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Searching for up to 100 curated homologs for HSERO_RS05695 FitnessBrowser__HerbieS:HSERO_RS05695 (441 a.a.)

Found high-coverage hits (≥70%) to 54 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

tynA / D7F5L6 tyramine oxidase subunit A (EC 1.4.3.4) from Pseudomonas putida (see paper)
    38% identity, 98% coverage of query (264 bits)

Q51890 L-amino-acid oxidase (EC 1.4.3.2) from Proteus mirabilis (see paper)
aad / AAA86752.1 amino acid deaminase from Proteus mirabilis (see paper)
    31% identity, 94% coverage of query (205 bits)

5hxwA / Q9LCB2 L-amino acid deaminase from proteus vulgaris (see paper)
    31% identity, 94% coverage of query (199 bits)

Q9LCB2 L-amino-acid oxidase (EC 1.4.3.2) from Proteus vulgaris (see paper)
    31% identity, 94% coverage of query (199 bits)

B2ZHY0 L-amino-acid oxidase (EC 1.4.3.2) from Proteus mirabilis (see paper)
    30% identity, 94% coverage of query (186 bits)

5fjmA / A0A158RFS7 Structure of l-amino acid deaminase from proteus myxofaciens (see paper)
    30% identity, 94% coverage of query (186 bits)

5fjnA Structure of l-amino acid deaminase from proteus myxofaciens in complex with anthranilate
    30% identity, 94% coverage of query (186 bits)

Build an alignment

Build an alignment for HSERO_RS05695 and 7 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

1y56B / O59089 Crystal structure of l-proline dehydrogenase from p.Horikoshii (see paper)
    26% identity, 90% coverage of query (139 bits)

O59089 proline dehydrogenase (EC 1.5.5.2) from Pyrococcus horikoshii (see paper)
    26% identity, 90% coverage of query (139 bits)

Q8U1G2 proline dehydrogenase (EC 1.5.5.2) from Pyrococcus furiosus (see paper)
    27% identity, 92% coverage of query (134 bits)

Q5JFG7 proline dehydrogenase (EC 1.5.5.2) from Thermococcus kodakarensis (see paper)
    26% identity, 90% coverage of query (129 bits)

lhpB / Q9I477 D-hydroxyproline dehydrogenase β subunit from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    28% identity, 95% coverage of query (127 bits)

Q5JFG2 proline dehydrogenase (EC 1.5.5.2) from Thermococcus kodakarensis (see paper)
    25% identity, 91% coverage of query (121 bits)

Q76M73 proline dehydrogenase (EC 1.5.5.2) from Thermococcus profundus (see 2 papers)
    26% identity, 91% coverage of query (119 bits)

SarDH / Q64380 sarcosine dehydrogenase (EC 1.5.8.3) from Rattus norvegicus (see 10 papers)
SARDH_RAT / Q64380 Sarcosine dehydrogenase, mitochondrial; SarDH; EC 1.5.8.3 from Rattus norvegicus (Rat) (see 2 papers)
    26% identity, 96% coverage of query (115 bits)

SARDH / Q9UL12 sarcosine dehydrogenase (EC 1.5.8.3) from Homo sapiens (see 5 papers)
SARDH_HUMAN / Q9UL12 Sarcosine dehydrogenase, mitochondrial; SarDH; BPR-2; EC 1.5.8.3 from Homo sapiens (Human) (see 2 papers)
    27% identity, 97% coverage of query (114 bits)

L7T8Y9 glycine oxidase (EC 1.4.3.19) from Bacillus cereus (see 2 papers)
    24% identity, 90% coverage of query (107 bits)

7cyxA / Q81HQ7 Crystal strcuture of glycine oxidase from bacillus cereus atcc 14579 (see paper)
    24% identity, 90% coverage of query (106 bits)

GLYOX_PSEPK / Q88Q83 Glycine oxidase; GO; EC 1.4.3.19 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
Q88Q83 glycine oxidase (EC 1.4.3.19) from Pseudomonas putida (see paper)
    26% identity, 91% coverage of query (103 bits)

mabO / Q8GAI3 4-methylaminobutyrate oxidase (demethylating) (EC 1.5.3.19) from Paenarthrobacter nicotinovorans (see 2 papers)
MABO1_PAENI / Q8GAI3 4-methylaminobutanoate oxidase (formaldehyde-forming); MABO; Demethylating gamma-N-methylaminobutyrate oxidase; Gamma-N-methylaminobutyrate oxidase 1; EC 1.5.3.19 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see 2 papers)
    25% identity, 95% coverage of query (98.6 bits)

PDPR_BOVIN / O46504 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial; PDPr from Bos taurus (Bovine) (see 2 papers)
    23% identity, 92% coverage of query (92.4 bits)

Q8NCN5 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) from Homo sapiens (see paper)
    24% identity, 90% coverage of query (86.7 bits)

dada* / AAB39269.1 dada* from Pseudomonas aeruginosa (see 2 papers)
    26% identity, 90% coverage of query (84.7 bits)

3if9A / O31616 Crystal structure of glycine oxidase g51s/a54r/h244a mutant in complex with inhibitor glycolate (see paper)
    24% identity, 86% coverage of query (79.7 bits)

Q9DBT9 dimethylglycine dehydrogenase (EC 1.5.8.4) from Mus musculus (see paper)
    24% identity, 96% coverage of query (79.3 bits)

thiO / O31616 glycine oxidase monomer (EC 1.4.3.19; EC 1.4.3.3) from Bacillus subtilis (strain 168) (see 3 papers)
GLYOX_BACSU / O31616 Glycine oxidase; GO; EC 1.4.3.19 from Bacillus subtilis (strain 168) (see 5 papers)
    24% identity, 86% coverage of query (79.0 bits)

1ng3A Complex of thio (glycine oxidase) with acetyl-glycine
    24% identity, 86% coverage of query (79.0 bits)

Dmgdh / Q63342 dimethylglycine dehydrogenase, mitochondrial (EC 1.5.8.4) from Rattus norvegicus (see 9 papers)
M2GD_RAT / Q63342 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Rattus norvegicus (Rat) (see 3 papers)
Q63342 dimethylglycine dehydrogenase (EC 1.5.8.4) from Rattus norvegicus (see 3 papers)
    24% identity, 96% coverage of query (78.6 bits)

Q5RKL4 dimethylglycine dehydrogenase (EC 1.5.8.4) from Rattus norvegicus (see paper)
    24% identity, 96% coverage of query (78.6 bits)

4pabB / Q63342 Crystal structure of the precursor form of rat dmgdh complexed with tetrahydrofolate (see paper)
    24% identity, 94% coverage of query (75.9 bits)

DMGDH / Q9UI17 dimethylglycine dehydrogenase (EC 1.5.8.4) from Homo sapiens (see 6 papers)
M2GD_HUMAN / Q9UI17 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Homo sapiens (Human) (see 2 papers)
Q9UI17 dimethylglycine dehydrogenase (EC 1.5.8.4) from Homo sapiens (see 2 papers)
    23% identity, 94% coverage of query (75.9 bits)

PIPOX / Q8N6Z6 L-pipecolate oxidase (EC 1.5.3.7) from Homo sapiens (see 2 papers)
    24% identity, 93% coverage of query (75.1 bits)

SOX_HUMAN / Q9P0Z9 Peroxisomal sarcosine oxidase; PSO; L-pipecolate oxidase; L-pipecolic acid oxidase; EC 1.5.3.1; EC 1.5.3.7 from Homo sapiens (Human) (see paper)
Q9P0Z9 L-pipecolate oxidase (EC 1.5.3.7) from Homo sapiens (see paper)
    24% identity, 93% coverage of query (74.7 bits)

GLYOX_BACLI / S5FMM4 Glycine oxidase; GO; BliGO; EC 1.4.3.19 from Bacillus licheniformis (see paper)
S5FMM4 glycine oxidase (EC 1.4.3.19) from Bacillus licheniformis (see paper)
    23% identity, 87% coverage of query (70.5 bits)

4yshA / Q5L2C2 Crystal structure of glycine oxidase from geobacillus kaustophilus
    26% identity, 90% coverage of query (67.8 bits)

4yshB Crystal structure of glycine oxidase from geobacillus kaustophilus
    26% identity, 90% coverage of query (67.8 bits)

AZOBR_RS08020 D-alanine dehydrogenase (EC 1.4.99.-) from Azospirillum brasilense Sp245
    22% identity, 91% coverage of query (66.6 bits)

GLYOX_GEOKA / Q5L2C2 Glycine oxidase; GO; GOX; GOXK; EC 1.4.3.19 from Geobacillus kaustophilus (strain HTA426) (see paper)
Q5L2C2 glycine oxidase (EC 1.4.3.19) from Geobacillus kaustophilus (see paper)
    26% identity, 90% coverage of query (64.3 bits)

dmg1 / Q9AGP8 dimethylglycine oxidase (EC 1.5.3.10) from Arthrobacter globiformis (see 7 papers)
DMGO_ARTGO / Q9AGP8 Dimethylglycine oxidase; DMGO; EC 1.5.3.10 from Arthrobacter globiformis (see 4 papers)
Q9AGP8 dimethylglycine oxidase (EC 1.5.3.10) from Arthrobacter globiformis (see paper)
    23% identity, 88% coverage of query (62.0 bits)

3gsiA Crystal structure of d552a dimethylglycine oxidase mutant of arthrobacter globiformis in complex with tetrahydrofolate
    23% identity, 88% coverage of query (62.0 bits)

1pj7A Structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folinic acid
    23% identity, 88% coverage of query (62.0 bits)

1pj6A / Q9AGP8 Crystal structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folic acid (see paper)
    23% identity, 88% coverage of query (61.6 bits)

Q6ITC6 sarcosine oxidase (EC 1.5.3.1) from Bacillus sp. (in: Bacteria) (see 2 papers)
    21% identity, 93% coverage of query (58.2 bits)

nmpC / A0A222FYP8 4-methylaminobutanoate oxidase (EC 1.5.3.21) from Alicycliphilus sp. (see paper)
    22% identity, 90% coverage of query (55.5 bits)

3qseA Crystal structure for the complex of substrate-reduced msox with sarcosine
    21% identity, 93% coverage of query (52.8 bits)

2gf3A Structure of the complex of monomeric sarcosine with its substrate analogue inhibitor 2-furoic acid at 1.3 a resolution.
    21% identity, 93% coverage of query (52.8 bits)

2a89A Monomeric sarcosine oxidase: structure of a covalently flavinylated amine oxidizing enzyme
    21% identity, 93% coverage of query (52.8 bits)

1eliA Complex of monomeric sarcosine oxidase with the inhibitor pyrrole-2- carboxylate
    21% identity, 93% coverage of query (52.8 bits)

1el9A Complex of monomeric sarcosine oxidase with the inhibitor [methylthio]acetate
    21% identity, 93% coverage of query (52.8 bits)

1el8A Complex of monomeric sarcosine oxidase with the inhibitor [methylseleno]cetate
    21% identity, 93% coverage of query (52.8 bits)

1el7A Complex of monomeric sarcosine oxidase with the inhibitor [methytelluro]acetate
    21% identity, 93% coverage of query (52.8 bits)

1el5A Complex of monomeric sarcosine oxidase with the inhibitor dimethylglycine
    21% identity, 93% coverage of query (52.8 bits)

Q6RH53 taurine dehydrogenase (EC 1.4.99.2) from Paracoccus pantotrophus (see paper)
    22% identity, 92% coverage of query (49.3 bits)

1zovA / P23342 Crystal structure of monomeric sarcosine oxidase from bacillus sp. Ns- 129
    20% identity, 93% coverage of query (48.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory