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Searching for up to 100 curated homologs for H281DRAFT_05028 FitnessBrowser__Burk376:H281DRAFT_05028 (429 a.a.)

Found high-coverage hits (≥70%) to 37 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

NICT_PSEPK / Q88FY6 Putative metabolite transport protein NicT; Nicotinate degradation protein T from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    44% identity, 95% coverage of query (335 bits)

TC 2.A.1.14.8 / Q9RPP3 Phthalate porter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
    41% identity, 97% coverage of query (312 bits)

ABAQ_ACIBT / P0DPR4 Quinolone resistance transporter from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see 2 papers)
    38% identity, 97% coverage of query (287 bits)

BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
    38% identity, 98% coverage of query (252 bits)

H281DRAFT_00642 2-deoxy-D-ribonate transporter from Paraburkholderia bryophila 376MFSha3.1
    36% identity, 93% coverage of query (241 bits)

PS417_07265 2-deoxy-D-ribonate transporter 1 from Pseudomonas simiae WCS417
    37% identity, 90% coverage of query (239 bits)

BPHYT_RS04765 2-deoxy-D-ribonate transporter from Burkholderia phytofirmans PsJN
    35% identity, 95% coverage of query (235 bits)

YfaV / b2246 putative transporter YfaV from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TC 2.A.1.14.35 / P76470 Inner membrane transport protein RhmT from Escherichia coli (strain K12) (see 4 papers)
    36% identity, 94% coverage of query (230 bits)

CH_124128 MFS transporter from Magnaporthe grisea 70-15 (see paper)
    32% identity, 71% coverage of query (166 bits)

CH_124132 transporter of Nicotinic Acid from Magnaporthe grisea 70-15 (see paper)
    31% identity, 73% coverage of query (164 bits)

Build an alignment

Build an alignment for H281DRAFT_05028 and 10 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

orf19.3232 putative transporter from Candida albicans (see paper)
    27% identity, 86% coverage of query (154 bits)

CH_124317 phthalate transporter from Magnaporthe grisea 70-15 (see paper)
    30% identity, 70% coverage of query (146 bits)

CH_124318 MFS transporter from Magnaporthe grisea 70-15 (see 2 papers)
    30% identity, 71% coverage of query (142 bits)

PFMAC_PESFW / W3X9K4 MFS transporter PfmaC; Conidial pigment biosynthesis cluster protein B from Pestalotiopsis fici (strain W106-1 / CGMCC3.15140) (see paper)
    28% identity, 78% coverage of query (110 bits)

HXNP_EMENI / C8VJW1 Major facilitator-type transporter hxnP; Nicotinate catabolism cluster protein hxnP from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
    27% identity, 71% coverage of query (103 bits)

CH_124204 putative monocarboxylate exporter from Magnaporthe grisea 70-15 (see paper)
    26% identity, 72% coverage of query (102 bits)

AO356_28540 D-mannose transporter from Pseudomonas fluorescens FW300-N2C3
    24% identity, 90% coverage of query (100 bits)

TC 2.A.1.14.11 / P53322 Plasma membrane, high affinity nicotinate permease, Tna1 from Saccharomyces cerevisiae (Baker's yeast) (see 5 papers)
TNA1 / RF|NP_011776.1 high-affinity nicotinic acid transporter from Saccharomyces cerevisiae
    25% identity, 81% coverage of query (90.9 bits)

P53322 High-affinity nicotinic acid transporter; Nicotinic acid permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    25% identity, 81% coverage of query (90.9 bits)

SAUU_CUPNH / Q0K843 Probable sulfoacetate transporter SauU from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
    25% identity, 90% coverage of query (87.4 bits)

YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
    24% identity, 90% coverage of query (79.3 bits)

6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
    24% identity, 90% coverage of query (79.0 bits)

LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
    21% identity, 92% coverage of query (75.5 bits)

PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
    22% identity, 92% coverage of query (73.2 bits)

6zguA Crystal structure of a mfs transporter with bound 3-(2-methylphenyl) propanoic acid at 2.41 angstroem resolution
    25% identity, 89% coverage of query (64.3 bits)

6zgtA Crystal structure of a mfs transporter with bound 2-naphthoic acid at 2.39 angstroem resolution
    25% identity, 89% coverage of query (64.3 bits)

6zgsA / A0LNN5 Crystal structure of a mfs transporter with bound 3-phenylpropanoic acid at 2.39 angstroem resolution
    25% identity, 89% coverage of query (64.3 bits)

6zgrA Crystal structure of a mfs transporter with bound 1- hydroxynaphthalene-2-carboxylic acid at 2.67 angstroem resolution
    26% identity, 87% coverage of query (62.8 bits)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
    24% identity, 90% coverage of query (62.4 bits)

SFMCT_SYNFM / A0LNN5 L-lactate transporter; SfMCT from Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) (see paper)
    25% identity, 89% coverage of query (62.0 bits)

6g9xA Crystal structure of a mfs transporter at 2.54 angstroem resolution
    26% identity, 83% coverage of query (60.1 bits)

MHBT_KLEOX / Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
    24% identity, 80% coverage of query (57.8 bits)

6zguB Crystal structure of a mfs transporter with bound 3-(2-methylphenyl) propanoic acid at 2.41 angstroem resolution
    26% identity, 86% coverage of query (55.5 bits)

6zgtB Crystal structure of a mfs transporter with bound 2-naphthoic acid at 2.39 angstroem resolution
    26% identity, 86% coverage of query (55.5 bits)

6zgsB Crystal structure of a mfs transporter with bound 3-phenylpropanoic acid at 2.39 angstroem resolution
    26% identity, 86% coverage of query (55.5 bits)

6zgrB Crystal structure of a mfs transporter with bound 1- hydroxynaphthalene-2-carboxylic acid at 2.67 angstroem resolution
    26% identity, 85% coverage of query (54.3 bits)

6g9xB / A0LNN5 Crystal structure of a mfs transporter at 2.54 angstroem resolution (see paper)
    26% identity, 85% coverage of query (53.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory