits)

ADRD_PENRW / B6HV32 Non-reducing polyketide synthase adrD; Andrastin A biosynthesis cluster protein D; EC 2.3.1.- from Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
    26% identity, 89% coverage of query (68.2 bits)

4n5iX Crystal structure of a c8-c4 sn3 inhibited esterase b from lactobacillus rhamnosis
    25% identity, 79% coverage of query (65.5 bits)

Q7WZT5 arylesterase (EC 3.1.1.2) from Lacticaseibacillus casei (see paper)
    25% identity, 84% coverage of query (64.7 bits)

A0A0E3GVY6 hormone-sensitive lipase (EC 3.1.1.79) from Saccharolobus solfataricus (see paper)
Q97VU2 carboxylesterase (EC 3.1.1.1); hormone-sensitive lipase (EC 3.1.1.79) from Saccharolobus solfataricus (see 2 papers)
    28% identity, 77% coverage of query (63.9 bits)

O28558 carboxylesterase (EC 3.1.1.1) from Archaeoglobus fulgidus (see 6 papers)
    28% identity, 73% coverage of query (63.5 bits)

E1VFE0 acylaminoacyl-peptidase (EC 3.4.19.1) from Sporosarcina psychrophila (see paper)
aph / CBQ78833.1 amino acyl peptidase from Sporosarcina psychrophila (see paper)
    25% identity, 75% coverage of query (63.5 bits)

AUSA_PENBI / A0A0F7U103 Non-reducing polyketide synthase ausA; Austinoid biosynthesis clusters protein A; EC 2.3.1.- from Penicillium brasilianum (see paper)
    25% identity, 92% coverage of query (62.0 bits)

Q7LX61 acylaminoacyl-peptidase (EC 3.4.19.1) from Saccharolobus solfataricus (see paper)
    27% identity, 76% coverage of query (60.5 bits)

MPAS_CLAUC / A0A0R8YWJ7 Methylphloroacetophenone synthase; MPAS; Non-reducing polyketide synthase MPAS; Usnic acid biosynthesis protein MPAS; EC 2.3.1.- from Cladonia uncialis (Cup lichen) (see 2 papers)
    24% identity, 72% coverage of query (60.1 bits)

ICML2_ARATH / Q1PET6 Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL2; Isoprenylcysteine methylesterase-like protein 2; EC 3.1.1.n2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    25% identity, 89% coverage of query (60.1 bits)

DAP4_PSEMX / Q6F3I7 Dipeptidyl aminopeptidase 4; Dipeptidyl aminopeptidase IV; DAP IV; EC 3.4.14.5 from Pseudoxanthomonas mexicana (see 2 papers)
Q6F3I7 dipeptidyl-peptidase IV (EC 3.4.14.5) from Pseudoxanthomonas mexicana (see paper)
    27% identity, 99% coverage of query (59.7 bits)

5yp4A Crystal structure of dipeptidyl peptidase iv (dpp iv) with lys-pro from pseudoxanthomonas mexicana wo24
    27% identity, 99% coverage of query (59.3 bits)

5yp3A Crystal structure of dipeptidyl peptidase iv (dpp iv) with ile-pro from pseudoxanthomonas mexicana
    27% identity, 99% coverage of query (59.3 bits)

5yp2A / Q6F3I7 Crystal structure of dipeptidyl peptidase iv (dpp iv) with dpp4 inhibitor from pseudoxanthomonas mexicana wo24 (see paper)
    27% identity, 99% coverage of query (59.3 bits)

ACPH_RAT / P13676 Acylamino-acid-releasing enzyme; AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase; EC 3.4.19.1 from Rattus norvegicus (Rat) (see paper)
    26% identity, 86% coverage of query (57.4 bits)

6ieyA / G3CR02 Crystal structure of chloramphenicol-metabolizaing enzyme estdl136- chloramphenicol complex (see paper)
    27% identity, 83% coverage of query (56.2 bits)

PRHL_PENBI / A0A1E1FFN8 Non-reducing polyketide synthase prhL; Paraherquonin biosynthesis cluster protein L; EC 2.3.1.- from Penicillium brasilianum (see 2 papers)
    24% identity, 92% coverage of query (55.5 bits)

ADRD_PENRO / A0A1Y0BRF1 Non-reducing polyketide synthase adrD; Andrastin A biosynthesis cluster protein D; EC 2.3.1.- from Penicillium roqueforti (see paper)
    24% identity, 89% coverage of query (55.5 bits)

are / B5BLW5 arylesterase (EC 3.1.1.2; EC 3.1.8.1) from Saccharolobus solfataricus (see paper)
ARE_SACSO / B5BLW5 Arylesterase; A-esterase; Paraoxonase; EC 3.1.1.2; EC 3.1.8.1 from Saccharolobus solfataricus (Sulfolobus solfataricus) (see paper)
B5BLW5 arylesterase (EC 3.1.1.2); aryldialkylphosphatase (EC 3.1.8.1) from Saccharolobus solfataricus (see paper)
    24% identity, 77% coverage of query (55.1 bits)

ICML1_ARATH / Q8VYP9 Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL1; Isoprenylcysteine methylesterase-like protein 1; EC 3.1.1.n2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    23% identity, 79% coverage of query (54.7 bits)

AARE_ARATH / Q84LM4 Acylamino-acid-releasing enzyme; AARE; Oxidized protein hydrolase; OPH; EC 3.4.19.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    26% identity, 77% coverage of query (52.8 bits)

4j0kA Tannin acyl hydrolase in complex with ethyl gallate
    24% identity, 79% coverage of query (50.8 bits)

6rkyA Structure of ester-hydrolase eh1ab1 from the metagenome of lake arreo complexed with a derivative of bipyridine phosphonate
    28% identity, 76% coverage of query (50.8 bits)

6rb0A Structure of ester-hydrolase eh1ab1 from the metagenome of lake arreo complexed with a derivative of methyl 4-nitrophenyl hexylphosphonate
    28% identity, 76% coverage of query (50.8 bits)

6i8dA Structure of ester-hydrolase eh1ab1 from the metagenome of lake arreo complexed with a derivative of butyl 4-nitrophenyl hexylphosphonate
    28% identity, 76% coverage of query (50.8 bits)

APEH / P13798 acylaminoacyl-peptidase monomer (EC 3.4.19.1) from Homo sapiens (see 24 papers)
ACPH_HUMAN / P13798 Acylamino-acid-releasing enzyme; AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase; Oxidized protein hydrolase; OPH; EC 3.4.19.1 from Homo sapiens (Human) (see 4 papers)
P13798 acylaminoacyl-peptidase (EC 3.4.19.1) from Homo sapiens (see 2 papers)
    25% identity, 80% coverage of query (47.4 bits)

P25154 Acylamino-acid-releasing enzyme; AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase; EC 3.4.19.1 from Oryctolagus cuniculus (Rabbit)
    25% identity, 80% coverage of query (46.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory