Sites on a Tree

 

Searching for up to 100 curated homologs for H281DRAFT_01929 FitnessBrowser__Burk376:H281DRAFT_01929 (171 a.a.)

Found high-coverage hits (≥70%) to 16 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PtsN / b3204 phosphotransferase system enzyme IIA(Ntr) from Escherichia coli K-12 substr. MG1655 (see 22 papers)
ptsN / AAB60165.1 Enzyme IIANtr from Escherichia coli (see 3 papers)
    37% identity, 76% coverage of query (92.4 bits)

Q8DWE6 protein-Npi-phosphohistidine-D-fructose phosphotransferase (subunit 1/2) (EC 2.7.1.202) from Streptococcus mutans serotype c (see paper)
TC 4.A.2.1.8 / Q1LZ68 Constitutive fructose permease aka FruD, component of The constitutive fructose porter FruC/FruD from Streptococcus mutans UA159 (see paper)
    34% identity, 81% coverage of query (77.0 bits)

Build an alignment

Build an alignment for H281DRAFT_01929 and 2 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

TC 4.A.2.1.4 / P71012 The fructose porter, FruA (fructose-1-P forming IIABC) (Delobbe et al. 1975) FruA is 39% identical to 4.A.2.1.1). fructose can be metabolized to Fru-1-P via this system as well as Fru-6-P by another PTS system from Bacillus subtilis (see paper)
    28% identity, 85% coverage of query (76.6 bits)

TC 4.A.2.1.9 / Q1R4S9 Putative phosphotransferase system (PTS), fructose-specific, component of The FrzABC PTS putative transporter (promotes bacterial fitness under stress conditions and promotes fimbrial (fim) gene expression indirectly (Rouquet et al., 2009). Might transport D-tagatose, D-psicose and/or D-sorbose, or a disaccharide of these (Rouquet et al. 2009); involved in environmental sensing, host adaptation and virulence from Escherichia coli (strain UTI89 / UPEC) (see paper)
    28% identity, 85% coverage of query (67.8 bits)

tagM / A0A1Y0YTF1 tagatose-specific PTS enzyme IIA component from Bacillus licheniformis (see 2 papers)
TC 4.A.2.1.23 / T5HNP5 PTS fructose transporter subunit IIA, component of The tagatose-1-P-forming tagatose phosphorylating Enzyme IIA/IIBC, TagM/L (Van der Heiden et al. 2015). The product is phosphorylated by tagatose-1-P kinase (TagK), and then cleaved by tagatose-1,6-bisphosphate aldolase (GatY) from Bacillus licheniformis CG-B52
    27% identity, 77% coverage of query (65.9 bits)

TC 4.A.2.1.20 / Q3K0G6 Chromosomal fructose Enzyme IIABC (Fru1) of 654 aas; in an operon with fructose-1-P kinase from Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
    28% identity, 71% coverage of query (65.9 bits)

FryA / b2383 putative PTS multiphosphoryl transfer protein FryA from Escherichia coli K-12 substr. MG1655 (see 4 papers)
fryA / RF|NP_416884 multiphosphoryl transfer protein 1 from Escherichia coli K12 (see paper)
    30% identity, 82% coverage of query (63.2 bits)

TC 4.A.2.1.5 / C0H3V2 Mannitol-specific phosphotransferase enzyme IIA component, component of The mannitol porter (MtlA) (mannitol-1-P forming), MtlAF from Bacillus subtilis (strain 168)
    29% identity, 84% coverage of query (51.6 bits)

C0H3V2 Mannitol-specific phosphotransferase enzyme IIA component; EIIA; EIII; PTS system mannitol-specific EIIA component from Bacillus subtilis (strain 168)
    29% identity, 84% coverage of query (51.6 bits)

TC 4.A.2.1.12 / Q9KKQ7 The mannitol/glucitol transporter, MtlA (IICBAMtl) from Vibrio cholerae (see paper)
    25% identity, 84% coverage of query (50.1 bits)

LicR / VIMSS279545 LicR regulator of Beta-glucosides utilization, effector HPr, phosphocarrier protein; LicB, lichenan-specific enzyme IIB PTS component (activator) from Oceanobacillus iheyensis HTE831
    25% identity, 93% coverage of query (50.1 bits)

FruB / b2169 fructose-specific PTS multiphosphoryl transfer protein FruB from Escherichia coli K-12 substr. MG1655 (see 4 papers)
FruB / P69811 fructose-specific PTS multiphosphoryl transfer protein FruB from Escherichia coli (strain K12) (see 2 papers)
PTFAH_ECOLI / P69811 Multiphosphoryl transfer protein; MTP; Diphosphoryl transfer protein; DTP; Phosphotransferase FPr protein; Pseudo-HPr from Escherichia coli (strain K12) (see paper)
TC 4.A.2.1.1 / P69811 PTFA aka FRUB aka FRUF aka FPR aka B2169, component of Fructose porter (FruAB) (fructose-1-P forming) from Escherichia coli (see 5 papers)
    28% identity, 81% coverage of query (47.8 bits)

MtlC / b3599 mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
mtlA / P00550 mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198) from Escherichia coli (strain K12) (see 24 papers)
PTM3C_ECOLI / P00550 PTS system mannitol-specific EIICBA component; EIICBA-Mtl; EII-Mtl; EC 2.7.1.197 from Escherichia coli (strain K12) (see 6 papers)
P00550 protein-Npi-phosphohistidine-D-mannitol phosphotransferase (EC 2.7.1.197) from Escherichia coli (see 7 papers)
TC 4.A.2.1.2 / P00550 Mannitol porter (MtlA) (mannitol-1-P forming), the mannitol IICBA complex from Escherichia coli (see 9 papers)
mtlA / GB|AAC76623.1 PTS system mannitol-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69 from Escherichia coli K12 (see 9 papers)
    26% identity, 81% coverage of query (44.7 bits)

MANR_BACSU / O31644 Transcriptional regulator ManR; Mannose operon transcriptional activator; EC 2.7.1.191 from Bacillus subtilis (strain 168) (see 2 papers)
    27% identity, 91% coverage of query (44.3 bits)

Pf1N1B4_1146 fructose-specific PTS system (fructose 1-phosphate forming), EI, Hpr, and EII-A components from Pseudomonas fluorescens FW300-N1B4
    29% identity, 81% coverage of query (44.3 bits)

1j6tA / P00550 Complex of enzyme iiamtl and the histidine-containing phosphocarrier protein hpr from escherichia coli nmr, restrained regularized mean structure (see paper)
    26% identity, 81% coverage of query (42.4 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory