Searching for up to 100 curated homologs for HSERO_RS02375 FitnessBrowser__HerbieS:HSERO_RS02375 (320 a.a.)
Found high-coverage hits (≥70%) to 72 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
wbpV / Q9RHC9 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Pseudomonas aeruginosa (see paper)
58% identity, 99% coverage of query (369 bits)
ORF35x7 / CAA69124.1 ORF35x7 from Vibrio cholerae (see paper)
52% identity, 99% coverage of query (322 bits)
wreQ / Q6TP29 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see 2 papers)
Q6TP29 UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see paper)
50% identity, 95% coverage of query (301 bits)
wbpK / P72144 UDP-N-acetyl-α-D-fucosamine dehydrogenase from Pseudomonas aeruginosa (see 2 papers)
40% identity, 98% coverage of query (224 bits)
wbiG / GI|3135686 putative epimerase/dehydratase WbiG from Burkholderia pseudomallei (see paper)
41% identity, 97% coverage of query (209 bits)
Build an alignment for HSERO_RS02375 and 5 homologs with ≥ 30% identity
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Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
26% identity, 100% coverage of query (90.1 bits)
cpsG polysaccharide capsule synthesis protein CpsG from Streptococcus iniae (see paper)
28% identity, 81% coverage of query (87.4 bits)
gnu / Q8X7P7 N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase (EC 5.1.3.26) from Escherichia coli O157:H7 (see 2 papers)
GNU_ECO57 / Q8X7P7 N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase; GlcNAc-P-P-Und 4-epimerase; EC 5.1.3.26 from Escherichia coli O157:H7 (see paper)
gne UDP-N-acetylglucosamine 4-epimerase; EC 5.1.3.7 from Escherichia coli O157:H7 (see paper)
25% identity, 98% coverage of query (86.7 bits)
F8U971 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Botrytis cinerea (see paper)
27% identity, 80% coverage of query (78.6 bits)
6bwlA / Q3ESA4 X-ray structure of pal from bacillus thuringiensis (see paper)
24% identity, 98% coverage of query (76.6 bits)
4id9B / A9CL58 Crystal structure of a short-chain dehydrogenase/reductase superfamily protein from agrobacterium tumefaciens (target efi-506441) with bound NAD, monoclinic form 1
28% identity, 72% coverage of query (73.6 bits)
3BHD_MYCNE / P0DX24 3-beta-hydroxysteroid dehydrogenase; 3beta-HSD; EC 1.1.1.51 from Mycolicibacterium neoaurum (Mycobacterium neoaurum) (see paper)
27% identity, 98% coverage of query (73.6 bits)
tylA2 / Q54144 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Streptomyces fradiae (see 2 papers)
27% identity, 99% coverage of query (73.6 bits)
4id9A Crystal structure of a short-chain dehydrogenase/reductase superfamily protein from agrobacterium tumefaciens (target efi-506441) with bound NAD, monoclinic form 1
28% identity, 72% coverage of query (73.6 bits)
jadT / Q939Q5 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see paper)
29% identity, 79% coverage of query (73.2 bits)
graE / AAA99939.1 dTDP-glucose dehydratase from Streptomyces violaceoruber (see paper)
27% identity, 99% coverage of query (72.8 bits)
JF740056 / F8U969 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Magnaporthe oryzae (see paper)
F8U969 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Pyricularia grisea (see paper)
28% identity, 80% coverage of query (72.8 bits)
hsdD / P9WQP7 3 β-hydroxysteroid dehydrogenase (EC 5.3.3.1; EC 1.1.1.145) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
3BHS_MYCTU / P9WQP7 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Cholesterol dehydrogenase; EC 1.1.1.145; EC 5.3.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WQP7 3beta-hydroxy-DELTA5-steroid dehydrogenase (EC 1.1.1.145) from Mycobacterium tuberculosis (see paper)
26% identity, 98% coverage of query (72.0 bits)
Q9N119 3beta-hydroxy-DELTA5-steroid dehydrogenase (EC 1.1.1.145) from Sus scrofa (see 2 papers)
27% identity, 97% coverage of query (72.0 bits)
TGDS_HUMAN / O95455 dTDP-D-glucose 4,6-dehydratase; EC 4.2.1.46 from Homo sapiens (Human) (see paper)
22% identity, 99% coverage of query (71.6 bits)
8vr2B / Q1QD53 Crystal structure of the pcryo_0617 oxidoreductase/decarboxylase from psychrobacter cryohalolentis k5 in the presence of NAD and udp
25% identity, 98% coverage of query (70.1 bits)
RHM2 / Q9LPG6 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM2 (EC 4.2.1.76) from Arabidopsis thaliana (see 2 papers)
RHM2_ARATH / Q9LPG6 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2; NDP-rhamnose synthase; Protein MUCILAGE-MODIFIED 4; Protein RHAMNOSE BIOSYNTHESIS 2; Rhamnose biosynthetic enzyme 2; AtRHM2; UDP-L-rhamnose synthase MUM4; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
27% identity, 72% coverage of query (69.7 bits)
3β-HSD/D1 / Q9FX01 plant 3β-hydroxysteroid dehydrogenase/C4-decarboxylase 1 (EC 1.1.1.418) from Arabidopsis thaliana (see 3 papers)
HSDD1_ARATH / Q9FX01 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1; At3BETAHSD/D1; 4alpha-carboxysterol-C3-dehydrogenase/C4-decarboxylase isoform 1-1; Reticulon-like protein B24; AtRTNLB24; Sterol-4-alpha-carboxylate 3-dehydrogenase 1, decarboxylating; EC 1.1.1.418 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
25% identity, 98% coverage of query (68.9 bits)
RMD_PSEAE / Q9HTB6 GDP-6-deoxy-D-mannose reductase; EC 1.1.1.281 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HTB6 GDP-4-dehydro-6-deoxy-D-mannose reductase (EC 1.1.1.281) from Pseudomonas aeruginosa (see paper)
26% identity, 98% coverage of query (68.9 bits)
oleD / Q8PDW5 2-alkyl-3-oxo-fatty acid reductase monomer (EC 1.1.1.412) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 2 papers)
OLED_XANCP / Q8PDW5 2-alkyl-3-oxoalkanoate reductase; EC 1.1.1.412 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 2 papers)
25% identity, 98% coverage of query (67.8 bits)
RMLB_BACSU / P39630 dTDP-glucose 4,6-dehydratase; Spore coat polysaccharide biosynthesis protein SpsJ; EC 4.2.1.46 from Bacillus subtilis (strain 168) (see paper)
23% identity, 98% coverage of query (67.8 bits)
6x3bA / Q9HTB6 Structure of rmd from pseudomonas aeruginosa complexed with NADPH
26% identity, 98% coverage of query (67.4 bits)
1r66A / Q9ZGH3 Crystal structure of desiv (dtdp-glucose 4,6-dehydratase) from streptomyces venezuelae with NAD and tyd bound (see paper)
27% identity, 99% coverage of query (67.4 bits)
1r6dA Crystal structure of desiv double mutant (dtdp-glucose 4,6- dehydratase) from streptomyces venezuelae with NAD and dau bound
27% identity, 99% coverage of query (67.4 bits)
6x3bB Structure of rmd from pseudomonas aeruginosa complexed with NADPH
26% identity, 98% coverage of query (65.9 bits)
desIV / Q9ZGH3 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Streptomyces venezuelae (see paper)
27% identity, 99% coverage of query (65.5 bits)
RmlB / b2041 dTDP-glucose 4,6-dehydratase 1 (EC 4.2.1.46) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
rfbB / P37759 dTDP-glucose 4,6-dehydratase 1 (EC 4.2.1.46) from Escherichia coli (strain K12) (see 6 papers)
RMLB1_ECOLI / P37759 dTDP-glucose 4,6-dehydratase 1; EC 4.2.1.46 from Escherichia coli (strain K12) (see paper)
25% identity, 99% coverage of query (65.5 bits)
RHM1 / Q9SYM5 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM1 (EC 4.2.1.76) from Arabidopsis thaliana (see 3 papers)
RHM1_ARATH / Q9SYM5 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; Protein REPRESSOR OF LRX1 1; Rhamnose biosynthetic enzyme 1; AtRHM1; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
24% identity, 99% coverage of query (65.1 bits)
RHM3 / Q9LH76 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM3 (EC 4.2.1.76) from Arabidopsis thaliana (see 2 papers)
RHM3_ARATH / Q9LH76 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM3; Probable rhamnose biosynthetic enzyme 3; AtRHM3; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
27% identity, 72% coverage of query (64.7 bits)
6zllA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-galacturonic acid and NAD (see paper)
23% identity, 100% coverage of query (64.7 bits)
A0A2Z5XEV7 dihydroflavonol 4-reductase (EC 1.1.1.219) from Fagopyrum esculentum subsp. esculentum (see paper)
26% identity, 80% coverage of query (64.7 bits)
ERG26_CANAL / Q5A1B0 Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating; C-3 sterol dehydrogenase ERG26; C-4 decarboxylase ERG26; EC 1.1.1.170 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
Q5A1B0 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) from Candida albicans (see paper)
ERG26 C-3 sterol dehydrogenase/C-4 decarboxylase from Candida albicans (see paper)
24% identity, 98% coverage of query (64.7 bits)
6zldA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-glucuronic acid and NAD
23% identity, 100% coverage of query (64.7 bits)
6zl6A Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp and NAD
23% identity, 100% coverage of query (64.7 bits)
YbjT / b0869 putative NAD(P)-dependent oxidoreductase YbjT from Escherichia coli K-12 substr. MG1655 (see paper)
26% identity, 83% coverage of query (64.3 bits)
agl12 / D4GU72 dTDP-glucose-4,6-dehydratase (EC 4.2.1.46) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
AGL12_HALVD / D4GU72 Low-salt glycan biosynthesis protein Agl12; EC 4.2.1.- from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
24% identity, 99% coverage of query (63.9 bits)
A7K9F4 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Acanthocystis turfacea chlorella virus 1 (see paper)
26% identity, 98% coverage of query (63.5 bits)
ravE / D1H0J1 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Streptomyces ravidus (see 2 papers)
26% identity, 99% coverage of query (63.2 bits)
rfbB / AAA63157.1 TDP-glucose-dehydratase from Neisseria meningitidis (see paper)
25% identity, 98% coverage of query (63.2 bits)
6zljA Crystal structure of udp-glucuronic acid 4-epimerase y149f mutant from bacillus cereus in complex with udp-4-deoxy-4-fluoro-glucuronic acid and NAD
22% identity, 100% coverage of query (63.2 bits)
RMLB1_ECOLX / P55293 dTDP-glucose 4,6-dehydratase; EC 4.2.1.46 from Escherichia coli (see paper)
rmlB / AAC63612.1 RmlB from Escherichia coli (see 6 papers)
25% identity, 99% coverage of query (62.4 bits)
OLED_STRMK / B2FI29 2-alkyl-3-oxoalkanoate reductase; EC 1.1.1.412 from Stenotrophomonas maltophilia (strain K279a) (see paper)
B2FI29 2-alkyl-3-oxoalkanoate reductase (EC 1.1.1.412) from Stenotrophomonas maltophilia (see 2 papers)
24% identity, 98% coverage of query (62.4 bits)
gdh / Q54116 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Saccharopolyspora erythraea (see 2 papers)
24% identity, 99% coverage of query (62.4 bits)
A0A5C1IY10 dihydroflavonol 4-reductase (EC 1.1.1.219) from Muscari aucheri (see paper)
28% identity, 73% coverage of query (62.0 bits)
mtmE / Q194R3 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Streptomyces argillaceus (see paper)
27% identity, 99% coverage of query (61.2 bits)
gdh / Q93EK0 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Saccharopolyspora spinosa (see 2 papers)
24% identity, 99% coverage of query (61.2 bits)
2hunA / O58151 Crystal structure of hypothetical protein ph0414 from pyrococcus horikoshii ot3
23% identity, 99% coverage of query (60.1 bits)
NSDHL_MOUSE / Q9R1J0 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; EC 1.1.1.170 from Mus musculus (Mouse) (see 4 papers)
Q9R1J0 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) from Mus musculus (see paper)
23% identity, 98% coverage of query (59.3 bits)
3c1tB / P51110 Binding of two substrate analogue molecules to dihydroflavonol 4- reductase alters the functional geometry of the catalytic site (see paper)
26% identity, 73% coverage of query (58.2 bits)
6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac
28% identity, 71% coverage of query (58.2 bits)
6wj9B / Q4KCF6 Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
28% identity, 71% coverage of query (57.8 bits)
Rff / b3788 dTDP-glucose 4,6-dehydratase 2 (EC 4.2.1.46) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
rffG / P27830 dTDP-glucose 4,6-dehydratase 2 (EC 4.2.1.46) from Escherichia coli (strain K12) (see 5 papers)
RMLB2_ECOLI / P27830 dTDP-glucose 4,6-dehydratase 2; EC 4.2.1.46 from Escherichia coli (strain K12) (see 3 papers)
24% identity, 98% coverage of query (57.8 bits)
auaH / H1ZZB0 4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide 3-reductase (EC 1.1.1.394) from Stigmatella aurantiaca (see 2 papers)
AUAH_STIAU / H1ZZB0 Aurachin B dehydrogenase; EC 1.1.1.394 from Stigmatella aurantiaca (see 2 papers)
H1ZZB0 aurachin B dehydrogenase (EC 1.1.1.394) from Stigmatella aurantiaca (see paper)
26% identity, 74% coverage of query (56.6 bits)
7ystA / P9WN67 Crystal structure of udp-glucose 4-epimerase (rv3634c) in complex with both udp-glucose and udp-galactose in chain b from mycobacterium tuberculosis
28% identity, 100% coverage of query (55.8 bits)
7ysmA Crystal structure of udp-glucose 4-epimerase (rv3634c) co-crystallized with udp-n-acetylglucosamine from mycobacterium tuberculosis
28% identity, 100% coverage of query (55.8 bits)
3bxxA Binding of two substrate analogue molecules to dihydroflavonol 4-reductase alters the functional geometry of the catalytic site
26% identity, 73% coverage of query (55.5 bits)
2nnlD Binding of two substrate analogue molecules to dihydroflavonol-4- reductase alters the functional geometry of the catalytic site
26% identity, 73% coverage of query (55.5 bits)
2c29D Structure of dihydroflavonol reductase from vitis vinifera at 1.8 a.
26% identity, 73% coverage of query (55.5 bits)
8femA / A0A8T0SQV2 Panicum vigratum dihydroflavonol 4-reductase complexed with NADP (see paper)
27% identity, 73% coverage of query (53.5 bits)
8fenA Panicum vigratum dihydroflavonol 4-reductase complexed with NADP and dhq
27% identity, 73% coverage of query (53.5 bits)
6bi4C / A0A6L7HMN5 2.9 angstrom resolution crystal structure of dtdp-glucose 4,6- dehydratase (rfbb) from bacillus anthracis str. Ames in complex with NAD. (see paper)
22% identity, 100% coverage of query (53.1 bits)
CCR1_PETHY / A0A059TC02 Cinnamoyl-CoA reductase 1; Ph-CCR1; Coniferylaldehyde synthase; Coumaroyl-CoA reductase; Feruloyl-CoA reductase; Sinapoyl-CoA reductase; EC 1.2.1.44 from Petunia hybrida (Petunia) (see 2 papers)
A0A059TC02 cinnamoyl-CoA reductase (EC 1.2.1.44) from Petunia x hybrida (see paper)
28% identity, 73% coverage of query (52.8 bits)
4r1sA / A0A059TC02 Crystal structure of petunia hydrida cinnamoyl-coa reductase (see paper)
28% identity, 73% coverage of query (52.8 bits)
8sk0B / A0A1C5ADV9 Crystal structure of evds6 decarboxylase in ligand bound state (see paper)
28% identity, 79% coverage of query (51.2 bits)
8sk0A Crystal structure of evds6 decarboxylase in ligand bound state
28% identity, 79% coverage of query (50.8 bits)
8b9zP / Q9VPE2 Drosophila melanogaster complex i in the active state (dm1) (see paper)
24% identity, 72% coverage of query (47.8 bits)
2p5uA / Q5SKQ2 Crystal structure of thermus thermophilus hb8 udp-glucose 4-epimerase complex with NAD
24% identity, 100% coverage of query (47.8 bits)
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Lawrence Berkeley National Laboratory