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Searching for up to 100 curated homologs for H281DRAFT_03377 FitnessBrowser__Burk376:H281DRAFT_03377 (352 a.a.)

Found high-coverage hits (≥70%) to 51 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

BPHYT_RS34225 L-fucose dehydrogenase (EC 1.1.1.122) from Burkholderia phytofirmans PsJN
    56% identity, 92% coverage of query (363 bits)

PLD_MICLT / Q76KC2 Pyridoxal 4-dehydrogenase; EC 1.1.1.107 from Microbacterium luteolum (Aureobacterium luteolum) (see paper)
    52% identity, 93% coverage of query (347 bits)

SMc02775 D-arabinose 1-dehydrogenase from Sinorhizobium meliloti 1021
    46% identity, 92% coverage of query (273 bits)

FCDH_PSESP / Q52472 D-threo-aldose 1-dehydrogenase; L-fucose dehydrogenase; EC 1.1.1.122 from Pseudomonas sp.
Q52472 D-threo-aldose 1-dehydrogenase (EC 1.1.1.122) from Pseudomonas sp. (see paper)
    42% identity, 88% coverage of query (228 bits)

Build an alignment

Build an alignment for H281DRAFT_03377 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q6BDJ2 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Spinacia oleracea (see paper)
GDH / BAD32687.1 L-galactose dehydrogenase from Spinacia oleracea (see paper)
    25% identity, 85% coverage of query (115 bits)

7svqA / Q6BDJ2 Crystal structure of l-galactose dehydrogenase from spinacia oleracea in complex with NAD+ (see paper)
    25% identity, 85% coverage of query (115 bits)

LGALDH / O81884 L-galactose dehydrogenase (EC 1.1.1.316) from Arabidopsis thaliana (see paper)
GALDH_ARATH / O81884 L-galactose dehydrogenase; At-GalDH; L-GalDH; EC 1.1.1.316 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
O81884 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Arabidopsis thaliana (see paper)
L-GalDH / CAD10386.1 L-galactose dehydrogenase from Arabidopsis thaliana (see paper)
    26% identity, 87% coverage of query (115 bits)

C0LVA5 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Actinidia eriantha (see paper)
    27% identity, 87% coverage of query (115 bits)

Q84L20 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Malus domestica (see paper)
    27% identity, 86% coverage of query (114 bits)

7eziA / Q2QQV2 Rice l-galactose dehydrogenase (apo form)
    28% identity, 84% coverage of query (114 bits)

7ezlA Rice l-galactose dehydrogenase (holo form)
    28% identity, 84% coverage of query (114 bits)

E9M5S4 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Citrus unshiu (see paper)
    26% identity, 87% coverage of query (106 bits)

lgaA / A6KWY2 L-galactose dehydrogenase from Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154) (see paper)
    24% identity, 89% coverage of query (102 bits)

1pz0A / P46336 Structure of NADPH-dependent family 11 aldo-keto reductase akr11a(holo) (see paper)
    25% identity, 88% coverage of query (85.9 bits)

IOLS_BACSU / P46336 Aldo-keto reductase IolS; AKR11A; Vegetative protein 147; VEG147; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 4 papers)
    25% identity, 88% coverage of query (85.9 bits)

1ynpB / Q9KE47 Aldo-keto reductase akr11c1 from bacillus halodurans (apo form) (see paper)
    26% identity, 91% coverage of query (79.7 bits)

1ynqB Aldo-keto reductase akr11c1 from bacillus halodurans (holo form)
    26% identity, 91% coverage of query (79.7 bits)

1ynpA Aldo-keto reductase akr11c1 from bacillus halodurans (apo form)
    25% identity, 88% coverage of query (73.6 bits)

YdjG / b1771 NADH-dependent methylglyoxal reductase from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ydjG / P77256 NADH-dependent methylglyoxal reductase from Escherichia coli (strain K12) (see 4 papers)
AKRMG_ECOLI / P77256 NADH-specific methylglyoxal reductase; AKR11B2; EC 1.1.1.- from Escherichia coli (strain K12) (see 3 papers)
ydjG / RF|NP_416285 uncharacterized oxidoreductase ydjG from Escherichia coli K12 (see paper)
    25% identity, 86% coverage of query (69.7 bits)

YajO / b0419 1-deoxyxylulose-5-phosphate synthase YajO from Escherichia coli K-12 substr. MG1655 (see 7 papers)
yajO / P77735 1-deoxyxylulose-5-phosphate synthase YajO from Escherichia coli (strain K12) (see 6 papers)
YAJO_ECOLI / P77735 1-deoxyxylulose-5-phosphate synthase YajO; EC 1.1.-.- from Escherichia coli (strain K12) (see 2 papers)
P77735 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) from Escherichia coli (see paper)
    25% identity, 87% coverage of query (65.5 bits)

Q988H5 4-pyridoxic acid dehydrogenase (EC 1.1.99.42); 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase (EC 1.2.1.100) from Mesorhizobium loti (see 2 papers)
    24% identity, 91% coverage of query (63.2 bits)

3n6qD Crystal structure of yghz from e. Coli
    27% identity, 89% coverage of query (62.8 bits)

6ow0B / Q194Q1 Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
    25% identity, 85% coverage of query (61.2 bits)

KCAB_ARATH / O23016 Probable voltage-gated potassium channel subunit beta; K(+) channel subunit beta; Potassium voltage beta 1; KV-beta1; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    24% identity, 85% coverage of query (60.5 bits)

AMT2_ALTAL / Q75ZG2 Aldo-keto reductase AMT2; AM-toxin biosynthesis protein 2; EC 1.1.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
    25% identity, 85% coverage of query (60.5 bits)

4aubB / Q46851 The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
    27% identity, 89% coverage of query (58.5 bits)

mtmW / Q194Q1 mithramycin dehydrogenase from Streptomyces argillaceus (see 2 papers)
    25% identity, 87% coverage of query (58.2 bits)

AFTS1_ALTAL / Q75ZG3 Aldo-keto reductase AFTS1; AF-toxin biosynthesis protein S1; EC 1.1.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
    23% identity, 84% coverage of query (57.8 bits)

YI7E_SCHPO / Q9P7U2 Putative aryl-alcohol dehydrogenase C977.14c; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    24% identity, 89% coverage of query (57.0 bits)

ALKR4_ARATH / Q93ZN2 Probable aldo-keto reductase 4; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    24% identity, 91% coverage of query (57.0 bits)

4exaF / Q9HUH3 Crystal structure of the pa4992, the putative aldo-keto reductase from pseudomona aeruginosa (see paper)
    27% identity, 77% coverage of query (57.0 bits)

6ow0A / Q194Q1 Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
    24% identity, 85% coverage of query (57.0 bits)

YgdS / b2834 putative NADP(H)-dependent aldo-keto reductase Tas from Escherichia coli K-12 substr. MG1655 (see 6 papers)
1lqaA / P0A9T4 Tas protein from escherichia coli in complex with NADPH (see paper)
tas protein Tas from Escherichia coli str. K12 substr. MG1655 (see paper)
    26% identity, 86% coverage of query (56.2 bits)

P0A9T4 Protein tas from Escherichia coli (strain K12)
    26% identity, 86% coverage of query (56.2 bits)

DHGRD_NOVAD / Q2G5J3 6-dehydroglucose reductase; NAD(P)-dependent D-glucose 6-dehydrogenase; EC 1.1.1.432 from Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199)
    26% identity, 85% coverage of query (55.8 bits)

3erpA Structure of idp01002, a putative oxidoreductase from and essential gene of salmonella typhimurium
    24% identity, 85% coverage of query (55.5 bits)

5t79A / Q8ZNA1 X-ray crystal structure of a novel aldo-keto reductases for the biocatalytic conversion of 3-hydroxybutanal to 1,3-butanediol (see paper)
    23% identity, 85% coverage of query (55.1 bits)

VRDA_ASPPA / B9WYE6 Versiconal hemiacetal acetate reductase; VHA reductase; EC 1.1.1.353 from Aspergillus parasiticus (see paper)
B9WYE6 versiconal hemiacetal acetate reductase (EC 1.1.1.353) from Aspergillus parasiticus (see paper)
    23% identity, 88% coverage of query (54.7 bits)

Gpr / b3001 L-glyceraldehyde 3-phosphate reductase from Escherichia coli K-12 substr. MG1655 (see 9 papers)
gpr / Q46851 L-glyceraldehyde 3-phosphate reductase (EC 1.1.1.21) from Escherichia coli (strain K12) (see 7 papers)
GPR_ECOLI / Q46851 L-glyceraldehyde 3-phosphate reductase; GAP reductase; EC 1.1.1.- from Escherichia coli (strain K12) (see 4 papers)
    26% identity, 89% coverage of query (54.7 bits)

4aubE The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate
    26% identity, 88% coverage of query (54.7 bits)

GME68_PESMI / A0A5B8YXI2 Aryl-alcohol dehydrogenase GME11368; Dibenzodioxocinones biosynthesis cluster protein GME11368; EC 1.1.1.- from Pestalotiopsis microspora (see 2 papers)
    23% identity, 88% coverage of query (51.6 bits)

megBIIb / Q9F833 MegBIIb from Micromonospora megalomicea subsp. nigra (see paper)
    25% identity, 84% coverage of query (51.2 bits)

4aubF / Q46851 The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
    26% identity, 89% coverage of query (50.8 bits)

KCAB_SCHPO / O59826 Putative voltage-gated potassium channel subunit beta; K(+) channel subunit beta; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    22% identity, 86% coverage of query (50.1 bits)

STCV_EMENI / Q00727 Norsolorinic acid reductase stcV; Sterigmatocystin biosynthesis cluster protein V; EC 1.1.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 8 papers)
stcV putative sterigmatocystin biosynthesis dehydrogenase stcV; EC 1.1.1.- from Emericella nidulans (see paper)
    25% identity, 87% coverage of query (50.1 bits)

eryBII / A4F7P4 dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-α-D-allose-forming) from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) (see 2 papers)
    26% identity, 85% coverage of query (50.1 bits)

6kiyA Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor epalrestat
    22% identity, 91% coverage of query (48.9 bits)

6kikA / Q9X265 Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor tolrestat (see paper)
    22% identity, 91% coverage of query (48.9 bits)

5danA Crystal structure of a novel aldo keto reductase tm1743 from thermotoga maritima in complex with NADP+
    22% identity, 91% coverage of query (48.9 bits)

AFLE_ASPPU / Q00258 Norsolorinic acid reductase A; Aflatoxin biosynthesis protein E; EC 1.1.1.- from Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) (see 2 papers)
nor / AAC49166.1 norsolorinic acid reductase from Aspergillus parasiticus (see paper)
    24% identity, 84% coverage of query (48.5 bits)

Q8X1V7 aryl-alcohol dehydrogenase (EC 1.1.1.90) from Trametes versicolor (see paper)
    22% identity, 85% coverage of query (47.0 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory