Searching for up to 100 curated homologs for H281DRAFT_04643 FitnessBrowser__Burk376:H281DRAFT_04643 (128 a.a.)
Found high-coverage hits (≥70%) to 50 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
P0A0T3 lactoylglutathione lyase (EC 4.4.1.5) from Neisseria meningitidis (see paper)
77% identity, 100% coverage of query (217 bits)
Q9HY85 lactoylglutathione lyase (EC 4.4.1.5) from Pseudomonas aeruginosa (see paper)
72% identity, 100% coverage of query (203 bits)
4mttA / Q9I5L8 Ni- and zn-bound gloa2 at low resolution (see paper)
62% identity, 98% coverage of query (173 bits)
Q9I5L8 lactoylglutathione lyase (EC 4.4.1.5) from Pseudomonas aeruginosa (see paper)
62% identity, 98% coverage of query (173 bits)
GloA / b1651 glyoxalase I (EC 4.4.1.5) from Escherichia coli K-12 substr. MG1655 (see 18 papers)
gloA / P0AC81 lactoylglutathione lyase (EC 4.4.1.5) from Escherichia coli (strain K12) (see 19 papers)
LGUL_ECOLI / P0AC81 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Escherichia coli (strain K12) (see 6 papers)
P0AC81 lactoylglutathione lyase (EC 4.4.1.5) from Escherichia coli (see 3 papers)
gloA / RF|NP_416168.1 lactoylglutathione lyase; EC 4.4.1.5 from Shigella flexneri (see 5 papers)
64% identity, 99% coverage of query (172 bits)
1fa5A / P0AC81 Crystal structure of the zn(ii)-bound glyoxalase i of escherichia coli (see paper)
63% identity, 98% coverage of query (171 bits)
1fa6A Crystal structure of the co(ii)-bound glyoxalase i of escherichia coli
63% identity, 98% coverage of query (171 bits)
GLX1_ARATH / O65398 Lactoylglutathione lyase GLX1; Glyoxalase I; AtGLX1; GlyI; EC 4.4.1.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
52% identity, 98% coverage of query (147 bits)
6bnnA / B6TPH0 Crystal structure of v278e-glyoxalase i mutant from zea mays in space group p4(1)2(1)2 (see paper)
53% identity, 98% coverage of query (146 bits)
LGUC_ARATH / Q8W593 Probable lactoylglutathione lyase, chloroplastic; Glyoxalase I; EC 4.4.1.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
54% identity, 98% coverage of query (146 bits)
5d7zA Crystal structure of glyoxalase i from zea mays
53% identity, 98% coverage of query (146 bits)
LGUL_ORYSJ / Q948T6 Lactoylglutathione lyase; Aldoketomutase; Allergen Glb33; Glyoxalase I; Glx I; Glyoxylase I 11; OsGLYI-11; OsGLYI11; Ketone-aldehyde mutase; Methylglyoxalase; PP33; S-D-lactoylglutathione methylglyoxal lyase; Allergen Ory s Glyoxalase I; EC 4.4.1.5 from Oryza sativa subsp. japonica (Rice) (see 7 papers)
Q948T6 lactoylglutathione lyase (EC 4.4.1.5) from Oryza sativa Japonica Group (see 2 papers)
52% identity, 98% coverage of query (137 bits)
Q2PYM9 lactoylglutathione lyase (EC 4.4.1.5) from Leishmania infantum (see paper)
46% identity, 98% coverage of query (114 bits)
Q68RJ8 lactoylglutathione lyase (EC 4.4.1.5) from Leishmania major (see 2 papers)
46% identity, 98% coverage of query (113 bits)
2c21A / Q68RJ8 Specificity of the trypanothione-dependednt leishmania major glyoxalase i: structure and biochemical comparison with the human enzyme (see paper)
46% identity, 98% coverage of query (113 bits)
Q5XQR1 lactoylglutathione lyase (EC 4.4.1.5) from Leishmania donovani (see paper)
45% identity, 98% coverage of query (111 bits)
Q9HU72 lactoylglutathione lyase (EC 4.4.1.5) from Pseudomonas aeruginosa (see paper)
42% identity, 95% coverage of query (106 bits)
CAA88233.1 glyoxalase-I from Solanum lycopersicum (see paper)
39% identity, 98% coverage of query (99.0 bits)
LGUL_SCHPO / Q09751 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
glo1 / RF|NP_596010.1 glyoxalase I; EC 4.4.1.5 from Schizosaccharomyces pombe (see 3 papers)
42% identity, 99% coverage of query (98.2 bits)
LGUL_SOYBN / Q9ZS21 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; GmGlyoxI; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Glycine max (Soybean) (Glycine hispida) (see paper)
Q9ZS21 lactoylglutathione lyase (EC 4.4.1.5) from Glycine max (see paper)
glxI / CAA09177.1 glyoxalase I from Glycine max (see paper)
39% identity, 98% coverage of query (96.3 bits)
7wt0A / Q04760 Human glyoxalase i (with c-ter his tag) in complex with tlsc702 (see paper)
38% identity, 98% coverage of query (96.3 bits)
LGUL_RAT / Q6P7Q4 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Rattus norvegicus (Rat) (see paper)
38% identity, 98% coverage of query (96.3 bits)
LGUL_HUMAN / Q04760 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Homo sapiens (Human) (see 6 papers)
Q04760 lactoylglutathione lyase (EC 4.4.1.5) from Homo sapiens (see 8 papers)
38% identity, 98% coverage of query (96.3 bits)
3w0tA Human glyoxalase i with an n-hydroxypyridone derivative inhibitor
38% identity, 98% coverage of query (96.3 bits)
3vw9A Human glyoxalase i with an n-hydroxypyridone inhibitor
38% identity, 98% coverage of query (96.3 bits)
1qipA Human glyoxalase i complexed with s-p- nitrobenzyloxycarbonylglutathione
38% identity, 98% coverage of query (96.3 bits)
1qinA Human glyoxalase i complexed with s-(n-hydroxy-n-p- iodophenylcarbamoyl) glutathione
38% identity, 98% coverage of query (96.3 bits)
1froA Human glyoxalase i with benzyl-glutathione inhibitor
38% identity, 98% coverage of query (96.3 bits)
LGUL_MOUSE / Q9CPU0 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Mus musculus (Mouse) (see paper)
Q9CPU0 lactoylglutathione lyase (EC 4.4.1.5) from Mus musculus (see 2 papers)
38% identity, 98% coverage of query (95.9 bits)
4kykA / Q9CPU0 Crystal structure of mouse glyoxalase i complexed with indomethacin (see paper)
38% identity, 98% coverage of query (95.9 bits)
3w0uA Human glyoxalase i with an n-hydroxypyridone inhibitor
38% identity, 98% coverage of query (95.9 bits)
2za0A Crystal structure of mouse glyoxalase i complexed with methyl-gerfelin
38% identity, 98% coverage of query (95.9 bits)
6l0uB Crystal structure of mouse glyoxalase i complexed with a small molecule inhibitor
38% identity, 98% coverage of query (95.9 bits)
4kykB Crystal structure of mouse glyoxalase i complexed with indomethacin
38% identity, 98% coverage of query (95.9 bits)
4x2aA Crystal structure of mouse glyoxalase i complexed with baicalein
38% identity, 98% coverage of query (95.9 bits)
7wszA Human glyoxalase i (with c-ter his tag) in glycerol-bound form
38% identity, 98% coverage of query (95.9 bits)
4pv5A Crystal structure of mouse glyoxalase i in complexed with 18-beta- glycyrrhetinic acid
38% identity, 98% coverage of query (95.9 bits)
4kyhA Crystal structure of mouse glyoxalase i complexed with zopolrestat
38% identity, 98% coverage of query (95.9 bits)
4opnA Crystal structure of mouse glyoxalase i complexed with mah
38% identity, 98% coverage of query (95.9 bits)
GLO1 / P50107 glyoxalase I (EC 4.4.1.5) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
LGUL_YEAST / P50107 Glyoxalase I; Glx I; Aldoketomutase; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; actoylglutathione lyase; EC 4.4.1.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
40% identity, 96% coverage of query (94.7 bits)
1bh5A Human glyoxalase i q33e, e172q double mutant
38% identity, 98% coverage of query (94.7 bits)
O04885 lactoylglutathione lyase (EC 4.4.1.5) from Brassica juncea (see 2 papers)
40% identity, 98% coverage of query (92.4 bits)
Q696X2 lactoylglutathione lyase (EC 4.4.1.5) from Parastagonospora nodorum (see paper)
39% identity, 98% coverage of query (91.3 bits)
gloA / P16635 glyoxalase I monomer (EC 4.4.1.5) from Pseudomonas putida (see 2 papers)
38% identity, 95% coverage of query (86.3 bits)
Q88GF8 lactoylglutathione lyase (EC 4.4.1.5) from Pseudomonas putida (see paper)
37% identity, 97% coverage of query (84.7 bits)
D6QLX5 lactoylglutathione lyase (EC 4.4.1.5) from Starmerella magnoliae (see paper)
38% identity, 98% coverage of query (83.6 bits)
Build an alignment for H281DRAFT_04643 and 46 homologs with ≥ 30% identity
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GLOD4_CAEEL / Q09253 Glyoxalase 1; CeGly; Glyoxalase domain-containing protein 4 from Caenorhabditis elegans (see 2 papers)
26% identity, 95% coverage of query (60.1 bits)
Msed_0639 / A4YEG2 methylmalonyl-CoA epimerase monomer (EC 5.1.99.1) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see 2 papers)
A4YEG2 methylmalonyl-CoA epimerase (EC 5.1.99.1) from Metallosphaera sedula (see paper)
31% identity, 95% coverage of query (57.4 bits)
Q71KM3 lactoylglutathione lyase (EC 4.4.1.5) from Plasmodium falciparum (see paper)
29% identity, 95% coverage of query (54.3 bits)
EPI_CERS4 / Q3IZP4 Ethylmalonyl-CoA/methylmalonyl-CoA epimerase; EC 5.1.99.-; EC 5.1.99.1 from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
31% identity, 85% coverage of query (45.8 bits)
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Lawrence Berkeley National Laboratory