Searching for up to 100 curated homologs for H281DRAFT_05405 FitnessBrowser__Burk376:H281DRAFT_05405 (358 a.a.)
Found high-coverage hits (≥70%) to 50 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.1.24 / TC 3.A.1.1.25 / Q72L52 Sugar-binding transport ATP-binding protein aka MalK1 aka TT_C0211, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
46% identity, 91% coverage of query (276 bits)
A0A142UTH4 ABC-type polyamine transporter (subunit 4/4) (EC 7.6.2.11) from Streptococcus suis (see paper)
50% identity, 74% coverage of query (270 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
48% identity, 87% coverage of query (267 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
45% identity, 92% coverage of query (266 bits)
YagC / b0262 CP4-6 prophage; ABC transporter ATP-binding protein AfuC from Escherichia coli K-12 substr. MG1655 (see 4 papers)
49% identity, 70% coverage of query (264 bits)
TC 3.A.1.11.7 / Q97Q42 Spermidine/putrescine import ATP-binding protein PotA, component of The spermidine/putrescine uptake porter, PotABCD from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
51% identity, 74% coverage of query (264 bits)
TC 3.A.1.20.3 / A3N296 Ferric ABC transporter ATP-binding protein, component of Iron (Fe3+) uptake porter, AfuABC (FbpABC) (Chin et al. 1996). AfuA has been characterized from Actinobacillus pleuropneumoniae serotype 5b (strain L20)
47% identity, 81% coverage of query (263 bits)
TC 3.A.1.1.22 / Q9X103 MalK; aka Sugar ABC transporter, ATP-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima (see paper)
44% identity, 92% coverage of query (261 bits)
TC 3.A.1.1.16 / Q8TZQ3 MalK aka PF1933, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
45% identity, 91% coverage of query (261 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
44% identity, 88% coverage of query (259 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
41% identity, 98% coverage of query (258 bits)
BWI76_RS01840 maltose ABC transporter, ATPase component (MalK) from Klebsiella michiganensis M5al
42% identity, 98% coverage of query (256 bits)
PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
44% identity, 85% coverage of query (254 bits)
PGA1_c13180 ABC transporter for D-Sorbitol, ATPase component from Phaeobacter inhibens BS107
44% identity, 89% coverage of query (254 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
40% identity, 98% coverage of query (254 bits)
Ac3H11_2066 glucose ABC transporter, ATPase component from Acidovorax sp. GW101-3H11
41% identity, 98% coverage of query (253 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
40% identity, 97% coverage of query (252 bits)
TC 3.A.1.1.12 / Q9AI63 PalK, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
41% identity, 99% coverage of query (252 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
40% identity, 97% coverage of query (252 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
40% identity, 97% coverage of query (252 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
40% identity, 97% coverage of query (252 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
40% identity, 97% coverage of query (252 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
40% identity, 97% coverage of query (252 bits)
B9J850 pterin deaminase (EC 3.5.4.11) from Agrobacterium tumefaciens (see paper)
44% identity, 86% coverage of query (251 bits)
TC 3.A.1.11.6 / Q1M7Q1 Putative ABC transporter component, component of The γ-aminobutyrate (GABA) uptake system, GtsABCD from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
42% identity, 88% coverage of query (250 bits)
mtlK / Q4KC54 polyol ABC-type transporterATP-binding component MtlK from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
42% identity, 100% coverage of query (249 bits)
MALK_THELN / Q9YGA6 Trehalose/maltose import ATP-binding protein MalK; EC 7.5.2.1 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 5 papers)
43% identity, 91% coverage of query (248 bits)
SMc03065 ABC transporter for D-maltose/D-trehalose/sucrose, ATPase component (AglK) from Sinorhizobium meliloti 1021
TC 3.A.1.1.8 / Q9Z3R9 AglK aka R00699 aka SMC03065, component of Sucrose/maltose/trehalose porter (sucrose-inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
44% identity, 86% coverage of query (248 bits)
TC 3.A.1.1.34 / O32151 Uncharacterized ABC transporter ATP-binding protein YurJ, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (strain 168)
45% identity, 84% coverage of query (246 bits)
TC 3.A.1.1.20 / Q7WWQ6 ATP-binding protein MsmK aka ABC transporter nucleotide binding protein, component of The fructooligosaccharide porter, MsmEFGK from Lactobacillus acidophilus (see 2 papers)
40% identity, 94% coverage of query (244 bits)
TC 3.A.1.20.1 / O54370 BitD, component of The iron transporter, BitABCDEF from Treponema hyodysenteriae (Serpulina hyodysenteriae) (see paper)
41% identity, 83% coverage of query (243 bits)
TC 3.A.1.1.10 / Q9KWT9 AlgS, component of Alginate (MW 27,000 Da) (and Alginate oligosaccharides) uptake porter. Sphingomonas species A1 is a 'pit-forming' bacterium that directly incorporates alginate into its cytoplasm through a pit-dependent transport system, termed a 'superchannel' (Murata et al., 2008). The pit is a novel organ acquired through the fluidity and reconstitution of cell surface molecules, and through cooperation with the transport machinery in the cells. It confers upon bacterial cells a more efficient way to secure and assimilate macromolecules from Sphingomonas sp (see paper)
algS / BAB03314.1 AlgS from Sphingomonas sp (see paper)
41% identity, 92% coverage of query (242 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
45% identity, 79% coverage of query (238 bits)
8hprC Lpqy-sugabc in state 4
45% identity, 79% coverage of query (236 bits)
8hprD Lpqy-sugabc in state 4
45% identity, 79% coverage of query (236 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
45% identity, 79% coverage of query (235 bits)
2awnC / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
39% identity, 93% coverage of query (219 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
41% identity, 79% coverage of query (213 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
41% identity, 79% coverage of query (213 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
41% identity, 79% coverage of query (213 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
34% identity, 93% coverage of query (212 bits)
2awnA / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
34% identity, 97% coverage of query (183 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
39% identity, 81% coverage of query (172 bits)
Build an alignment for H281DRAFT_05405 and 43 homologs with ≥ 30% identity
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3gd7A / P13569,P68187 Crystal structure of human nbd2 complexed with n6-phenylethyl-atp (p- atp)
24% identity, 98% coverage of query (88.2 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
25% identity, 71% coverage of query (76.3 bits)
5yv5A Crystal structure of the complex of archaeal ribosomal stalk protein ap1 and archaeal ribosome recycling factor aabce1.
25% identity, 92% coverage of query (73.9 bits)
1yqtA Rnase-l inhibitor
25% identity, 85% coverage of query (72.0 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
21% identity, 76% coverage of query (67.0 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
22% identity, 76% coverage of query (65.1 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
20% identity, 75% coverage of query (57.4 bits)
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Lawrence Berkeley National Laboratory