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Searching for up to 100 curated homologs for HSERO_RS05805 FitnessBrowser__HerbieS:HSERO_RS05805 (447 a.a.)

Found high-coverage hits (≥70%) to 38 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ABAQ_ACIBT / P0DPR4 Quinolone resistance transporter from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see 2 papers)
    39% identity, 93% coverage of query (314 bits)

PS417_07265 2-deoxy-D-ribonate transporter 1 from Pseudomonas simiae WCS417
    41% identity, 90% coverage of query (312 bits)

BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
    40% identity, 89% coverage of query (291 bits)

NICT_PSEPK / Q88FY6 Putative metabolite transport protein NicT; Nicotinate degradation protein T from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    37% identity, 91% coverage of query (273 bits)

TC 2.A.1.14.8 / Q9RPP3 Phthalate porter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
    34% identity, 97% coverage of query (265 bits)

YfaV / b2246 putative transporter YfaV from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TC 2.A.1.14.35 / P76470 Inner membrane transport protein RhmT from Escherichia coli (strain K12) (see 4 papers)
    34% identity, 93% coverage of query (260 bits)

BPHYT_RS04765 2-deoxy-D-ribonate transporter from Burkholderia phytofirmans PsJN
    38% identity, 92% coverage of query (258 bits)

H281DRAFT_00642 2-deoxy-D-ribonate transporter from Paraburkholderia bryophila 376MFSha3.1
    34% identity, 92% coverage of query (234 bits)

Build an alignment

Build an alignment for HSERO_RS05805 and 8 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

CH_124128 MFS transporter from Magnaporthe grisea 70-15 (see paper)
    29% identity, 85% coverage of query (171 bits)

orf19.3232 putative transporter from Candida albicans (see paper)
    30% identity, 71% coverage of query (160 bits)

CH_124029 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see paper)
    29% identity, 74% coverage of query (158 bits)

CH_124132 transporter of Nicotinic Acid from Magnaporthe grisea 70-15 (see paper)
    29% identity, 85% coverage of query (155 bits)

CH_124319 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see paper)
    29% identity, 94% coverage of query (152 bits)

TNA1 putative nicotinic acid transporter from Candida albicans (see paper)
    26% identity, 81% coverage of query (127 bits)

PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
    26% identity, 92% coverage of query (124 bits)

CH_124204 putative monocarboxylate exporter from Magnaporthe grisea 70-15 (see paper)
    28% identity, 74% coverage of query (123 bits)

CH_124323 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see 2 papers)
    25% identity, 72% coverage of query (120 bits)

VHT1_SCHPO / O13880 Vitamin H transporter 1; H(+)/biotin symporter vht1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
TC 2.A.1.14.19 / O13880 Plasma membrane, high affinity vitamin H transporter 1 (H+:biotin symporter), Vht1 (Stolz, 2003) from Schizosaccharomyces pombe (Fission yeast) (see 2 papers)
vht1 / GB|AAO22560.1 vitamin H transporter 1 from Schizosaccharomyces pombe (see 3 papers)
    27% identity, 82% coverage of query (110 bits)

SAUU_CUPNH / Q0K843 Probable sulfoacetate transporter SauU from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
    24% identity, 96% coverage of query (110 bits)

YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
    24% identity, 83% coverage of query (108 bits)

GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP.  Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
    25% identity, 92% coverage of query (108 bits)

GUDP_BACSU / P42237 Probable galactarate/D-glucarate transporter GudP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.14.1 / P42237 Glucarate porter from Bacillus subtilis (see 3 papers)
    25% identity, 95% coverage of query (108 bits)

orf19.2397.3 putative uncharacterized protein VHT1 from Candida albicans (see paper)
    23% identity, 97% coverage of query (107 bits)

6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
    24% identity, 83% coverage of query (101 bits)

LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
    25% identity, 97% coverage of query (99.8 bits)

GarP / b3127 galactarate/D-glucarate transporter GarP from Escherichia coli K-12 substr. MG1655 (see 6 papers)
garP / P0AA80 galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 5 papers)
GARP_ECOLI / P0AA80 Probable galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 2 papers)
    25% identity, 89% coverage of query (99.4 bits)

TC 2.A.1.14.14 / Q8FDB7 Probable D-galactarate (glucarate?):H+ symporter, GarP or YhaU from Escherichia coli O6 (see paper)
    25% identity, 89% coverage of query (99.4 bits)

AO356_28540 D-mannose transporter from Pseudomonas fluorescens FW300-N2C3
    23% identity, 88% coverage of query (90.9 bits)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
    24% identity, 83% coverage of query (90.1 bits)

YGDF_SCHPO / O94572 Uncharacterized transporter C1773.15 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    21% identity, 71% coverage of query (87.4 bits)

HSERO_RS23010 D-galacturonate transporter ExuT from Herbaspirillum seropedicae SmR1
    23% identity, 89% coverage of query (87.0 bits)

FEN2_YEAST / P25621 Pantothenate transporter FEN2; Fenpropimorph resistance protein 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
TC 2.A.1.14.18 / P25621 Pantothenate:H+ symporter, Fen2 from Saccharomyces cerevisiae (Baker's yeast) (see 7 papers)
FEN2 / RF|NP_009957.1 pantothenate transporter FEN2 from Saccharomyces cerevisiae
    25% identity, 85% coverage of query (85.1 bits)

TC 2.A.1.14.11 / P53322 Plasma membrane, high affinity nicotinate permease, Tna1 from Saccharomyces cerevisiae (Baker's yeast) (see 5 papers)
TNA1 / RF|NP_011776.1 high-affinity nicotinic acid transporter from Saccharomyces cerevisiae
    22% identity, 95% coverage of query (83.6 bits)

P53322 High-affinity nicotinic acid transporter; Nicotinic acid permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    22% identity, 95% coverage of query (83.6 bits)

S17A9_HUMAN / Q9BYT1 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.14.21 / Q9BYT1 The vesicular purine nucleotide (ADP, ATP, GTP) transporter, VNUT or SLC17A9. It is found in synaptic vesicles and chromafin granules (Sawada et al., 2008)) and is associated with disseminated superficial actinic porokeratosis (DSAP), a rare autosomal dominant genodermatosis (Cui et al. 2014). It plays a key role in purinergic signaling through its ability to transport nucleotides using the pmf. It catalyzes Cl--dependent transport activity involving essential arginines in the transmembrane region. Ketoacids inhibit these transporters through modulation of Cl- activation, but Cl- and the arginine residues are not important for ATP binding (Iwai et al. 2019). High expression of SLC17A9 correlates with a poor prognosis for colorectal cancer from Homo sapiens (Human) (see 5 papers)
    25% identity, 82% coverage of query (82.8 bits)

Q03567 Uncharacterized transporter slc-17.2 from Caenorhabditis elegans
    23% identity, 74% coverage of query (61.6 bits)

VGLU2_RAT / Q9JI12 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Rattus norvegicus (Rat) (see 10 papers)
TC 2.A.1.14.16 / Q9JI12 The broad specificity brain synaptic vesicle anion transporter (transports glutamate in a Δψ-dependent fashion requiring Cl- but phosphate by a Na+-dependent mechanism via a different pathway/mechanism from Rattus norvegicus (see 8 papers)
    21% identity, 76% coverage of query (58.5 bits)

7t3nA / Q9JI12 R184q/e191q mutant of rat vesicular glutamate transporter 2 (vglut2)
    21% identity, 76% coverage of query (56.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory