Searching for up to 100 curated homologs for H281DRAFT_01595 FitnessBrowser__Burk376:H281DRAFT_01595 (459 a.a.)
Found high-coverage hits (≥70%) to 56 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
RR42_RS32055 3-carboxymuconate cycloisomerase PcaB (EC 5.5.1.2) from Cupriavidus basilensis FW507-4G11
62% identity, 93% coverage of query (457 bits)
pcaB / AAC37149.1 beta-carboxy-cis,cis-muconate cycloisomerase from Acinetobacter baylyi (see 11 papers)
47% identity, 96% coverage of query (395 bits)
YBN5_SCHPO / O42889 Uncharacterized protein C8E4.05c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
41% identity, 95% coverage of query (346 bits)
pcaB2 / Q2HNY9 3-carboxymuconate lactonizing enzyme type 2 (EC 5.5.1.2) from Hydrogenophaga intermedia (see 2 papers)
42% identity, 97% coverage of query (314 bits)
TAD1 / A0A0U2UYC4 trans-aconitate decarboxylase (EC 4.1.1.113) from Ustilago maydis (see paper)
TAD1_USTMD / A0A0U2UYC4 Trans-aconitate decarboxylase 1; Itaconic acid/2-hydroxyparaconate biosynthesis cluster protein TAD1; EC 4.1.1.113 from Ustilago maydis (Corn smut fungus) (see 2 papers)
A0A0U2UYC4 trans-aconitate decarboxylase (EC 4.1.1.113) from Ustilago maydis (see paper)
39% identity, 97% coverage of query (313 bits)
2SL_DICD3 / E0SKP1 N-acetyl-S-(2-succino)cysteine lyase; S-(2-succino) lyase; 2SL; EC 4.3.2.- from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see paper)
39% identity, 95% coverage of query (307 bits)
CREDH_STRDJ / K4R6W4 Nitrosuccinate lyase; EC 4.3.99.5 from Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768) (see paper)
43% identity, 96% coverage of query (287 bits)
2SL_ENTI1 / E6LDH5 N-acetyl-S-(2-succino)cysteine lyase; S-(2-succino) lyase; 2SL; EC 4.3.2.- from Enterococcus italicus (strain DSM 15952 / CCUG 50447 / LMG 22039 / TP 1.5) (see paper)
37% identity, 94% coverage of query (284 bits)
creD / A0A0K2JL82 nitrosuccinate lyase (EC 4.3.99.5) from Streptomyces cremeus (see paper)
CRED_STRCM / A0A0K2JL82 Nitrosuccinate lyase; EC 4.3.99.5 from Streptomyces cremeus (see 3 papers)
A0A0K2JL82 nitrosuccinate lyase (EC 4.3.99.5) from Streptomyces cremeus (see paper)
43% identity, 97% coverage of query (264 bits)
5xnzA / A0A0K2JL82 Crystal structure of cred complex with fumarate (see paper)
42% identity, 97% coverage of query (252 bits)
MJ0929 / Q58339 adenylosuccinate lyase (EC 4.3.2.2) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
32% identity, 94% coverage of query (212 bits)
Q2HNZ1 3-Carboxy-cis,cis-muconate cycloisomerase (EC 5.5.1.2) from Agrobacterium tumefaciens (see paper)
35% identity, 77% coverage of query (181 bits)
pcaB / AAF34266.1 3-carboxy-cis,cis-muconate cycloisomerase from Agrobacterium tumefaciens (see 2 papers)
36% identity, 77% coverage of query (179 bits)
Build an alignment for H281DRAFT_01595 and 13 homologs with ≥ 30% identity
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PUR8_THEMA / Q9X0I0 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
27% identity, 92% coverage of query (176 bits)
PUR8_STAAW / Q7A0G9 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Staphylococcus aureus (strain MW2) (see paper)
Q7A0G9 adenylosuccinate lyase (EC 4.3.2.2) from Staphylococcus aureus (see paper)
28% identity, 93% coverage of query (173 bits)
2x75A / Q7A0G9 Staphylococcus aureus adenylosuccinate lyase (see paper)
27% identity, 93% coverage of query (168 bits)
PUR8_BACSU / P12047 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; Glutamyl--tRNA ligase regulatory factor; EC 4.3.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
P12047 adenylosuccinate lyase (EC 4.3.2.2) from Bacillus subtilis (see paper)
purB / GI|143366 (glutamyl-trna synthetase regulatory factor); EC 4.3.2.2 from Bacillus subtilis (see 4 papers)
30% identity, 90% coverage of query (167 bits)
toyF / B6CWI9 succinylo-toyocamycin phosphate lyase from Streptomyces rimosus (see paper)
33% identity, 94% coverage of query (161 bits)
Q8ZY28 adenylosuccinate lyase (EC 4.3.2.2) from Pyrobaculum aerophilum (see paper)
28% identity, 79% coverage of query (111 bits)
ADE13 enzyme of adenine biosynthesis from Candida albicans (see paper)
27% identity, 73% coverage of query (81.6 bits)
ade13 / Q05911 Ade13 (EC 4.3.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
25% identity, 74% coverage of query (76.3 bits)
Q05911 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
25% identity, 74% coverage of query (76.3 bits)
B2LS18 adenylosuccinate lyase (EC 4.3.2.2) from Ctenopharyngodon idella (see paper)
27% identity, 74% coverage of query (75.5 bits)
5eytA / G4VQX9 Crystal structure of adenylosuccinate lyase from schistosoma mansoni in complex with amp (see paper)
26% identity, 76% coverage of query (75.1 bits)
D3ZW08 adenylosuccinate lyase (EC 4.3.2.2) from Rattus norvegicus (see paper)
25% identity, 74% coverage of query (73.9 bits)
5nx9D / A0A384E0N4 Crystal structure of neanderthal adenylosuccinate lyase (adsl) in complex with its products amp and fumarate (see paper)
25% identity, 76% coverage of query (73.9 bits)
PUR8_CHICK / P21265 Adenylosuccinate lyase; ADSL; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Gallus gallus (Chicken) (see paper)
26% identity, 74% coverage of query (73.6 bits)
ADSL / P30566 adenylosuccinate lyase (EC 4.3.2.2) from Homo sapiens (see 3 papers)
PUR8_HUMAN / P30566 Adenylosuccinate lyase; ADSL; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Homo sapiens (Human) (see 14 papers)
P30566 adenylosuccinate lyase (EC 4.3.2.2) from Homo sapiens (see 5 papers)
25% identity, 76% coverage of query (72.4 bits)
5vkwB / A0A1D8PT56 Crystal structure of adenylosuccinate lyase ade13 from candida albicans
26% identity, 73% coverage of query (70.1 bits)
5nxaB Crystal structure of neanderthal adenylosuccinate lyase (adsl)in complex with its products aicar and fumarate
25% identity, 74% coverage of query (69.3 bits)
PUR8_VIBC3 / A0A0H3AL67 Adenylosuccinate lyase; ASL; Adenylosuccinase; EC 4.3.2.2 from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) (see paper)
26% identity, 74% coverage of query (68.2 bits)
Q8NRN8 fumarate hydratase (EC 4.2.1.2) from Corynebacterium glutamicum (see 2 papers)
25% identity, 81% coverage of query (63.2 bits)
FUMH_RAT / P14408 Fumarate hydratase, mitochondrial; Fumarase; EC 4.2.1.2 from Rattus norvegicus (Rat) (see paper)
P14408 fumarate hydratase (EC 4.2.1.2) from Rattus norvegicus (see paper)
26% identity, 73% coverage of query (62.4 bits)
FUMH_PIG / P10173 Fumarate hydratase, mitochondrial; Fumarase; EC 4.2.1.2 from Sus scrofa (Pig) (see paper)
26% identity, 73% coverage of query (58.9 bits)
7lubB / P07954 Crystal structure of recombinant human fumarase in complex with d-2- amino-3-phosphono-propionic acid (see paper)
26% identity, 73% coverage of query (58.2 bits)
FH / P07954 fumarate hydratase monomer (EC 4.2.1.2) from Homo sapiens (see 7 papers)
FUMH_HUMAN / P07954 Fumarate hydratase, mitochondrial; Fumarase; HsFH; EC 4.2.1.2 from Homo sapiens (Human) (see 10 papers)
P07954 fumarate hydratase (EC 4.2.1.2) from Homo sapiens (see 3 papers)
26% identity, 73% coverage of query (57.8 bits)
6g3iA Crystal structure of edds lyase in complex with n-(2-aminoethyl) aspartic acid (aeaa)
27% identity, 72% coverage of query (57.8 bits)
6g3hA Crystal structure of edds lyase in complex with ss-edds
27% identity, 72% coverage of query (57.4 bits)
6g3gA Crystal structure of edds lyase in complex with succinate
27% identity, 72% coverage of query (57.4 bits)
6g3fA / Q11KV9 Crystal structure of edds lyase in complex with fumarate (see paper)
27% identity, 72% coverage of query (57.4 bits)
ARLY1_CHICK / P02521 Delta-1 crystallin; Delta crystallin I from Gallus gallus (Chicken) (see 2 papers)
25% identity, 76% coverage of query (56.2 bits)
3oceA / Q2YLW1 Crystal structure of fumarate lyase:delta crystallin from brucella melitensis bound to cobalt
27% identity, 71% coverage of query (55.5 bits)
4adlA Crystal structures of rv1098c in complex with malate
27% identity, 80% coverage of query (55.5 bits)
5nxaA Crystal structure of neanderthal adenylosuccinate lyase (adsl)in complex with its products aicar and fumarate
24% identity, 76% coverage of query (55.1 bits)
FUMC_MYCTU / P9WN93 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WN93 fumarate hydratase (EC 4.2.1.2) from Mycobacterium tuberculosis (see paper)
27% identity, 80% coverage of query (55.1 bits)
4apbD / P9WN93 Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318c in complex with fumarate (see paper)
26% identity, 80% coverage of query (53.5 bits)
FUMC_RICPR / Q9ZCQ4 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Rickettsia prowazekii (strain Madrid E) (see paper)
Q9ZCQ4 fumarate hydratase (EC 4.2.1.2) from Rickettsia prowazekii (see paper)
27% identity, 73% coverage of query (52.8 bits)
5nx9C / A0A384E0N4 Crystal structure of neanderthal adenylosuccinate lyase (adsl) in complex with its products amp and fumarate (see paper)
23% identity, 76% coverage of query (48.5 bits)
6s88A Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(2-methoxy-5-((1,2,4,5-tetrahydro- 3h-benzo[d]azepin-3-yl)sulfonyl)phenyl)-2-(4-oxo-3,4- dihydrophthalazin-1-yl)acetamide
26% identity, 80% coverage of query (44.7 bits)
6s7wA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azepan-1-ylsulfonyl)-2- methoxyphenyl)-2-(quinolin-4-yl)acetamide
26% identity, 80% coverage of query (44.7 bits)
6s7sA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(2-methoxy-5-(n-phenylsulfamoyl) phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
26% identity, 80% coverage of query (44.7 bits)
5f91A Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator (n-(5-(azepan-1-ylsulfonyl)-2- methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide)
26% identity, 80% coverage of query (43.9 bits)
6s7uA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azepan-1-ylsulfonyl)-2- methoxyphenyl)-2-(1h-indol-3-yl)acetamide
26% identity, 80% coverage of query (43.9 bits)
6s7kA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(2-methoxy-5-(n-methylsulfamoyl) phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
26% identity, 80% coverage of query (43.9 bits)
6s43A Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azocan-1-ylsulfonyl)-2- methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
26% identity, 80% coverage of query (43.9 bits)
6s7zA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-((3,4-dihydroisoquinolin-2(1h)- yl)sulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl) acetamide
26% identity, 80% coverage of query (43.5 bits)
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Lawrence Berkeley National Laboratory