Searching for up to 100 curated homologs for H281DRAFT_05687 H281DRAFT_05687 amino acid/polyamine/organocation transporter, APC superfamily (531 a.a.)
Found high-coverage hits (≥70%) to 58 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
BPHYT_RS17540 L-aspartate/L-glutamate/L-glutamine:H+ symporter from Burkholderia phytofirmans PsJN
95% identity, 100% coverage of query (1014 bits)
AIMA_BACSU / Q45577 Glutamate/serine transporter AimA; Amino acid importer A from Bacillus subtilis (strain 168) (see 2 papers)
62% identity, 99% coverage of query (702 bits)
ASPP_BACSU / O07002 Aspartate-proton symporter; L-aspartate transporter from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.11.1 / O07002 The aspartate uptake permease, YveA from Bacillus subtilis (see 3 papers)
39% identity, 96% coverage of query (323 bits)
Build an alignment for H281DRAFT_05687 and 3 homologs with ≥ 30% identity
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BCAP_BACSU / O07576 Branched-chain amino acid permease BcaP; BCAA permease from Bacillus subtilis (strain 168) (see 4 papers)
27% identity, 84% coverage of query (109 bits)
6f34A / Q5L1G5 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. (see paper)
26% identity, 83% coverage of query (108 bits)
5oqtA Crystal structure of a bacterial cationic amino acid transporter (cat) homologue
26% identity, 83% coverage of query (108 bits)
MTRTR_BACSU / Q797A7 Methylthioribose transporter from Bacillus subtilis (strain 168) (see paper)
24% identity, 84% coverage of query (106 bits)
YhfM / b3370 fructoselysine/psicoselysine transporter from Escherichia coli K-12 substr. MG1655 (see 4 papers)
frlA / P45539 fructoselysine/psicoselysine transporter from Escherichia coli (strain K12) (see 4 papers)
FRLA_ECOLI / P45539 Probable fructoselysine/psicoselysine transporter FrlA from Escherichia coli (strain K12) (see paper)
25% identity, 84% coverage of query (103 bits)
CAAT5_ARATH / O64759 Cationic amino acid transporter 5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.12 / O64759 Cationic amino acid transporter 5 from Arabidopsis thaliana (see 3 papers)
24% identity, 76% coverage of query (101 bits)
CAAT9_ARATH / Q9C5D6 Cationic amino acid transporter 9, chloroplastic from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 73% coverage of query (96.3 bits)
6f2wA / A8UCQ5 Bacterial asc transporter crystal structure in open to in conformation (see paper)
25% identity, 81% coverage of query (94.4 bits)
N515DRAFT_2924 L-proline transporter from Dyella japonica UNC79MFTsu3.2
25% identity, 72% coverage of query (93.6 bits)
CAAT1_ARATH / Q84MA5 Cationic amino acid transporter 1; Amino acid transporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
24% identity, 70% coverage of query (90.9 bits)
CTR1_HUMAN / P30825 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor homolog; Ecotropic retrovirus receptor homolog; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Homo sapiens (Human) (see 4 papers)
TC 2.A.3.3.9 / P30825 High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homologue) (Ecotropic retrovirus receptor homologue) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) from Homo sapiens (see 6 papers)
24% identity, 73% coverage of query (87.4 bits)
TC 2.A.3.8.9 / Q19834 Heteromeric amino acid transporter #1 (transports most neutral aas with highest rates for Ala and Ser (Km≈100 μM)). They function by obligatory aa:aa exchange (Veljkovic et al., 2004b) (see paper)
25% identity, 80% coverage of query (81.3 bits)
LAT2_RABIT / Q9N1Q4 Large neutral amino acids transporter small subunit 2; 4F2-LC5; L-type amino acid transporter 2; Solute carrier family 7 member 8 from Oryctolagus cuniculus (Rabbit) (see paper)
25% identity, 83% coverage of query (81.3 bits)
LAT2_RAT / Q9WVR6 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; Solute carrier family 7 member 8 from Rattus norvegicus (Rat) (see 4 papers)
TC 2.A.3.8.6 / Q9WVR6 L-type neutral amino acid transporter, LAT2 (Na+-independent with broad specificity for all L-isomers of neutral amino acids; preferred substrate: Phe, His, Trp, Ile, Val, Leu, Gln, Cys, Ser; catalyzes obligatory exchange with μM affinities on the outside and mM affinities on the inside [1000x difference]). Both LAT2 and LAT1 (2.A.3.8.1) catalyze uptake of S-nitro-L-cysteine (Li and Whorton, 2005). Also transports thyroid hormones from Rattus norvegicus (Rat) (see 3 papers)
25% identity, 83% coverage of query (80.1 bits)
BAT1_RABIT / Q9N1R6 b(0,+)-type amino acid transporter 1; b(0,+)AT; 4F2-LC6; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Oryctolagus cuniculus (Rabbit) (see paper)
24% identity, 75% coverage of query (79.7 bits)
CAAT2_ARATH / Q9ASS7 Cationic amino acid transporter 2, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.3.3.13 / Q9ASS7 Cationic amino acid transporter 2, vacuolar from Arabidopsis thaliana (see 4 papers)
23% identity, 76% coverage of query (79.3 bits)
SLC7A8 / Q9UHI5 large neutral amino acids transporter small subunit 2 from Homo sapiens (see 4 papers)
LAT2_HUMAN / Q9UHI5 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) (see 14 papers)
TC 2.A.3.8.20 / Q9UHI5 Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8). Certain detergents stabilize and allow purification of the 4F2hc-LAT2 complex, allowing the measurement of substrate binding. In addition, an improved 3D map could be obtained from Homo sapiens (see 12 papers)
25% identity, 83% coverage of query (79.3 bits)
LAT2_MOUSE / Q9QXW9 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; mLAT2; Solute carrier family 7 member 8 from Mus musculus (Mouse) (see 6 papers)
24% identity, 83% coverage of query (79.3 bits)
7cmhB / Q9UHI5 The lat2-4f2hc complex in complex with tryptophan (see paper)
25% identity, 80% coverage of query (78.6 bits)
7b00A Human lat2-4f2hc complex in the apo-state
25% identity, 80% coverage of query (78.6 bits)
7cmiB The lat2-4f2hc complex in complex with leucine
25% identity, 80% coverage of query (78.6 bits)
BAT1_HUMAN / P82251 b(0,+)-type amino acid transporter 1; b(0,+)AT1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Homo sapiens (Human) (see 16 papers)
TC 2.A.3.8.19 / P82251 B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9) from Homo sapiens (see 9 papers)
24% identity, 75% coverage of query (78.2 bits)
GABP_BACSU / P46349 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) (see 3 papers)
TC 2.A.3.1.5 / P46349 β-alanine/γ-aminobutyrate/proline/3,4-dehydroproline:H+ symporter, GabP from Bacillus subtilis (see 4 papers)
gabP / AAC44641.1 gamma-aminobutyrate permease from Bacillus subtilis (see 2 papers)
24% identity, 74% coverage of query (78.2 bits)
gabP / AAB62306.1 GabP from Bacillus subtilis (see 4 papers)
24% identity, 74% coverage of query (78.2 bits)
CAAT8_ARATH / Q9SHH0 Cationic amino acid transporter 8, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.11 / Q9SHH0 Cationic amino acid transporter 8, vacuolar from Arabidopsis thaliana (see 4 papers)
23% identity, 74% coverage of query (77.8 bits)
STET_BACSU / O34739 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.8.12 / O34739 The Ser/Thr exchange transporter (SteT) (also transports aromatic amino acids with lower efficiency) (Reig et al., 2007). The substrate-bound state of SteT shows increased conformational flexibility and kinetic stability, enabling transport of substrate across the cell membrane (Bippes et al. 2009). TMS8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT (Bartoccioni et al., 2010). Mutations allow substrate binding but not translocation. Other mutations stabilize the protein and result in higher production levels from Bacillus subtilis (see 2 papers)
25% identity, 84% coverage of query (77.8 bits)
BCAP_LACLM / A2RHI9 Branched-chain amino acid permease BcaP; BCAA permease; BCAA transporter from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
24% identity, 76% coverage of query (77.4 bits)
BAT1_MOUSE / Q9QXA6 b(0,+)-type amino acid transporter 1; b(0,+)AT1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Mus musculus (Mouse) (see 2 papers)
24% identity, 83% coverage of query (77.4 bits)
TC 2.A.3.3.23 / S6EX81 Branched chain amino acid (Leucine/isoleucine/valine) uptake transporter of 469 aas and 12 TMSs, BcaP or CitA from Lactococcus lactis subsp. lactis A12
24% identity, 76% coverage of query (77.0 bits)
S7A13_MOUSE / Q91WN3 Solute carrier family 7 member 13; Sodium-independent aspartate/glutamate transporter 1; X-amino acid transporter 2 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.3.8.8 / Q91WN3 Aspartate/glutamate Na+-independent transporter, AGT1 from Mus musculus (Mouse) (see 5 papers)
25% identity, 76% coverage of query (77.0 bits)
CTR1_RAT / P30823 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; EcoR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Rattus norvegicus (Rat) (see paper)
24% identity, 73% coverage of query (76.6 bits)
LAT1_RABIT / Q7YQK4 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; L-type amino acid transporter 1; LAT1; Solute carrier family 7 member 5 from Oryctolagus cuniculus (Rabbit) (see 4 papers)
24% identity, 82% coverage of query (76.6 bits)
TC 2.A.3.8.2 / O13020 L-type neutral amino acid transporter, ASUR4 (Na+-independent) of 507 aas and 12 TMSs. Pregabalin (PGB), a drug for the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder, may be transported by L-type transporters from Xenopus laevis (African clawed frog) (see 2 papers)
23% identity, 82% coverage of query (75.9 bits)
PheP / b0576 phenylalanine:H+ symporter PheP from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pheP / P24207 phenylalanine:H+ symporter PheP from Escherichia coli (strain K12) (see 3 papers)
PHEP_ECOLI / P24207 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) (see 6 papers)
TC 2.A.3.1.1 / P24207 Phenylalanine:H+ symporter, PheP of 458 aas and 12 established TMSs from Escherichia coli (see 6 papers)
24% identity, 83% coverage of query (75.5 bits)
YLAT2_RAT / D3ZMM8 Y+L amino acid transporter 2; Solute carrier family 7 member 6; y(+)L-type amino acid transporter 2; Y+LAT2; y+LAT-2 from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 79% coverage of query (75.5 bits)
YLAT2_MOUSE / Q8BGK6 Y+L amino acid transporter 2; Solute carrier family 7 member 6; y(+)L-type amino acid transporter 2; Y+LAT2; y+LAT-2 from Mus musculus (Mouse) (see 5 papers)
25% identity, 79% coverage of query (75.5 bits)
CTR1_MOUSE / Q09143 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; ERR; EcoR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Mus musculus (Mouse) (see 7 papers)
TC 2.A.3.3.1 / Q09143 System Y+ high affinity basic amino acid transporter (CAT1) (ecotropic retrovival leukemia virus receptor (ERR)) (transports arginine, lysine and ornithine; Na+-independent) from Mus musculus (Mouse) (see 2 papers)
Slc7a1 / RF|NP_031539.3 high affinity cationic amino acid transporter 1 from Mus musculus
24% identity, 73% coverage of query (75.1 bits)
6li9B / P82251 Heteromeric amino acid transporter b0,+at-rbat complex bound with arginine (see paper)
24% identity, 72% coverage of query (74.3 bits)
7dskB / Q01650 Overall structure of the lat1-4f2hc bound with jx-075 (see paper)
24% identity, 82% coverage of query (73.9 bits)
SLC7A5 / Q01650 large neutral amino acids transporter small subunit 1 from Homo sapiens (see 4 papers)
LAT1_HUMAN / Q01650 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) (see 19 papers)
TC 2.A.3.8.25 / Q01650 Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain; SLC3A2) (Integral membrane protein E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic and neutral amino acid transporter) from Homo sapiens (see 24 papers)
24% identity, 82% coverage of query (73.9 bits)
7dsqB Overall structure of the lat1-4f2hc bound with 3,5-diiodo-l-tyrosine
24% identity, 82% coverage of query (73.9 bits)
7dsnB Overall structure of the lat1-4f2hc bound with jx-119
24% identity, 82% coverage of query (73.9 bits)
7dslB Overall structure of the lat1-4f2hc bound with jx-078
24% identity, 82% coverage of query (73.9 bits)
H281DRAFT_04042 phenylacetate transporter from Paraburkholderia bryophila 376MFSha3.1
25% identity, 73% coverage of query (73.6 bits)
Ga0059261_1577 L-glutamine and L-histidine transporter from Sphingomonas koreensis DSMZ 15582
24% identity, 73% coverage of query (72.4 bits)
CAAT4_ARATH / Q8W4K3 Cationic amino acid transporter 4, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.3.3.14 / Q8W4K3 Cationic amino acid transporter 4, vacuolar from Arabidopsis thaliana (see 4 papers)
21% identity, 73% coverage of query (72.4 bits)
AroR / b0112 aromatic amino acid:H+ symporter AroP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
aroP / P15993 aromatic amino acid:H+ symporter AroP from Escherichia coli (strain K12) (see 6 papers)
AROP_ECOLI / P15993 Aromatic amino acid transport protein AroP; Aromatic amino acid:H(+) symporter AroP; General aromatic amino acid permease; General aromatic transport system from Escherichia coli (strain K12) (see 8 papers)
TC 2.A.3.1.3 / P15993 Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan from Escherichia coli (see 6 papers)
23% identity, 73% coverage of query (71.2 bits)
6irtB Human lat1-4f2hc complex bound with bch
24% identity, 80% coverage of query (70.1 bits)
SLC7A11 / Q9UPY5 cystine/glutamate transporter from Homo sapiens (see paper)
XCT_HUMAN / Q9UPY5 Cystine/glutamate transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT from Homo sapiens (Human) (see 9 papers)
TC 2.A.3.8.18 / Q9UPY5 Cystine/glutamate antiporter (Amino acid transport system xCT) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) from Homo sapiens (see 7 papers)
24% identity, 82% coverage of query (67.0 bits)
7p9uB / Q9UPY5 Cryo em structure of system xc- in complex with glutamate (see paper)
24% identity, 76% coverage of query (67.0 bits)
7epzB Overall structure of erastin-bound xct-4f2hc complex
24% identity, 76% coverage of query (67.0 bits)
7nf6B / A0A6P3EL78 Ovine b0,+at-rbat heterodimer (see paper)
23% identity, 74% coverage of query (64.3 bits)
AAT6_CAEEL / Q22397 Amino acid transporter protein 6 from Caenorhabditis elegans (see 2 papers)
TC 2.A.3.8.27 / Q22397 Amino acid transporter 6 (AAT-6). Interacts with NRFL-1, the C. elegans NHERF orthologue to promote localization to the intestinal luminal membrane from Caenorhabditis elegans
24% identity, 75% coverage of query (58.9 bits)
RMV1_ARATH / Q9FFL1 Polyamine transporter RMV1; Protein RESISTANT TO METHYL VIOLOGEN 1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.12.3 / Q9FFL1 Plasma membrane polyamine/paraquot uptake transporter of 490 aas, RMV1. Also called PUT3 and LAT1. Mutations give rise to partial paraquot (a toxic common herbicide that generates superoxide and reactive oxygen species (ROS)) from Arabidopsis thaliana
23% identity, 71% coverage of query (54.3 bits)
GNP1_YEAST / P48813 High-affinity glutamine permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
TC 2.A.3.10.5 / P48813 High affinity glutamine permease from Saccharomyces cerevisiae (Baker's yeast) (see 12 papers)
GNP1 / GI|927778 high-affinity glutamine permease from Saccharomyces cerevisiae
22% identity, 75% coverage of query (43.9 bits)
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Lawrence Berkeley National Laboratory