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Searching for up to 100 curated homologs for H281DRAFT_05870 FitnessBrowser__Burk376:H281DRAFT_05870 (283 a.a.)

Found high-coverage hits (≥70%) to 55 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

5t0wA Crystal structure of the ancestral amino acid-binding protein anccdt- 1, a precursor of cyclohexadienyl dehydratase
    39% identity, 80% coverage of query (150 bits)

4zv2A An ancestral arginine-binding protein bound to glutamine
    36% identity, 78% coverage of query (139 bits)

4zv1A An ancestral arginine-binding protein bound to arginine (see paper)
    36% identity, 78% coverage of query (134 bits)

6svfA / Q9WZ62 Crystal structure of the p235gk mutant of argbp from t. Maritima (see paper)
    36% identity, 80% coverage of query (132 bits)

3k4uE / Q7MAG0 Crystal structure of putative binding component of abc transporter from wolinella succinogenes dsm 1740 complexed with lysine
    37% identity, 80% coverage of query (130 bits)

TC 3.A.1.3.21 / Q9I484 Amino acid ABC transporter periplasmic binding protein, component of Hydroxy L-proline uptake porter, HprABC from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    31% identity, 83% coverage of query (115 bits)

2yjpA / Q5F5B5 Crystal structure of the solute receptors for l-cysteine of neisseria gonorrhoeae (see paper)
    33% identity, 73% coverage of query (113 bits)

AO356_00480 ABC transporter for D-Glucosamine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    35% identity, 83% coverage of query (108 bits)

1xt8B / Q0P9S0 Crystal structure of cysteine-binding protein from campylobacter jejuni at 2.0 a resolution (see paper)
    30% identity, 82% coverage of query (108 bits)

Build an alignment

Build an alignment for H281DRAFT_05870 and 9 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

cjaA / CAJ20048.1 glutamine-binding protein from Campylobacter jejuni (see paper)
    29% identity, 90% coverage of query (108 bits)

Pf6N2E2_2053 ABC transporter for D-Glucosamine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    35% identity, 81% coverage of query (106 bits)

5eyfB / Q3XZW5 Crystal structure of solute-binding protein from enterococcus faecium with bound glutamate
    34% identity, 72% coverage of query (105 bits)

AO353_21710 ABC transporter for D-glucosamine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E3
    34% identity, 83% coverage of query (105 bits)

GLNH_BACSU / O34563 ABC transporter glutamine-binding protein GlnH from Bacillus subtilis (strain 168) (see paper)
    32% identity, 71% coverage of query (103 bits)

TcyJ / b1920 cystine ABC transporter periplasmic binding protein (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
tcyJ / P0AEM9 cystine ABC transporter periplasmic binding protein (EC 7.4.2.12) from Escherichia coli (strain K12) (see 13 papers)
TCYJ_ECOLI / P0AEM9 L-cystine-binding protein TcyJ; CBP; Protein FliY; Sulfate starvation-induced protein 7; SSI7 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.3.10 / P0AEM9 Cystine-binding periplasmic protein FLIY aka CysX aka B1920, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 7 papers)
    28% identity, 97% coverage of query (97.1 bits)

ArtJ / b0860 L-arginine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see paper)
ArtJ / P30860 L-arginine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli (strain K12) (see paper)
ARTJ_ECOLI / P30860 ABC transporter arginine-binding protein 1 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.3 / P30860 ArtJ aka B0860, component of Arginine porter from Escherichia coli (see 7 papers)
artJ / GB|BAA35574.1 arginine ABC transporter, periplasmic arginine-binding protein ArtJ from Escherichia coli K12 (see 8 papers)
    30% identity, 76% coverage of query (94.0 bits)

4ymxA / Q8RCC4 Crystal structure of the substrate binding protein of an amino acid abc transporter (see paper)
    29% identity, 77% coverage of query (92.4 bits)

6h20A Glnh bound to asn, mycobacterium tuberculosis
    28% identity, 78% coverage of query (91.3 bits)

6h1uA Glnh bound to asp, mycobacterium tuberculosis
    28% identity, 78% coverage of query (91.3 bits)

6h2tA / P96257 Glnh bound to glu, mycobacterium tuberculosis (see paper)
    28% identity, 78% coverage of query (90.9 bits)

3vvdA / Q72JG5 Crystal structure of ttc0807 complexed with ornithine (see paper)
    26% identity, 82% coverage of query (90.5 bits)

3vvfA Crystal structure of ttc0807 complexed with arginine
    26% identity, 82% coverage of query (90.5 bits)

3vveA Crystal structure of ttc0807 complexed with lysine
    26% identity, 82% coverage of query (90.5 bits)

3vv5A Crystal structure of ttc0807 complexed with (s)-2-aminoethyl-l- cysteine (aec)
    26% identity, 82% coverage of query (90.1 bits)

2y7iA / Q8ZKA9 Structural basis for high arginine specificity in salmonella typhimurium periplasmic binding protein stm4351. (see paper)
    25% identity, 77% coverage of query (85.1 bits)

2pvuA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus
    30% identity, 77% coverage of query (84.7 bits)

PHEC_PSEAE / Q01269 Cyclohexadienyl dehydratase; EC 4.2.1.51; EC 4.2.1.91 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q01269 arogenate dehydratase (EC 4.2.1.91) from Pseudomonas aeruginosa (see 3 papers)
    28% identity, 83% coverage of query (84.3 bits)

2q2aA / D0VWX8 Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus (see paper)
    30% identity, 77% coverage of query (84.3 bits)

2q2cA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus
    30% identity, 77% coverage of query (84.3 bits)

4ohnA / A0A0H2UKY8 Crystal structure of an abc uptake transporter substrate binding protein from streptococcus pneumoniae with bound histidine
    25% identity, 78% coverage of query (82.8 bits)

GLUB_CORGL / P48242 Glutamate-binding protein GluB; Glutamate uptake system protein GluB from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 2 papers)
TC 3.A.1.3.9 / P48242 GluB aka CGL1951, component of Glutamate porter from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
    26% identity, 94% coverage of query (82.4 bits)

TC 3.A.1.3.17 / Q8YSA2 Basic amino acid uptake transporter, BgtAB (see paper)
    29% identity, 79% coverage of query (80.9 bits)

HISJ_CAMJE / Q46125 Probable histidine-binding protein; HBP; p29 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
    29% identity, 72% coverage of query (79.3 bits)

ArtI / b0863 putative ABC transporter periplasmic binding protein ArtI from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ARTI_ECOLI / P30859 Putative ABC transporter arginine-binding protein 2 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.3 / P30859 ArtI aka B0863, component of Arginine porter from Escherichia coli (see 7 papers)
    26% identity, 77% coverage of query (77.4 bits)

8eyzA / P0AEQ3 Engineered glutamine binding protein bound to gln and a cobaloxime ligand (see paper)
    25% identity, 75% coverage of query (73.6 bits)

2v25A / Q0P9X8 Structure of the campylobacter jejuni antigen peb1a, an aspartate and glutamate receptor with bound aspartate (see paper)
    27% identity, 79% coverage of query (73.2 bits)

3i6vA / Q5LTV6 Crystal structure of a periplasmic his/glu/gln/arg/opine family- binding protein from silicibacter pomeroyi in complex with lysine
    26% identity, 78% coverage of query (72.4 bits)

6detA / S3MDF0 The crystal structure of tv2483 bound to l-arginine (see paper)
    24% identity, 74% coverage of query (68.2 bits)

HisJ / b2309 histidine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
HISJ_ECOLI / P0AEU0 Histidine-binding periplasmic protein; HBP from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.29 / P0AEU0 Histidine-binding periplasmic protein, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
hisJ / GB|AAC75369.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Escherichia coli (see 7 papers)
    25% identity, 77% coverage of query (68.2 bits)

5kkwA / Q4FLR5 Crystal structure of sar11_1068 bound to a sulfobetaine (3-(1- methylpiperidinium-1-yl)propane-1-sulfonate)
    27% identity, 74% coverage of query (68.2 bits)

2ia4B / A0A0H2UXX1 Crystal structure of novel amino acid binding protein from shigella flexneri
    24% identity, 86% coverage of query (67.8 bits)

HISJ_SALTY / P02910 Histidine-binding periplasmic protein; HBP from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
hisJ / GB|AAV76512.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Salmonella enterica subsp. enterica serovar Typhimurium (see 5 papers)
    25% identity, 77% coverage of query (66.2 bits)

2vhaA Debp
    24% identity, 86% coverage of query (66.2 bits)

1hslA / P0AEU0 Refined 1.89 angstroms structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport(slash)chemosensory receptors (see paper)
    25% identity, 77% coverage of query (66.2 bits)

P16575 Virulence sensor protein BvgS; EC 2.7.13.3 from Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
    24% identity, 75% coverage of query (57.4 bits)

5lomB / Q7D447 Crystal structure of the pbp soca from agrobacterium tumefaciens c58 in complex with dfg at 1.5 a resolution (see paper)
    24% identity, 80% coverage of query (56.6 bits)

5l9oB Crystal structure of agrobacterium tumefaciens c58 strain pbp soca in complex with glucopine
    24% identity, 78% coverage of query (56.6 bits)

5l9oA Crystal structure of agrobacterium tumefaciens c58 strain pbp soca in complex with glucopine
    24% identity, 80% coverage of query (56.6 bits)

3qaxB / Q9Z869 Crystal structure analysis of the cpb0502
    23% identity, 75% coverage of query (54.3 bits)

1iitA Glur0 ligand binding core complex with l-serine
    25% identity, 73% coverage of query (52.0 bits)

1ii5A / P73797 Crystal structure of the glur0 ligand binding core complex with l- glutamate (see paper)
    25% identity, 73% coverage of query (52.0 bits)

2q89A Crystal structure of ehub in complex with hydroxyectoine
    24% identity, 72% coverage of query (52.0 bits)

2q88A / Q92WC8 Crystal structure of ehub in complex with ectoine (see paper)
    24% identity, 72% coverage of query (52.0 bits)

2pyyB / D0VWX9 Crystal structure of the glur0 ligand-binding core from nostoc punctiforme in complex with (l)-glutamate (see paper)
    25% identity, 71% coverage of query (47.8 bits)

4z9nB / A0A0M3KL33 Abc transporter / periplasmic binding protein from brucella ovis with glutathione bound
    24% identity, 79% coverage of query (47.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory