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Searching for up to 100 curated homologs for H281DRAFT_04143 FitnessBrowser__Burk376:H281DRAFT_04143 (416 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

BPHYT_RS16030 Kynureninase (EC 3.7.1.3) from Burkholderia phytofirmans PsJN
    94% identity, 100% coverage of query (799 bits)

kyn / P83788 kynureninase subunit (EC 3.7.1.3) from Pseudomonas fluorescens (see 2 papers)
KYNU_PSEFL / P83788 Kynureninase; L-kynurenine hydrolase; EC 3.7.1.3 from Pseudomonas fluorescens (see paper)
    68% identity, 100% coverage of query (592 bits)

AO353_05935 Kynureninase (EC 3.7.1.3) from Pseudomonas fluorescens FW300-N2E3
    67% identity, 100% coverage of query (587 bits)

PfGW456L13_4288 Kynureninase (EC 3.7.1.3) from Pseudomonas fluorescens GW456-L13
    67% identity, 100% coverage of query (584 bits)

1qz9A / P83788 The three dimensional structure of kynureninase from pseudomonas fluorescens (see paper)
    70% identity, 96% coverage of query (584 bits)

PS417_23650 Kynureninase (EC 3.7.1.3) from Pseudomonas simiae WCS417
    66% identity, 100% coverage of query (577 bits)

RR42_RS15385 Kynureninase (EC 3.7.1.3) from Cupriavidus basilensis FW507-4G11
    68% identity, 99% coverage of query (575 bits)

acmH / D6R244 3-hydroxy-4-methyl-D-kynurenine hydrolase monomer from Streptomyces anulatus (see 4 papers)
    43% identity, 96% coverage of query (301 bits)

sibQ / C0LTN1 kynureninase (EC 3.7.1.3) from Streptosporangium sibiricum (see paper)
    41% identity, 93% coverage of query (276 bits)

B7XB98 kynureninase (EC 3.7.1.3) from Bombyx mori (see paper)
    32% identity, 95% coverage of query (230 bits)

KYNU_YEAST / Q05979 Kynureninase; Biosynthesis of nicotinic acid protein 5; L-kynurenine hydrolase; EC 3.7.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    30% identity, 95% coverage of query (158 bits)

Build an alignment

Build an alignment for H281DRAFT_04143 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

KYNU_MOUSE / Q9CXF0 Kynureninase; L-kynurenine hydrolase; EC 3.7.1.3 from Mus musculus (Mouse) (see paper)
    28% identity, 94% coverage of query (158 bits)

KYNU_CAEEL / Q18026 Kynureninase; Abnormal fluorescence under UV illumination; L-kynurenine hydrolase; EC 3.7.1.3 from Caenorhabditis elegans (see paper)
    28% identity, 95% coverage of query (158 bits)

Kynu / P70712 kynureninase subunit (EC 3.7.1.3) from Rattus norvegicus (see paper)
KYNU_RAT / P70712 Kynureninase; L-kynurenine hydrolase; EC 3.7.1.3 from Rattus norvegicus (Rat) (see paper)
    27% identity, 94% coverage of query (157 bits)

2hzpA / Q16719 Crystal structure of homo sapiens kynureninase (see paper)
    28% identity, 94% coverage of query (154 bits)

3e9kA Crystal structure of homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex
    28% identity, 94% coverage of query (152 bits)

KYNU / Q16719 Kynureninase (EC 3.7.1.3) from Homo sapiens (see 5 papers)
KYNU_HUMAN / Q16719 Kynureninase; L-kynurenine hydrolase; EC 3.7.1.3 from Homo sapiens (Human) (see 6 papers)
Q16719 kynureninase (EC 3.7.1.3) from Homo sapiens (see 4 papers)
    28% identity, 94% coverage of query (150 bits)

cefD / P18549 isopenicillin N epimerase (EC 5.1.1.17) from Streptomyces clavuligerus (see 3 papers)
    24% identity, 84% coverage of query (52.4 bits)

5b87A Crystal structure of a cysteine desulfurase from thermococcus onnurineus na1 in complex with alanine at 2.3 angstrom resolution
    23% identity, 80% coverage of query (48.1 bits)

5b7uA / B6YT87 Apo structure of cysteine desulfurase from thermococcus onnurineus na1 at 1.89a (see paper)
    23% identity, 80% coverage of query (48.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory