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Searching for up to 100 curated homologs for H281DRAFT_00429 FitnessBrowser__Burk376:H281DRAFT_00429 (432 a.a.)

Found high-coverage hits (≥70%) to 58 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HSERO_RS05235 L-fuconate dehydratase (EC 4.2.1.68) from Herbaspirillum seropedicae SmR1
    66% identity, 98% coverage of query (584 bits)

ENOF1_HUMAN / Q7L5Y1 Mitochondrial enolase superfamily member 1; Antisense RNA to thymidylate synthase; rTS; L-fuconate dehydratase; EC 4.2.1.68 from Homo sapiens (Human) (see 4 papers)
    62% identity, 99% coverage of query (566 bits)

4a35A / Q7L5Y1 Crystal structure of human mitochondrial enolase superfamily member 1 (enosf1) (see paper)
    62% identity, 99% coverage of query (566 bits)

G3Y683 L-fuconate dehydratase (EC 4.2.1.68) from Aspergillus niger (see paper)
    60% identity, 100% coverage of query (541 bits)

4ip4A / Q1GLV3 Crystal structure of l-fuconate dehydratase from silicibacter sp. Tm1040 liganded with mg
    60% identity, 98% coverage of query (531 bits)

4ip5A Crystal structure of l-fuconate dehydratase from silicibacter sp. Tm1040 liganded with mg and d-erythronohydroxamate
    60% identity, 98% coverage of query (531 bits)

LGD1 / Q0QWS4 L-galactonate dehydratase (EC 4.2.1.146) from Hypocrea jecorina (see paper)
LGD1_HYPJE / Q0QWS4 L-galactonate dehydratase; EC 4.2.1.146 from Hypocrea jecorina (Trichoderma reesei) (see paper)
Q0QWS4 L-galactonate dehydratase (EC 4.2.1.146) from Trichoderma reesei (see 2 papers)
    60% identity, 98% coverage of query (527 bits)

fucD / Q8P3K2 L-fuconate dehydratase monomer (EC 4.2.1.68) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
FUCD_XANCP / Q8P3K2 L-fuconate dehydratase; FucD; EC 4.2.1.68 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
    56% identity, 100% coverage of query (509 bits)

1yeyC / Q8P3K2 Crystal structure of l-fuconate dehydratase from xanthomonas campestris pv. Campestris str. Atcc 33913
    56% identity, 100% coverage of query (508 bits)

2hxtA Crystal structure of l-fuconate dehydratase from xanthomonas campestris liganded with mg++ and d-erythronohydroxamate
    56% identity, 99% coverage of query (506 bits)

2hxuA Crystal structure of k220a mutant of l-fuconate dehydratase from xanthomonas campestris liganded with mg++ and l-fuconate
    56% identity, 99% coverage of query (504 bits)

SM_b21107 dehydratase involved in L-fucose catabolism from Sinorhizobium meliloti 1021
    30% identity, 95% coverage of query (133 bits)

Build an alignment

Build an alignment for H281DRAFT_00429 and 12 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

4h19A / Q7CU39 Crystal structure of an enolase (mandelate racemase subgroup, target efi-502087) from agrobacterium tumefaciens, with bound mg and d- ribonohydroxamate, ordered loop
    29% identity, 82% coverage of query (126 bits)

araD / Q97U96 D-arabinonate dehydratase subunit (EC 4.2.1.5) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
ARAD_SACS2 / Q97U96 Arabinonate dehydratase; EC 4.2.1.5 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q97U96 Arabinonate dehydratase (EC 4.2.1.5) from Saccharolobus solfataricus (see paper)
    25% identity, 92% coverage of query (100 bits)

3cb3A / Q12GE3 Crystal structure of l-talarate dehydratase from polaromonas sp. Js666 complexed with mg and l-glucarate
    27% identity, 88% coverage of query (91.3 bits)

2og9A Crystal structure of mandelate racemase/muconate lactonizing enzyme from polaromonas sp. Js666
    27% identity, 88% coverage of query (91.3 bits)

5xd8B / H2IFX0 Crystal structure analysis of 3,6-anhydro-l-galactonate cycloisomerase (see paper)
    25% identity, 98% coverage of query (86.3 bits)

3rcyF Crystal structure of mandelate racemase/muconate lactonizing enzyme- like protein from roseovarius sp. Tm1035
    27% identity, 93% coverage of query (82.8 bits)

3tteA / A4YVM8 Crystal structure of enolase brado_4202 (target efi-501651) from bradyrhizobium complexed with magnesium and mandelic acid
    24% identity, 98% coverage of query (81.3 bits)

3toyA Crystal structure of enolase brado_4202 (target efi-501651) from bradyrhizobium sp. Ors278 with calcium and acetate bound
    24% identity, 97% coverage of query (80.9 bits)

SSO26655 / Q97VG1 D-xylonate dehydratase subunit (EC 4.2.1.25; EC 4.2.1.82) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
    22% identity, 73% coverage of query (77.4 bits)

2ox4C / Q5NN22 Crystal structure of putative dehydratase from zymomonas mobilis zm4
    25% identity, 82% coverage of query (67.8 bits)

IMAND_ENTBW / A8RQK7 D-galactonate dehydratase family member CLOBOL_02770 from Enterocloster bolteae (strain ATCC BAA-613 / DSM 15670 / CCUG 46953 / JCM 12243 / WAL 16351) (Clostridium bolteae) (see paper)
    22% identity, 75% coverage of query (67.4 bits)

MAND_ENT38 / A4WA78 D-galactonate dehydratase family member Ent638_1932; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.8 from Enterobacter sp. (strain 638) (see paper)
    22% identity, 92% coverage of query (66.2 bits)

4e6mA / Q8ZNH1 Crystal structure of putative dehydratase protein from salmonella enterica subsp. Enterica serovar typhimurium (salmonella typhimurium)
    23% identity, 98% coverage of query (63.9 bits)

IMAND_CLOB8 / A6M2W4 D-galactonate dehydratase family member Cbei_4837 from Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) (see paper)
    21% identity, 92% coverage of query (62.4 bits)

IMAND_VIBH1 / D0X4R4 D-galactonate dehydratase family member VME_00770 from Vibrio harveyi (strain 1DA3) (see paper)
    22% identity, 78% coverage of query (61.6 bits)

4girB / D0X4R4 Crystal structure of an enolase family member from vibrio harveyi (efi-target 501692) with homology to mannonate dehydratase, with mg, ethylene glycol and sulfate bound (ordered loops, space group p41212)
    22% identity, 73% coverage of query (61.6 bits)

IMND2_VIBCY / A6AMN2 D-galactonate dehydratase family member A1Q3065 from Vibrio campbellii (strain HY01) (see paper)
    22% identity, 78% coverage of query (61.2 bits)

DGD_STRBB / D7BPX0 D-galactonate dehydratase family member SBI_01856; D-gluconate dehydratase; EC 4.2.1.-; EC 4.2.1.39 from Streptomyces bingchenggensis (strain BCW-1) (see paper)
    24% identity, 92% coverage of query (60.8 bits)

IMAND_PECPW / D0KC90 D-galactonate dehydratase family member Pecwa_4254 from Pectobacterium parmentieri (strain WPP163) (Pectobacterium wasabiae (strain WPP163)) (see paper)
    22% identity, 92% coverage of query (59.7 bits)

3gy1B / A6M2W4 Crystal structure of putative mandelate racemase/muconate lactonizing protein from clostridium beijerinckii ncimb 8052
    21% identity, 92% coverage of query (58.5 bits)

MAND_PECCP / C6D9S0 D-galactonate dehydratase family member PC1_0802; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.8 from Pectobacterium carotovorum subsp. carotovorum (strain PC1) (see paper)
    22% identity, 92% coverage of query (58.2 bits)

MAND_ECOL6 / Q8FHC7 D-galactonate dehydratase family member RspA; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.8 from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see paper)
    23% identity, 92% coverage of query (57.8 bits)

4il2B / Q8FHC7 Crystal structure of d-mannonate dehydratase (rspa) from e. Coli cft073 (efi target efi-501585)
    23% identity, 92% coverage of query (57.8 bits)

3sjnA / A8H9D1 Crystal structure of enolase spea_3858 (target efi-500646) from shewanella pealeana with magnesium bound
    20% identity, 95% coverage of query (57.0 bits)

2o56A / Q8ZKY6 Crystal structure of a member of the enolase superfamily from salmonella typhimurium
    21% identity, 92% coverage of query (57.0 bits)

IMAND_PECAS / Q6DAR4 D-galactonate dehydratase family member ECA0189 from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) (see paper)
    22% identity, 92% coverage of query (56.2 bits)

3t8qB / A9D2J3 Crystal structure of mandelate racemase/muconate lactonizing enzyme family protein from hoeflea phototrophica
    24% identity, 70% coverage of query (55.8 bits)

MAND_ESCAT / B1ELW6 D-galactonate dehydratase family member RspA; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.8 from Escherichia albertii (strain TW07627) (see paper)
    23% identity, 92% coverage of query (55.5 bits)

RspA / b1581 mandelate racemase/muconate lactonizing enzyme family protein RspA from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RSPA_ECOLI / P38104 Starvation-sensing protein RspA from Escherichia coli (strain K12) (see 2 papers)
rspA / RF|NP_416098 starvation-sensing protein rspA from Escherichia coli K12 (see 6 papers)
    23% identity, 92% coverage of query (55.1 bits)

3n4eA / A1AYL4 Crystal structure of mandelate racemase/muconate lactonizing protein from paracoccus denitrificans pd1222
    25% identity, 73% coverage of query (54.7 bits)

3tjiA / A4W7D6 Crystal structure of an enolase from enterobacter sp. 638 (efi target efi-501662) with bound mg
    20% identity, 88% coverage of query (54.3 bits)

A4W7D6 D-galactonate dehydratase family member Ent638_0932 from Enterobacter sp. (strain 638)
    20% identity, 88% coverage of query (54.3 bits)

IMND1_VIBCR / C9NUM5 D-galactonate dehydratase family member VIC002985 from Vibrio coralliilyticus (strain ATCC BAA-450 / DSM 19607 / CCUG 48437 / LMG 20984 / YB1) (see paper)
    22% identity, 73% coverage of query (53.9 bits)

RhmD / b2247 L-rhamnonate dehydratase (EC 4.2.1.90) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
rhmD / P77215 L-rhamnonate dehydratase (EC 4.2.1.90) from Escherichia coli (strain K12) (see paper)
RHMD_ECOLI / P77215 L-rhamnonate dehydratase; RhamD; EC 4.2.1.90 from Escherichia coli (strain K12) (see paper)
P77215 L-rhamnonate dehydratase (EC 4.2.1.90) from Escherichia coli K-12 (see paper)
    24% identity, 74% coverage of query (53.5 bits)

4mggA / A0NXQ8 Crystal structure of an enolase (mandelate racemase subgroup) from labrenzia aggregata iam 12614 (target nysgrc-012903) with bound mg, space group p212121
    23% identity, 80% coverage of query (53.5 bits)

C3HPD_ROSAI / A0NXQ8 Cis-3-hydroxy-L-proline dehydratase; c3LHyp dehydratase; c3LHypD; EC 4.2.1.171 from Roseibium aggregatum (strain ATCC 25650 / DSM 13394 / JCM 20685 / NBRC 16684 / NCIMB 2208 / IAM 12614 / B1) (Stappia aggregata) (see paper)
A0NXQ8 cis-L-3-hydroxyproline dehydratase (EC 4.2.1.171) from Roseibium aggregatum (see paper)
    23% identity, 80% coverage of query (53.5 bits)

IMAND_PECCP / C6DI84 D-galactonate dehydratase family member PC1_4063 from Pectobacterium carotovorum subsp. carotovorum (strain PC1) (see paper)
    21% identity, 92% coverage of query (53.1 bits)

IMAND_CATAD / C7PW26 D-galactonate dehydratase family member Caci_4410 from Catenulispora acidiphila (strain DSM 44928 / JCM 14897 / NBRC 102108 / NRRL B-24433 / ID139908) (see paper)
    21% identity, 90% coverage of query (52.4 bits)

3t6cA / D4GJ14 Crystal structure of an enolase from pantoea ananatis (efi target efi- 501676) with bound d-gluconate and mg
    23% identity, 92% coverage of query (52.0 bits)

DGD_PANAM / D4GJ14 D-galactonate dehydratase family member RspA; D-gluconate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.39 from Pantoea ananatis (strain LMG 20103) (see paper)
    23% identity, 92% coverage of query (52.0 bits)

MAND_MARMS / A6VRA1 D-galactonate dehydratase family member Mmwyl1_0037; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.8 from Marinomonas sp. (strain MWYL1) (see paper)
    21% identity, 92% coverage of query (49.7 bits)

IMND2_ENTGE / C9A1P5 D-galactonate dehydratase family member EGBG_02030 from Enterococcus gallinarum (strain EG2) (see paper)
    20% identity, 92% coverage of query (48.5 bits)

GAD_SACS2 / Q97U27 D-gluconate/D-galactonate dehydratase; GAD; GNAD; EC 4.2.1.140; EC 4.2.1.39; EC 4.2.1.6 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
Q97U27 gluconate/galactonate dehydratase (EC 4.2.1.140) from Saccharolobus solfataricus (see paper)
    20% identity, 84% coverage of query (48.1 bits)

3sn4A Crystal structure of putative l-alanine-dl-glutamate epimerase from burkholderia xenovorans strain lb400 bound to magnesium and alpha- ketoglutarate
    24% identity, 71% coverage of query (45.8 bits)

3sn0A / Q13PB7 Crystal structure of putative l-alanine-dl-glutamate epimerase from burkholderia xenovorans strain lb400 bound to magnesium and fumarate
    24% identity, 71% coverage of query (45.8 bits)

4h83F / A4AFX2 Crystal structure of mandelate racemase/muconate lactonizing enzyme (efi target:502127)
    26% identity, 81% coverage of query (45.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory