Searching for up to 100 curated homologs for HSERO_RS06785 FitnessBrowser__HerbieS:HSERO_RS06785 (249 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.4.11 / Q6N8W2 Branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
60% identity, 96% coverage of query (272 bits)
1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
51% identity, 95% coverage of query (232 bits)
HSERO_RS00900 L-proline ABC transporter, ATPase component 2 from Herbaspirillum seropedicae SmR1
49% identity, 96% coverage of query (228 bits)
Ac3H11_1692 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, ATPase component 2 from Acidovorax sp. GW101-3H11
48% identity, 95% coverage of query (225 bits)
TC 3.A.1.4.10 / Q8DQH7 ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
46% identity, 94% coverage of query (219 bits)
LivF / b3454 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
LivF / P22731 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.4.1 / P22731 LivF aka B3454, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 4 papers)
livF / GB|AAC76479.2 high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivF from Escherichia coli K12 (see 5 papers)
48% identity, 96% coverage of query (212 bits)
TC 3.A.1.4.6 / Q8YT15 NatE, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
46% identity, 96% coverage of query (211 bits)
Pf6N2E2_2926 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 2 LivF from Pseudomonas fluorescens FW300-N2E2
48% identity, 94% coverage of query (202 bits)
TC 3.A.1.4.8 / P21630 High-affinity branched-chain amino acid transport ATP-binding protein BraG, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
48% identity, 94% coverage of query (200 bits)
AZOBR_RS08250 L-proline and D-alanine ABC transporter, ATPase component 2 from Azospirillum brasilense Sp245
46% identity, 94% coverage of query (196 bits)
braG / CAB75552.1 ATPase from Rhizobium leguminosarum bv. viciae (see 2 papers)
43% identity, 97% coverage of query (189 bits)
TC 3.A.1.4.2 / P73650 NatE aka LivF aka SLR1881, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
47% identity, 95% coverage of query (185 bits)
TC 3.A.1.4.9 / Q0S720 ABC branched-chain amino acid transporter, ATP-binding component, component of Uptake transporter, CamABCD of cholate (steroid) metabolites, 1β(2'-propanoate)-3aα-H-4α(3"(R)-hydroxy-3"-propanoate)-7aβ-methylhexahydro-5-indanone and a desaturated analog from Rhodococcus sp. (strain RHA1)
42% identity, 95% coverage of query (161 bits)
TC 3.A.1.4.7 / Q92TN4 Putative branched-chain amino acid uptake ABC transporter ATP-binding protein, component of The protocatechuate (3,4-dihydroxybenzoate) uptake porter, PcaMNVWX from Rhizobium meliloti (strain 1021)
40% identity, 96% coverage of query (155 bits)
TC 3.A.1.4.5 / Q8NRV7 UrtE, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
36% identity, 92% coverage of query (140 bits)
TC 3.A.1.4.4 / Q9L3S2 UrtE, component of The high-affinity (<1 μM) urea porter (see paper)
39% identity, 88% coverage of query (136 bits)
E6MYT4 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Neisseria meningitidis serogroup B / serotype 15 (see 2 papers)
32% identity, 96% coverage of query (131 bits)
6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
31% identity, 94% coverage of query (127 bits)
Build an alignment for HSERO_RS06785 and 18 homologs with ≥ 30% identity
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1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
28% identity, 94% coverage of query (127 bits)
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
28% identity, 94% coverage of query (126 bits)
TC 3.A.1.4.8 / P21629 High-affinity branched-chain amino acid transport ATP-binding protein BraF, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
32% identity, 96% coverage of query (124 bits)
lptB / O25417 lipopolysaccharide transport system ATP-binding protein LptB (EC 7.5.2.5) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
29% identity, 94% coverage of query (124 bits)
lptB / Q7CPN9 LPS export ABC transporter ATP-binding protein (EC 7.5.2.5) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 9 papers)
32% identity, 94% coverage of query (124 bits)
LptB / b3201 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
LptB / P0A9V1 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli (strain K12) (see 10 papers)
LPTB_ECOLI / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB; EC 7.5.2.- from Escherichia coli (strain K12) (see 5 papers)
P0A9V1 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Escherichia coli (see 3 papers)
TC 1.B.42.1.2 / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB, component of LPS export porin complex, LptBCFG-A-DE, consists of LptD (Omp; OmpA; 784 aas)-LptE (RlpB; 193 aas; O.M. lipoprotein)-LptA (KdsD; YhbN; OstA small; 185 aas periplasmic chaparone protein)-LptB (KdsC; YhbG; 241 aas cytoplasmic ABC-type ATPase)-LptC (YrbK, 199aas;1 N-terminal TMS)- LptFG, part of the ABC transporter. LptDE (1:1 stoichiometry) comprise a two-protein β-barrel-lipoprotein complex in the outer membrane that assembles and exports LPS from Escherichia coli (strain K12)
lptB lipopolysaccharide ABC transporter, ATP-binding protein LptB; EC 3.6.3.- from Escherichia coli K12 (see 9 papers)
33% identity, 94% coverage of query (122 bits)
AO353_21725 ABC transporter for D-glucosamine, ATPase component from Pseudomonas fluorescens FW300-N2E3
33% identity, 89% coverage of query (122 bits)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
33% identity, 94% coverage of query (122 bits)
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
33% identity, 94% coverage of query (122 bits)
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
33% identity, 94% coverage of query (122 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
32% identity, 94% coverage of query (121 bits)
A0A071L2Z5 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Pseudomonas aeruginosa (see paper)
TC 3.A.1.152.1 / Q9HVV6 Probable ATP-binding component of ABC transporter, component of LPS export system, LptF (M), LptG (M) and LptB (C) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
30% identity, 94% coverage of query (121 bits)
6b89A E. Coli lptb in complex with adp and novobiocin
33% identity, 94% coverage of query (120 bits)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
33% identity, 94% coverage of query (120 bits)
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
32% identity, 93% coverage of query (119 bits)
TC 3.A.1.4.2 / Q55164 NatA aka BRAF aka SLR0467, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
30% identity, 96% coverage of query (118 bits)
Pf6N2E2_2925 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 1 LivG from Pseudomonas fluorescens FW300-N2E2
30% identity, 96% coverage of query (118 bits)
PGA1_c12640 D-lactate transporter, ATP-binding component from Phaeobacter inhibens BS107
29% identity, 95% coverage of query (117 bits)
TC 3.A.1.3.14 / P39456 TcyC (YckI), component of Uptake system for L-cystine from Bacillus subtilis (see 7 papers)
31% identity, 89% coverage of query (117 bits)
lptB / Q2YP14 lipopolysaccharide transport system ATP-binding protein (EC 7.5.2.5) from Brucella abortus (strain 2308) (see paper)
30% identity, 94% coverage of query (117 bits)
Q73KK2 ABC-type D-galactose transporter (EC 7.5.2.11) from Treponema denticola (see paper)
30% identity, 96% coverage of query (116 bits)
TC 3.A.1.4.6 / Q7A2H0 NatA, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
29% identity, 94% coverage of query (116 bits)
HSERO_RS00895 L-proline ABC transporter, ATPase component 1 from Herbaspirillum seropedicae SmR1
30% identity, 96% coverage of query (115 bits)
TC 3.A.1.4.10 / Q8DQH8 ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
29% identity, 94% coverage of query (115 bits)
LivG / b3455 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivG (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
LivG / P0A9S7 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivG (EC 7.4.2.2) from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.4.1 / P0A9S7 High-affinity branched-chain amino acid transport ATP-binding protein LivG aka B3455, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 4 papers)
30% identity, 96% coverage of query (115 bits)
TC 3.A.1.4.3 / Q8VM83 BraF aka Bra2F, component of General L- (and D-)amino acid uptake porter (transports acidic, basic, polar, semipolar and hydrophobic amino acids). The amino and carboxyl groups do not need to be α since γ-aminobutyric acid (GABA) is a substrate. The system may function with additional binding proteins since L-alanine uptake is not dependent on BraC from Rhizobium leguminosarum (biovar viciae) (see paper)
30% identity, 94% coverage of query (115 bits)
Pf6N2E2_2050 ABC transporter for D-Glucosamine, putative ATPase component from Pseudomonas fluorescens FW300-N2E2
32% identity, 89% coverage of query (114 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
28% identity, 89% coverage of query (103 bits)
ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
30% identity, 89% coverage of query (99.0 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
28% identity, 85% coverage of query (94.7 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
28% identity, 85% coverage of query (94.7 bits)
2olkA Abc protein artp in complex with adp-beta-s
28% identity, 85% coverage of query (94.7 bits)
2oljA Abc protein artp in complex with adp/mg2+
28% identity, 85% coverage of query (94.7 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
31% identity, 80% coverage of query (90.1 bits)
7ch6C / P63386 Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
30% identity, 90% coverage of query (89.7 bits)
6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state
30% identity, 90% coverage of query (89.4 bits)
ABCAD_MOUSE / Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
28% identity, 82% coverage of query (89.4 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
28% identity, 82% coverage of query (88.2 bits)
7cgnB The overall structure of the mlafedb complex in atp-bound eqtall conformation (mutation of e170q on mlaf)
30% identity, 90% coverage of query (88.2 bits)
5l22B / O67184 Prtd t1ss abc transporter (see paper)
30% identity, 84% coverage of query (87.4 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
28% identity, 86% coverage of query (87.4 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
31% identity, 90% coverage of query (87.0 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
31% identity, 90% coverage of query (87.0 bits)
6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
31% identity, 90% coverage of query (86.7 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
30% identity, 94% coverage of query (86.7 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
28% identity, 89% coverage of query (83.6 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
29% identity, 94% coverage of query (82.0 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
29% identity, 94% coverage of query (82.0 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
29% identity, 94% coverage of query (82.0 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
29% identity, 94% coverage of query (82.0 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
29% identity, 94% coverage of query (82.0 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
29% identity, 94% coverage of query (82.0 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
29% identity, 94% coverage of query (82.0 bits)
7o12B / P19844 Abc transporter nosdfy, amppnp-bound in gdn (see paper)
30% identity, 90% coverage of query (81.6 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
27% identity, 89% coverage of query (80.9 bits)
3gd7A / P13569,P68187 Crystal structure of human nbd2 complexed with n6-phenylethyl-atp (p- atp)
27% identity, 94% coverage of query (80.5 bits)
7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc
30% identity, 90% coverage of query (80.5 bits)
ABC1_MYCTU / O65934 ABC transporter ATP-binding/permease protein Rv1747; EC 7.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
30% identity, 89% coverage of query (79.0 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
27% identity, 85% coverage of query (78.6 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
29% identity, 86% coverage of query (78.6 bits)
1g291 / Q9YGA6 Malk (see paper)
29% identity, 87% coverage of query (77.8 bits)
8g4cB / O34697 Bceabs atpgs high res tm (see paper)
25% identity, 80% coverage of query (77.8 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
27% identity, 87% coverage of query (77.0 bits)
6d3rA Thermostablilized dephosphorylated chicken cftr (see paper)
29% identity, 85% coverage of query (77.0 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
25% identity, 89% coverage of query (76.6 bits)
P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
33% identity, 75% coverage of query (76.6 bits)
7svrA The complex of dephosphorylated human cystic fibrosis transmembrane conductance regulator (cftr) and lumacaftor (vx-809)
26% identity, 93% coverage of query (76.3 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
29% identity, 88% coverage of query (76.3 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
29% identity, 88% coverage of query (76.3 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 88% coverage of query (76.3 bits)
7tchB Bceab e169q variant atp-bound conformation
25% identity, 80% coverage of query (76.3 bits)
4q4aA / Q9WYC3 Improved model of amp-pnp bound tm287/288 (see paper)
29% identity, 83% coverage of query (75.9 bits)
CFTR / P13569 cystic fibrosis transmembrane conductance regulator (EC 5.6.1.6) from Homo sapiens (see 23 papers)
CFTR_HUMAN / P13569 Cystic fibrosis transmembrane conductance regulator; CFTR; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; EC 5.6.1.6 from Homo sapiens (Human) (see 120 papers)
P13569 adenylate kinase (EC 2.7.4.3); channel-conductance-controlling ATPase (EC 5.6.1.6) from Homo sapiens (see 17 papers)
TC 3.A.1.202.1 / P13569 Cystic fibrosis transmembrane conductance regulator (CFTR) (also called ABCC7); cyclic AMP-dependent chloride channel; also catalyzes nucleotide (ATP-ADP)-dependent glutathione and glutathione-conjugate flux (Kogan et al., 2003) (may also activate inward rectifying K+ channels). The underlying mechanism by which ATP hydrolysis controls channel opening is described by Gadsby et al., 2006. The most common cause of cystic fibrosis (CF) is defective folding of a cystic fibrosis transmembrane conductance regulator (CFTR) mutant lacking Phe508 (DeltaF508)(Riordan, 2008). The DeltaF508 protein appears to be trapped in a prefolded state with incomplete packing of the transmembrane segments, a defect that can be repaired by direct interaction with correctors such as corr-4a, VRT-325, and VRT-532 (Wang et al., 2007). CFTR interacts directly with MRP4 (3.A.1.208.7) to control Cl- secretion (Li et al., 2007). It has intrinsic adenylate kinase activity that may be of functional importance (Randak and Welsh, 2007). The intact CFTR protein mediates ATPase rather than adenylate kinase activity (Ramjeesingh et al., 2008). Regulated by Na+/H+ exchange regulatory cofactors (NHERF; O14745; TC #8.A.24.1.1) (Seidler et al., 2009). Regulated by protein kinase A and C phosphorylation (Csanády et al., 2010). It is also activated by membrane stretch induced by negative pressures (Zhang et al., 2010). TMS6 plays roles in gating and permeation (Bai et al., 2010; 2011). The 3-D structure revealed the probable location of the channel gate (Rosenberg et al., 2011). Conformational changes opening the CFTR chloride channel pore, coupled to ATP-dependent gating, have been studied (Wang and Linsdell, 2012). Alternating access to the transmembrane domain of CFTR has been demonstrated from Homo sapiens (Human) (see 71 papers)
CFTR / RF|NP_000483.3 cystic fibrosis transmembrane conductance regulator from Homo sapiens (see paper)
26% identity, 95% coverage of query (75.9 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
25% identity, 88% coverage of query (75.9 bits)
5uakA / P13569 Dephosphorylated, atp-free human cystic fibrosis transmembra conductance regulator (cftr) (see paper)
26% identity, 91% coverage of query (75.9 bits)
TAP1_HUMAN / Q03518 Antigen peptide transporter 1; APT1; ATP-binding cassette sub-family B member 2; Peptide supply factor 1; Peptide transporter PSF1; PSF-1; Peptide transporter TAP1; Peptide transporter involved in antigen processing 1; Really interesting new gene 4 protein; RING4; EC 7.4.2.14 from Homo sapiens (Human) (see 30 papers)
Q03518 ABC-type antigen peptide transporter (EC 7.4.2.14); bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see 2 papers)
29% identity, 93% coverage of query (75.5 bits)
6quzA Structure of atpgs-bound outward-facing tm287/288 in complex with sybody sb_tm35
29% identity, 83% coverage of query (75.5 bits)
6qv0A Structure of atp-bound outward-facing tm287/288 in complex with sybody sb_tm35
29% identity, 83% coverage of query (75.5 bits)
1jj7A / Q03518 Crystal structure of thE C-terminal atpase domain of human tap1 (see paper)
29% identity, 93% coverage of query (75.5 bits)
CFTR_RAT / P34158 Cystic fibrosis transmembrane conductance regulator; CFTR; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; EC 5.6.1.6 from Rattus norvegicus (Rat) (see 5 papers)
26% identity, 96% coverage of query (75.5 bits)
5w81A / Q1LX78 Phosphorylated, atp-bound structure of zebrafish cystic fibrosis transmembrane conductance regulator (cftr) (see paper)
28% identity, 90% coverage of query (74.7 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
27% identity, 80% coverage of query (74.7 bits)
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Lawrence Berkeley National Laboratory