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Searching for up to 100 curated homologs for H281DRAFT_03347 FitnessBrowser__Burk376:H281DRAFT_03347 (322 a.a.)

Found high-coverage hits (≥70%) to 44 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HUTGL_PSEAE / Q9HZ59 Formimidoylglutamase; Formiminoglutamase; Formiminoglutamate hydrolase; EC 3.5.3.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    51% identity, 97% coverage of query (272 bits)

BWI76_RS08725 Formiminoglutamase (EC 3.5.3.8) from Klebsiella michiganensis M5al
    41% identity, 99% coverage of query (214 bits)

Build an alignment

Build an alignment for H281DRAFT_03347 and 2 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

4mynA / Q4DSA0 Crystal structure of trypanosoma cruzi formiminoglutamase n114h variant with mn2+2 (see paper)
    29% identity, 90% coverage of query (93.2 bits)

Q4DSA0 formimidoylglutamase (EC 3.5.3.8) from Trypanosoma cruzi (see paper)
    29% identity, 90% coverage of query (90.1 bits)

6dktE / P39138 Crystal structure of arginase from bacillus subtilis
    26% identity, 86% coverage of query (74.7 bits)

HUTG_BACSU / P42068 Formimidoylglutamase; Formiminoglutamase; Formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase; EC 3.5.3.8 from Bacillus subtilis (strain 168) (see paper)
    26% identity, 81% coverage of query (72.4 bits)

3m1rD / P42068 The crystal structure of formimidoylglutamase from bacillus subtilis subsp. Subtilis str. 168
    26% identity, 81% coverage of query (72.4 bits)

speB / P70999 agmatinase (EC 3.5.3.11) from Bacillus subtilis (strain 168) (see paper)
    27% identity, 82% coverage of query (70.5 bits)

gbuA / A0A0A1DPD5 5-guanidino-2-oxopentanoate ureohydrolase (EC 3.5.3.7) from Nocardioides simplex (see paper)
    29% identity, 87% coverage of query (68.6 bits)

AGMAT / Q9BSE5 agmatinase (EC 3.5.3.11) from Homo sapiens (see paper)
GDAH_HUMAN / Q9BSE5 Guanidino acid hydrolase, mitochondrial; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial; EC 3.5.3.-; EC 3.5.3.1; EC 3.5.3.7; EC 3.5.3.17 from Homo sapiens (Human) (see 3 papers)
Q9BSE5 agmatinase (EC 3.5.3.11) from Homo sapiens (see paper)
    25% identity, 86% coverage of query (65.5 bits)

SPEB_METJA / Q57757 Agmatinase; EC 3.5.3.11 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q57757 agmatinase (EC 3.5.3.11) from Methanocaldococcus jannaschii (see paper)
    28% identity, 71% coverage of query (65.1 bits)

3lhlA / Q18A84 Crystal structure of a putative agmatinase from clostridium difficile
    25% identity, 84% coverage of query (64.7 bits)

W5PHZ9 agmatinase (EC 3.5.3.11) from Ovis aries (see 2 papers)
    26% identity, 86% coverage of query (64.3 bits)

3nipB / Q9I6K2 Crystal structure of pseudomonas aeruginosa guanidinopropionase complexed with 1,6-diaminohexane (see paper)
    26% identity, 86% coverage of query (64.3 bits)

GPUA_PSEAE / Q9I6K2 Guanidinopropionase; EC 3.5.3.17 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I6K2 Guanidinopropionase (EC 3.5.3.17) from Pseudomonas aeruginosa (see paper)
    26% identity, 86% coverage of query (63.9 bits)

3niqA Crystal structure of pseudomonas aeruginosa guanidinopropionase
    26% identity, 86% coverage of query (63.9 bits)

gbh / Q8KZT5 guanidinobutyrase subunit (EC 3.5.3.7) from Arthrobacter sp. (strain KUJ 8602) (see paper)
Q8KZT5 D-arginase (EC 3.5.3.10); guanidinobutyrase (EC 3.5.3.7) from Arthrobacter sp. (see paper)
    25% identity, 89% coverage of query (62.0 bits)

3nioA / Q9I3S3 Crystal structure of pseudomonas aeruginosa guanidinobutyrase (see paper)
    26% identity, 82% coverage of query (62.0 bits)

gbuA / Q9I3S3 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
GBUA_PSEAE / Q9I3S3 Guanidinobutyrase; EC 3.5.3.7 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9I3S3 guanidinobutyrase (EC 3.5.3.7) from Pseudomonas aeruginosa (see paper)
    26% identity, 82% coverage of query (61.6 bits)

gbuA / Q88EE2 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
    26% identity, 74% coverage of query (58.9 bits)

gdmH / P73270 Ni2+-dependent guanidine hydrolase monomer from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    22% identity, 85% coverage of query (56.6 bits)

7esrA / P73270 Crystal structure of synechocystis sp pcc6803 guanidinium hydrolase (r32) (see paper)
    22% identity, 85% coverage of query (56.2 bits)

Sama_3201 Formiminoglutamase (EC 3.5.3.8) from Shewanella amazonensis SB2B
    27% identity, 80% coverage of query (55.8 bits)

4dz4B / Q2T3W4 X-ray crystal structure of a hypothetical agmatinase from burkholderia thailandensis (see paper)
    28% identity, 74% coverage of query (55.1 bits)

3pzlB / Q97BB8 The crystal structure of agmatine ureohydrolase of thermoplasma volcanium
    22% identity, 92% coverage of query (55.1 bits)

6vstD / G7JFU5 Arginase from medicago truncatula in complex with ornithine (see paper)
    27% identity, 73% coverage of query (54.3 bits)

ARGI_MEDTR / G7JFU5 Arginase, mitochondrial; Agmatinase ARGAH; Arginine amidohydrolase; MtARGAH; EC 3.5.3.1; EC 3.5.3.11 from Medicago truncatula (Barrel medic) (Medicago tribuloides) (see paper)
    27% identity, 73% coverage of query (54.3 bits)

6vstA Arginase from medicago truncatula in complex with ornithine
    27% identity, 73% coverage of query (54.3 bits)

ARG1 / Q5UNS2 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
Q5UNS2 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
    27% identity, 74% coverage of query (52.8 bits)

ARGI1_ORYSI / B8AU84 Arginase 1, mitochondrial; Arginine amidohydrolase 1; EC 3.5.3.1 from Oryza sativa subsp. indica (Rice) (see paper)
    28% identity, 73% coverage of query (52.4 bits)

A0A146AXJ2 agmatinase (EC 3.5.3.11) from Apostichopus japonicus (see paper)
    23% identity, 87% coverage of query (52.0 bits)

2ef5A / Q5SI78 Crystal structure of the arginase from thermus thermophilus
    25% identity, 74% coverage of query (51.6 bits)

ARG2 / Q5UNS1 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
Q5UNS1 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
    27% identity, 72% coverage of query (51.6 bits)

ARGI2_ARATH / Q9ZPF5 Arginase 2, chloroplastic/mitochondrial; Agmatinase ARGAH2; Arginine amidohydrolase 2; EC 3.5.3.1; EC 3.5.3.11 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    27% identity, 73% coverage of query (50.8 bits)

arginase / P46637 arginase (EC 3.5.3.1) from Arabidopsis thaliana (see paper)
ARGI1_ARATH / P46637 Arginase 1, mitochondrial; Agmatinase ARGAH1; Arginine amidohydrolase 1; AtARGAH1; EC 3.5.3.1; EC 3.5.3.11 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    27% identity, 73% coverage of query (50.8 bits)

6vsuE / P46637 Arginase from arabidopsis thaliana in complex with ornithine (see paper)
    27% identity, 73% coverage of query (50.4 bits)

SpeB / b2937 agmatinase (EC 3.5.3.11) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
speB / P60651 agmatinase (EC 3.5.3.11) from Escherichia coli (strain K12) (see 35 papers)
SPEB_ECOLI / P60651 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Escherichia coli (strain K12) (see 2 papers)
speB / RF|NP_417412 agmatinase; EC 3.5.3.11 from Escherichia coli K12 (see 7 papers)
    25% identity, 77% coverage of query (49.7 bits)

7lbaB / P60651 E. Coli agmatinase (see paper)
    26% identity, 77% coverage of query (49.7 bits)

7lolA The structure of agmatinase from e. Coli at 1.8 a displaying urea and agmatine
    25% identity, 78% coverage of query (49.7 bits)

1wogA / Q9RZ04 Crystal structure of agmatinase reveals structural conservation and inhibition mechanism of the ureohydrolase superfamily (see paper)
    24% identity, 82% coverage of query (48.1 bits)

7loxA The structure of agmatinase from e. Coli at 3.2 a displaying guanidine in the active site
    25% identity, 76% coverage of query (45.8 bits)

4q41A Crystal structure of schistosoma mansoni arginase in complex with l- lysine
    26% identity, 78% coverage of query (45.1 bits)

1gq6B / P0DJQ3 Proclavaminate amidino hydrolase from streptomyces clavuligerus (see paper)
    25% identity, 87% coverage of query (44.3 bits)

pah / P0DJQ3 proclavaminate amidino hydrolase subunit (EC 3.5.3.22) from Streptomyces clavuligerus (see paper)
PAH_STRCL / P0DJQ3 Proclavaminate amidinohydrolase; Proclavaminic acid amidino hydrolase; EC 3.5.3.22 from Streptomyces clavuligerus (see paper)
    25% identity, 87% coverage of query (43.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory