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Searching for up to 100 curated homologs for H281DRAFT_00597 FitnessBrowser__Burk376:H281DRAFT_00597 (379 a.a.)

Found high-coverage hits (≥70%) to 29 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

dapE / CAA08876.1 DapE from Bordetella pertussis (see paper)
    65% identity, 99% coverage of query (509 bits)

DAPE_NEIMB / Q9JYL2 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Neisseria meningitidis serogroup B (strain MC58) (see paper)
Q9JYL2 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Neisseria meningitidis (see paper)
    62% identity, 99% coverage of query (487 bits)

4o23A / Q9JYL2 Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
    62% identity, 99% coverage of query (487 bits)

4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril
    62% identity, 99% coverage of query (486 bits)

7t1qA / A3M8H2 Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
    61% identity, 96% coverage of query (469 bits)

DAPE_SALTY / Q8ZN75 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; Aspartyl peptidase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    58% identity, 99% coverage of query (447 bits)

7lgpB / P0AED8 Dape enzyme from shigella flexneri
    57% identity, 99% coverage of query (437 bits)

MsgB / b2472 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
dapE / P0AED7 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Escherichia coli (strain K12) (see paper)
DAPE_ECOLI / P0AED7 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Escherichia coli (strain K12) (see paper)
dapE / RF|NP_416967 succinyl-diaminopimelate desuccinylase; EC 3.5.1.18 from Escherichia coli K12 (see 7 papers)
    57% identity, 99% coverage of query (437 bits)

DAPE_VIBCH / Q9KQ52 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Q9KQ52 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Vibrio cholerae (see paper)
    59% identity, 99% coverage of query (432 bits)

5vo3A / P44514 Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
    51% identity, 99% coverage of query (409 bits)

dapE / P44514 N-succinyl-L,L-diaminopimelate desuccinylase subunit (EC 3.5.1.18) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
DAPE_HAEIN / P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 7 papers)
P44514 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Haemophilus influenzae (see 3 papers)
    51% identity, 99% coverage of query (409 bits)

DAPE_HELPY / O25002 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
O25002 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Helicobacter pylori (see paper)
    38% identity, 98% coverage of query (254 bits)

Build an alignment

Build an alignment for H281DRAFT_00597 and 12 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

ArgE / b3957 acetylornithine deacetylase (EC 3.5.1.16) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
argE / P23908 acetylornithine deacetylase (EC 3.5.1.16) from Escherichia coli (strain K12) (see 5 papers)
ARGE_ECOLI / P23908 Acetylornithine deacetylase; AO; Acetylornithinase; N-acetylornithinase; NAO; EC 3.5.1.16 from Escherichia coli (strain K12) (see 2 papers)
    26% identity, 93% coverage of query (84.0 bits)

7uoiA / A0A1S8KJG1 Crystallographic structure of dape from enterococcus faecium
    24% identity, 99% coverage of query (83.6 bits)

7rsfA / P23908 Acetylornithine deacetylase from escherichia coli
    26% identity, 93% coverage of query (82.4 bits)

P9WHS9 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Mycobacterium tuberculosis (see 2 papers)
    30% identity, 91% coverage of query (79.0 bits)

Q92Y75 acetylornithine deacetylase (EC 3.5.1.16) from Sinorhizobium meliloti (see paper)
    29% identity, 77% coverage of query (77.4 bits)

DAPE_MYCS2 / A0R2G4 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    26% identity, 98% coverage of query (73.9 bits)

argE / CAB95019.1 acetylornithinase (n2-acetyl-l-ornithine amidohydrolase) from Moritella abyssi (see paper)
    25% identity, 92% coverage of query (72.8 bits)

P20D1_HUMAN / Q6GTS8 N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Peptidase M20 domain-containing protein 1; EC 3.5.1.114; EC 3.5.1.14 from Homo sapiens (Human) (see 2 papers)
    24% identity, 91% coverage of query (67.4 bits)

YgeY / b2872 putative peptidase YgeY from Escherichia coli K-12 substr. MG1655 (see 3 papers)
    23% identity, 71% coverage of query (67.0 bits)

Echvi_3851 N-succinylcitrulline desuccinylase (EC 3.5.1.-) from Echinicola vietnamensis KMM 6221, DSM 17526
    23% identity, 77% coverage of query (62.0 bits)

ACY1 / Q03154 aminoacylase 1 monomer (EC 3.5.1.14) from Homo sapiens (see 7 papers)
ACY1_HUMAN / Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 5 papers)
Q03154 N-acyl-aliphatic-L-amino acid amidohydrolase (EC 3.5.1.14) from Homo sapiens (see 4 papers)
    24% identity, 82% coverage of query (59.7 bits)

Q59284 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Corynebacterium glutamicum (see paper)
    24% identity, 85% coverage of query (54.3 bits)

2pokA / A0A0H2UN21 Crystal structure of a m20 family metallo peptidase from streptococcus pneumoniae
    22% identity, 82% coverage of query (53.9 bits)

lysK / Q4JAP7 [amino group carrier protein]-lysine/ornithine hydrolase (EC 3.5.1.130; EC 3.5.1.132) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
    24% identity, 83% coverage of query (53.1 bits)

P37111 N-acyl-aliphatic-L-amino acid amidohydrolase (EC 3.5.1.14) from Sus scrofa (see 6 papers)
    22% identity, 81% coverage of query (53.1 bits)

P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig)
    22% identity, 81% coverage of query (53.1 bits)

ACY1B_RAT / Q6PTT0 Aminoacylase-1B; ACY-1B; ACY IB; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Rattus norvegicus (Rat) (see paper)
    22% identity, 82% coverage of query (52.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory