Searching for up to 100 curated homologs for H281DRAFT_01666 FitnessBrowser__Burk376:H281DRAFT_01666 (351 a.a.)
Found high-coverage hits (≥70%) to 40 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
todH / P51018 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
83% identity, 97% coverage of query (576 bits)
todH / AAA61944.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see paper)
82% identity, 97% coverage of query (572 bits)
carE / BAC41556.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas resinovorans (see 9 papers)
84% identity, 95% coverage of query (566 bits)
HOA_PSESP / Q9KWS0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp. (see paper)
79% identity, 95% coverage of query (560 bits)
MhpE / b0352 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
mhpE / P51020 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli (strain K12) (see 3 papers)
HOA_ECOLI / P51020 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Escherichia coli (strain K12) (see 2 papers)
mhpE / GB|BAA13057.1 4-hydroxy-2-oxovalerate aldolase; EC 4.1.3.39 from Escherichia coli K12 (see 4 papers)
85% identity, 94% coverage of query (557 bits)
xylK / P51019 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (see 5 papers)
82% identity, 95% coverage of query (556 bits)
dmpG / P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (strain CF600) (see paper)
HOA_PSEUF / P51016 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp. (strain CF600) (see 3 papers)
P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (see paper)
dmpG / CAA43227.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas sp. CF600 (see paper)
80% identity, 97% coverage of query (548 bits)
cmtG / Q51983 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
cmtG / AAB62295.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see 3 papers)
77% identity, 95% coverage of query (546 bits)
1nvmA / P51016 Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate (see paper)
80% identity, 96% coverage of query (545 bits)
P51017 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (see paper)
nahM / AAA89107.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see paper)
55% identity, 94% coverage of query (389 bits)
nahM / BAE92172.1 4-hydroxy-2-oxovalerate aldolase NahM from Pseudomonas putida (see 2 papers)
55% identity, 94% coverage of query (387 bits)
HOA4_PARXL / P51015 4-hydroxy-2-oxovalerate aldolase 4; HOA 4; 4-hydroxy-2-keto-pentanoic acid aldolase 4; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase 4; EC 4.1.3.39; EC 4.1.3.43 from Paraburkholderia xenovorans (strain LB400) (see 3 papers)
P51015 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39); 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Paraburkholderia xenovorans LB400 (see 2 papers)
bphI / GB|ABE37049.1 4-hydroxy-2-oxovalerate aldolase; EC 4.1.3.39 from Burkholderia xenovorans LB400 (see paper)
56% identity, 94% coverage of query (372 bits)
bphI / CAA54036.1 4-hydroxy-2-oxovalerate aldolase from Paraburkholderia xenovorans LB400 (see paper)
55% identity, 94% coverage of query (370 bits)
tesG / Q83VZ3 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Comamonas testosteroni (see 2 papers)
54% identity, 96% coverage of query (369 bits)
hsaF / Q0S815 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Rhodococcus jostii (strain RHA1) (see paper)
52% identity, 93% coverage of query (346 bits)
4lrsA / D1A3K8 Crystal and solution structures of the bifunctional enzyme (aldolase/aldehyde dehydrogenase) from thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and coa accommodation whithin the shared cofactor-binding site
53% identity, 94% coverage of query (344 bits)
HOA_THET8 / Q53WI0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39; EC 4.1.3.43 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
Q53WI0 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Thermus thermophilus (see paper)
52% identity, 95% coverage of query (342 bits)
4jn6C / P9WMK5 Crystal structure of the aldolase-dehydrogenase complex from mycobacterium tuberculosis hrv37 (see paper)
51% identity, 93% coverage of query (332 bits)
hsaF / P9WMK5 4-hydroxy-2-oxohexanoate aldolase monomer (EC 4.1.3.43) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
HOA_MYCTU / P9WMK5 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; 4-hydroxy-2-oxovalerate aldolase; HOA; EC 4.1.3.43; EC 4.1.3.39 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WMK5 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Mycobacterium tuberculosis (see paper)
51% identity, 93% coverage of query (332 bits)
HOA_STRTE / Q9X9Q0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Streptomyces tendae (see paper)
42% identity, 94% coverage of query (230 bits)
OAADC_MYCTU / O06334 Oxaloacetate decarboxylase; OAA decarboxylase; EC 4.1.1.112 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
32% identity, 89% coverage of query (144 bits)
Build an alignment for H281DRAFT_01666 and 21 homologs with ≥ 30% identity
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rhiG / D4HRI4 rhiG aldolase subunit from Bacillus subtilis subsp. spizizenii ATCC 6633 (see paper)
27% identity, 82% coverage of query (105 bits)
nifV / P05342 homocitrate synthase monomer (EC 2.3.3.14) from Azotobacter vinelandii (see paper)
NIFV_AZOVI / P05342 Homocitrate synthase; EC 2.3.3.14 from Azotobacter vinelandii (see paper)
27% identity, 71% coverage of query (59.3 bits)
cimA / Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
CIMA_GEOSL / Q74C76 (R)-citramalate synthase; Citramalate synthase; EC 2.3.3.21 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (see paper)
26% identity, 76% coverage of query (57.8 bits)
P58637 homocitrate synthase (EC 2.3.3.14) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
26% identity, 77% coverage of query (57.4 bits)
A0A0S6UXF5 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. DOA9 (see paper)
27% identity, 72% coverage of query (57.0 bits)
LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis (see 2 papers)
26% identity, 78% coverage of query (55.5 bits)
3rmjB / Q9JZG1 Crystal structure of truncated alpha-isopropylmalate synthase from neisseria meningitidis (see paper)
26% identity, 78% coverage of query (55.1 bits)
HOSA_SULTO / Q971S5 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
25% identity, 72% coverage of query (52.8 bits)
AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
26% identity, 76% coverage of query (51.6 bits)
LEU1_SULAC / Q4JA78 2-isopropylmalate synthase; IPMS; Alpha-isopropylmalate synthase; Alpha-IPM synthase; EC 2.3.3.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
24% identity, 74% coverage of query (50.8 bits)
hcs / O87198 homocitrate synthase (EC 2.3.3.14) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
HOSA_THET2 / O87198 Homocitrate synthase; HCS; EC 2.3.3.14 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
25% identity, 72% coverage of query (50.1 bits)
pmmS / Q9LCB4 2-phosphinomethylmalate synthase monomer (EC 2.3.3.18) from Streptomyces hygroscopicus (see paper)
PMMS_STRHY / Q9LCB4 2-phosphinomethylmalate synthase; PMS; PMM synthase; EC 2.3.3.18 from Streptomyces hygroscopicus (see 2 papers)
Q9LCB4 2-phosphinomethylmalate synthase (EC 2.3.3.18); 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces hygroscopicus (see 4 papers)
25% identity, 72% coverage of query (49.7 bits)
3a9iA / O87198 Crystal structure of homocitrate synthase from thermus thermophilus complexed with lys (see paper)
23% identity, 72% coverage of query (48.9 bits)
Q6A1F6 oxaloacetate decarboxylase (EC 4.1.1.112) from Vibrio cholerae (see paper)
TC 3.B.1.1.6 / Q6A1F6 Oxaloacetate decarboxylase, component of Na+-exporting oxaloacetate decarboxylase with three subunits, OadA (α), OadB (β) and OadG (γ) of 599 aas and 0 TMSs, 433 aas and 11 TMSs, and 90 aas and 1 TMS, respectively from Vibrio cholerae
22% identity, 74% coverage of query (48.5 bits)
2zyfA Crystal structure of homocitrate synthase from thermus thermophilus complexed with magnesuim ion and alpha-ketoglutarate
25% identity, 71% coverage of query (48.5 bits)
2nx9B / Q6A1F6 Crystal structure of the carboxyltransferase domain of the oxaloacetate decarboxylase na+ pump from vibrio cholerae (see paper)
22% identity, 72% coverage of query (47.8 bits)
HMGCL_MOUSE / P38060 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Mus musculus (Mouse) (see paper)
23% identity, 78% coverage of query (47.8 bits)
2ztjA Crystal structure of homocitrate synthase from thermus thermophilus complexed with alpha-ketoglutarate
24% identity, 71% coverage of query (47.4 bits)
PYCB_METJA / Q58628 Pyruvate carboxylase subunit B; Pyruvic carboxylase B; EC 6.4.1.1 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
19% identity, 74% coverage of query (46.6 bits)
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Lawrence Berkeley National Laboratory