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Searching for up to 100 curated homologs for H281DRAFT_02117 FitnessBrowser__Burk376:H281DRAFT_02117 (427 a.a.)

Found high-coverage hits (≥70%) to 43 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

BPHYT_RS02050 D-mannose isomerase (EC 5.3.1.7) from Burkholderia phytofirmans PsJN
    94% identity, 96% coverage of query (806 bits)

Ac3H11_2078 D-mannose isomerase (EC 5.3.1.7) from Acidovorax sp. GW101-3H11
    57% identity, 93% coverage of query (463 bits)

MANI_MARM1 / F2JVT6 D-mannose isomerase; MI; EC 5.3.1.7 from Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1) (see paper)
    56% identity, 91% coverage of query (439 bits)

Sama_0560 D-mannose isomerase (EC 5.3.1.7) from Shewanella amazonensis SB2B
    50% identity, 91% coverage of query (390 bits)

HSERO_RS03650 Mannose isomerase (EC 5.3.1.7) from Herbaspirillum seropedicae SmR1
    50% identity, 91% coverage of query (356 bits)

MANI_THEFU / A0A077LPS9 D-mannose isomerase; EC 5.3.1.7 from Thermobifida fusca (Thermomonospora fusca)
    35% identity, 77% coverage of query (161 bits)

AO353_03400 D-mannose isomerase (EC 5.3.1.7) from Pseudomonas fluorescens FW300-N2E3
    32% identity, 86% coverage of query (157 bits)

Build an alignment

Build an alignment for H281DRAFT_02117 and 7 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

SQUS_SALTY / Q8ZKT7 Sulfoquinovose isomerase; SQ isomerase; Sulfoquinovose-sulfofructose isomerase; SQ-SF isomerase; EC 5.3.1.31 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
    29% identity, 92% coverage of query (145 bits)

PGA1_c16670 D-mannose isomerase (EC 5.3.1.7) from Phaeobacter inhibens BS107
    31% identity, 89% coverage of query (145 bits)

SquS / b3880 sulfoquinovose isomerase (EC 5.3.1.31; EC 5.3.1.7) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
yihS / P32140 sulfoquinovose isomerase (EC 5.3.1.31; EC 5.3.1.7) from Escherichia coli (strain K12) (see 6 papers)
SQUS_ECOLI / P32140 Sulfoquinovose isomerase; SQ isomerase; Sulfoquinovose-sulfofructose isomerase; SQ-SF isomerase; EC 5.3.1.31 from Escherichia coli (strain K12) (see 3 papers)
yihS / RF|NP_418316 uncharacterized sugar isomerase yihS from Escherichia coli K12 (see paper)
    29% identity, 92% coverage of query (145 bits)

PS417_22150 D-mannose isomerase (EC 5.3.1.7) from Pseudomonas simiae WCS417
    33% identity, 87% coverage of query (144 bits)

7ag4D / Q8ZKT7 Crystal structure of active site mutant of sq isomerase (yihs-h248a) from salmonella enterica in complex with sulfofructose (sf) (see paper)
    29% identity, 92% coverage of query (142 bits)

Pf1N1B4_597 D-mannose isomerase (EC 5.3.1.7) from Pseudomonas fluorescens FW300-N1B4
    33% identity, 83% coverage of query (142 bits)

2zblA Functional annotation of salmonella enterica yihs-encoded protein
    29% identity, 92% coverage of query (142 bits)

MANI_PSEC1 / A0A0P9JFY5 D-mannose isomerase; PsMIaseA; EC 5.3.1.7 from Pseudomonas cannabina pv. alisalensis (strain ATCC BAA-566 / CFBP 6866 / ICMP 15200 / BS91) (see paper)
    32% identity, 79% coverage of query (135 bits)

AO356_05200 D-mannose isomerase (EC 5.3.1.7) from Pseudomonas fluorescens FW300-N2C3
    33% identity, 75% coverage of query (132 bits)

8h1lB / A0A7U4E834 Crystal structure of glucose-2-epimerase in complex with d-glucitol from runella slithyformis runsl_4512 (see paper)
    24% identity, 88% coverage of query (95.9 bits)

3wkgA / F8WRK9 Crystal structure of cellobiose 2-epimerase in complex with glucosylmannose (see paper)
    25% identity, 92% coverage of query (92.8 bits)

CEEP_RHOMR / F8WRK9 Cellobiose 2-epimerase; CE; EC 5.1.3.11 from Rhodothermus marinus (Rhodothermus obamensis) (see paper)
F8WRK9 cellobiose epimerase (EC 5.1.3.11) from Rhodothermus marinus (see 5 papers)
    25% identity, 92% coverage of query (92.8 bits)

3wkhA Crystal structure of cellobiose 2-epimerase in complex with epilactose
    25% identity, 92% coverage of query (92.8 bits)

3wkiA Crystal structure of cellobiose 2-epimerase in complex with cellobiitol
    25% identity, 92% coverage of query (92.8 bits)

A9AYF3 cellobiose epimerase (EC 5.1.3.11) from Herpetosiphon aurantiacus (see paper)
    24% identity, 88% coverage of query (91.3 bits)

Dfer_5652 / C6VWU2 mannose 2-epimerase monomer (EC 5.1.3.44) from Dyadobacter fermentans (strain ATCC 700827 / DSM 18053 / CIP 107007 / KCTC 52180 / NS114) (see paper)
C6VWU2 mannose 2-epimerase (EC 5.1.3.44) from Runella slithyformis (see paper)
    24% identity, 90% coverage of query (90.5 bits)

D0MF61 cellobiose epimerase (EC 5.1.3.11) from Rhodothermus marinus (see paper)
    25% identity, 92% coverage of query (89.7 bits)

Q3M763 N-acylglucosamine 2-epimerase (EC 5.1.3.8) from Trichormus variabilis (see 2 papers)
    25% identity, 88% coverage of query (86.7 bits)

A0A0A1HAT7 cellobiose epimerase (EC 5.1.3.11) from uncultured bacterium (see paper)
    23% identity, 89% coverage of query (75.5 bits)

G0GBL0 cellobiose epimerase (EC 5.1.3.11) from Spirochaeta thermophila (see paper)
    26% identity, 92% coverage of query (75.5 bits)

E0RU15 cellobiose epimerase (EC 5.1.3.11) from Spirochaeta thermophila (see 2 papers)
    28% identity, 80% coverage of query (73.9 bits)

A5FA14 cellobiose epimerase (EC 5.1.3.11) from Flavobacterium johnsoniae (see 2 papers)
    21% identity, 89% coverage of query (70.5 bits)

A7LVG6 N-acylglucosamine 2-epimerase (EC 5.1.3.8) from Bacteroides ovatus (see paper)
    22% identity, 89% coverage of query (70.5 bits)

D2QDA5 cellobiose epimerase (EC 5.1.3.11) from Spirosoma linguale (see paper)
    22% identity, 87% coverage of query (68.2 bits)

SMc03111 mannose 6-phosphate isomerase (EC 5.3.1.8) from Sinorhizobium meliloti 1021
PMI / AAA26356.1 phosphomannose isomerase from Sinorhizobium meliloti (see paper)
    26% identity, 85% coverage of query (66.2 bits)

ce-ne1 / P0DKY4 lactose 2-epimerase (EC 5.1.3.11) from Ruminococcus albus (see 5 papers)
CEEP_RUMAL / P0DKY4 Cellobiose 2-epimerase; CE; EC 5.1.3.11 from Ruminococcus albus (see 2 papers)
P0DKY4 cellobiose epimerase (EC 5.1.3.11) from Ruminococcus albus (see 5 papers)
    21% identity, 86% coverage of query (64.3 bits)

C6VW66 cellobiose epimerase (EC 5.1.3.11) from Dyadobacter fermentans (see 2 papers)
    21% identity, 85% coverage of query (63.5 bits)

CEEP_EUBCE / B3XZI5 Cellobiose 2-epimerase; CE; EC 5.1.3.11 from Eubacterium cellulosolvens (see paper)
B3XZI5 cellobiose epimerase (EC 5.1.3.11) from [Eubacterium] cellulosolvens (see 2 papers)
    24% identity, 90% coverage of query (62.4 bits)

F5ITJ6 cellobiose epimerase (EC 5.1.3.11) from Dysgonomonas gadei (see paper)
    20% identity, 89% coverage of query (59.7 bits)

C6XVU9 cellobiose epimerase (EC 5.1.3.11) from Pedobacter heparinus (see 2 papers)
    23% identity, 84% coverage of query (59.7 bits)

A4XGA6 cellobiose epimerase (EC 5.1.3.11) from Caldicellulosiruptor saccharolyticus (see 7 papers)
    22% identity, 91% coverage of query (58.9 bits)

7d5gA Crystal structure of the csce with ligand to have a insight into the catalytic mechanism
    22% identity, 91% coverage of query (58.5 bits)

8wbuA / A4XGA6 The crystal structure of circular mannose with mutant h247f of the cellobiose 2-epimerase from caldicellulosiruptor saccharolyticus
    22% identity, 91% coverage of query (55.8 bits)

8wbvA The crystal structure of linear mannose with mutant h247f of the cellobiose 2-epimerase from caldicellulosiruptor saccharolyticus
    22% identity, 91% coverage of query (55.8 bits)

bfce / Q5LH66 cellobiose 2-epimerase (EC 5.1.3.11) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) (see 3 papers)
CEEP_BACFN / Q5LH66 Cellobiose 2-epimerase; CE; Mannobiose 2-epimerase; MBE; EC 5.1.3.11 from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) (see 2 papers)
Q5LH66 cellobiose epimerase (EC 5.1.3.11) from Bacteroides fragilis (see 3 papers)
    23% identity, 86% coverage of query (55.1 bits)

R7AVK7 cellobiose epimerase (EC 5.1.3.11) from Firmicutes bacterium (see paper)
    22% identity, 82% coverage of query (50.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory