Searching for up to 100 curated homologs for H281DRAFT_00987 FitnessBrowser__Burk376:H281DRAFT_00987 (429 a.a.)
Found high-coverage hits (≥70%) to 18 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PROV_SALTY / P17328 Glycine betaine/proline betaine transport system ATP-binding protein ProV from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
52% identity, 91% coverage of query (383 bits)
A0A077T7Z1 ABC-type quaternary amine transporter (subunit 1/3) (EC 7.6.2.9) from Vibrio anguillarum serotype O1 (see paper)
50% identity, 91% coverage of query (379 bits)
ProU / b2677 glycine betaine ABC transporter ATP binding subunit ProV (EC 7.6.2.9) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
proV / P14175 glycine betaine ABC transporter ATP binding subunit ProV (EC 7.6.2.9) from Escherichia coli (strain K12) (see 6 papers)
PROV_ECOLI / P14175 Glycine betaine/proline betaine transport system ATP-binding protein ProV from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.12.1 / P14175 ProV aka B2677, component of Glycine betaine/proline porter, ProU or ProVWX (also transports proline betaine, carnitine, dimethyl proline, homobetaine, γ-butyrobetaine and choline with low affinity) from Escherichia coli (see 6 papers)
proV / GB|AAC75724.1 glycine betaine/l-proline transport atp-binding protein prov from Escherichia coli K12 (see 6 papers)
52% identity, 90% coverage of query (379 bits)
OUSV_DICD3 / E0SCY1 Glycine betaine/choline transport system ATP-binding protein OusV from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see paper)
50% identity, 91% coverage of query (364 bits)
TC 3.A.1.12.9 / Q8U4S5 OtaA, component of The salt-induced glycine betaine OtaABC transporter from Methanosarcina mazei (see 2 papers)
48% identity, 88% coverage of query (354 bits)
GBUA_LISM4 / Q9RR46 Glycine betaine/carnitine transport ATP-binding protein GbuA; EC 7.6.2.9 from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
45% identity, 89% coverage of query (329 bits)
OPUAA_BACSU / P46920 Glycine betaine transport ATP-binding protein OpuAA; Quaternary-amine-transporting ATPase; EC 7.6.2.9 from Bacillus subtilis (strain 168) (see 2 papers)
P46920 ABC-type quaternary amine transporter (EC 7.6.2.9) from Bacillus subtilis (see paper)
TC 3.A.1.12.2 / P46920 OPAA aka OpuAA, component of Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate) from Bacillus subtilis (see 4 papers)
43% identity, 93% coverage of query (327 bits)
TC 3.A.1.12.5 / Q9RQ06 BusAA, component of Uptake system for glycine-betaine (high affinity) and proline (low affinity) (OpuAA-OpuABC) or BusAA-ABC of Lactococcus lactis). BusAA, the ATPase subunit, has a C-terminal tandem cystathionine β-synthase (CBS) domain which is the cytoplasmic K+ sensor for osmotic stress (osmotic strength)while the BusABC subunit has the membrane and receptor domains fused to each other (Biemans-Oldehinkel et al., 2006; Mahmood et al., 2006; Gul et al. 2012). An N-terminal amphipathic α-helix of OpuA is necessary for high activity but is not critical for biogenesis or the ionic regulation of transport from Lactococcus lactis (see paper)
45% identity, 87% coverage of query (323 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
43% identity, 90% coverage of query (311 bits)
7ahhC Opua inhibited inward-facing, sbd docked
43% identity, 90% coverage of query (311 bits)
TMOW_PELUB / Q4FL37 Trimethylamine N-oxide transport system ATP-binding protein TmoW; TMAO transport system ATP-binding protein TmoW; EC 7.6.2.9 from Pelagibacter ubique (strain HTCC1062) (see paper)
44% identity, 77% coverage of query (271 bits)
TC 3.A.1.12.7 / Q92N35 ChoV, component of High affinity (3 μM) choline-specific uptake system from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
46% identity, 71% coverage of query (251 bits)
OPUCA_BACSU / O34992 Glycine betaine/carnitine/choline transport ATP-binding protein OpuCA from Bacillus subtilis (strain 168) (see 4 papers)
TC 3.A.1.12.4 / O34992 OPCA aka OpuCA, component of Uptake system for choline, L-carnitine, D-carnitine, glycine betaine, proline betaine, crotonobetaine, γ-butyrobetaine, dimethylsulfonioacetate, dimethylsulfoniopropionate, ectoine and choline-O-sulfate from Bacillus subtilis (see 2 papers)
35% identity, 80% coverage of query (203 bits)
OPUBA_BACSU / Q45460 Choline transport ATP-binding protein OpuBA from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.12.3 / Q45460 OPBA aka OpuBA aka PROV, component of Choline porter from Bacillus subtilis (see 3 papers)
35% identity, 80% coverage of query (194 bits)
OPUCA_LISM4 / G2JZ44 Carnitine transport ATP-binding protein OpuCA; EC 7.6.2.9 from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
OPUCA_LISMN / Q9KHT9 Carnitine transport ATP-binding protein OpuCA; EC 7.6.2.9 from Listeria monocytogenes (see paper)
34% identity, 80% coverage of query (192 bits)
Build an alignment for H281DRAFT_00987 and 15 homologs with ≥ 30% identity
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8f5bA / P78363 Human abca4 structure in complex with amp-pnp
28% identity, 72% coverage of query (96.7 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
25% identity, 70% coverage of query (85.9 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
25% identity, 70% coverage of query (85.9 bits)
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Lawrence Berkeley National Laboratory