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Searching for up to 100 curated homologs for HSERO_RS02535 FitnessBrowser__HerbieS:HSERO_RS02535 (249 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

7krmC / A0A077GFB1 Putative fabg bound to nadh from acinetobacter baumannii
    62% identity, 100% coverage of query (305 bits)

FabG / b1093 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
fabG / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli (strain K12) (see 22 papers)
FABG_ECOLI / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 9 papers)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Escherichia coli (see 2 papers)
    38% identity, 100% coverage of query (169 bits)

4nbuB Crystal structure of fabg from bacillus sp (see paper)
    39% identity, 99% coverage of query (169 bits)

1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+
    37% identity, 99% coverage of query (169 bits)

6t77A / W9B6I8 Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
    37% identity, 100% coverage of query (167 bits)

1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment
    37% identity, 99% coverage of query (167 bits)

4jroC / Q8Y690 Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
    38% identity, 100% coverage of query (166 bits)

FABG_SALTY / P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    37% identity, 100% coverage of query (165 bits)

lra1 / C1DMX5 NAD(P)+-dependent L-rhamnose 1-dehydrogenase (EC 1.1.1.378; EC 1.1.1.173) from Azotobacter vinelandii (strain DJ / ATCC BAA-1303) (see paper)
    41% identity, 100% coverage of query (164 bits)

bacC / P39640 dihydroanticapsin dehydrogenase (EC 1.1.1.385) from Bacillus subtilis (strain 168) (see paper)
BACC_BACSU / P39640 Dihydroanticapsin 7-dehydrogenase; Bacilysin biosynthesis oxidoreductase BacC; EC 1.1.1.385 from Bacillus subtilis (strain 168) (see 3 papers)
P39640 dihydroanticapsin dehydrogenase (EC 1.1.1.385) from Bacillus subtilis (see paper)
    38% identity, 98% coverage of query (163 bits)

5itvA / P39640 Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
    38% identity, 98% coverage of query (163 bits)

3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
    37% identity, 100% coverage of query (162 bits)

7b81A / C1DMX5 Crystal structure of azotobacter vinelandii l-rhamnose 1-dehydrogenase (NAD bound-form) (see paper)
    40% identity, 100% coverage of query (162 bits)

7do7A Crystal structure of azotobacter vinelandii l-rhamnose 1- dehydrogenase(NAD and l-rhamnose bound-form)
    40% identity, 100% coverage of query (162 bits)

4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH
    37% identity, 100% coverage of query (160 bits)

4nbtA / A9NFJ2 Crystal structure of fabg from acholeplasma laidlawii (see paper)
    40% identity, 98% coverage of query (159 bits)

BBSD_THAAR / Q9KJF1 (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase subunit BbsD; (S,R)-2-(alpha-hydroxybenzyl)succinyl-CoA dehydrogenase subunit BbsD; EC 1.1.1.429 from Thauera aromatica (see 2 papers)
    42% identity, 98% coverage of query (159 bits)

fabG / P51831 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Bacillus subtilis (strain 168) (see 3 papers)
    36% identity, 99% coverage of query (158 bits)

7pcsB / Q9KJF1 Structure of the heterotetrameric sdr family member bbscd (see paper)
    42% identity, 98% coverage of query (158 bits)

7tzpG / A0A332H2K8 Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
    38% identity, 100% coverage of query (156 bits)

BWI76_RS23705 2-deoxy-D-ribonyl-CoA 3-dehydrogenase from Klebsiella michiganensis M5al
    38% identity, 100% coverage of query (155 bits)

C0IR58 aryl-alcohol dehydrogenase (NADP+) (EC 1.1.1.91) from Ralstonia sp. (see paper)
4bmsF / C0IR58 Short chain alcohol dehydrogenase from ralstonia sp. Dsm 6428 in complex with NADPH
    38% identity, 98% coverage of query (154 bits)

A5HIF6 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Pseudomonas putida (see paper)
    39% identity, 100% coverage of query (154 bits)

FABG_AQUAE / O67610 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Aquifex aeolicus (strain VF5)
    36% identity, 98% coverage of query (154 bits)

fabG / D4YGY5 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Aerococcus viridans (strain ATCC 11563 / DSM 20340 / CCUG 4311 / JCM 20461 / NBRC 12219 / NCTC 8251 / M1) (see paper)
    37% identity, 98% coverage of query (153 bits)

Q2FZ53 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Staphylococcus aureus (see paper)
    37% identity, 98% coverage of query (153 bits)

FABG_STAAM / P0A0H9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Staphylococcus aureus (strain Mu50 / ATCC 700699)
3osuA / P0A0H9 Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
    37% identity, 98% coverage of query (153 bits)

7emgB Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
    35% identity, 99% coverage of query (152 bits)

Q31QF3 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Synechococcus elongatus PCC 7942 = FACHB-805 (see paper)
    39% identity, 99% coverage of query (151 bits)

6ihhA Crystal structure of rasadh f12 from ralstonia.Sp in complex with NADPH and a6o
    38% identity, 98% coverage of query (151 bits)

PHAB_SYNY3 / P73826 Acetoacetyl-CoA reductase; EC 1.1.1.36 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    37% identity, 97% coverage of query (149 bits)

BPHYT_RS16120 sorbitol dehydrogenase, D-fructose forming (EC 1.1.1.14) from Burkholderia phytofirmans PsJN
    37% identity, 98% coverage of query (149 bits)

Atu3164 / A9CES4 galactitol 2-dehydrogenase (EC 1.1.1.16) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
GDH_AGRFC / A9CES4 Galactitol 2-dehydrogenase; GDH; Sorbitol dehydrogenase; SorbD; EC 1.1.1.16; EC 1.1.1.- from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
    37% identity, 98% coverage of query (149 bits)

BPHYT_RS28235 L-rhamnose-1-dehydrogenase ( EC 1.1.1.173) from Burkholderia phytofirmans PsJN
    37% identity, 100% coverage of query (147 bits)

ptmO8 / D8L2W5 ent-kauranol 7β-dehydrogenase from Streptomyces platensis (see paper)
    37% identity, 99% coverage of query (147 bits)

3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH
    36% identity, 98% coverage of query (147 bits)

YgeC / b2842 putative 2-keto-3-deoxy-D-gluconate dehydrogenase (EC 1.1.1.127) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
kduD / P37769 putative 2-keto-3-deoxy-D-gluconate dehydrogenase (EC 1.1.1.127) from Escherichia coli (strain K12) (see 5 papers)
KDUD_ECOLI / P37769 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase; 2-deoxy-D-gluconate 3-dehydrogenase; 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase; 20-ketosteroid reductase; EC 1.1.1.127; EC 1.1.1.- from Escherichia coli (strain K12) (see 3 papers)
    38% identity, 98% coverage of query (146 bits)

CHNA_RHOS6 / Q6TMA3 Cyclohexanol dehydrogenase; Cyclohexanol dehydrogenase II; CHD II; EC 1.1.1.245 from Rhodococcus sp. (strain TK6)
    38% identity, 98% coverage of query (146 bits)

5itvD / P39640 Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
    35% identity, 98% coverage of query (146 bits)

7do6A Crystal structure of azotobacter vinelandii l-rhamnose 1- dehydrogenase(NADP bound-form)
    38% identity, 100% coverage of query (145 bits)

5vt6A / Q3JJT1 Crystal structure of acetoacetyl-coa reductase from burkholderia pseudomallei 1710b complexed with NADP
    34% identity, 97% coverage of query (144 bits)

4dmmB / Q31QF3 3-oxoacyl-[acyl-carrier-protein] reductase from synechococcus elongatus pcc 7942 in complex with NADP
    37% identity, 99% coverage of query (144 bits)

5t5qC / Q2YL80 Crystal structure of short-chain dehydrogenase/reductase sdr:glucose/ribitol dehydrogenase from brucella melitensis
    33% identity, 99% coverage of query (144 bits)

FABG_SYNY3 / P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    37% identity, 99% coverage of query (143 bits)

6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii
    35% identity, 100% coverage of query (143 bits)

4nbwA / A6G411 Crystal structure of fabg from plesiocystis pacifica (see paper)
    36% identity, 98% coverage of query (142 bits)

hdhA / Q9S3U5 7α-hydroxysteroid dehydrogenase subunit (EC 1.1.1.159) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) (see paper)
HDHA_BACFN / Q5LA59 7alpha-hydroxysteroid dehydrogenase; 7alpha-HSDH; Aromatic aldehyde reductase; NAD-dependent 7alpha-hydroxysteroid dehydrogenase; EC 1.1.1.159; EC 1.1.1.- from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / LMG 10263 / NCTC 9343 / Onslow / VPI 2553 / EN-2) (see 2 papers)
Q9S3U5 7alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) from Bacteroides fragilis (see paper)
    36% identity, 99% coverage of query (142 bits)

6t62A / V5VHN7 Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
    35% identity, 100% coverage of query (142 bits)

3tzcA Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg)(y155f) from vibrio cholerae (see paper)
    35% identity, 99% coverage of query (142 bits)

AO356_20240 L-arabinose 1-dehydrogenase (EC 1.1.1.46) from Pseudomonas fluorescens FW300-N2C3
    39% identity, 98% coverage of query (142 bits)

YfeF / b2426 oxidoreductase UcpA (EC 1.1.1.304) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
ucpA / P37440 oxidoreductase UcpA (EC 1.1.1.304) from Escherichia coli (strain K12) (see 6 papers)
    37% identity, 98% coverage of query (142 bits)

Pf6N2E2_5967 L-arabinose 1-dehydrogenase / D-galactose 1-dehydrogenase (EC 1.1.1.46; EC 1.1.1.48) from Pseudomonas fluorescens FW300-N2E2
    39% identity, 98% coverage of query (141 bits)

baiA3 / P07914 3α-hydroxysteroyl-CoA 3-dehydrogenase monomer (EC 1.1.1.395) from Clostridium scindens (strain JCM 10418 / VPI 12708) (see 8 papers)
BAIA1_CLOSV / P07914 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 1/3; 3alpha-hydroxysteroid dehydrogenase 1/3; 3alpha-HSDH 1/3; Bile acid-inducible protein BaiA1; Bile acid-inducible protein BaiA3; EC 1.1.1.395 from Clostridium scindens (strain JCM 10418 / VPI 12708) (see paper)
    33% identity, 98% coverage of query (141 bits)

kduD / Q05528 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (EC 1.1.1.127) from Dickeya dadantii (strain 3937) (see 3 papers)
KDUD_DICD3 / Q05528 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase; 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase; EC 1.1.1.127 from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see paper)
    35% identity, 98% coverage of query (141 bits)

A0A5P1R8U8 acetoacetyl-CoA reductase (subunit 2/2) (EC 1.1.1.36) from Neptunomonas concharum (see paper)
    39% identity, 75% coverage of query (141 bits)

tsaC / P94681 4-sulfobenzyl alcohol dehydrogenase subunit (EC 1.1.1.257) from Comamonas testosteroni (see paper)
TSAC_COMTE / P94681 4-formylbenzenesulfonate dehydrogenase TsaC1/TsaC2; Toluenesulfonate zinc-independent alcohol dehydrogenase TsaC; EC 1.2.1.62 from Comamonas testosteroni (Pseudomonas testosteroni) (see 2 papers)
    36% identity, 100% coverage of query (141 bits)

Q4AE87 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Pseudomonas sp. (see paper)
fabG / BAE19680.1 3-oxoacyl-(acyl-carrier-protein) reductase from Pseudomonas sp. 61-3 (see paper)
    36% identity, 100% coverage of query (140 bits)

Q4UN54 acetoacetyl-CoA reductase (EC 1.1.1.36) from Rickettsia felis (see paper)
    34% identity, 96% coverage of query (140 bits)

2ewmB / Q5P5I4 Crystal structure of the (s)-specific 1-phenylethanol dehydrogenase of the denitrifying bacterium strain ebn1 (see paper)
    39% identity, 99% coverage of query (140 bits)

ped / Q5P5I4 1-phenylethanol dehydrogenase subunit (EC 1.1.1.311) from Aromatoleum aromaticum (strain EbN1) (see paper)
PED_AROAE / Q5P5I4 (S)-1-Phenylethanol dehydrogenase; EC 1.1.1.311 from Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) (see 2 papers)
Q5P5I4 (S)-1-phenylethanol dehydrogenase (EC 1.1.1.311) from Azoarcus sp. (see paper)
ped / CAI07428.1 (S)-1-Phenylethanol dehydrogenase from Aromatoleum aromaticum EbN1 (see 4 papers)
    39% identity, 99% coverage of query (140 bits)

4za2D Crystal structure of pectobacterium carotovorum 2-keto-3-deoxy-d- gluconate dehydrogenase complexed with NAD+ (see paper)
    36% identity, 98% coverage of query (140 bits)

phbB / P23238 acetoacetyl-CoA reductase subunit (EC 1.1.1.36) from Shinella zoogloeoides (see 2 papers)
PHAB_SHIZO / P23238 Acetoacetyl-CoA reductase; EC 1.1.1.36 from Shinella zoogloeoides (Crabtreella saccharophila) (see paper)
    35% identity, 98% coverage of query (140 bits)

DHRS4_HUMAN / Q9BTZ2 Dehydrogenase/reductase SDR family member 4; NADPH-dependent carbonyl reductase; CR; NADPH-dependent retinol dehydrogenase/reductase; NRDR; humNRDR; Peroxisomal short-chain alcohol dehydrogenase; PSCD; SCAD-SRL; Short chain dehydrogenase/reductase family 25C member 2; Protein SDR25C2; Short-chain dehydrogenase/reductase family member 4; EC 1.1.1.184 from Homo sapiens (Human) (see 7 papers)
Q9BTZ2 NADP-retinol dehydrogenase (EC 1.1.1.300) from Homo sapiens (see paper)
    35% identity, 98% coverage of query (140 bits)

DHG_PRIMG / P40288 Glucose 1-dehydrogenase; EC 1.1.1.47 from Priestia megaterium (Bacillus megaterium) (see paper)
P40288 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Priestia megaterium (see 9 papers)
    31% identity, 98% coverage of query (140 bits)

1g6kA / P40288 Crystal structure of glucose dehydrogenase mutant e96a complexed with NAD+
    31% identity, 98% coverage of query (140 bits)

3o4rA / Q9BTZ2 Crystal structure of human dehydrogenase/reductase (sdr family) member 4 (dhrs4)
    35% identity, 98% coverage of query (139 bits)

P39482 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Priestia megaterium (see paper)
    31% identity, 98% coverage of query (139 bits)

4cqlI / Q92506 Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD (see paper)
    36% identity, 99% coverage of query (139 bits)

1vl8B / Q9WYS2 Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
    33% identity, 98% coverage of query (139 bits)

uxaD / Q9WYS2 fructuronate reductase from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    33% identity, 98% coverage of query (139 bits)

Pf1N1B4_412 L-arabinose 1-dehydrogenase / D-galactose 1-dehydrogenase (EC 1.1.1.46; EC 1.1.1.48) from Pseudomonas fluorescens FW300-N1B4
    38% identity, 98% coverage of query (139 bits)

FABG_RICPR / P50941 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Rickettsia prowazekii (strain Madrid E)
P50941 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Rickettsia prowazekii (see paper)
    33% identity, 99% coverage of query (138 bits)

budC / H9XP47 meso-butanediol dehydrogenase [(R)-acetoin-forming] (EC 1.1.1.304; EC 1.1.1.76) from Serratia marcescens (see paper)
MBDH_SERMA / H9XP47 Meso-2,3-butanediol dehydrogenase; BDH; meso-2,3-BDH; (R,S)-butane-2,3-diol dehydrogenase; NAD(H)-dependent meso-2,3-BDH; SmBdh; EC 1.1.1.- from Serratia marcescens (see 3 papers)
    36% identity, 98% coverage of query (138 bits)

SDH_CERSP / Q59787 Sorbitol dehydrogenase; SDH; Galactitol 2-dehydrogenase; L-iditol 2-dehydrogenase; Polyol dehydrogenase; EC 1.1.1.-; EC 1.1.1.16; EC 1.1.1.14 from Cereibacter sphaeroides (Rhodobacter sphaeroides) (see 2 papers)
polS / GI|2338763 L-iditol 2-dehydrogenase; EC 1.1.1.14 from Rhodobacter sphaeroides (see 2 papers)
    34% identity, 98% coverage of query (138 bits)

P39485 glucose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.47) from Priestia megaterium (see paper)
    33% identity, 98% coverage of query (138 bits)

3ay6B / P39485 Crystal structure of bacillus megaterium glucose dehydrogenase 4 a258f mutant in complex with nadh and d-glucose (see paper)
    33% identity, 98% coverage of query (138 bits)

lra1 / Q1NEJ0 NAD(P)+-dependent L-rhamnose 1-dehydrogenase (EC 1.1.1.378; EC 1.1.1.173) from Sphingomonas sp. (strain SKA58) (see paper)
    40% identity, 80% coverage of query (138 bits)

3ak4A / G1K3P5 Crystal structure of nadh-dependent quinuclidinone reductase from agrobacterium tumefaciens
    35% identity, 98% coverage of query (137 bits)

9clyB / Q8E0R2 Crystal structure of the 3-ketoacyl-(acyl-carrier-protein) reductase, cylg, from streptococcus agalactiae 2603v/r
    31% identity, 97% coverage of query (137 bits)

6qheA / A0A545BBS8 Alcohol dehydrogenase from arthrobacter sp. Ts-15 in complex with NAD+
    34% identity, 99% coverage of query (137 bits)

6xewA Structure of serratia marcescens 2,3-butanediol dehydrogenase
    36% identity, 98% coverage of query (136 bits)

6vspB / H9XP47 Structure of serratia marcescens 2,3-butanediol dehydrogenase mutant q247a (see paper)
    36% identity, 98% coverage of query (136 bits)

6vspA Structure of serratia marcescens 2,3-butanediol dehydrogenase mutant q247a
    36% identity, 98% coverage of query (136 bits)

phbB / D3UAK7 hydroxyvaleryl-CoA reductase (EC 1.1.1.36) from Cupriavidus necator (see 2 papers)
PHAB_CUPNH / P14697 Acetoacetyl-CoA reductase; EC 1.1.1.36 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see 4 papers)
P14697 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); acetoacetyl-CoA reductase (EC 1.1.1.36) from Cupriavidus necator (see 3 papers)
    32% identity, 98% coverage of query (136 bits)

Q9LBG2 Levodione reductase; (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase; EC 1.1.1.- from Leifsonia aquatica (Corynebacterium aquaticum)
    37% identity, 98% coverage of query (136 bits)

1iy8A / Q9LBG2 Crystal structure of levodione reductase (see paper)
    37% identity, 98% coverage of query (135 bits)

3vzsB / P14697 Crystal structure of phab from ralstonia eutropha in complex with acetoacetyl-coa and NADP (see paper)
    33% identity, 97% coverage of query (135 bits)

4cqmA Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP
    35% identity, 99% coverage of query (135 bits)

4ag3A Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with NADPH at 1.8a resolution
    37% identity, 100% coverage of query (135 bits)

4cqmF / Q8N4T8 Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP (see paper)
    35% identity, 97% coverage of query (135 bits)

CBR4 / Q8N4T8 carbonyl reductase family member 4 (EC 1.1.1.100) from Homo sapiens (see 2 papers)
CBR4_HUMAN / Q8N4T8 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; KAR beta subunit; Carbonyl reductase family member 4; CBR4; Quinone reductase CBR4; Short chain dehydrogenase/reductase family 45C member 1; EC 1.1.1.100; EC 1.6.5.10 from Homo sapiens (Human) (see 3 papers)
    35% identity, 97% coverage of query (135 bits)

HSD17B8 / Q92506 estradiol 17β-dehydrogenase 8 (EC 1.1.1.100) from Homo sapiens (see 4 papers)
DHB8_HUMAN / Q92506 (3R)-3-hydroxyacyl-CoA dehydrogenase; 17-beta-hydroxysteroid dehydrogenase 8; 17-beta-HSD 8; HSD17B8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; KAR alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; Estradiol 17-beta-dehydrogenase 8; Protein Ke6; Ke6; Short chain dehydrogenase/reductase family 30C member 1; Testosterone 17-beta-dehydrogenase 8; EC 1.1.1.n12; EC 1.1.1.62; EC 1.1.1.239 from Homo sapiens (Human) (see 5 papers)
Q92506 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Homo sapiens (see paper)
    34% identity, 99% coverage of query (134 bits)

8w0oA / M9TFE3 Gdh-105 crystal structure
    32% identity, 99% coverage of query (134 bits)

8cxaA / A0QVD5 Crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase from mycobacterium smegmatis with bound NAD
    34% identity, 98% coverage of query (133 bits)

2zatA / Q8WNV7 Crystal structure of a mammalian reductase (see paper)
    34% identity, 98% coverage of query (132 bits)

5vmlA / Q3JRS9 Crystal structure of acetoacetyl-coa reductase from burkholderia pseudomallei 1710b with bound NADP
    33% identity, 97% coverage of query (132 bits)

DHRS4_PIG / Q8WNV7 Dehydrogenase/reductase SDR family member 4; NADPH-dependent carbonyl reductase; CR; PHCR; NADPH-dependent retinol dehydrogenase/reductase; NDRD; Peroxisomal carbonyl reductase; PerCR; Peroxisomal short-chain alcohol dehydrogenase; PSCD; Short chain dehydrogenase/reductase family 25C member 2; Protein SDR25C2; EC 1.1.1.184; EC 1.1.1.300 from Sus scrofa (Pig) (see 3 papers)
    34% identity, 98% coverage of query (132 bits)

4bo4C / O54438 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-methoxyphenyl)-3,4- dihydro-2h-quinoline-1-carboxamide at 2.7a resolution (see paper)
    37% identity, 100% coverage of query (132 bits)

3lf2A NADPH bound structure of the short chain oxidoreductase q9hya2 from pseudomonas aeruginosa pao1 containing an atypical catalytic center
    36% identity, 99% coverage of query (130 bits)

fabG1 / P9WGT2 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see paper)
MABA_MYCTU / P9WGT3 3-oxoacyl-[acyl-carrier-protein] reductase MabA; 3-ketoacyl reductase; 3-ketoacyl-acyl carrier protein reductase; Acetoacetyl-CoA reductase; Beta-ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; Mycolic acid biosynthesis A; EC 1.1.1.100; EC 1.1.1.36 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 10 papers)
P9WGT3 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Mycobacterium tuberculosis (see paper)
    33% identity, 96% coverage of query (130 bits)

Build an alignment

Build an alignment for HSERO_RS02535 and 100 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory