Sites on a Tree

 

Searching for up to 100 curated homologs for H281DRAFT_02167 FitnessBrowser__Burk376:H281DRAFT_02167 (368 a.a.)

Found high-coverage hits (≥70%) to 11 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

L2HDH_ACHAE / A0A0M7LBC1 L-2-hydroxyglutarate dehydrogenase; EC 1.1.99.2 from Achromobacter aegrifaciens (see paper)
    66% identity, 98% coverage of query (480 bits)

3dmeA / Q7VU70 Crystal structure of conserved exported protein from bordetella pertussis. Northeast structural genomics target ber141
    65% identity, 98% coverage of query (469 bits)

L2HDH_ACCRE / A0A011QK89 L-2-hydroxyglutarate dehydrogenase; EC 1.1.99.2 from Accumulibacter regalis (see paper)
    58% identity, 96% coverage of query (414 bits)

L2HDH_ARATH / Q9LES4 L-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    50% identity, 98% coverage of query (389 bits)

Build an alignment

Build an alignment for H281DRAFT_02167 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

L2HDH_INDAL / S2DJ52 L-2-hydroxyglutarate dehydrogenase; EC 1.1.99.2 from Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1) (see paper)
    29% identity, 91% coverage of query (136 bits)

8w7fB / Q9VJ28 Structure of drosophila melanogaster l-2-hydroxyglutarate dehydrogenase bound with fad and a sulfate ion (see paper)
    30% identity, 94% coverage of query (131 bits)

GLPDH_CALMK / A0A0R3K2G2 Glycerol 3-phosphate dehydrogenase; EC 1.1.99.- from Caloramator mitchellensis (see paper)
    27% identity, 98% coverage of query (131 bits)

8w78A Structure of drosophila melanogaster l-2-hydroxyglutarate dehydrogenase in complex with fad and 2-oxoglutarate
    30% identity, 94% coverage of query (128 bits)

LHGD_SALHO / A0A5Y6MCT2 L-2-hydroxyglutarate dehydrogenase; L2HG dehydrogenase; L2HG:quinone oxidoreductase; EC 1.1.5.13 from Salmonella houtenae (see paper)
    27% identity, 82% coverage of query (112 bits)

lhgO / Q88IT9 (S)-2-hydroxyglutarate oxidase from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
    25% identity, 92% coverage of query (108 bits)

Q70GP9 glycerol-3-phosphate oxidase (EC 1.1.3.21) from Mycoplasma mycoides subsp. mycoides (see paper)
glpO glycerol-3-phosphate oxidase; EC 1.1.3.21 from Mycoplasma mycoides subsp. mycoides SC (see paper)
    26% identity, 96% coverage of query (82.0 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory