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Searching for up to 100 curated homologs for HSERO_RS05260 FitnessBrowser__HerbieS:HSERO_RS05260 (312 a.a.)

Found high-coverage hits (≥70%) to 68 curated proteins.

Removed hits that are identical to the query, leaving 67

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4rxtA / B9JKX8 Crystal structure of carbohydrate transporter solute binding protein arad_9553 from agrobacterium radiobacter, target efi-511541, in complex with d-arabinose
    36% identity, 91% coverage of query (157 bits)

4wutA / B9K0B2 Crystal structure of an abc transporter solute binding protein (ipr025997) from agrobacterium vitis (avi_5133, target efi-511220) with bound d-fucose
    35% identity, 91% coverage of query (153 bits)

2ioyA / Q8RD41 Crystal structure of thermoanaerobacter tengcongensis ribose binding protein (see paper)
    30% identity, 88% coverage of query (118 bits)

5dkvA / B9K0T2 Crystal structure of an abc transporter solute binding protein from agrobacterium vitis(avis_5339, target efi-511225) bound with alpha-d- tagatopyranose
    30% identity, 77% coverage of query (115 bits)

Build an alignment

Build an alignment for HSERO_RS05260 and 4 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

5dteB / A6VKG5 Crystal structure of an abc transporter periplasmic solute binding protein (ipr025997) from actinobacillus succinogenes 130z(asuc_0081, target efi-511065) with bound d-allose
    29% identity, 83% coverage of query (105 bits)

6gt9A / W8QN64 Crystal structure of ganp, a glucose-galactose binding protein from geobacillus stearothermophilus, in complex with galactose
    27% identity, 86% coverage of query (101 bits)

7e7mC / Q8E283 Crystal structure analysis of the streptococcus agalactiae ribose binding protein rbsb
    28% identity, 85% coverage of query (101 bits)

6guqA Crystal structure of ganp, a glucose-galactose binding protein from geobacillus stearothermophilus, in complex with glucose
    27% identity, 84% coverage of query (101 bits)

3ksmA / Q2S7D2 Crystal structure of abc-type sugar transport system, periplasmic component from hahella chejuensis
    25% identity, 84% coverage of query (95.5 bits)

APIBP_ACTSZ / A6VKQ8 D-apiose import binding protein; D-apiose binding SBP from Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z) (see paper)
    29% identity, 82% coverage of query (94.4 bits)

5hqjA / B1G1H7 Crystal structure of abc transporter solute binding protein b1g1h7 from burkholderia graminis c4d1m, target efi-511179, in complex with d-arabinose
    28% identity, 88% coverage of query (94.0 bits)

AlsB / b4088 D-allose ABC transporter periplasmic binding protein (EC 7.5.2.8) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
AlsB / P39265 D-allose ABC transporter periplasmic binding protein (EC 7.5.2.8) from Escherichia coli (strain K12) (see 5 papers)
ALSB_ECOLI / P39265 D-allose-binding periplasmic protein; ALBP from Escherichia coli (strain K12) (see paper)
P39265 ABC-type D-allose transporter (EC 7.5.2.8) from Escherichia coli (see paper)
TC 3.A.1.2.6 / P39265 AlsB aka B4088, component of D-allose porter from Escherichia coli (see 6 papers)
alsB / GB|AAC77049.1 D-allose-binding periplasmic protein; EC 3.6.3.17 from Escherichia coli K12 (see 6 papers)
    29% identity, 90% coverage of query (91.7 bits)

Pf1N1B4_6035 D-ribose ABC transporter, substrate-binding component RbsB from Pseudomonas fluorescens FW300-N1B4
    28% identity, 85% coverage of query (89.7 bits)

2h3hA / Q9WXW9 Crystal structure of the liganded form of thermotoga maritima glucose binding protein (see paper)
    29% identity, 76% coverage of query (89.7 bits)

3c6qC Apo and ligand-bound form of a thermophilic glucose/xylose binding protein
    28% identity, 76% coverage of query (89.4 bits)

8wlbA X-ray structure of enterobacter cloacae allose-binding protein in complex with d-psicose
    28% identity, 82% coverage of query (89.0 bits)

8wl9A X-ray structure of enterobacter cloacae allose-binding protein in complex with d-ribose
    28% identity, 82% coverage of query (89.0 bits)

5xssA / A6LW07 Xylfii molecule (see paper)
    29% identity, 82% coverage of query (88.6 bits)

1gudA / P39265 Hinge-bending motion of d-allose binding protein from escherichia coli: three open conformations (see paper)
    29% identity, 83% coverage of query (88.6 bits)

1rpjA Crystal structure of d-allose binding protein from escherichia coli
    29% identity, 83% coverage of query (88.6 bits)

HSERO_RS11480 D-ribose ABC transporter, substrate-binding component RbsB from Herbaspirillum seropedicae SmR1
    29% identity, 89% coverage of query (87.4 bits)

APIBP_RHIR8 / B9JK76 D-apiose import binding protein; D-apiose binding SBP from Rhizobium rhizogenes (strain K84 / ATCC BAA-868) (Agrobacterium radiobacter) (see paper)
    26% identity, 91% coverage of query (86.3 bits)

TC 3.A.1.2.9 / Q7BSH5 RhaS, component of Rhamnose porter (Richardson et al., 2004) (Transport activity is dependent on rhamnokinase (RhaK; AAQ92412) activity (Richardson and Oresnik, 2007) This could be an example of group translocation!) from Rhizobium leguminosarum (biovar trifolii) (see paper)
    27% identity, 89% coverage of query (86.3 bits)

APIBP_RHIEC / Q2JZQ5 D-apiose import binding protein; D-apiose binding SBP from Rhizobium etli (strain CFN 42 / ATCC 51251) (see paper)
    26% identity, 83% coverage of query (85.9 bits)

5ibqA / Q2JZQ5 Crystal structure of an abc solute binding protein from rhizobium etli cfn 42 (rhe_pf00037,target efi-511357) in complex with alpha-d-apiose
    26% identity, 83% coverage of query (85.9 bits)

PS417_18405 D-ribose ABC transporter, substrate-binding component RbsB from Pseudomonas simiae WCS417
    26% identity, 85% coverage of query (85.9 bits)

4ry0A Crystal structure of ribose transporter solute binding protein rhe_pf00037 from rhizobium etli cfn 42, target efi-511357, in complex with d-ribose
    26% identity, 83% coverage of query (85.9 bits)

2fn8A / Q9X053 Thermotoga maritima ribose binding protein ribose bound form (see paper)
    28% identity, 74% coverage of query (81.3 bits)

TC 3.A.1.2.19 / Q9X053 Periplasmic binding protein/LacI transcriptional regulator, component of D-ribose porter (Nanavati et al., 2006). Induced by ribose from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    28% identity, 74% coverage of query (81.3 bits)

7x0hA / A3DCF2 Crystal structure of sugar binding protein cbpa complexed wtih glucose from clostridium thermocellum (see paper)
    26% identity, 85% coverage of query (80.9 bits)

TC 3.A.1.2.11 / Q92WK4 EryG aka RB0335, component of The erythritol permease, EryEFG (Geddes et al., 2010) (probably orthologous to 3.A.1.2.16) from Rhizobium meliloti (Sinorhizobium meliloti) (see paper)
    26% identity, 75% coverage of query (79.7 bits)

TC 3.A.1.2.13 / A6VKT0 RbsB, component of The probable autoinducer-2 (AI-2;, a furanosyl borate diester: 3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Shao et al., 2007) (50-70% identical to RbsABC of E. coli; TC# 3.A.1.2.1) from Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
    26% identity, 88% coverage of query (79.3 bits)

PS417_11885 Inositol transport system sugar-binding protein from Pseudomonas simiae WCS417
    26% identity, 95% coverage of query (79.0 bits)

RBSB_BACSU / P36949 Ribose import binding protein RbsB from Bacillus subtilis (strain 168) (see 2 papers)
    25% identity, 88% coverage of query (79.0 bits)

APIBP_PARG4 / B1G898 D-apiose import binding protein; D-apiose binding SBP from Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M) (see paper)
    28% identity, 88% coverage of query (78.2 bits)

RALBP_PSEAE / Q9I2F8 D-ribose/D-allose-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    26% identity, 75% coverage of query (76.3 bits)

4zjpA / A6VKT0 Structure of an abc-transporter solute binding protein (sbp_ipr025997) from actinobacillus succinogenes (asuc_0197, target efi-511067) with bound beta-d-ribopyranose
    24% identity, 82% coverage of query (75.1 bits)

UxuR / VIMSS6113503 UxuR regulator of Glucuronate utilization, effector Glucuronate (repressor) from Bacteroides plebeius DSM 17135
    25% identity, 80% coverage of query (73.6 bits)

LsrB / b1516 Autoinducer-2 ABC transporter periplasmic binding protein (EC 7.6.2.13) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
LsrB / P76142 Autoinducer-2 ABC transporter periplasmic binding protein (EC 7.6.2.13) from Escherichia coli (strain K12) (see 5 papers)
LSRB_ECOLI / P76142 Autoinducer 2-binding protein LsrB; AI-2-binding protein LsrB from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.2.8 / P76142 LsrB(R), component of Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003) from Escherichia coli (see 4 papers)
lsrB autoinducer 2 ABC transporter, periplasmic substrate-binding protein LsrB from Escherichia coli K12 (see paper)
    26% identity, 82% coverage of query (70.9 bits)

3ejwA / Q926H7 Crystal structure of the sinorhizobium meliloti ai-2 receptor, smlsrb (see paper)
    27% identity, 75% coverage of query (69.3 bits)

LSRB_SALTY / Q8ZKQ1 Autoinducer 2-binding protein LsrB; AI-2-binding protein LsrB from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    25% identity, 80% coverage of query (69.3 bits)

H281DRAFT_01114 deoxynucleoside transporter, substrate-binding component from Paraburkholderia bryophila 376MFSha3.1
    26% identity, 74% coverage of query (66.2 bits)

TC 3.A.1.2.16 / Q1M4Q9 Periplasmic erythritol binding protein, component of The erythritol uptake permease, EryEFG (Yost et al., 2006) (probably orthologous to 3.A.1.2.11) from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
    26% identity, 71% coverage of query (65.9 bits)

1tjyA / Q8ZKQ1 Crystal structure of salmonella typhimurium ai-2 receptor lsrb in complex with r-thmf (see paper)
    24% identity, 74% coverage of query (65.1 bits)

3t95A / Q74PW2 Crystal structure of lsrb from yersinia pestis complexed with autoinducer-2 (see paper)
    26% identity, 74% coverage of query (62.4 bits)

UxuR / VIMSS350962 UxuR regulator of Glucuronate utilization, effector Glucuronate (repressor) from Bacteroides thetaiotaomicron VPI-5482
    21% identity, 88% coverage of query (62.0 bits)

KdgR / VIMSS6281949 KdgR regulator of Glucuronate utilization; Galacturonate utilization, effector 2-keto-3-deoxygluconate (repressor) from Bacteroides dorei DSM 17855
    23% identity, 85% coverage of query (62.0 bits)

KdgR / VIMSS4261021 KdgR regulator of Glucuronate utilization; Galacturonate utilization, effector 2-keto-3-deoxygluconate (repressor) from Bacteroides uniformis ATCC 8492
    21% identity, 85% coverage of query (60.8 bits)

TC 3.A.1.2.20 / G4FGN5 LacI family transcriptional regulator, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    23% identity, 80% coverage of query (60.8 bits)

Shewana3_2073 L-arabinose ABC transporter, substrate-binding component AraU from Shewanella sp. ANA-3
    28% identity, 92% coverage of query (60.8 bits)

6hbdA / A0QT50 Crystal structure of msmeg_1712 from mycobacterium smegmatis in complex with beta-d-galactofuranose (see paper)
    24% identity, 85% coverage of query (60.5 bits)

6hyhA Crystal structure of msmeg_1712 from mycobacterium smegmatis in complex with beta-d-fucofuranose
    24% identity, 85% coverage of query (60.5 bits)

6hbmA Crystal structure of msmeg_1712 from mycobacterium smegmatis in complex with alpha-l-arabinofuranose
    24% identity, 85% coverage of query (60.5 bits)

4rsmA / A0QYB5 Crystal structure of carbohydrate transporter msmeg_3599 from mycobacterium smegmatis str. Mc2 155, target efi-510970, in complex with d-threitol (see paper)
    23% identity, 72% coverage of query (59.7 bits)

THPA_MYCS2 / A0QYB5 D-threitol-binding protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    23% identity, 72% coverage of query (59.7 bits)

5ocpA / A0KWY4 The periplasmic binding protein component of the arabinose abc transporter from shewanella sp. Ana-3 bound to alpha and beta-l- arabinofuranose
    27% identity, 82% coverage of query (57.0 bits)

KdgR / VIMSS6110630 KdgR regulator of Glucuronate utilization; Galacturonate utilization, effector 2-keto-3-deoxygluconate (repressor) from Bacteroides plebeius DSM 17135
    22% identity, 89% coverage of query (57.0 bits)

HSERO_RS03635 D-mannose ABC transporter, substrate-binding component from Herbaspirillum seropedicae SmR1
    29% identity, 73% coverage of query (57.0 bits)

YphF / b2548 putative ABC transporter periplasmic binding protein YphF from Escherichia coli K-12 substr. MG1655 (see 4 papers)
    25% identity, 77% coverage of query (57.0 bits)

B9K0Q5 ABC-type D-galactose transporter (EC 7.5.2.11) from Agrobacterium vitis (see paper)
    26% identity, 83% coverage of query (55.1 bits)

KdgR / VIMSS828335 KdgR regulator of Glucuronate utilization; Galacturonate utilization, effector 2-keto-3-deoxygluconate (repressor) from Bacteroides fragilis NCTC 9343
    19% identity, 92% coverage of query (51.2 bits)

4ru1A / A0LVW8 Crystal structure of carbohydrate transporter acei_1806 from acidothermus cellulolyticus 11b, target efi-510965, in complex with myo-inositol
    26% identity, 84% coverage of query (50.4 bits)

4rs3A / A0QYB3 Crystal structure of carbohydrate transporter a0qyb3 from mycobacterium smegmatis str. Mc2 155, target efi-510969, in complex with xylitol (see paper)
    20% identity, 71% coverage of query (48.9 bits)

5hkoA Crystal structure of abc transporter solute binding protein msmeg_3598 from mycobacterium smegmatis str. Mc2 155, target efi-510969, in complex with l-sorbitol
    20% identity, 71% coverage of query (48.9 bits)

XYPA_MYCS2 / A0QYB3 Xylitol-binding protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    20% identity, 71% coverage of query (48.1 bits)

4ry9B Crystal structure of carbohydrate transporter solute binding protein veis_2079 from verminephrobacter eiseniae ef01-2, target efi-511009, a complex with d-talitol
    23% identity, 93% coverage of query (43.1 bits)

4ry9A / A1WJM2 Crystal structure of carbohydrate transporter solute binding protein veis_2079 from verminephrobacter eiseniae ef01-2, target efi-511009, a complex with d-talitol
    23% identity, 93% coverage of query (43.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory