Searching for up to 100 curated homologs for Ga0059261_4235 FitnessBrowser__Korea:Ga0059261_4235 (310 a.a.)
Found high-coverage hits (≥70%) to 90 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YbhF / b0794 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
ybhF / P0A9U1 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli (strain K12) (see 6 papers)
YBHF_ECOLI / P0A9U1 Probable multidrug ABC transporter ATP-binding protein YbhF from Escherichia coli (strain K12) (see paper)
ybhF / MB|P0A9U1 uncharacterized ABC transporter ATP-binding protein ybhF from Escherichia coli K12 (see paper)
46% identity, 72% coverage of query (214 bits)
TC 3.A.1.105.4 / Q4VWC9 PltI, component of The pyoluteorin (a chlorinated polyketide) efflux pump, PltHIJKN (see 2 papers)
49% identity, 71% coverage of query (206 bits)
YhiG / b3486 ribosome-associated ATPase from Escherichia coli K-12 substr. MG1655 (see 13 papers)
RBBA_ECOLI / P37624 Ribosome-associated ATPase; Ribosomal bound ATPase from Escherichia coli (strain K12) (see 5 papers)
yhiH / RF|YP_026225 uncharacterized ABC transporter ATP-binding protein yhiH from Escherichia coli K12 (see paper)
39% identity, 84% coverage of query (178 bits)
nodI / GB|AAB16898.1 nodulation ATP-binding protein I from Rhizobium sp. N33 (see paper)
36% identity, 95% coverage of query (169 bits)
TC 3.A.1.105.8 / Q7UE58 ABC-type multidrug transport system, ATPase component, component of ABC-2 transporter from Rhodopirellula baltica (strain SH1)
41% identity, 71% coverage of query (160 bits)
LNRL_BACSU / P94440 Linearmycin resistance ATP-binding protein LnrL; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 2 papers)
33% identity, 94% coverage of query (156 bits)
DRRA_STRPE / P32010 Daunorubicin/doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Streptomyces peucetius (see 2 papers)
P32010 ABC-type xenobiotic transporter (EC 7.6.2.2) from Streptomyces peucetius (see paper)
TC 3.A.1.105.1 / P32010 DrrA, component of Daunorubicin, doxorubicin etc. (multidrug resistance) exporter, DrrAB from Streptomyces peucetius (see 2 papers)
36% identity, 97% coverage of query (155 bits)
TC 3.A.1.105.2 / Q53716 OleC4, component of Oleandomycin (drug resistance) exporter from Streptomyces antibioticus (see paper)
39% identity, 71% coverage of query (155 bits)
TC 3.A.1.102.1 / P50332 NodI, component of Lipooligosaccharide exporter (nodulation proteins, NodIJ) from Rhizobium galegae (see paper)
34% identity, 94% coverage of query (155 bits)
TC 3.A.1.132.1 / O30489 GldA, component of The GldAFG putative ABC transporter required for ratchet-type gliding motility; may function in secretion of a macromolecule such as an exopolysaccharide. (Agarwal et al., 1997; Hunnicutt et al., 2002; McBride and Zhu 2013). Soluble GldG homologues (no TMSs) are found in eukaryotes (e.g. intraflagellar protein transporter, IPT52 of Chlamydomonas reinhardtii; XP_001692161) from Cytophaga johnsonae (Flavobacterium johnsoniae) (see paper)
30% identity, 93% coverage of query (151 bits)
sagG / GI|23305059 ABC transporter, ATP-binding protein SagG from Streptococcus iniae (see paper)
30% identity, 95% coverage of query (148 bits)
TC 3.A.1.148.1 / W2ET84 ABC transporter ATP binding domain, component of ABC lantibiotic NAI-107 immunity exporter, MlbYZ from Microbispora sp. ATCC PTA-5024
35% identity, 99% coverage of query (142 bits)
TC 3.A.1.105.3 / Q70J75 CmrA, component of The 4A-4E-O-dideacetyl-chromomycin A3 (biosynthetic precursor of chromomycin) exporter (may also export chromomycin and mithramycin from Streptomyces griseus subsp. griseus
37% identity, 94% coverage of query (142 bits)
TC 3.A.1.132.2 / Q52900 NosF, component of The NosDFY Copper ABC transporter from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
nosF / AAC44025.1 NosF protein from Sinorhizobium meliloti (see paper)
34% identity, 95% coverage of query (140 bits)
ABCA2_MOUSE / P41234 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Mus musculus (Mouse) (see 5 papers)
34% identity, 83% coverage of query (139 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
35% identity, 70% coverage of query (128 bits)
TC 3.A.1.211.3 / Q9BZC7 Multidrug resistance pump, ABCA2 (ABC2) from Homo sapiens (Human) (see 6 papers)
ABCA2 / GI|55962682 ATP-binding cassette sub-family A member 2 from Homo sapiens
36% identity, 71% coverage of query (122 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
36% identity, 71% coverage of query (122 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
35% identity, 75% coverage of query (122 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
32% identity, 72% coverage of query (122 bits)
ABCA4_MOUSE / O35600 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Mus musculus (Mouse) (see 4 papers)
35% identity, 75% coverage of query (121 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
35% identity, 72% coverage of query (121 bits)
ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
33% identity, 72% coverage of query (121 bits)
7o12B / P19844 Abc transporter nosdfy, amppnp-bound in gdn (see paper)
31% identity, 95% coverage of query (120 bits)
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
34% identity, 70% coverage of query (120 bits)
6b89A E. Coli lptb in complex with adp and novobiocin
34% identity, 70% coverage of query (120 bits)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
34% identity, 70% coverage of query (120 bits)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
34% identity, 70% coverage of query (119 bits)
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
34% identity, 70% coverage of query (119 bits)
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
34% identity, 70% coverage of query (119 bits)
7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc
30% identity, 95% coverage of query (119 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
33% identity, 70% coverage of query (118 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
35% identity, 71% coverage of query (116 bits)
8eopA / Q8IZY2 Cryo-em structure of nanodisc reconstituted human abca7 eq mutant in atp bound closed state (see paper)
35% identity, 71% coverage of query (115 bits)
7ahhC Opua inhibited inward-facing, sbd docked
30% identity, 88% coverage of query (115 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
30% identity, 88% coverage of query (115 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
33% identity, 70% coverage of query (113 bits)
TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
31% identity, 72% coverage of query (112 bits)
7ahdC Opua (e190q) occluded
33% identity, 70% coverage of query (112 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
35% identity, 73% coverage of query (112 bits)
6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
32% identity, 70% coverage of query (111 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
33% identity, 70% coverage of query (110 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
31% identity, 74% coverage of query (108 bits)
TC 3.A.1.211.1 / P41233 The cholesterol/phospholipid flippase, ABC1 (called ABCA1 in humans; Tangier disease proteins; 2261 aas; sp: O95477). An amphipathic helical region of the N-terminal barrel of the phospholipid transfer protein (PLTP) is critical for ABCA1-dependent cholesterol efflux (Oram et al., 2008). PLTP helix 144-163 removes lipid domains formed by ABCA1, stabilizing ABCA1, interacting with phospholipids, and promoting phospholipid transfer by direct interactions with ABCA1. May transport sphingosine-1-phosphate (Kobayashi et al., 2009). May protect from cardiovascular disease and diabetes from Mus musculus (Mouse) (see 7 papers)
Abca1 ATP-binding cassette sub-family A member 1 from Mus musculus (see paper)
31% identity, 74% coverage of query (107 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
31% identity, 74% coverage of query (107 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
34% identity, 71% coverage of query (105 bits)
4hluC / Q9X1Z1 Structure of the ecfa-a' heterodimer bound to adp (see paper)
32% identity, 71% coverage of query (105 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
32% identity, 75% coverage of query (102 bits)
1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
30% identity, 72% coverage of query (101 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
30% identity, 72% coverage of query (99.4 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
32% identity, 73% coverage of query (99.0 bits)
1g291 / Q9YGA6 Malk (see paper)
33% identity, 74% coverage of query (97.4 bits)
FhuC / b0151 iron(III) hydroxamate ABC transporter ATP binding subunit (EC 7.2.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
FhuC / P07821 iron(III) hydroxamate ABC transporter ATP binding subunit (EC 7.2.2.16) from Escherichia coli (strain K12) (see paper)
FHUC_ECOLI / P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.14.3 / P07821 FhuC aka B0151, component of Iron (Fe3+)-hydroxamate (ferrichrome, coprogen, aerobactin, ferrioxamine B, schizakinen, rhodotorulic acid) porter, albomycin porter from Escherichia coli (see 6 papers)
fhuC / GB|BAB96727.2 ferrichrome transport ATP-binding protein FhuC; EC 3.6.3.34 from Escherichia coli K12 (see 8 papers)
31% identity, 71% coverage of query (95.5 bits)
Build an alignment for Ga0059261_4235 and 53 homologs with ≥ 30% identity
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7t55A / A3DCU1 Cryo-em structure of pcat1 in the inward-facing wide conformation under atp turnover condition (see paper)
28% identity, 73% coverage of query (94.7 bits)
ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
31% identity, 77% coverage of query (94.4 bits)
4s0fA Crystal structure of the peptidase-containing abc transporter pcat1 e648q mutant complexed with atpgs in an occluded conformation
28% identity, 73% coverage of query (93.2 bits)
8bmsA Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
29% identity, 71% coverage of query (87.8 bits)
5d3mA / Q1GBJ0 Folate ecf transporter: amppnp bound state (see paper)
29% identity, 71% coverage of query (87.4 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
29% identity, 74% coverage of query (86.7 bits)
3vx4D / Q8DW05 Crystal structure of the nucleotide-binding domain of s. Mutans coma, a bifunctional atp-binding cassette transporter involved in the quorum-sensing pathway (see paper)
27% identity, 72% coverage of query (86.3 bits)
8hprC Lpqy-sugabc in state 4
28% identity, 74% coverage of query (85.9 bits)
8hprD Lpqy-sugabc in state 4
28% identity, 74% coverage of query (85.9 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
28% identity, 74% coverage of query (85.5 bits)
3nhaA Nucleotide binding domain of human abcb6 (adp mg bound structure)
30% identity, 72% coverage of query (83.2 bits)
7qkrA / F2QQK6 Cryo-em structure of abc transporter ste6-2p from pichia pastoris with verapamil at 3.2 a resolution (see paper)
29% identity, 72% coverage of query (82.4 bits)
7m33C The structure of bacillus subtilis bmrcd in the inward-facing conformation bound to hoechst-33342 and atp
29% identity, 72% coverage of query (80.5 bits)
8fhkC / O07550 Heterodimeric abc transporter bmrcd in the occluded conformation bound to atp: bmrcd_oc-atp (see paper)
29% identity, 72% coverage of query (80.5 bits)
Q00748 Multidrug resistance protein homolog 65; P-glycoprotein 65; EC 7.6.2.2 from Drosophila melanogaster (Fruit fly)
27% identity, 72% coverage of query (80.5 bits)
8t1pC Heterodimeric abc transporter bmrcd in the occluded conformation bound to adpvi: bmrcd_oc-adpvi
29% identity, 72% coverage of query (80.1 bits)
7mewA E. Coli msba in complex with g247
29% identity, 74% coverage of query (80.1 bits)
8dmmA Structure of the vanadate-trapped msba bound to kdl
29% identity, 74% coverage of query (79.7 bits)
6bppA E. Coli msba in complex with lps and inhibitor g092
29% identity, 74% coverage of query (79.7 bits)
6bplA E. Coli msba in complex with lps and inhibitor g907
29% identity, 74% coverage of query (79.7 bits)
7selA E. Coli msba in complex with lps and inhibitor g7090 (compound 3)
28% identity, 74% coverage of query (79.3 bits)
8bmpB / Q1GBI9 Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp (see paper)
29% identity, 73% coverage of query (79.0 bits)
5d3mB Folate ecf transporter: amppnp bound state
29% identity, 73% coverage of query (79.0 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
25% identity, 79% coverage of query (79.0 bits)
HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
29% identity, 71% coverage of query (79.0 bits)
ABCB9_HUMAN / Q9NP78 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL; EC 7.4.2.6 from Homo sapiens (Human) (see 16 papers)
Q9NP78 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see 2 papers)
TC 3.A.1.209.2 / Q9NP78 Homodimeric transporter ABCB9 or TAPL. Transports a broad spectrum of peptides (low affinity) from the cytosol to the lysosomal lumen. It exists in two forms (812 aas and 1257 aas). The latter full length protein confers resistance to taxanes and anthracyclines (Kawanobe et al., 2012). Resistance and transport were demonstrated for paclitaxel and docetaxel. TapL transports a broad range of peptides of 6-60aas (23aas optimal). It has also been detected in the ER. It is stabilized by interaction with LAMP-1 and LAMP-2 (see 9.A.16) from Homo sapiens (see 18 papers)
25% identity, 76% coverage of query (78.6 bits)
8bmsB Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
28% identity, 73% coverage of query (77.8 bits)
7v5cA / Q9JJ59 Cryo-em structure of the mouse abcb9 (adp.Bef3-bound) (see paper)
25% identity, 72% coverage of query (77.4 bits)
7vfiA Cryo-em structure of the mouse tapl (9mer-peptide bound)
25% identity, 72% coverage of query (77.4 bits)
6p6jA / Q1RAG2 Structure of ybtpq importer with substrate ybt-fe bound (see paper)
29% identity, 72% coverage of query (76.3 bits)
6tejB / A0A100XE85 Structure of apo irtab devoid sid in complex with sybody syb_nl5 (see paper)
31% identity, 72% coverage of query (76.3 bits)
5dgxA / Q14JW6 1.73 angstrom resolution crystal structure of the abc-atpase domain (residues 357-609) of lipid a transport protein (msba) from francisella tularensis subsp. Tularensis schu s4 in complex with adp
27% identity, 72% coverage of query (75.1 bits)
ABCB7_ORYLA / H2LNR5 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial from Oryzias latipes (Japanese rice fish) (Japanese killifish) (see paper)
25% identity, 78% coverage of query (74.3 bits)
4q4aA / Q9WYC3 Improved model of amp-pnp bound tm287/288 (see paper)
28% identity, 71% coverage of query (73.2 bits)
4f4cA / P34712 The crystal structure of the multi-drug transporter (see paper)
26% identity, 73% coverage of query (67.0 bits)
ABCBB_RAT / O70127 Bile salt export pump; ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein; EC 7.6.2.- from Rattus norvegicus (Rat) (see 12 papers)
28% identity, 71% coverage of query (55.8 bits)
ABCBB_HUMAN / O95342 Bile salt export pump; ATP-binding cassette sub-family B member 11; EC 7.6.2.- from Homo sapiens (Human) (see 21 papers)
TC 3.A.1.201.2 / O95342 Bile salt export pump, BSEP, ABCB11 or SPGP in the canalicular membrane of liver cells, is associated with progressive familial intrahepatic cholestasis-2 and benign recurrent intrahepatic cholestasis (Kagawa et al., 2008; Stindt et al. 2013; Park et al. 2016). It exports unconjugaged bile salts and glycine conjugates > taurine conjugates as well as the statin, pravastatin (Nigam 2015). BSEP mediates biliary excretion of bile acids from hepatocytes. Compounds based on GW4064 (Q96RI1), a representative farnesoid X receptor (RXR) agonist, enhance E297G BSEP transport activity from Homo sapiens (Human) (see 11 papers)
26% identity, 70% coverage of query (53.1 bits)
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Lawrence Berkeley National Laboratory