Searching for up to 100 curated homologs for HSERO_RS06575 FitnessBrowser__HerbieS:HSERO_RS06575 (455 a.a.)
Found high-coverage hits (≥70%) to 70 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.1.15.5 / O30513 Benzoate porter, BenK from Acinetobacter calcoaceticus (see 2 papers)
45% identity, 99% coverage of query (413 bits)
TC 2.A.1.15.7 / Q6FBB3 Aromatic compound (benzoate) uptake transporter of 450 aas from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
47% identity, 95% coverage of query (398 bits)
PCAK_ACIAD / Q43975 4-hydroxybenzoate transporter PcaK; 4-HB transporter from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
36% identity, 88% coverage of query (246 bits)
genK / Q8NLB7 gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
GENK_CORGL / Q8NLB7 Gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
39% identity, 84% coverage of query (241 bits)
proT / BAB32694.1 putative transporter from Pseudomonas straminea (see 2 papers)
33% identity, 95% coverage of query (227 bits)
GALT_PSEPU / E8ZB61 Gallate transporter; Gallate permease from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
galT / CBJ94499.1 gallic acid permease from Pseudomonas putida (see paper)
36% identity, 87% coverage of query (222 bits)
PCAK_PSEPU / Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
TC 2.A.1.15.1 / Q51955 4-Hydroxybenzoate/protocatechuate porter from Pseudomonas putida (see paper)
pcaK / AAA85137.1 PcaK from Pseudomonas putida (see paper)
35% identity, 93% coverage of query (217 bits)
MHBT_KLEOX / Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
34% identity, 97% coverage of query (211 bits)
NIAP_ACIAD / Q6FFF7 Niacin transporter NiaP from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
30% identity, 91% coverage of query (210 bits)
TC 2.A.1.15.14 / Q8VUZ0 Probable uptake transporter for 2,4-dichlorophenoxyacetic acid (2,4-D), CadK from Bradyrhizobium sp. HW13
32% identity, 96% coverage of query (200 bits)
TC 2.A.1.15.3 / Q46M63 2,4-Dichlorophenoxyacetate porter (see 5 papers)
31% identity, 98% coverage of query (195 bits)
TC 2.A.1.15.6 / O24842 Vanillate porter, VanK (see 4 papers)
30% identity, 88% coverage of query (180 bits)
YaiK / b0353 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
mhpT / P77589 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
MHPT_ECOLI / P77589 3-(3-hydroxy-phenyl)propionate transporter; 3HPP transporter; 3-(3-hydroxy-phenyl)propionate:H(+) symporter; 3HPP:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.15.2 / P77589 MhpT. A specific 3-(3-hydroxyphenyl)propionate (3HPP) transporter; vital for E. coli K-12 W3110 to grow on this substrate from Escherichia coli (see 3 papers)
31% identity, 93% coverage of query (149 bits)
Build an alignment for HSERO_RS06575 and 13 homologs with ≥ 30% identity
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TC 2.A.1.15.11 / Q6M372 The Vanillate porter, VanK from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
27% identity, 99% coverage of query (149 bits)
NIAP_BACSU / O34691 Putative niacin/nicotinamide transporter NiaP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.82.4 / O34691 Niacin uptake porter NiaP from Bacillus subtilis (see 2 papers)
29% identity, 86% coverage of query (147 bits)
TC 2.A.1.15.4 / P94131 cis,cis-muconate porter, MucK from Acinetobacter calcoaceticus (see 2 papers)
mucK / AAC27117.1 cis,cis-muconate transport protein MucK from Acinetobacter baylyi (see paper)
28% identity, 89% coverage of query (139 bits)
SVOP_BOVIN / Q1JP63 Synaptic vesicle 2-related protein; SV2-related protein from Bos taurus (Bovine) (see paper)
28% identity, 93% coverage of query (130 bits)
SVOP_XENLA / Q2XWK0 Synaptic vesicle 2-related protein; SV2-related protein from Xenopus laevis (African clawed frog) (see paper)
27% identity, 93% coverage of query (130 bits)
TC 2.A.1.15.8 / O24723 Probable 1-hydroxy-2-naphthoate transporter, orf1 (see paper)
28% identity, 93% coverage of query (119 bits)
SVOP_RAT / Q9Z2I7 Synaptic vesicle 2-related protein; SV2-related protein from Rattus norvegicus (Rat) (see paper)
27% identity, 93% coverage of query (117 bits)
TC 2.A.1.82.3 / Q8BFT9 Synaptic vesicle 2-related protein (SV2-related protein), SVOP from Mus musculus (see 4 papers)
27% identity, 89% coverage of query (115 bits)
YgcS / b2771 putative transporter YgcS from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 2.A.1.1.95 / Q46909 Inner membrane metabolite transport protein YgcS from Escherichia coli (strain K12) (see 3 papers)
29% identity, 84% coverage of query (115 bits)
YaaU / b0045 putative transporter YaaU from Escherichia coli K-12 substr. MG1655 (see 4 papers)
25% identity, 85% coverage of query (102 bits)
NanX / b4279 sialic acid transporter NanX from Escherichia coli K-12 substr. MG1655 (see 5 papers)
nanX / P39352 sialic acid transporter NanX from Escherichia coli (strain K12) (see 4 papers)
YJHB_ECOLI / P39352 Putative metabolite transport protein YjhB from Escherichia coli (strain K12) (see paper)
24% identity, 80% coverage of query (95.9 bits)
NanT / b3224 N-acetylneuraminate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
nanT / P41036 N-acetylneuraminate:H+ symporter from Escherichia coli (strain K12) (see 16 papers)
NANT_ECOLI / P41036 Sialic acid transporter NanT; Sialic acid permease; Sialic acid/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.12.1 / P41036 The sialic acid porter, NanT. N-acetylneuraminic acid (Neu5Ac) serves as a sole source of carbon and nitrogen for E. coli. It is a mucus-derived carbon source in the mammalian gut. NanT can also take up and allow efficient growth on the related sialic acids, N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-d-glycero-d-galactonononic acid (KDN) from Escherichia coli (see 4 papers)
26% identity, 86% coverage of query (94.4 bits)
OCT7_ARATH / Q940M4 Organic cation/carnitine transporter 7; AtOCT7 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 96% coverage of query (93.2 bits)
Q49B45 ABC-type phosphate transporter (EC 7.3.2.1) from Zea mays (see paper)
26% identity, 85% coverage of query (92.0 bits)
S22AK_MOUSE / Q80UJ1 Solute carrier family 22 member 20; Organic anion transporter 6 from Mus musculus (Mouse) (see 5 papers)
TC 2.A.1.19.16 / Q80UJ1 The organic anion transporter, Oat6 or SLC22a20 of 556 aas and 12 TMSs from Mus musculus (Mouse) (see 6 papers)
26% identity, 88% coverage of query (92.0 bits)
TC 2.A.1.15.9 / O51798 Probable 4-methylmuconolactone transporter, MmlH from Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) (see paper)
26% identity, 78% coverage of query (92.0 bits)
TC 2.A.1.82.1 / F2CRE4 The barley copper uptake porter, CT-1 of 749 aas; nearly identical to the wheat orthologue from Hordeum vulgare var. distichum
24% identity, 94% coverage of query (91.3 bits)
Q49B43 ABC-type phosphate transporter (EC 7.3.2.1) from Zea mays (see paper)
27% identity, 85% coverage of query (90.1 bits)
TC 2.A.1.19.35 / A6NK97 Solute carrier family 22 member 20 (Organic anion transporter 6; OAT6) of 555 aas and 12 probable TMSs. This protein is an apparent anionic odorant transporter in the olfactory epithelium of mice from Homo sapiens (see 3 papers)
27% identity, 84% coverage of query (89.7 bits)
Q49B46 ABC-type phosphate transporter (EC 7.3.2.1) from Zea mays (see paper)
25% identity, 85% coverage of query (89.4 bits)
S22AD_HUMAN / Q9Y226 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3; ORCTL3 from Homo sapiens (Human) (see 5 papers)
TC 2.A.1.19.17 / Q9Y226 Kidney organic cation transporter-like 3 ORCTL-3 (OAT10; SLC22A13; Like-3) (Bahn et al., 2008) (transports nicotinate, p-aminohippurate and urate; KM=20-40 mμM) via exchange for lactate) from Homo sapiens (Human) (see 4 papers)
26% identity, 90% coverage of query (87.4 bits)
PHT14_ORYSJ / Q8H6H2 Probable inorganic phosphate transporter 1-4; OsPT4; OsPht1;4; H(+)/Pi cotransporter; OsPT1 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
24% identity, 85% coverage of query (86.3 bits)
TC 2.A.1.9.4 / Q01MW8 Pht1;2(1;4) (PT2), a low affinity Pi uptake transporter, functioning throughout the plant (Ai et al., 2009) (76% identical to 2.A.1.9.3) from Oryza sativa subsp. indica (see paper)
24% identity, 85% coverage of query (86.3 bits)
TC 2.A.1.1.53 / Q8NTX0 Myo-Inositol uptake porter, IolT1 (Km=0.2mM) from Corynebacterium glutamicum (Brevibacterium flavum) (see paper)
26% identity, 76% coverage of query (86.3 bits)
PT112_ORYSJ / Q8H074 Probable inorganic phosphate transporter 1-12; OsPT12; OsPht1;12; H(+)/Pi cotransporter from Oryza sativa subsp. japonica (Rice) (see paper)
24% identity, 86% coverage of query (83.2 bits)
PHT13_ARATH / O48639 Probable inorganic phosphate transporter 1-3; AtPht1;3; H(+)/Pi cotransporter from Arabidopsis thaliana (Mouse-ear cress) (see paper)
23% identity, 86% coverage of query (83.2 bits)
PHT13_ORYSJ / Q7XDZ7 Probable inorganic phosphate transporter 1-3; OsPT3; OsPht1;3; H(+)/Pi cotransporter; OsPT1 from Oryza sativa subsp. japonica (Rice) (see paper)
25% identity, 89% coverage of query (82.8 bits)
S22AD_MOUSE / Q6A4L0 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3 from Mus musculus (Mouse) (see paper)
27% identity, 72% coverage of query (82.0 bits)
TC 2.A.1.9.3 / Q43650 Pi uptake porter. Four close paralogues in Medicago truncatula (PT1-4), all localized to roots, show differing affinities for phosphate from Solanum tuberosum (Potato) (see paper)
24% identity, 86% coverage of query (82.0 bits)
PHT19_ARATH / Q9S735 Probable inorganic phosphate transporter 1-9; AtPht1;9; H(+)/Pi cotransporter from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
24% identity, 87% coverage of query (81.3 bits)
Q49B42 ABC-type phosphate transporter (EC 7.3.2.1) from Zea mays (see paper)
24% identity, 86% coverage of query (81.3 bits)
8bw7A Cryo-em structure of rat slc22a6 bound to alpha-ketoglutaric acid
26% identity, 79% coverage of query (80.9 bits)
PHT11_PETHY / A7KTC5 Low affinity inorganic phosphate transporter 1; PhPT1; PhPht1;1; Arbuscular mycorrhiza-induced phosphate transporter PT1; AM-induced phosphate transporter PT1; H(+)/Pi cotransporter PT1 from Petunia hybrida (Petunia) (see paper)
22% identity, 86% coverage of query (80.1 bits)
S22AD_RAT / B2GV36 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3 from Rattus norvegicus (Rat) (see paper)
26% identity, 72% coverage of query (80.1 bits)
S22A6_RAT / O35956 Solute carrier family 22 member 6; Organic anion transporter 1; rOAT1; renal organic anion transporter 1; rROAT1 from Rattus norvegicus (Rat) (see 7 papers)
TC 2.A.1.19.4 / O35956 The polyspecific organic anion, cation and neutral molecule transporter, Oat1 (Slc22a6) (transports neutral compounds such as cardiac glycosides [i.e., ouabain] and steroids [i.e., aldosterone; cortisol; dexamethasone]; cationic compounds such as N-propylajmalinium, and anionic compounds such as p-aminohippurate, dicarboxylates, cyclic nucleotides, prostaglandins, urate, β-lactam antibiotics, nonsteroidal anti-inflammatory drugs, diuretics, bile salts and steroid conjugates [i.e., estrone-3-sulfate and estradiol-17-glucuronide]) transporter (H+ symporter or uniporter) Probably catalyzes organic anion (uptake):dicarboxylate (efflux) antiport in the basolateral membrane of kidney proximal tubules) (Eraly et al., 2003a,b). A 3-dimensional model of OAT1 has led to the identification of residues involved in differential transport of substrates such as p-aminohippurate and cidofovir (Perry et al., 2006). Oat1 transports many antiviral agents from Rattus norvegicus (Rat) (see 7 papers)
Slc22a6 / RF|NP_058920.1 solute carrier family 22 member 6 from Rattus norvegicus (see paper)
25% identity, 79% coverage of query (79.7 bits)
8bvtA / O35956 Cryo-em structure of rat slc22a6 bound to probenecid (see paper)
26% identity, 79% coverage of query (79.7 bits)
8bvsA Cryo-em structure of rat slc22a6 bound to tenofovir
26% identity, 79% coverage of query (79.7 bits)
S22A6_MOUSE / Q8VC69 Solute carrier family 22 member 6; Kidney-specific transport protein; Novel kidney transcript; mNKT; Organic anion transporter 1; mOAT1; Renal organic anion transporter 1; mROAT1 from Mus musculus (Mouse) (see 6 papers)
25% identity, 73% coverage of query (79.3 bits)
S22A8_HUMAN / Q8TCC7 Organic anion transporter 3; hOAT3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8 from Homo sapiens (Human) (see 15 papers)
TC 2.A.1.19.34 / Q8TCC7 Multispecific drug transporter, solute carrier family 22 member 8 (Organic anion transporter 3) (hOAT3) from Homo sapiens (see 9 papers)
25% identity, 79% coverage of query (79.3 bits)
S22A8_MACFA / Q4W8A2 Organic anion transporter 3; mKOAT3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
25% identity, 79% coverage of query (79.3 bits)
S22A6_PSEAM / O57379 Solute carrier family 22 member 6; Organic anion transporter 1; Renal organic anion transporter 1; ROAT1; fROAT1 from Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) (see paper)
25% identity, 72% coverage of query (79.0 bits)
S22A6_HUMAN / Q4U2R8 Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; hROAT1 from Homo sapiens (Human) (see 20 papers)
TC 2.A.1.19.31 / Q4U2R8 Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1), from Homo sapiens (see 17 papers)
25% identity, 80% coverage of query (73.6 bits)
S22A5_HUMAN / O76082 Organic cation/carnitine transporter 2; High-affinity sodium-dependent carnitine cotransporter; Solute carrier family 22 member 5 from Homo sapiens (Human) (see 28 papers)
TC 2.A.1.19.3 / O76082 The polyspecific organic cation (L- and D-carnitine, butyryl-L-carnitine, acetyl carnitine, γ-butyro-betaine, glycinebetaine, β-lactam antibiotics with a quaternary nitrogen such as cephaloridine, and others):Na+ symporter, OCTN2 (SLC22A5). Carnitine is transporter with high affinity (2 - 20 μM0 (Ingoglia et al. 2015). Associated with Crohn''s disease (Barton et al., 2005) as well as primary carnitine deficiency from Homo sapiens (Human) (see 28 papers)
25% identity, 79% coverage of query (68.6 bits)
S22AE_MOUSE / Q497L9 Solute carrier family 22 member 14 from Mus musculus (Mouse) (see 2 papers)
23% identity, 76% coverage of query (68.6 bits)
S22A1_MOUSE / O08966 Solute carrier family 22 member 1; Organic cation transporter 1; mOCT1 from Mus musculus (Mouse) (see 12 papers)
25% identity, 78% coverage of query (66.6 bits)
S22AB_HUMAN / Q9NSA0 Solute carrier family 22 member 11; Organic anion transporter 4; OAT4; Organic anion:dicarboxylate exchanger OAT4 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.10 / Q9NSA0 The apical proximal tubular kidney/placenta organic anion transporter 4, Oat4 (Slc22a11) (transports estrone sulfate (Km = 1 µM), dehydroepiandrosterone sulfate (Km = 60µM), many anionic drugs, diuretics, bile salts, urate and ochratoxin A). Catalyzes Na+-independent efflux, possibly using glutamate as a counter anion in an exchange reaction, especially in the placenta from Homo sapiens (Human) (see 7 papers)
SLC22A11 / GB|BAA95316.1 solute carrier family 22 member 11 from Homo sapiens
28% identity, 72% coverage of query (66.2 bits)
S22A7_HUMAN / Q9Y694 Solute carrier family 22 member 7; Novel liver transporter; NLT; Organic anion transporter 2; hOAT2 from Homo sapiens (Human) (see 9 papers)
TC 2.A.1.19.25 / Q9Y694 Solute carrier family 22 member 7 (liver transporter) (Organic anion transporter 2) (hOAT2), transports cyclic nucleotodes and the anti-viral drug, acyclovir (Dahlin et al. 2013). Expressed in liver, kidney, brain and red blood cells from Homo sapiens (see 9 papers)
25% identity, 76% coverage of query (65.9 bits)
Q9VCA2 Organic cation transporter protein from Drosophila melanogaster (Fruit fly)
24% identity, 76% coverage of query (65.5 bits)
S22A1_RAT / Q63089 Solute carrier family 22 member 1; Organic cation transporter 1; rOCT1 from Rattus norvegicus (Rat) (see 27 papers)
TC 2.A.1.19.1 / Q63089 The basolateral multivalent, potential-sensitive, organic cation (tetramethyl-ammonium; N'-methylnicotinamide; cationic drugs, xenobiotics, vitamins, neuro-transmitters, etc.) transporter (uni-porter)-1, Oct1 from Rattus norvegicus (Rat) (see 18 papers)
25% identity, 79% coverage of query (63.9 bits)
S22A1_HUMAN / O15245 Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1 from Homo sapiens (Human) (see 26 papers)
TC 2.A.1.19.29 / O15245 Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) from Homo sapiens (see 18 papers)
26% identity, 78% coverage of query (60.1 bits)
7zh6A Structure of human oct3 in complex with inhibitor corticosterone
24% identity, 80% coverage of query (57.4 bits)
S22A3_HUMAN / O75751 Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3; OCT3 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.24 / O75751 Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) from Homo sapiens (see 3 papers)
23% identity, 80% coverage of query (57.4 bits)
8et8A Cryo-em structure of the organic cation transporter 1 in complex with verapamil
25% identity, 78% coverage of query (57.0 bits)
8et7A / O15245 Cryo-em structure of the organic cation transporter 1 in complex with diphenhydramine (see paper)
25% identity, 78% coverage of query (57.0 bits)
7zhaA / O75751 Structure of human oct3 in complex with inhibitor decynium-22 (see paper)
23% identity, 80% coverage of query (55.5 bits)
8sc2A / O15245 Human oct1 bound to diltiazem in inward-open conformation (see paper)
25% identity, 78% coverage of query (48.5 bits)
8sc6A Human oct1 bound to thiamine in inward-open conformation
25% identity, 78% coverage of query (45.1 bits)
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Lawrence Berkeley National Laboratory