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Searching for up to 100 curated homologs for H281DRAFT_05660 FitnessBrowser__Burk376:H281DRAFT_05660 (136 a.a.)

Found high-coverage hits (≥70%) to 9 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HSERO_RS20310 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) from Herbaspirillum seropedicae SmR1
    78% identity, 92% coverage of query (215 bits)

HIS3_METTH / O26347 Phosphoribosyl-AMP cyclohydrolase; PRA-CH; EC 3.5.4.19 from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) (see paper)
    51% identity, 95% coverage of query (119 bits)

hisI / CAX46381.1 phosphoribosyl AMP-cyclohydrolase, partial from Chromohalobacter salexigens (see paper)
    54% identity, 74% coverage of query (116 bits)

Q8YH95 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) from Brucella melitensis bv. 1 (see paper)
    51% identity, 72% coverage of query (100 bits)

7bgmA / A0A072U2X9 Crystal structure of mthisn2, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
    45% identity, 75% coverage of query (97.1 bits)

At-IE / O82768 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19; EC 3.6.1.31) from Arabidopsis thaliana (see paper)
HIS2_ARATH / O82768 Histidine biosynthesis bifunctional protein hisIE, chloroplastic; Protein HISTIDINE BIOSYNTHESIS 2; EC 3.5.4.19; EC 3.6.1.31 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    44% identity, 75% coverage of query (97.1 bits)

7bgnA Crystal structure of mthisn2-amp complex, a bifunctional enzyme from the histidine biosynthetic pathway
    45% identity, 75% coverage of query (97.1 bits)

HIS3_METVA / Q50837 Phosphoribosyl-AMP cyclohydrolase; PRA-CH; EC 3.5.4.19 from Methanococcus vannielii (see paper)
Q50837 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) from Methanococcus vannielii (see paper)
    48% identity, 74% coverage of query (85.1 bits)

HIS4 multifunctional enzyme that catalyzes three steps of histidine biosynthesis from Candida albicans (see 4 papers)
    30% identity, 76% coverage of query (47.8 bits)

Build an alignment

Build an alignment for H281DRAFT_05660 and 9 homologs with ≥ 30% identity

Select sequences

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory