Sites on a Tree

 

Searching for up to 100 curated homologs for HSERO_RS09465 HSERO_RS09465 aldehyde dehydrogenase (506 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

aldA / AAC13641.1 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (see paper)
    82% identity, 100% coverage of query (861 bits)

aldB / AAC13644.1 NAD-dependent chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (see paper)
    81% identity, 97% coverage of query (838 bits)

adh / A1B4L2 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Paracoccus denitrificans (strain Pd 1222) (see paper)
ALDH_PARDP / A1B4L2 Aldehyde dehydrogenase; Acetaldehyde dehydrogenase; EC 1.2.1.3 from Paracoccus denitrificans (strain Pd 1222) (see paper)
    79% identity, 97% coverage of query (837 bits)

adh3 / Q768S6 NAD+-dependent secondary alcohol dehydrogenase III monomer from Gordonia sp. (strain TY-5) (see paper)
    76% identity, 97% coverage of query (796 bits)

ALD1_ACISP / Q9FDS1 Long-chain-aldehyde dehydrogenase; Aldehyde dehydrogenase 1; EC 1.2.1.48 from Acinetobacter sp. (see paper)
    72% identity, 100% coverage of query (787 bits)

Q4F895 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Rhodococcus erythropolis (see paper)
    77% identity, 97% coverage of query (783 bits)

thcA / AAC77472.1 ThcA from Rhodococcus erythropolis (see 3 papers)
    77% identity, 97% coverage of query (773 bits)

YiaX / b3588 aldehyde dehydrogenase B (EC 1.2.1.4) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
aldB / P37685 aldehyde dehydrogenase B (EC 1.2.1.4) from Escherichia coli (strain K12) (see 7 papers)
ALDB_ECOLI / P37685 Aldehyde dehydrogenase B; Acetaldehyde dehydrogenase; EC 1.2.1.4 from Escherichia coli (strain K12) (see 2 papers)
aldB / GB|AAC76612.2 aldehyde dehydrogenase B; EC 1.2.1.- from Escherichia coli K12 (see 5 papers)
aldB / AAC36939.1 aldehyde dehydrogenase B from Escherichia coli (see paper)
    71% identity, 97% coverage of query (752 bits)

FLUDE_STREN / F8JX40 Fluoroacetaldehyde dehydrogenase; EC 1.2.1.69 from Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057) (Streptomyces cattleya) (see paper)
    73% identity, 97% coverage of query (749 bits)

HP15_3144 Aldehyde dehydrogenase (EC 1.2.1.3) from Marinobacter adhaerens HP15
    67% identity, 100% coverage of query (736 bits)

Q8KZT4 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Cytophaga sp. (see paper)
    68% identity, 98% coverage of query (728 bits)

ACLDH_PSEAI / Q9ZAA1 Acetaldehyde dehydrogenase; EC 1.2.1.- from Pseudomonas aeruginosa (see paper)
    71% identity, 97% coverage of query (724 bits)

Psest_2276 Aldehyde dehydrogenase (EC 1.2.1.3) from Pseudomonas stutzeri RCH2
    70% identity, 97% coverage of query (721 bits)

pedI / B1N7J6 phenylacetaldehyde dehydrogenase (EC 1.2.1.39) from Pseudomonas putida (see paper)
    69% identity, 97% coverage of query (706 bits)

BWI76_RS21985 acetaldehyde dehydrogenase (EC 1.2.1.3) from Klebsiella michiganensis M5al
    66% identity, 97% coverage of query (701 bits)

ald / Q8NLZ0 acetaldehyde dehydrogenase (EC 1.2.1.3; EC 1.2.1.46) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
    68% identity, 97% coverage of query (688 bits)

Q402C7 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Sphingomonas sp. (see paper)
phnN / BAE19973.1 aldehyde dehydrogenase from Sphingomonas sp. 14DN-61 (see paper)
    45% identity, 97% coverage of query (424 bits)

ALDH4_BACSU / O34660 Putative aldehyde dehydrogenase DhaS; EC 1.2.1.3 from Bacillus subtilis (strain 168) (see paper)
    45% identity, 94% coverage of query (400 bits)

4o6rA / B4EJX1 Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
    44% identity, 94% coverage of query (398 bits)

ALDH2 / P05091 mitochondrial aldehyde dehydrogenase subunit (EC 1.2.1.3; EC 1.2.1.39) from Homo sapiens (see 14 papers)
ALDH2_HUMAN / P05091 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Homo sapiens (Human) (see 2 papers)
P05091 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Homo sapiens (see 13 papers)
    44% identity, 95% coverage of query (390 bits)

4fr8C / P05091 Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
    44% identity, 95% coverage of query (390 bits)

5l13A Structure of aldh2 in complex with 2p3
    44% identity, 95% coverage of query (390 bits)

4kwgA Crystal structure analysis of aldh2+aldib13
    44% identity, 95% coverage of query (390 bits)

4kwfA Crystal structure analysis of aldh2+aldib33
    44% identity, 95% coverage of query (390 bits)

3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one
    44% identity, 95% coverage of query (390 bits)

3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1
    44% identity, 95% coverage of query (390 bits)

2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase
    44% identity, 95% coverage of query (390 bits)

1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+
    44% identity, 95% coverage of query (390 bits)

1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+
    44% identity, 95% coverage of query (390 bits)

4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin
    44% identity, 95% coverage of query (390 bits)

P47738 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Mus musculus (see 4 papers)
    44% identity, 95% coverage of query (389 bits)

P11884 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Rattus norvegicus (see 4 papers)
    44% identity, 95% coverage of query (387 bits)

1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+
    45% identity, 95% coverage of query (386 bits)

2onmA Human mitochondrial aldehyde dehydrogenase asian variant, aldh2 2, Complexed with NAD+
    45% identity, 92% coverage of query (386 bits)

ALD4 / P46367 potassium-activated aldehyde dehydrogenase, mitochondrial (EC 1.2.1.4; EC 1.2.1.3) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
ALDH4_YEAST / P46367 Potassium-activated aldehyde dehydrogenase, mitochondrial; K(+)-activated acetaldehyde dehydrogenase; K(+)-ACDH; EC 1.2.1.-; EC 1.2.1.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
P46367 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Saccharomyces cerevisiae (see paper)
    45% identity, 94% coverage of query (384 bits)

orf19.6306 trimethylaminobutyraldehyde dehydrogenase from Candida albicans (see paper)
    44% identity, 95% coverage of query (384 bits)

pnpD / C6FI42 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) from Pseudomonas putida (see paper)
    43% identity, 94% coverage of query (384 bits)

P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine)
    43% identity, 95% coverage of query (380 bits)

PP5278 / Q88CA3 4-guanidinobutyraldehyde dehydrogenase (EC 1.2.1.54) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    45% identity, 93% coverage of query (379 bits)

5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
    43% identity, 94% coverage of query (379 bits)

5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
    43% identity, 94% coverage of query (379 bits)

O14293 Putative aldehyde dehydrogenase-like protein C9E9.09c; EC 1.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    44% identity, 94% coverage of query (378 bits)

F8TW85 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) from Sphingomonas sp. (see paper)
    43% identity, 96% coverage of query (377 bits)

AL2B4_ARATH / Q9SU63 Aldehyde dehydrogenase family 2 member B4, mitochondrial; ALDH2a; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    43% identity, 95% coverage of query (374 bits)

LADH / A3LNE3 NAD(P)+ L-lactaldehyde dehydrogenase from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (see paper)
    43% identity, 96% coverage of query (372 bits)

Q9CZS1 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Mus musculus (see 2 papers)
    43% identity, 95% coverage of query (372 bits)

pnpE / C1I208 maleylacetate reductase (EC 1.3.1.32) from Pseudomonas sp. (strain WBC-3) (see paper)
C1I208 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) from Pseudomonas sp. WBC-3 (see paper)
    42% identity, 96% coverage of query (371 bits)

7mjcA / P30837 Crystal structure analysis of aldh1b1
    42% identity, 95% coverage of query (371 bits)

AL2B7_ARATH / Q8S528 Aldehyde dehydrogenase family 2 member B7, mitochondrial; ALDH2b; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    43% identity, 98% coverage of query (371 bits)

7radA Crystal structure analysis of aldh1b1
    42% identity, 95% coverage of query (371 bits)

7mjdA Crystal structure analysis of aldh1b1
    42% identity, 95% coverage of query (371 bits)

P30837 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Homo sapiens (see 2 papers)
    42% identity, 95% coverage of query (370 bits)

4go4A / C1I208 Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
    42% identity, 95% coverage of query (370 bits)

pdcG / D2STN3 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) from Pseudomonas sp. 1-7 (see paper)
    42% identity, 95% coverage of query (369 bits)

praB / C4TP02 2-hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.85) from Paenibacillus sp. JJ-1b (see paper)
praB / BAH79100.1 2-hydroxymuconate-6-semialdehyde dehydrogenase from Paenibacillus sp. JJ-1b (see paper)
    42% identity, 94% coverage of query (369 bits)

2d4eC / Q5SJP9 Crystal structure of the hpcc from thermus thermophilus hb8
    42% identity, 97% coverage of query (368 bits)

5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa
    41% identity, 96% coverage of query (365 bits)

5iuvA / Q88BC5 Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
    41% identity, 96% coverage of query (365 bits)

8t0nA Structure of compound 4 bound to human aldh1a1
    42% identity, 95% coverage of query (362 bits)

7jwwA Crystal structure of human aldh1a1 bound to compound (r)-28
    42% identity, 95% coverage of query (362 bits)

7jwvA Crystal structure of human aldh1a1 bound to compound (r)-28
    42% identity, 95% coverage of query (362 bits)

7jwuA Crystal structure of human aldh1a1 bound to compound (r)-28
    42% identity, 95% coverage of query (362 bits)

7jwtA Crystal structure of human aldh1a1 bound to compound (r)-28
    42% identity, 95% coverage of query (362 bits)

7jwsA Crystal structure of human aldh1a1 bound to compound (r)-28
    42% identity, 95% coverage of query (362 bits)

6dumA Aldh1a1 n121s in complex with 6-{[(3-fluorophenyl)methyl]sulfanyl}-2- (oxetan-3-yl)-5-phenyl-2,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-one (compound 13g)
    42% identity, 95% coverage of query (362 bits)

4wp7A Structure of human aldh1a1 with inhibitor cm026
    42% identity, 95% coverage of query (362 bits)

5teiA Structure of human aldh1a1 with inhibitor cm039
    42% identity, 95% coverage of query (362 bits)

4x4lA Structure of human aldh1a1 with inhibitor cm037
    42% identity, 95% coverage of query (362 bits)

ALDH1A2 / O94788 retinal dehydrogenase 2 (EC 1.2.1.36) from Homo sapiens (see 4 papers)
AL1A2_HUMAN / O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 3 papers)
O94788 retinal dehydrogenase (EC 1.2.1.36) from Homo sapiens (see 6 papers)
    42% identity, 95% coverage of query (361 bits)

6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121)
    42% identity, 95% coverage of query (361 bits)

6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118)
    42% identity, 95% coverage of query (361 bits)

6aljA / O94788 Aldh1a2 liganded with NAD and compound win18,446 (see paper)
    42% identity, 95% coverage of query (361 bits)

ALDH1A1 / P00352 retinal dehydrogenase 1 (EC 1.2.1.36) from Homo sapiens (see 10 papers)
AL1A1_HUMAN / P00352 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Homo sapiens (Human) (see 7 papers)
P00352 retinal dehydrogenase (EC 1.2.1.36) from Homo sapiens (see 6 papers)
    42% identity, 95% coverage of query (361 bits)

7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa
    41% identity, 96% coverage of query (361 bits)

4wb9A Human aldh1a1 complexed with nadh
    42% identity, 95% coverage of query (360 bits)

8t0tA Structure of compound 4 bound to human aldh1a1
    42% identity, 95% coverage of query (360 bits)

7um9A Human aldh1a1 with bound compound cm38
    42% identity, 95% coverage of query (360 bits)

5l2oA Crystal structure of aldh1a1 in complex with buc22
    42% identity, 95% coverage of query (360 bits)

5l2nA Structure of aldh1a1 in complex with buc25
    42% identity, 95% coverage of query (360 bits)

5l2mA Structure of aldh1a1 in complex with buc11
    42% identity, 95% coverage of query (360 bits)

4wpnA Structure of human aldh1a1 with inhibitor cm053
    42% identity, 95% coverage of query (360 bits)

AL1A2_RAT / Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
Q63639 retinal dehydrogenase (EC 1.2.1.36) from Rattus norvegicus (see 4 papers)
    42% identity, 95% coverage of query (358 bits)

AL2C4_ARATH / Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    43% identity, 94% coverage of query (357 bits)

4pxlA / Q8S532 Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
    42% identity, 94% coverage of query (356 bits)

AL1A1_HORSE / P15437 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Equus caballus (Horse) (see paper)
    42% identity, 95% coverage of query (353 bits)

AL1A1_SHEEP / P51977 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Ovis aries (Sheep) (see 2 papers)
    41% identity, 95% coverage of query (353 bits)

5ac0A Ovis aries aldehyde dehydrogenase 1a1 in complex with a duocarmycin analog
    41% identity, 95% coverage of query (353 bits)

5abmA / P51977 Sheep aldehyde dehydrogenase 1a1 (see paper)
    41% identity, 95% coverage of query (353 bits)

1bxsA Sheep liver class 1 aldehyde dehydrogenase with NAD bound
    41% identity, 95% coverage of query (353 bits)

BETB_PSEAE / Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
Q9HTJ1 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Pseudomonas aeruginosa (see 5 papers)
    42% identity, 94% coverage of query (352 bits)

4cazA / Q9HTJ1 Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
    42% identity, 94% coverage of query (352 bits)

2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct.
    42% identity, 94% coverage of query (352 bits)

2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa
    42% identity, 94% coverage of query (352 bits)

4pz2B / W8SZG1 Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
    44% identity, 94% coverage of query (351 bits)

6tgwA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with a selective inhibitor
    41% identity, 94% coverage of query (350 bits)

7qk9A Crystal structure of the aldh1a3-atp complex
    41% identity, 94% coverage of query (350 bits)

ALDH1A3 / P47895 retinal dehydrogenase 3 (EC 1.2.1.36) from Homo sapiens (see 3 papers)
AL1A3_HUMAN / P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 9 papers)
P47895 retinal dehydrogenase (EC 1.2.1.36); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Homo sapiens (see 6 papers)
    41% identity, 95% coverage of query (350 bits)

7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound
    41% identity, 94% coverage of query (349 bits)

7a6qA / P47895 Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
    41% identity, 94% coverage of query (349 bits)

5fhzA Human aldehyde dehydrogenase 1a3 complexed with NAD(+) and retinoic acid
    41% identity, 94% coverage of query (349 bits)

Build an alignment

Build an alignment for HSERO_RS09465 and 100 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory