Searching for up to 100 curated homologs for HSERO_RS07850 FitnessBrowser__HerbieS:HSERO_RS07850 (336 a.a.)
Found high-coverage hits (≥70%) to 70 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.24.5 / Q9HT70 Methionine import ATP-binding protein MetN 2, component of L-Histidine uptake porter, MetIQN from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
54% identity, 100% coverage of query (350 bits)
METN_BACSU / O32169 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.24.2 / O32169 MetN (C) (aka YusC), component of The L- and D-methionine porter (also transports methionine sulfoxide from Bacillus subtilis subsp. subtilis str. 168 (see 2 papers)
47% identity, 100% coverage of query (319 bits)
TC 3.A.1.24.3 / Q8K8K8 AtmD (MetN), component of The methionine porter, AtmBDE from Streptococcus pyogenes serotype M3 (see 2 papers)
44% identity, 95% coverage of query (278 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
43% identity, 100% coverage of query (275 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
43% identity, 100% coverage of query (273 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
43% identity, 100% coverage of query (273 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
43% identity, 100% coverage of query (273 bits)
TC 3.A.1.24.4 / Q8NSN2 Methionine import ATP-binding protein metN, component of L-Methionine uptake porter, MetQNI from Corynebacterium glutamicum (see paper)
45% identity, 91% coverage of query (261 bits)
ARTM_BACSU / P54537 Arginine transport ATP-binding protein ArtM from Bacillus subtilis (strain 168) (see paper)
41% identity, 73% coverage of query (196 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
45% identity, 72% coverage of query (195 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
44% identity, 73% coverage of query (194 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
44% identity, 73% coverage of query (194 bits)
2olkA Abc protein artp in complex with adp-beta-s
44% identity, 73% coverage of query (194 bits)
2oljA Abc protein artp in complex with adp/mg2+
44% identity, 73% coverage of query (194 bits)
TC 3.A.1.5.15 / Q9X272 TM1750, component of Probable mannose/mannoside porter. Induced by beta-mannan (Conners et al., 2005). Regulated by mannose-responsive regulator manR (see paper)
41% identity, 73% coverage of query (182 bits)
TCYN_BACSU / O34900 L-cystine import ATP-binding protein TcyN; EC 7.4.2.- from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.3.13 / O34900 TcyN (YtmN), component of Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine from Bacillus subtilis (see 4 papers)
43% identity, 72% coverage of query (182 bits)
TC 3.A.1.3.25 / Q9CES4 Glutamine ABC transporter ATP-binding protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity from Lactococcus lactis subsp. lactis (strain IL1403)
41% identity, 72% coverage of query (181 bits)
YXEO_BACSU / P54954 Probable amino-acid import ATP-binding protein YxeO; EC 7.4.2.- from Bacillus subtilis (strain 168) (see paper)
42% identity, 70% coverage of query (176 bits)
TcyN / b1917 cystine ABC transporter ATP binding subunit (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
tcyN / P37774 cystine ABC transporter ATP binding subunit (EC 7.4.2.12) from Escherichia coli (strain K12) (see 7 papers)
TCYN_ECOLI / P37774 L-cystine transport system ATP-binding protein TcyN; EC 7.4.2.12 from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.3.10 / P37774 YECC aka CysZ aka B1917, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 5 papers)
42% identity, 72% coverage of query (172 bits)
8j5qD / P9WQJ5 Cryo-em structure of mycobacterium tuberculosis oppabcd in the pre- translocation state (see paper)
39% identity, 72% coverage of query (159 bits)
8j5tD Cryo-em structure of mycobacterium tuberculosis oppabcd in the catalytic intermediate state
39% identity, 72% coverage of query (158 bits)
8j5sD Cryo-em structure of mycobacterium tuberculosis oppabcd in the pre- catalytic intermediate state
39% identity, 72% coverage of query (158 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
35% identity, 72% coverage of query (148 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
35% identity, 72% coverage of query (148 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
35% identity, 72% coverage of query (148 bits)
HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
39% identity, 71% coverage of query (139 bits)
1b0uA / P02915 Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
39% identity, 71% coverage of query (139 bits)
ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
35% identity, 71% coverage of query (139 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
37% identity, 75% coverage of query (133 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
32% identity, 72% coverage of query (129 bits)
DPPD_CALS4 / Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
36% identity, 77% coverage of query (124 bits)
4q9iA P-glycoprotein cocrystallised with qz-ala
33% identity, 74% coverage of query (124 bits)
1g291 / Q9YGA6 Malk (see paper)
30% identity, 73% coverage of query (123 bits)
4fwiB / Q8RDH4 Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
36% identity, 72% coverage of query (122 bits)
MsbA / b0914 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli K-12 substr. MG1655 (see 54 papers)
msbA / P60752 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli (strain K12) (see 57 papers)
MSBA_ECOLI / P60752 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; Lipid flippase; EC 7.5.2.6 from Escherichia coli (strain K12) (see 17 papers)
P60752 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6); P-type phospholipid transporter (EC 7.6.2.1) from Escherichia coli (see 13 papers)
TC 3.A.1.106.1 / P60752 Phospholipid, LPS, lipid A and drug exporter, MsbA, which flips the substrate from the inner leaflet of the cytoplasmic membrane to the outer leaflet (Eckford and Sharom, 2010). MsbA also confers drug resistance to azidopine, daunomycin, vinblastine, Hoechst 33342 and ethidium (Reuter et al., 2003). Four x-ray structures, trapped in different conformations, two with and two without nucleotide, have been solved (Ward et al., 2007). They suggest an alternating accessibility mode of transport with major conformational changes from Escherichia coli (see 11 papers)
msbA / MB|P60752 lipid A export ATP-binding/permease protein msbA; EC 3.6.3.- from Escherichia coli K12 (see 24 papers)
36% identity, 74% coverage of query (121 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
33% identity, 76% coverage of query (121 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
33% identity, 76% coverage of query (121 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
33% identity, 76% coverage of query (121 bits)
7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
33% identity, 73% coverage of query (121 bits)
ABCBA_MOUSE / Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 9 papers)
36% identity, 72% coverage of query (121 bits)
6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
33% identity, 73% coverage of query (121 bits)
4xwkA P-glycoprotein co-crystallized with bde-100
33% identity, 73% coverage of query (121 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
33% identity, 73% coverage of query (120 bits)
6qeeA Nanodisc reconstituted human-mouse chimeric abcb1 (abcb1hm)-eq mutant in complex with uic2 fab and zosuquidar.
33% identity, 73% coverage of query (120 bits)
7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
33% identity, 72% coverage of query (120 bits)
5koyA Mouse pgp 34 linker deleted bound with atp
33% identity, 73% coverage of query (120 bits)
7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
33% identity, 72% coverage of query (120 bits)
7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
33% identity, 72% coverage of query (120 bits)
7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
33% identity, 72% coverage of query (120 bits)
P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
34% identity, 81% coverage of query (116 bits)
8wooA Structure of the wild-type arabidopsis abcb19 in the brassinolide and amp-pnp bound state
36% identity, 72% coverage of query (116 bits)
8womA / Q9LJX0 Structure of the wild-type arabidopsis abcb19 in the brassinolide- bound state (see paper)
36% identity, 72% coverage of query (116 bits)
SapD / b1291 putrescine ABC exporter ATP binding protein SapD (EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
SapD / P0AAH4 putrescine ABC exporter ATP binding protein SapD (EC 7.6.2.16) from Escherichia coli (strain K12) (see 5 papers)
SAPD_ECOLI / P0AAH4 Putrescine export system ATP-binding protein SapD from Escherichia coli (strain K12) (see 2 papers)
32% identity, 71% coverage of query (115 bits)
8wp0A Structure of the arabidopsis e529q/e1174q abcb19 in the atp bound state
36% identity, 72% coverage of query (115 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
31% identity, 78% coverage of query (114 bits)
ABCBA_HUMAN / Q9NRK6 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2 from Homo sapiens (Human) (see 7 papers)
Q9NRK6 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
33% identity, 72% coverage of query (112 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
31% identity, 72% coverage of query (110 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
31% identity, 72% coverage of query (110 bits)
7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
30% identity, 72% coverage of query (109 bits)
Build an alignment for HSERO_RS07850 and 59 homologs with ≥ 30% identity
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8f5bA / P78363 Human abca4 structure in complex with amp-pnp
28% identity, 89% coverage of query (107 bits)
8bmpB / Q1GBI9 Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp (see paper)
30% identity, 82% coverage of query (102 bits)
5d3mB Folate ecf transporter: amppnp bound state
30% identity, 82% coverage of query (102 bits)
ABCB7_HUMAN / O75027 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Homo sapiens (Human) (see 8 papers)
TC 3.A.1.210.4 / O75027 ABC7 or ABCB7 iron transporter (X-linked sideroblastis anemia protein, XLSA/A (Fujiwara and Harigae 2013)) from Homo sapiens (Human) (see 9 papers)
31% identity, 73% coverage of query (102 bits)
8bmsB Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
29% identity, 82% coverage of query (101 bits)
ABCB7_MOUSE / Q61102 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Mus musculus (Mouse) (see 4 papers)
30% identity, 78% coverage of query (99.0 bits)
YOR1_YEAST / P53049 Oligomycin resistance ATP-dependent permease YOR1; ABC transporter YOR1; ABC-type Cd(2+) transporter; ABC-type glutathione-S-conjugate transporter; Yeast oligomycin resistance protein 1; EC 7.2.2.2; EC 7.6.2.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 9 papers)
TC 3.A.1.208.3 / P53049 Oligomycin-resistance protein YOR1 in plasma membrane (confers resistance to oligomycin, rhodamine B, tetracycline, verapamil, eosin Y and ethidium bromide; Grigoras et al., 2007)) from Saccharomyces cerevisiae (Baker's yeast) (see 10 papers)
YOR1 / RF|NP_011797.1 oligomycin resistance ATP-dependent permease YOR1 from Saccharomyces cerevisiae (see paper)
31% identity, 73% coverage of query (96.7 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
29% identity, 80% coverage of query (96.7 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
28% identity, 80% coverage of query (84.7 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
27% identity, 80% coverage of query (83.2 bits)
ABC2_SCHPO / Q10185 ATP-binding cassette transporter abc2; ABC transporter abc2; ATP-energized glutathione S-conjugate pump abc2; Glutathione S-conjugate-transporting ATPase abc2; EC 7.-.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
TC 3.A.1.208.16 / Q10185 The vacuolar Abc2p (SPAC3F10.11c) transporter for xenobiotics, glutathione S-conjugates and monochlorobimane from Schizosaccharomyces pombe (Fission yeast) (see 3 papers)
abc2 / RF|NP_593943.2 ATP-binding cassette transporter abc2 from Schizosaccharomyces pombe (see 3 papers)
26% identity, 88% coverage of query (58.5 bits)
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Lawrence Berkeley National Laboratory