Sites on a Tree

 

Searching for up to 100 curated homologs for HSERO_RS05235 FitnessBrowser__HerbieS:HSERO_RS05235 (425 a.a.)

Found high-coverage hits (≥70%) to 38 curated proteins.

Removed hits that are identical to the query, leaving 37

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4ip4A / Q1GLV3 Crystal structure of l-fuconate dehydratase from silicibacter sp. Tm1040 liganded with mg
    72% identity, 99% coverage of query (638 bits)

4ip5A Crystal structure of l-fuconate dehydratase from silicibacter sp. Tm1040 liganded with mg and d-erythronohydroxamate
    72% identity, 99% coverage of query (638 bits)

G3Y683 L-fuconate dehydratase (EC 4.2.1.68) from Aspergillus niger (see paper)
    59% identity, 100% coverage of query (528 bits)

LGD1 / Q0QWS4 L-galactonate dehydratase (EC 4.2.1.146) from Hypocrea jecorina (see paper)
LGD1_HYPJE / Q0QWS4 L-galactonate dehydratase; EC 4.2.1.146 from Hypocrea jecorina (Trichoderma reesei) (see paper)
Q0QWS4 L-galactonate dehydratase (EC 4.2.1.146) from Trichoderma reesei (see 2 papers)
    59% identity, 99% coverage of query (528 bits)

fucD / Q8P3K2 L-fuconate dehydratase monomer (EC 4.2.1.68) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
FUCD_XANCP / Q8P3K2 L-fuconate dehydratase; FucD; EC 4.2.1.68 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
    57% identity, 100% coverage of query (495 bits)

1yeyC / Q8P3K2 Crystal structure of l-fuconate dehydratase from xanthomonas campestris pv. Campestris str. Atcc 33913
    57% identity, 100% coverage of query (495 bits)

2hxtA Crystal structure of l-fuconate dehydratase from xanthomonas campestris liganded with mg++ and d-erythronohydroxamate
    57% identity, 99% coverage of query (493 bits)

2hxuA Crystal structure of k220a mutant of l-fuconate dehydratase from xanthomonas campestris liganded with mg++ and l-fuconate
    57% identity, 99% coverage of query (491 bits)

4a35A / Q7L5Y1 Crystal structure of human mitochondrial enolase superfamily member 1 (enosf1) (see paper)
    54% identity, 99% coverage of query (490 bits)

ENOF1_HUMAN / Q7L5Y1 Mitochondrial enolase superfamily member 1; Antisense RNA to thymidylate synthase; rTS; L-fuconate dehydratase; EC 4.2.1.68 from Homo sapiens (Human) (see 4 papers)
    54% identity, 99% coverage of query (490 bits)

Build an alignment

Build an alignment for HSERO_RS05235 and 10 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

4h19A / Q7CU39 Crystal structure of an enolase (mandelate racemase subgroup, target efi-502087) from agrobacterium tumefaciens, with bound mg and d- ribonohydroxamate, ordered loop
    26% identity, 99% coverage of query (112 bits)

SM_b21107 dehydratase involved in L-fucose catabolism from Sinorhizobium meliloti 1021
    27% identity, 88% coverage of query (110 bits)

3ozmA / A0A0H3LT39 Crystal structure of enolase superfamily member from bordetella bronchiseptica complexed with mg, m-xylarate and l-lyxarate
    27% identity, 81% coverage of query (102 bits)

3ozmD Crystal structure of enolase superfamily member from bordetella bronchiseptica complexed with mg, m-xylarate and l-lyxarate
    27% identity, 81% coverage of query (102 bits)

3op2A Crystal structure of putative mandelate racemase from bordetella bronchiseptica rb50 complexed with 2-oxoglutarate/phosphate
    28% identity, 74% coverage of query (100 bits)

aci / H2IFX0 3,6-anhydro-L-galactonate cycloisomerase (EC 5.5.1.25) from Vibrio sp. (strain EJY3) (see paper)
ACI_VIBSJ / H2IFX0 3,6-anhydro-alpha-L-galactonate cycloisomerase; AHGA cycloisomerase; EC 5.5.1.25 from Vibrio sp. (strain EJY3) (see paper)
H2IFX0 3,6-anhydro-L-galactonate cycloisomerase (EC 5.5.1.25) from Vibrio sp. (see paper)
    26% identity, 75% coverage of query (83.2 bits)

5xd8B / H2IFX0 Crystal structure analysis of 3,6-anhydro-l-galactonate cycloisomerase (see paper)
    26% identity, 75% coverage of query (83.2 bits)

SSO26655 / Q97VG1 D-xylonate dehydratase subunit (EC 4.2.1.25; EC 4.2.1.82) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
    24% identity, 74% coverage of query (82.4 bits)

3sqsA / A8LS88 Crystal structure of a putative mandelate racemase/muconate lactonizing protein from dinoroseobacter shibae dfl 12
    26% identity, 75% coverage of query (75.5 bits)

A0NP48 L-lyxonate dehydratase (EC 4.2.1.176) from Roseibium aggregatum (see paper)
3stpA / A0NP48 Crystal structure of a putative galactonate dehydratase
    24% identity, 75% coverage of query (72.4 bits)

A3LZU6 L-rhamnonate dehydratase (EC 4.2.1.90) from Scheffersomyces stipitis (see 2 papers)
    26% identity, 70% coverage of query (68.9 bits)

4e6mA / Q8ZNH1 Crystal structure of putative dehydratase protein from salmonella enterica subsp. Enterica serovar typhimurium (salmonella typhimurium)
    22% identity, 99% coverage of query (67.8 bits)

3rcyF Crystal structure of mandelate racemase/muconate lactonizing enzyme- like protein from roseovarius sp. Tm1035
    23% identity, 73% coverage of query (60.1 bits)

3t8qB / A9D2J3 Crystal structure of mandelate racemase/muconate lactonizing enzyme family protein from hoeflea phototrophica
    25% identity, 73% coverage of query (59.7 bits)

3tteA / A4YVM8 Crystal structure of enolase brado_4202 (target efi-501651) from bradyrhizobium complexed with magnesium and mandelic acid
    25% identity, 72% coverage of query (59.3 bits)

3toyA Crystal structure of enolase brado_4202 (target efi-501651) from bradyrhizobium sp. Ors278 with calcium and acetate bound
    25% identity, 72% coverage of query (59.3 bits)

2o56A / Q8ZKY6 Crystal structure of a member of the enolase superfamily from salmonella typhimurium
    21% identity, 74% coverage of query (58.2 bits)

3u4fA / A3SMJ4 Crystal structure of a mandelate racemase (muconate lactonizing enzyme family protein) from roseovarius nubinhibens
    25% identity, 74% coverage of query (57.0 bits)

DGD_STRBB / D7BPX0 D-galactonate dehydratase family member SBI_01856; D-gluconate dehydratase; EC 4.2.1.-; EC 4.2.1.39 from Streptomyces bingchenggensis (strain BCW-1) (see paper)
    24% identity, 71% coverage of query (56.6 bits)

4kemA / D3P639 Crystal structure of a tartrate dehydratase from azospirillum, target efi-502395, with bound mg and a putative acrylate ion, ordered active site
    25% identity, 73% coverage of query (53.5 bits)

3tcsB / Q161M1 Crystal structure of a putative racemase from roseobacter denitrificans
    25% identity, 74% coverage of query (52.4 bits)

IMAND_CLOB8 / A6M2W4 D-galactonate dehydratase family member Cbei_4837 from Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) (see paper)
    19% identity, 92% coverage of query (52.4 bits)

tarD / Q89FH0 D-tartrate dehydratase (EC 4.2.1.81) from Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) (see paper)
TARD_BRADU / Q89FH0 D(-)-tartrate dehydratase; EC 4.2.1.81 from Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) (see paper)
    23% identity, 73% coverage of query (52.0 bits)

IMAND_ENTBW / A8RQK7 D-galactonate dehydratase family member CLOBOL_02770 from Enterocloster bolteae (strain ATCC BAA-613 / DSM 15670 / CCUG 46953 / JCM 12243 / WAL 16351) (Clostridium bolteae) (see paper)
    21% identity, 76% coverage of query (48.5 bits)

DGD_PANAM / D4GJ14 D-galactonate dehydratase family member RspA; D-gluconate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.39 from Pantoea ananatis (strain LMG 20103) (see paper)
    22% identity, 89% coverage of query (47.0 bits)

3t6cA / D4GJ14 Crystal structure of an enolase from pantoea ananatis (efi target efi- 501676) with bound d-gluconate and mg
    22% identity, 89% coverage of query (47.0 bits)

3n4eA / A1AYL4 Crystal structure of mandelate racemase/muconate lactonizing protein from paracoccus denitrificans pd1222
    22% identity, 74% coverage of query (46.6 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory