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Searching for up to 100 curated homologs for H281DRAFT_00642 FitnessBrowser__Burk376:H281DRAFT_00642 (448 a.a.)

Found high-coverage hits (≥70%) to 27 curated proteins.

Removed hits that are identical to the query, leaving 26

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

BPHYT_RS04765 2-deoxy-D-ribonate transporter from Burkholderia phytofirmans PsJN
    71% identity, 97% coverage of query (607 bits)

PS417_07265 2-deoxy-D-ribonate transporter 1 from Pseudomonas simiae WCS417
    43% identity, 94% coverage of query (302 bits)

ABAQ_ACIBT / P0DPR4 Quinolone resistance transporter from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see 2 papers)
    36% identity, 94% coverage of query (270 bits)

BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
    38% identity, 94% coverage of query (258 bits)

YfaV / b2246 putative transporter YfaV from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TC 2.A.1.14.35 / P76470 Inner membrane transport protein RhmT from Escherichia coli (strain K12) (see 4 papers)
    36% identity, 93% coverage of query (239 bits)

NICT_PSEPK / Q88FY6 Putative metabolite transport protein NicT; Nicotinate degradation protein T from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    35% identity, 91% coverage of query (229 bits)

TC 2.A.1.14.8 / Q9RPP3 Phthalate porter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
    34% identity, 93% coverage of query (226 bits)

Build an alignment

Build an alignment for H281DRAFT_00642 and 7 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

CH_124128 MFS transporter from Magnaporthe grisea 70-15 (see paper)
    25% identity, 91% coverage of query (144 bits)

CH_124317 phthalate transporter from Magnaporthe grisea 70-15 (see paper)
    29% identity, 88% coverage of query (141 bits)

YHDC_SCHPO / Q9P6J0 Uncharacterized transporter C1683.12 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    27% identity, 72% coverage of query (132 bits)

CH_124318 MFS transporter from Magnaporthe grisea 70-15 (see 2 papers)
    25% identity, 88% coverage of query (129 bits)

CH_124204 putative monocarboxylate exporter from Magnaporthe grisea 70-15 (see paper)
    25% identity, 84% coverage of query (104 bits)

VHT1_SCHPO / O13880 Vitamin H transporter 1; H(+)/biotin symporter vht1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
TC 2.A.1.14.19 / O13880 Plasma membrane, high affinity vitamin H transporter 1 (H+:biotin symporter), Vht1 (Stolz, 2003) from Schizosaccharomyces pombe (Fission yeast) (see 2 papers)
vht1 / GB|AAO22560.1 vitamin H transporter 1 from Schizosaccharomyces pombe (see 3 papers)
    27% identity, 87% coverage of query (100 bits)

CH_124316 allantoate permease from Magnaporthe grisea 70-15 (see paper)
    25% identity, 92% coverage of query (99.8 bits)

YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
    27% identity, 79% coverage of query (90.9 bits)

6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
    27% identity, 79% coverage of query (90.9 bits)

YC7A_SCHPO / O94491 Uncharacterized transporter C417.10 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    24% identity, 88% coverage of query (89.7 bits)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
    28% identity, 79% coverage of query (83.2 bits)

AO356_28540 D-mannose transporter from Pseudomonas fluorescens FW300-N2C3
    26% identity, 92% coverage of query (81.3 bits)

HSERO_RS23010 D-galacturonate transporter ExuT from Herbaspirillum seropedicae SmR1
    24% identity, 85% coverage of query (75.9 bits)

TC 2.A.1.14.11 / P53322 Plasma membrane, high affinity nicotinate permease, Tna1 from Saccharomyces cerevisiae (Baker's yeast) (see 5 papers)
TNA1 / RF|NP_011776.1 high-affinity nicotinic acid transporter from Saccharomyces cerevisiae
    24% identity, 71% coverage of query (71.2 bits)

P53322 High-affinity nicotinic acid transporter; Nicotinic acid permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    24% identity, 71% coverage of query (71.2 bits)

TC 2.A.1.14.14 / Q8FDB7 Probable D-galactarate (glucarate?):H+ symporter, GarP or YhaU from Escherichia coli O6 (see paper)
    25% identity, 78% coverage of query (70.1 bits)

GarP / b3127 galactarate/D-glucarate transporter GarP from Escherichia coli K-12 substr. MG1655 (see 6 papers)
garP / P0AA80 galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 5 papers)
GARP_ECOLI / P0AA80 Probable galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 2 papers)
    25% identity, 78% coverage of query (70.1 bits)

S17A5_HUMAN / Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 10 papers)
TC 2.A.1.14.10 / Q9NRA2 Lysosomal sialate transporter (Salla disease and infantile sialate storage disease protein (Morin et al., 2004)). Also transports glucuronic acid and aspartate. Structure-function studies have identify crucial residues and substrate-induced conformational changes (Courville et al., 2010). Also called SLC17A5. The substrate binding pocket has been identified based on modeling studies (see 8 papers)
    22% identity, 77% coverage of query (55.8 bits)

S17A5_RAT / Q5Q0U0 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 (Anion/sugar transporter), member 5; Vesicular excitatory amino acid transporter; VEAT from Rattus norvegicus (Rat) (see 2 papers)
    21% identity, 75% coverage of query (45.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory