Searching for up to 100 curated homologs for H281DRAFT_04849 FitnessBrowser__Burk376:H281DRAFT_04849 (318 a.a.)
Found high-coverage hits (≥70%) to 81 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
wbiG / GI|3135686 putative epimerase/dehydratase WbiG from Burkholderia pseudomallei (see paper)
61% identity, 99% coverage of query (392 bits)
wbpV / Q9RHC9 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Pseudomonas aeruginosa (see paper)
46% identity, 97% coverage of query (253 bits)
ORF35x7 / CAA69124.1 ORF35x7 from Vibrio cholerae (see paper)
40% identity, 98% coverage of query (228 bits)
wreQ / Q6TP29 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see 2 papers)
Q6TP29 UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see paper)
40% identity, 95% coverage of query (202 bits)
wbpK / P72144 UDP-N-acetyl-α-D-fucosamine dehydrogenase from Pseudomonas aeruginosa (see 2 papers)
40% identity, 99% coverage of query (201 bits)
Build an alignment for H281DRAFT_04849 and 5 homologs with ≥ 30% identity
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gnu / Q8X7P7 N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase (EC 5.1.3.26) from Escherichia coli O157:H7 (see 2 papers)
GNU_ECO57 / Q8X7P7 N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase; GlcNAc-P-P-Und 4-epimerase; EC 5.1.3.26 from Escherichia coli O157:H7 (see paper)
gne UDP-N-acetylglucosamine 4-epimerase; EC 5.1.3.7 from Escherichia coli O157:H7 (see paper)
25% identity, 98% coverage of query (94.0 bits)
cpsG polysaccharide capsule synthesis protein CpsG from Streptococcus iniae (see paper)
25% identity, 89% coverage of query (83.6 bits)
JF740056 / F8U969 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Magnaporthe oryzae (see paper)
F8U969 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Pyricularia grisea (see paper)
28% identity, 79% coverage of query (80.5 bits)
F8U971 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Botrytis cinerea (see paper)
28% identity, 79% coverage of query (80.1 bits)
6bwlA / Q3ESA4 X-ray structure of pal from bacillus thuringiensis (see paper)
23% identity, 98% coverage of query (79.7 bits)
3BHD_MYCNE / P0DX24 3-beta-hydroxysteroid dehydrogenase; 3beta-HSD; EC 1.1.1.51 from Mycolicibacterium neoaurum (Mycobacterium neoaurum) (see paper)
24% identity, 99% coverage of query (79.7 bits)
hsdD / P9WQP7 3 β-hydroxysteroid dehydrogenase (EC 5.3.3.1; EC 1.1.1.145) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
3BHS_MYCTU / P9WQP7 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Cholesterol dehydrogenase; EC 1.1.1.145; EC 5.3.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WQP7 3beta-hydroxy-DELTA5-steroid dehydrogenase (EC 1.1.1.145) from Mycobacterium tuberculosis (see paper)
26% identity, 99% coverage of query (79.7 bits)
Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
24% identity, 99% coverage of query (76.3 bits)
8du1A / A0A077ELH2 Crystal structure of NAD bound dtdp-glucose 4,6-dehydratase from elizabethkingia anophelis
24% identity, 99% coverage of query (74.3 bits)
rhsB / AAC44074.1 dTDP-D-glucose-4,6-dehydratase from Sphingomonas sp. S88 (see paper)
27% identity, 98% coverage of query (73.6 bits)
YbjS / b0868 putative epimerase YbjS from Escherichia coli K-12 substr. MG1655 (see paper)
27% identity, 72% coverage of query (72.4 bits)
2hunA / O58151 Crystal structure of hypothetical protein ph0414 from pyrococcus horikoshii ot3
27% identity, 79% coverage of query (72.0 bits)
A7K9F4 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Acanthocystis turfacea chlorella virus 1 (see paper)
25% identity, 98% coverage of query (71.2 bits)
ERG26_CANAL / Q5A1B0 Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating; C-3 sterol dehydrogenase ERG26; C-4 decarboxylase ERG26; EC 1.1.1.170 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
Q5A1B0 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) from Candida albicans (see paper)
ERG26 C-3 sterol dehydrogenase/C-4 decarboxylase from Candida albicans (see paper)
27% identity, 79% coverage of query (70.5 bits)
uxs1 / Q92WA4 UDP-xylose synthase 1 subunit (EC 4.1.1.35) from Rhizobium meliloti (strain 1021) (see paper)
26% identity, 98% coverage of query (69.7 bits)
3BHD_KLEAE / P0DX23 3-beta-hydroxysteroid dehydrogenase; 3beta-HSD; EC 1.1.1.51 from Klebsiella aerogenes (Enterobacter aerogenes) (see paper)
26% identity, 72% coverage of query (68.9 bits)
RMLB_STRGR / P29782 dTDP-glucose 4,6-dehydratase; EC 4.2.1.46 from Streptomyces griseus (see paper)
28% identity, 98% coverage of query (68.2 bits)
tylA2 / Q54144 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Streptomyces fradiae (see 2 papers)
27% identity, 98% coverage of query (67.4 bits)
UGA4E_THEGP / F8C4X8 UDP-glucuronate 4-epimerase; UGA4E; TgUGAE; EC 5.1.3.6 from Thermodesulfobacterium geofontis (strain OPF15)
22% identity, 100% coverage of query (65.9 bits)
8b9zP / Q9VPE2 Drosophila melanogaster complex i in the active state (dm1) (see paper)
26% identity, 78% coverage of query (65.9 bits)
2p5uA / Q5SKQ2 Crystal structure of thermus thermophilus hb8 udp-glucose 4-epimerase complex with NAD
27% identity, 98% coverage of query (65.5 bits)
TGDS_HUMAN / O95455 dTDP-D-glucose 4,6-dehydratase; EC 4.2.1.46 from Homo sapiens (Human) (see paper)
24% identity, 80% coverage of query (65.5 bits)
WBJC_PSEA1 / Q9XC60 UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase; EC 1.1.1.367 from Pseudomonas aeruginosa (strain ATCC 29260 / BCRC 12902 / CIP 102967 / NCIMB 11965 / PA103) (see 2 papers)
26% identity, 76% coverage of query (65.5 bits)
Echvi_1472 UDP-glucose 4-epimerase (EC 5.1.3.2) from Echinicola vietnamensis KMM 6221, DSM 17526
23% identity, 99% coverage of query (65.1 bits)
oleD / Q8PDW5 2-alkyl-3-oxo-fatty acid reductase monomer (EC 1.1.1.412) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 2 papers)
OLED_XANCP / Q8PDW5 2-alkyl-3-oxoalkanoate reductase; EC 1.1.1.412 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 2 papers)
25% identity, 97% coverage of query (64.7 bits)
wbjC / Q9KIC9 UDP-N-acetyl-β-L-pneumosamine dehydrogenase (EC 1.1.1.367) from Pseudomonas aeruginosa (see 2 papers)
26% identity, 76% coverage of query (64.7 bits)
GALE_MYCS2 / A0R5C5 UDP-glucose 4-epimerase; UDP-galactose 4-epimerase; Uridine diphosphate galactose 4-epimerase; EC 5.1.3.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
26% identity, 98% coverage of query (64.3 bits)
5u4qA 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
22% identity, 99% coverage of query (63.9 bits)
3β-HSD/D1 / Q9FX01 plant 3β-hydroxysteroid dehydrogenase/C4-decarboxylase 1 (EC 1.1.1.418) from Arabidopsis thaliana (see 3 papers)
HSDD1_ARATH / Q9FX01 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1; At3BETAHSD/D1; 4alpha-carboxysterol-C3-dehydrogenase/C4-decarboxylase isoform 1-1; Reticulon-like protein B24; AtRTNLB24; Sterol-4-alpha-carboxylate 3-dehydrogenase 1, decarboxylating; EC 1.1.1.418 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
25% identity, 79% coverage of query (63.2 bits)
OLED_STRMK / B2FI29 2-alkyl-3-oxoalkanoate reductase; EC 1.1.1.412 from Stenotrophomonas maltophilia (strain K279a) (see paper)
B2FI29 2-alkyl-3-oxoalkanoate reductase (EC 1.1.1.412) from Stenotrophomonas maltophilia (see 2 papers)
27% identity, 79% coverage of query (63.2 bits)
oleD / Q8EG63 hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oate reductase (EC 1.1.1.412) from Shewanella oneidensis (strain MR-1) (see paper)
OLED_SHEON / Q8EG63 2-alkyl-3-oxoalkanoate reductase; EC 1.1.1.412 from Shewanella oneidensis (strain MR-1) (see paper)
24% identity, 97% coverage of query (63.2 bits)
oleE / Q9RR28 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Streptomyces antibioticus (see paper)
OLEE_STRAT / Q9RR28 dTDP-glucose 4,6-dehydratase; EC 4.2.1.46 from Streptomyces antibioticus (see paper)
29% identity, 99% coverage of query (63.2 bits)
F6DEY6 UDP-glucose 4-epimerase (EC 5.1.3.2) from Thermus thermophilus (see paper)
27% identity, 98% coverage of query (62.8 bits)
rmd / AAK53475.1 putative NDP-hexose epimerase/oxydoreductase from Xanthomonas campestris pv. campestris (see 4 papers)
28% identity, 88% coverage of query (62.8 bits)
A3MUJ4 UDP-glucose 4-epimerase (EC 5.1.3.2) from Pyrobaculum calidifontis (see paper)
26% identity, 97% coverage of query (62.4 bits)
A0A345GNZ1 3beta-hydroxy-DELTA5-steroid dehydrogenase (EC 1.1.1.145) from Bufo gargarizans (see paper)
25% identity, 78% coverage of query (62.4 bits)
5u4qB 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
22% identity, 99% coverage of query (61.2 bits)
6wj9B / Q4KCF6 Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
28% identity, 80% coverage of query (60.5 bits)
Rff / b3788 dTDP-glucose 4,6-dehydratase 2 (EC 4.2.1.46) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
rffG / P27830 dTDP-glucose 4,6-dehydratase 2 (EC 4.2.1.46) from Escherichia coli (strain K12) (see 5 papers)
RMLB2_ECOLI / P27830 dTDP-glucose 4,6-dehydratase 2; EC 4.2.1.46 from Escherichia coli (strain K12) (see 3 papers)
26% identity, 99% coverage of query (60.5 bits)
6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac
28% identity, 80% coverage of query (60.5 bits)
graE / AAA99939.1 dTDP-glucose dehydratase from Streptomyces violaceoruber (see paper)
27% identity, 98% coverage of query (60.1 bits)
Q9SZB3 farnesol dehydrogenase (NAD+) (EC 1.1.1.354) from Arabidopsis thaliana (see paper)
26% identity, 98% coverage of query (60.1 bits)
dnmV / O33708 dTDP-3-amino-4-dehydro-2,3,6-trideoxy-β-L-glucose 4-ketoreductase from Streptomyces peucetius (see paper)
29% identity, 93% coverage of query (59.7 bits)
1r6dA Crystal structure of desiv double mutant (dtdp-glucose 4,6- dehydratase) from streptomyces venezuelae with NAD and dau bound
30% identity, 79% coverage of query (59.7 bits)
RMLB_ACTS5 / Q9ZAE8 dTDP-glucose 4,6-dehydratase; EC 4.2.1.46 from Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) (see paper)
27% identity, 79% coverage of query (59.3 bits)
1r66A / Q9ZGH3 Crystal structure of desiv (dtdp-glucose 4,6-dehydratase) from streptomyces venezuelae with NAD and tyd bound (see paper)
30% identity, 79% coverage of query (59.3 bits)
epsS / BAC55147.1 UDP-glucose 4-epimerase EpsS from Methylobacillus sp. 12S (see paper)
23% identity, 94% coverage of query (59.3 bits)
UXS1 / Q8VZC0 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
UXS1_ARATH / Q8VZC0 UDP-glucuronic acid decarboxylase 1; UDP-XYL synthase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1; EC 4.1.1.35 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q8VZC0 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
25% identity, 98% coverage of query (59.3 bits)
ravE / D1H0J1 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Streptomyces ravidus (see 2 papers)
28% identity, 99% coverage of query (58.9 bits)
desIV / Q9ZGH3 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Streptomyces venezuelae (see paper)
30% identity, 79% coverage of query (58.9 bits)
2b69A / Q8NBZ7 Crystal structure of human udp-glucoronic acid decarboxylase
22% identity, 98% coverage of query (57.0 bits)
UXS1_HUMAN / Q8NBZ7 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1; hUXS; hUXS1; EC 4.1.1.35 from Homo sapiens (Human) (see 3 papers)
21% identity, 98% coverage of query (56.2 bits)
2udpA Udp-galactose 4-epimerase complexed with udp-phenol
24% identity, 90% coverage of query (55.8 bits)
1udcA Structure of udp-galactose-4-epimerase complexed with udp-mannose
24% identity, 90% coverage of query (55.8 bits)
GalD / b0759 UDP-glucose 4-epimerase (EC 5.1.3.2) from Escherichia coli K-12 substr. MG1655 (see 42 papers)
galE / P09147 UDP-glucose 4-epimerase (EC 5.1.3.2) from Escherichia coli (strain K12) (see 38 papers)
GALE_ECOLI / P09147 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Escherichia coli (strain K12) (see 13 papers)
24% identity, 90% coverage of query (55.8 bits)
4lk3B / Q8NBZ7 Crystal structure of human udp-xylose synthase r236a substitution (see paper)
22% identity, 98% coverage of query (55.5 bits)
6kv9A / A0A003 Moee5 in complex with udp-glucuronic acid and NAD (see paper)
27% identity, 98% coverage of query (55.5 bits)
6kvcA Moee5 in complex with udp-glucose and NAD
28% identity, 98% coverage of query (55.5 bits)
2q1sA / O87989 Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with nadh (see paper)
26% identity, 99% coverage of query (55.5 bits)
3aw9A / A3MUJ4 Structure of udp-galactose 4-epimerase mutant
26% identity, 97% coverage of query (55.5 bits)
1bxkB / P27830 Dtdp-glucose 4,6-dehydratase from e. Coli
26% identity, 94% coverage of query (55.5 bits)
1kvrA Udp-galactose 4-epimerase complexed with udp-phenol
24% identity, 90% coverage of query (54.7 bits)
1udaA Structure of udp-galactose-4-epimerase complexed with udp-4-deoxy-4- fluoro-alpha-d-galactose
24% identity, 90% coverage of query (53.9 bits)
1naiA Udp-galactose 4-epimerase from escherichia coli, oxidized
24% identity, 90% coverage of query (53.9 bits)
1lrjA Crystal structure of e. Coli udp-galactose 4-epimerase complexed with udp-n-acetylglucosamine
24% identity, 90% coverage of query (53.9 bits)
6bi4B 2.9 angstrom resolution crystal structure of dtdp-glucose 4,6- dehydratase (rfbb) from bacillus anthracis str. Ames in complex with NAD.
19% identity, 99% coverage of query (53.5 bits)
1a9yA / P09147 Udp-galactose 4-epimerase mutant s124a/y149f complexed with udp- glucose (see paper)
24% identity, 90% coverage of query (53.1 bits)
2cnbA Trypanosoma brucei udp-galactose-4-epimerase in ternary complex with NAD and the substrate analogue udp-4-deoxy-4- fluoro-alpha-d-galactose
23% identity, 80% coverage of query (52.4 bits)
6x3bA / Q9HTB6 Structure of rmd from pseudomonas aeruginosa complexed with NADPH
24% identity, 97% coverage of query (51.2 bits)
6x3bB Structure of rmd from pseudomonas aeruginosa complexed with NADPH
24% identity, 97% coverage of query (50.8 bits)
UXS1_DANRE / Q6GMI9 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UXS-1; EC 4.1.1.35 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
23% identity, 98% coverage of query (50.4 bits)
8sk0A Crystal structure of evds6 decarboxylase in ligand bound state
26% identity, 99% coverage of query (50.1 bits)
7k3pA / Q0P9C3 The structure of the udp-glc/glcnac 4-epimerase from the human pathogen campylobacter jejuni
22% identity, 99% coverage of query (50.1 bits)
8sk0B / A0A1C5ADV9 Crystal structure of evds6 decarboxylase in ligand bound state (see paper)
26% identity, 99% coverage of query (50.1 bits)
1gy8C / Q8T8E9 Trypanosoma brucei udp-galactose 4' epimerase (see paper)
24% identity, 80% coverage of query (45.8 bits)
1n7hA Crystal structure of gdp-mannose 4,6-dehydratase ternary complex with NADPH and gdp
25% identity, 93% coverage of query (45.1 bits)
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Lawrence Berkeley National Laboratory