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Searching for up to 100 curated homologs for H281DRAFT_04495 H281DRAFT_04495 3-oxoacid CoA-transferase subunit A (234 a.a.)

Found high-coverage hits (≥70%) to 38 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q63TL3 3-oxoacid CoA-transferase (EC 2.8.3.5) from Burkholderia pseudomallei (see paper)
    89% identity, 100% coverage of query (432 bits)

RR42_RS06555 3-oxoacid CoA-transferase (EC 2.8.3.5), subunit A from Cupriavidus basilensis FW507-4G11
    80% identity, 100% coverage of query (396 bits)

Psest_1078 acetyl-CoA:acetoacetate CoA transferase, A subunit (EC 2.8.3.8) from Pseudomonas stutzeri RCH2
    77% identity, 99% coverage of query (358 bits)

lpsI / AAK53462.1 alpha subunit of putative 3-oxoacid CoA-transferase from Xanthomonas campestris pv. campestris (see 4 papers)
    71% identity, 99% coverage of query (347 bits)

OXCT1 / P55809 succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) from Homo sapiens (see 4 papers)
SCOT1_HUMAN / P55809 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; SCOT; 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s; Succinyl-CoA:3-oxoacid CoA transferase; EC 2.8.3.5 from Homo sapiens (Human) (see 7 papers)
P55809 3-oxoacid CoA-transferase (EC 2.8.3.5) from Homo sapiens (see 3 papers)
    57% identity, 100% coverage of query (288 bits)

SCOT1_RAT / B2GV06 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; SCOT; 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s; Succinyl-CoA:3-oxoacid CoA transferase; EC 2.8.3.5 from Rattus norvegicus (Rat) (see paper)
B2GV06 3-oxoacid CoA-transferase (EC 2.8.3.5) from Rattus norvegicus (see 2 papers)
    57% identity, 99% coverage of query (287 bits)

SCOT1_PIG / Q29551 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; SCOT; 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s; Succinate-coenzyme A transferase; Succinyl-CoA:3-oxoacid CoA transferase; EC 2.8.3.5 from Sus scrofa (Pig) (see 6 papers)
Q29551 3-oxoacid CoA-transferase (EC 2.8.3.5) from Sus scrofa (see 3 papers)
    58% identity, 99% coverage of query (286 bits)

Q9D0K2 3-oxoacid CoA-transferase (EC 2.8.3.5) from Mus musculus (see paper)
    57% identity, 97% coverage of query (286 bits)

1o9lA / Q29551 Succinate:coenzyme-a transferase (pig heart)
    58% identity, 97% coverage of query (285 bits)

3k6mC Dynamic domains of succinyl-coa:3-ketoacid-coenzyme a transferase from pig heart.
    58% identity, 97% coverage of query (285 bits)

3oxoE Succinyl-coa:3-ketoacid coa transferase from pig heart covalently bound to coa
    58% identity, 97% coverage of query (285 bits)

2nrbA / Q29551 C28s mutant of succinyl-coa:3-ketoacid coa transferase from pig heart (see paper)
    58% identity, 97% coverage of query (281 bits)

Sama_1357 3-oxoacid CoA-transferase (EC 2.8.3.5), subunit A from Shewanella amazonensis SB2B
    68% identity, 92% coverage of query (281 bits)

scoA / P56006 succinyl-CoA-transferase subunit A (EC 2.8.3.5) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
SCOA_HELPY / P56006 Succinyl-CoA:3-ketoacid coenzyme A transferase subunit A; Succinyl-CoA:3-oxoacid CoA-transferase; OXCT A; EC 2.8.3.5 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
    60% identity, 99% coverage of query (281 bits)

Pf6N2E2_2111 Dehydrocarnitine CoA-transferase and acetoacetate CoA-transferase, subunit A from Pseudomonas fluorescens FW300-N2E2
    64% identity, 94% coverage of query (273 bits)

SCOT_DROME / Q9W058 Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial; 3-oxoacid CoA-transferase; EC 2.8.3.5 from Drosophila melanogaster (Fruit fly) (see paper)
Q9W058 3-oxoacid CoA-transferase (EC 2.8.3.5) from Drosophila melanogaster (see paper)
    53% identity, 98% coverage of query (251 bits)

SCOT2_HUMAN / Q9BYC2 Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial; 3-oxoacid CoA-transferase 2A; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase; SCOT-t; EC 2.8.3.5 from Homo sapiens (Human) (see paper)
Q9BYC2 3-oxoacid CoA-transferase (EC 2.8.3.5) from Homo sapiens (see paper)
    53% identity, 99% coverage of query (249 bits)

Q9JJN4 3-oxoacid CoA-transferase (EC 2.8.3.5) from Mus musculus (see paper)
    53% identity, 92% coverage of query (237 bits)

SCO2B_MOUSE / Q9ESL0 Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial; 3-oxoacid CoA-transferase 2B; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 2; SCOT-t2; EC 2.8.3.5 from Mus musculus (Mouse) (see paper)
    53% identity, 92% coverage of query (234 bits)

SCO2A_RAT / Q5XIJ9 Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; 3-oxoacid CoA-transferase 2A; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1; SCOT-t1; EC 2.8.3.5 from Rattus norvegicus (Rat) (see paper)
    51% identity, 97% coverage of query (232 bits)

8i3yD / Q386P1 Crystal structure of asct from trypanosoma brucei in complex with succinyl-coa.
    47% identity, 94% coverage of query (231 bits)

8i40A Crystal structure of asct from trypanosoma brucei in complex with coa.
    47% identity, 94% coverage of query (231 bits)

8i3yA Crystal structure of asct from trypanosoma brucei in complex with succinyl-coa.
    47% identity, 94% coverage of query (231 bits)

pcaI / Q01103 α subunit of β-ketoadipate succinyl-CoA transferase (EC 2.8.3.6) from Pseudomonas putida (see 3 papers)
Q01103 3-oxoadipate CoA-transferase (subunit 2/2) (EC 2.8.3.6) from Pseudomonas putida (see paper)
pcaI / GB|AAA25922.1 3-oxoadipate CoA-transferase subunit A; EC 2.8.3.6 from Pseudomonas putida (see paper)
    52% identity, 91% coverage of query (213 bits)

pcaI / Q0K4S5 adipate CoA-transferase α subunit (EC 6.2.1.5) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
    49% identity, 92% coverage of query (207 bits)

catI / AAC46432.1 beta-ketoadipate succinyl-CoA transferase alpha-subunit from Acinetobacter baylyi (see 8 papers)
    49% identity, 88% coverage of query (200 bits)

CTFA_CLOAB / P33752 Acetoacetyl-CoA:acetate/butyrate CoA transferase alpha subunit; Butyrate--acetoacetate CoA-transferase subunit A; Coat A; EC 2.8.3.9 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 3 papers)
    43% identity, 88% coverage of query (181 bits)

1k6dB / P76458 Crystal structure of acetate coa-transferase alpha subunit (see paper)
    42% identity, 86% coverage of query (179 bits)

AtoD / b2221 acetyl-CoA:acetoacetyl-CoA transferase subunit α from Escherichia coli K-12 substr. MG1655 (see 2 papers)
atoD / P76458 acetyl-CoA:acetoacetyl-CoA transferase subunit α from Escherichia coli (strain K12) (see 2 papers)
ATOD_ECOLI / P76458 Acetate CoA-transferase subunit alpha; Acetoacetyl-CoA transferase subunit alpha; AA-CoA transferase subunit alpha; Acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; EC 2.8.3.8 from Escherichia coli (strain K12) (see 4 papers)
    42% identity, 86% coverage of query (179 bits)

Build an alignment

Build an alignment for H281DRAFT_04495 and 29 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q9L3F7 propionate CoA-transferase (EC 2.8.3.1) from Anaerotignum propionicum (see paper)
    28% identity, 94% coverage of query (62.4 bits)

CARA_ACEWO / F1CYZ5 Caffeate CoA-transferase; Hydrocaffeyl-CoA:caffeate CoA transferase; EC 2.8.3.23 from Acetobacterium woodii (see 2 papers)
F1CYZ5 caffeate CoA-transferase (EC 2.8.3.23) from Acetobacterium woodii (see 2 papers)
    25% identity, 91% coverage of query (54.7 bits)

IPDA_RHOJR / Q0S7P9 Cholesterol ring-cleaving hydrolase IpdA subunit; (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA hydrolase alpha subunit; COCHEA-CoA hydrolase alpha subunit; EC 4.1.99.- from Rhodococcus jostii (strain RHA1) (see 2 papers)
    25% identity, 86% coverage of query (51.2 bits)

6co9A / Q0S7P9 Crystal structure of rhodococcus jostii rha1 ipdab cochea-coa complex (see paper)
    25% identity, 86% coverage of query (50.8 bits)

YdiF / b1694 putative acetate-CoA transferase YdiF (EC 2.8.3.9) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
    22% identity, 90% coverage of query (48.9 bits)

2ahvA / Q8X5X6 Crystal structure of acyl-coa transferase from e. Coli o157:h7 (ydif)- thioester complex with coa- 1 (see paper)
    22% identity, 90% coverage of query (48.5 bits)

YDIF_ECO57 / Q8X5X6 Acetate CoA-transferase YdiF; Short-chain acyl-CoA:acetate CoA-transferase; EC 2.8.3.8 from Escherichia coli O157:H7 (see paper)
    22% identity, 90% coverage of query (48.5 bits)

pct / G0VND6 propanoyl-CoA transferase monomer (EC 2.8.3.1) from Megasphaera elsdenii DSM 20460 (see 3 papers)
A0A140JTF0 propionate CoA-transferase (EC 2.8.3.1) from Megasphaera elsdenii (see paper)
    27% identity, 95% coverage of query (46.2 bits)

BWI76_RS23700 glycerate CoA-transferase from Klebsiella michiganensis M5al
    22% identity, 88% coverage of query (45.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory