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Searching for up to 100 curated homologs for H281DRAFT_04159 FitnessBrowser__Burk376:H281DRAFT_04159 (440 a.a.)

Found high-coverage hits (≥70%) to 39 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

BPHYT_RS16115 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Burkholderia phytofirmans PsJN
    96% identity, 100% coverage of query (873 bits)

AO356_00025 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    61% identity, 96% coverage of query (547 bits)

mtlE / Q4KC57 polyol ABC-type transporter periplasmic substrate-binding protein from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    60% identity, 100% coverage of query (545 bits)

Pf6N2E2_1963 ABC transporter for D-sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    61% identity, 96% coverage of query (543 bits)

PS417_12715 ABC transporter for D-Mannitol and D-Sorbitol, periplasmic substrate-binding protein from Pseudomonas simiae WCS417
    62% identity, 96% coverage of query (538 bits)

4ryaA / B9JRF8 Crystal structure of abc transporter solute binding protein avi_3567 from agrobacterium vitis s4, target efi-510645, with bound d-mannitol
    61% identity, 94% coverage of query (538 bits)

TC 3.A.1.1.49 / O30491 MtlE, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
    61% identity, 97% coverage of query (538 bits)

MANBP_PSEAE / Q9I1E0 Mannitol-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    60% identity, 94% coverage of query (527 bits)

Ac3H11_2944 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Acidovorax sp. GW101-3H11
    59% identity, 94% coverage of query (507 bits)

TC 3.A.1.1.5 / O30831 SmoE, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
    57% identity, 97% coverage of query (493 bits)

PGA1_c13210 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Phaeobacter inhibens BS107
    57% identity, 99% coverage of query (490 bits)

Build an alignment

Build an alignment for H281DRAFT_04159 and 11 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

5iaiA / B9JM84 Crystal structure of abc transporter solute binding protein arad_9887 from agrobacterium radiobacter k84, target efi-510945 in complex with ribitol
    27% identity, 92% coverage of query (111 bits)

HSERO_RS17000 ABC transporter for D-sorbitol/xylitol, substrate-binding component from Herbaspirillum seropedicae SmR1
    28% identity, 74% coverage of query (105 bits)

1eu8A / Q7LYW7 Structure of trehalose maltose binding protein from thermococcus litoralis (see paper)
    27% identity, 93% coverage of query (103 bits)

TC 3.A.1.1.7 / O51923 MalE aka PF1739, component of Maltose/trehalose porter (see paper)
    27% identity, 93% coverage of query (103 bits)

MALE_THELN / Q7LYW7 Trehalose/maltose-binding protein MalE; TMBP from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 4 papers)
    26% identity, 93% coverage of query (101 bits)

6dtqA / G4XU73 Maltose bound t. Maritima male3 (see paper)
    26% identity, 87% coverage of query (89.4 bits)

TC 3.A.1.1.41 / G4FGN8 Extracellular solute-binding protein family 1, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    26% identity, 87% coverage of query (89.4 bits)

7qhvAAA / A9CEY9 7qhvAAA (see paper)
    24% identity, 92% coverage of query (80.1 bits)

smoF / A9CEY9 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol binding protein from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
SMOF_AGRFC / A9CEY9 Sulfoquinovosyl glycerol-binding protein SmoF; SQGro-binding protein SmoF; SQ monooxygenase cluster protein F from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
    23% identity, 95% coverage of query (79.3 bits)

7ofyA Crystal structure of sq binding protein from agrobacterium tumefaciens in complex with sulfoquinovosyl glycerol (sqgro)
    23% identity, 92% coverage of query (79.0 bits)

7yzsAAA Sulfoquinovosyl binding protein
    24% identity, 88% coverage of query (79.0 bits)

7yzuA Crystal structure of the sulfoquinovosyl binding protein smof complexed with sqme
    24% identity, 88% coverage of query (78.2 bits)

5ci5A / A8F7X5 Crystal structure of an abc transporter solute binding protein from thermotoga lettingae tmo (tlet_1705, target efi-510544) bound with alpha-d-tagatose
    24% identity, 78% coverage of query (75.1 bits)

SM_b21221 ABC transporter for D-Glucosamine, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    23% identity, 87% coverage of query (68.6 bits)

3jzjA / B0B0V1 Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium. (see paper)
    25% identity, 75% coverage of query (67.4 bits)

3k02A Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium.
    25% identity, 75% coverage of query (67.4 bits)

TC 3.A.1.1.16 / P58300 MalE aka PF1938, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus (see paper)
    22% identity, 73% coverage of query (66.2 bits)

1eljA / P58300 The crystal structure of liganded maltodextrin-binding protein from pyrococcus furiosus (see paper)
    22% identity, 73% coverage of query (63.9 bits)

Dshi_0547 ABC transporter for Xylitol, periplasmic substrate-binding component from Dinoroseobacter shibae DFL-12
    25% identity, 74% coverage of query (63.5 bits)

5f7vA / Q8YAE9 Abc substrate-binding protein lmo0181 from listeria monocytogenes in complex with cycloalternan (see paper)
    26% identity, 73% coverage of query (62.0 bits)

YcjN / b1310 putative ABC transporter periplasmic binding protein YcjN from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TC 3.A.1.1.46 / P76042 Putative ABC transporter periplasmic-binding protein YcjN, component of Probable glucoside uptake porter, YcjNOPV from Escherichia coli (strain K12)
    24% identity, 90% coverage of query (60.1 bits)

7v09A / A0A0H3CHG3 Crystal structure of ecl_rs08780, putative sugar transport system periplasmic sugar-binding protein
    24% identity, 86% coverage of query (58.9 bits)

7ehpA Chitin oligosaccharide binding protein (see paper)
    22% identity, 89% coverage of query (57.0 bits)

Pf1N1B4_5112 sucrose ABC transporter, substrate-binding component from Pseudomonas fluorescens FW300-N1B4
    23% identity, 71% coverage of query (52.8 bits)

TC 3.A.1.1.44 / Q7AKP1 Putative maltose-binding protein, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    24% identity, 86% coverage of query (52.0 bits)

TC 3.A.1.1.33 / Q8KN19 Putative sugar transporter sugar-binding protein, component of The N,N'-diacetylchitobiose uptake transporter, DasABC/MsiK (MsiK energizes several ABC transporters (see 3.A.1.1.23)) from Streptomyces sp. 139 (see 2 papers)
    25% identity, 71% coverage of query (51.2 bits)

MSME_STRMU / Q00749 Multiple sugar-binding protein from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
TC 3.A.1.1.28 / Q00749 MsmE aka SMU.878, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides from Streptococcus mutans (see 2 papers)
    24% identity, 76% coverage of query (50.8 bits)

SM_b21103 ABC transporter for L-Fucose, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    24% identity, 84% coverage of query (48.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory