Searching for up to 100 curated homologs for H281DRAFT_04144 FitnessBrowser__Burk376:H281DRAFT_04144 (313 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

T23O_CUPMC / Q1LK00 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans) (see 2 papers)
kynA tryptophan 2,3-dioxygenase; EC 1.13.11.11 from Ralstonia metallidurans CH34 (see 2 papers)
    71% identity, 95% coverage of query (444 bits)

RR42_RS15390 Tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Cupriavidus basilensis FW507-4G11
    69% identity, 95% coverage of query (434 bits)

2noxB / Q1LK00 Crystal structure of tryptophan 2,3-dioxygenase from ralstonia metallidurans (see paper)
    73% identity, 86% coverage of query (417 bits)

PS417_23705 Tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Pseudomonas simiae WCS417
    67% identity, 94% coverage of query (412 bits)

PfGW456L13_4292 Tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Pseudomonas fluorescens GW456-L13
    66% identity, 90% coverage of query (406 bits)

AO353_05970 Tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Pseudomonas fluorescens FW300-N2E3
    69% identity, 86% coverage of query (404 bits)

T23O_PSEFL / Q84HF6 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Pseudomonas fluorescens (see paper)
    58% identity, 90% coverage of query (348 bits)

T23O_XANCP / Q8PDA8 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 2 papers)
Q8PDA8 tryptophan 2,3-dioxygenase (EC 1.13.11.11); indoleamine 2,3-dioxygenase (EC 1.13.11.52) from Xanthomonas campestris pv. campestris (see 6 papers)
kynA tryptophan 2,3-dioxygenase; EC 1.13.11.11 from Xanthomonas campestris pv. campestris (see 3 papers)
    51% identity, 84% coverage of query (264 bits)

2nw9A Crystal structure of tryptophan 2,3-dioxygenase (tdo) from xanthomonas campestris in complex with ferrous heme and 6-fluoro-tryptophan. Northeast structural genomics target xcr13
    51% identity, 82% coverage of query (262 bits)

7p46A / Q8PDA8 Crystal structure of xanthomonas campestris tryptophan 2,3-dioxygenase (tdo) (see paper)
    50% identity, 84% coverage of query (261 bits)

1yw0A Crystal structure of the tryptophan 2,3-dioxygenase from xanthomonas campestris. Northeast structural genomics target xcr13.
    47% identity, 82% coverage of query (221 bits)

acmG / D6R243 tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Streptomyces anulatus (see 3 papers)
    41% identity, 96% coverage of query (208 bits)

sibP / C0LTN0 tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Streptosporangium sibiricum (see paper)
    37% identity, 84% coverage of query (173 bits)

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Build an alignment for H281DRAFT_04144 and 13 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

T23O_AEDAE / Q17P71 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Aedes aegypti (Yellowfever mosquito) (Culex aegypti) (see paper)
    29% identity, 94% coverage of query (125 bits)

T23O_DROME / P20351 Tryptophan 2,3-dioxygenase; TDO; Protein vermilion; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Drosophila melanogaster (Fruit fly) (see 2 papers)
P20351 tryptophan 2,3-dioxygenase (EC 1.13.11.11); indoleamine 2,3-dioxygenase (EC 1.13.11.52) from Drosophila melanogaster (see 3 papers)
    30% identity, 95% coverage of query (125 bits)

4hkaA / P20351 Crystal structure of drosophila melanogaster tryptophan 2,3- dioxygenase in complex with heme (see paper)
    31% identity, 82% coverage of query (124 bits)

5ti9C Crystal structure of human tdo in complex with trp and dioxygen, northeast structural genomics consortium target hr6161
    30% identity, 83% coverage of query (109 bits)

T23O_RAT / P21643 Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; EC 1.13.11.11 from Rattus norvegicus (Rat) (see paper)
P21643 tryptophan 2,3-dioxygenase (EC 1.13.11.11); indoleamine 2,3-dioxygenase (EC 1.13.11.52) from Rattus norvegicus (see 2 papers)
    28% identity, 95% coverage of query (108 bits)

6pyzC / P48775 Crystal structure of human tryptophan 2,3-dioxygenase in complex with pf-06840003 in active site (see paper)
    30% identity, 83% coverage of query (106 bits)

A9V766 tryptophan 2,3-dioxygenase (EC 1.13.11.11) from Monosiga brevicollis (see paper)
    33% identity, 79% coverage of query (99.0 bits)

6a4iD / P48775 Crystal structure of human tdo inhibitor complex
    32% identity, 73% coverage of query (98.2 bits)

6a4iB Crystal structure of human tdo inhibitor complex
    30% identity, 83% coverage of query (95.9 bits)

6a4iA Crystal structure of human tdo inhibitor complex
    28% identity, 83% coverage of query (94.0 bits)

8qv7B / P48775 Crystal structure of human tdo with alpha-methyl-l-tryptophan
    29% identity, 72% coverage of query (89.0 bits)

7lu7CCC Tryptophan 2,3-dioxygenase
    29% identity, 72% coverage of query (88.6 bits)

8r5qC Structure of apo tdo with a bound inhibitor
    29% identity, 72% coverage of query (87.8 bits)

swb10 / D2KTX9 β-hydroxy-L-tryptophan 2,3-dioxygenase from Streptomyces sp. SNA15896 (see 2 papers)
    28% identity, 83% coverage of query (86.3 bits)

8r5qA Structure of apo tdo with a bound inhibitor
    28% identity, 72% coverage of query (86.3 bits)

tioF / Q333W0 β-hydroxy-L-tryptophan 2,3-dioxygenase from Micromonospora sp. ML1 (see 2 papers)
    25% identity, 82% coverage of query (85.5 bits)

8r5qB Structure of apo tdo with a bound inhibitor
    28% identity, 72% coverage of query (85.5 bits)

ecm11 / Q0X0B4 β-hydroxy-L-tryptophan 2,3-dioxygenase from Streptomyces lasalocidi (see 2 papers)
    28% identity, 79% coverage of query (72.8 bits)

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