Sites on a Tree

 

Searching for up to 100 curated homologs for HSERO_RS08375 FitnessBrowser__HerbieS:HSERO_RS08375 (433 a.a.)

Found high-coverage hits (≥70%) to 35 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

DadR / b1189 D-amino acid dehydrogenase (EC 1.4.5.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
dadA / P0A6J5 D-amino acid dehydrogenase (EC 1.4.5.1) from Escherichia coli (strain K12) (see 22 papers)
DADA_ECOLI / P0A6J5 D-amino acid dehydrogenase; D-alanine dehydrogenase; EC 1.4.99.- from Escherichia coli (strain K12) (see 4 papers)
dadA / AAC36880.1 D-amino acid dehydrogenase from Escherichia coli (see paper)
    70% identity, 97% coverage of query (611 bits)

DADA_KLEAE / O30745 D-amino acid dehydrogenase; D-alanine dehydrogenase; EC 1.4.99.- from Klebsiella aerogenes (Enterobacter aerogenes) (see paper)
    68% identity, 100% coverage of query (606 bits)

DADA1_PSEAE / Q9HTQ0 D-amino acid dehydrogenase 1; D-alanine dehydrogenase 1; EC 1.4.99.- from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9HTQ0 D-arginine dehydrogenase (EC 1.4.99.6) from Pseudomonas aeruginosa (see paper)
    66% identity, 100% coverage of query (592 bits)

Psest_3793 D-alanine dehydrogenase (EC 1.4.99.-) from Pseudomonas stutzeri RCH2
    67% identity, 97% coverage of query (581 bits)

AZOBR_RS08020 D-alanine dehydrogenase (EC 1.4.99.-) from Azospirillum brasilense Sp245
    57% identity, 100% coverage of query (499 bits)

Ac3H11_4848 D-alanine dehydrogenase (EC 1.4.99.-) from Acidovorax sp. GW101-3H11
    39% identity, 100% coverage of query (311 bits)

RR42_RS25930 glycine dehydrogenase (deaminating) (EC 1.4.1.10) from Cupriavidus basilensis FW507-4G11
    35% identity, 92% coverage of query (227 bits)

Build an alignment

Build an alignment for HSERO_RS08375 and 7 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

dadA / A3KEZ1 D-amino acid dehydrogenase (EC 1.4.5.1) from Helicobacter pylori (see paper)
DADA_HELPX / A3KEZ1 D-amino acid dehydrogenase; DAD; EC 1.4.5.1 from Helicobacter pylori (Campylobacter pylori) (see paper)
A3KEZ1 D-amino acid dehydrogenase (quinone) (EC 1.4.5.1); D-arginine dehydrogenase (EC 1.4.99.6) from Helicobacter pylori (see 2 papers)
    25% identity, 90% coverage of query (120 bits)

amaD / Q88GX1 D-lysine oxidase (EC 1.4.3.3) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    28% identity, 96% coverage of query (107 bits)

lhpB / Q88NF6 D-hydroxyproline dehydrogenase subunit from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
    26% identity, 92% coverage of query (105 bits)

Q5JFG7 proline dehydrogenase (EC 1.5.5.2) from Thermococcus kodakarensis (see paper)
    24% identity, 73% coverage of query (81.3 bits)

L7T8Y9 glycine oxidase (EC 1.4.3.19) from Bacillus cereus (see 2 papers)
    24% identity, 93% coverage of query (75.9 bits)

7cyxA / Q81HQ7 Crystal strcuture of glycine oxidase from bacillus cereus atcc 14579 (see paper)
    24% identity, 93% coverage of query (73.2 bits)

lhpB / Q9I477 D-hydroxyproline dehydrogenase β subunit from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    27% identity, 73% coverage of query (72.4 bits)

6j38A / X5IYZ1 Crystal structure of cmis2 (see paper)
    29% identity, 76% coverage of query (72.4 bits)

2gagB Heteroteterameric sarcosine: structure of a diflavin metaloenzyme at 1.85 a resolution
    22% identity, 76% coverage of query (72.4 bits)

6j39A Crystal structure of cmis2 with inhibitor
    29% identity, 76% coverage of query (72.4 bits)

6pxsA / Q11HA4 Crystal structure of iminodiacetate oxidase (idaa) from chelativorans sp. Bnc1 (see paper)
    27% identity, 97% coverage of query (70.5 bits)

soxB / P40875 sarcosine oxidase β subunit (EC 1.5.3.24) from Corynebacterium sp. (strain P-1) (see 3 papers)
TSOXB_CORS1 / P40875 Sarcosine oxidase subunit beta; Sarcosine oxidase subunit B; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit beta; Tetrameric sarcosine oxidase subunit beta; TSOX subunit beta; EC 1.5.3.24 from Corynebacterium sp. (strain P-1) (see 7 papers)
    21% identity, 76% coverage of query (68.9 bits)

GLYOX_GEOKA / Q5L2C2 Glycine oxidase; GO; GOX; GOXK; EC 1.4.3.19 from Geobacillus kaustophilus (strain HTA426) (see paper)
Q5L2C2 glycine oxidase (EC 1.4.3.19) from Geobacillus kaustophilus (see paper)
    25% identity, 73% coverage of query (68.6 bits)

TSOXB_ARTSP / Q9AGP3 Sarcosine oxidase subunit beta; Sarcosine oxidase subunit B; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit beta; Tetrameric sarcosine oxidase subunit beta; TSOX subunit beta; EC 1.5.3.24 from Arthrobacter sp.
    22% identity, 76% coverage of query (68.6 bits)

4yshA / Q5L2C2 Crystal structure of glycine oxidase from geobacillus kaustophilus
    25% identity, 72% coverage of query (68.6 bits)

mabO / Q8GAI3 4-methylaminobutyrate oxidase (demethylating) (EC 1.5.3.19) from Paenarthrobacter nicotinovorans (see 2 papers)
MABO1_PAENI / Q8GAI3 4-methylaminobutanoate oxidase (formaldehyde-forming); MABO; Demethylating gamma-N-methylaminobutyrate oxidase; Gamma-N-methylaminobutyrate oxidase 1; EC 1.5.3.19 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see 2 papers)
    23% identity, 97% coverage of query (68.2 bits)

4yshB Crystal structure of glycine oxidase from geobacillus kaustophilus
    25% identity, 72% coverage of query (68.2 bits)

C7E717 glycine dehydrogenase (cyanide-forming) (subunit 1/3) (EC 1.4.99.5) from Pseudomonas fluorescens (see paper)
    23% identity, 92% coverage of query (63.9 bits)

Q8U022 proline dehydrogenase (EC 1.5.5.2) from Pyrococcus furiosus (see paper)
    24% identity, 71% coverage of query (60.1 bits)

HCNC_PSEAE / G3XD12 Hydrogen cyanide synthase subunit HcnC; HcnC; Glycine dehydrogenase (cyanide-forming); EC 1.4.99.5 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 6 papers)
    23% identity, 92% coverage of query (58.5 bits)

PDPR_BOVIN / O46504 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial; PDPr from Bos taurus (Bovine) (see 2 papers)
    22% identity, 71% coverage of query (57.8 bits)

1pj6A / Q9AGP8 Crystal structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folic acid (see paper)
    21% identity, 96% coverage of query (55.5 bits)

dmg1 / Q9AGP8 dimethylglycine oxidase (EC 1.5.3.10) from Arthrobacter globiformis (see 7 papers)
DMGO_ARTGO / Q9AGP8 Dimethylglycine oxidase; DMGO; EC 1.5.3.10 from Arthrobacter globiformis (see 4 papers)
Q9AGP8 dimethylglycine oxidase (EC 1.5.3.10) from Arthrobacter globiformis (see paper)
    21% identity, 96% coverage of query (55.5 bits)

1pj7A Structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folinic acid
    21% identity, 96% coverage of query (55.5 bits)

3gsiA Crystal structure of d552a dimethylglycine oxidase mutant of arthrobacter globiformis in complex with tetrahydrofolate
    21% identity, 96% coverage of query (55.5 bits)

Q8NCN5 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) from Homo sapiens (see paper)
    21% identity, 71% coverage of query (53.1 bits)

dpdh / A1RVM8 D-proline dehydrogenase monomer (EC 1.5.99.13) from Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) (see paper)
DPDH_PYRIL / A1RVM8 D-proline dehydrogenase; D-Pro DH; D-Pro dehydrogenase; EC 1.5.99.13 from Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) (see 2 papers)
A1RVM8 D-proline dehydrogenase (EC 1.5.99.13) from Pyrobaculum islandicum (see paper)
    25% identity, 97% coverage of query (52.0 bits)

5i39A / Q9LCB2 High resolution structure of l-amino acid deaminase from proteus vulgaris with the deletion of the specific insertion sequence (see paper)
    25% identity, 71% coverage of query (48.5 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory