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Searching for up to 100 curated homologs for HSERO_RS11090 FitnessBrowser__HerbieS:HSERO_RS11090 (403 a.a.)

Found high-coverage hits (≥70%) to 41 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

purT / Q58881 phosphoribosylglycinamide formyltransferase monomer (EC 6.3.1.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
    60% identity, 97% coverage of query (462 bits)

PurT / b1849 phosphoribosylglycinamide formyltransferase 2 (EC 2.7.2.15; EC 2.7.2.1) from Escherichia coli K-12 substr. MG1655 (see 10 papers)
purT / P33221 phosphoribosylglycinamide formyltransferase 2 (EC 6.3.1.21; EC 2.7.2.15) from Escherichia coli (strain K12) (see 8 papers)
PURT_ECOLI / P33221 Formate-dependent phosphoribosylglycinamide formyltransferase; 5'-phosphoribosylglycinamide transformylase 2; Formate-dependent GAR transformylase; GAR transformylase 2; GART 2; GAR transformylase T; Non-folate glycinamide ribonucleotide transformylase; Phosphoribosylglycinamide formyltransferase 2; EC 6.3.1.21 from Escherichia coli (strain K12) (see 6 papers)
P33221 phosphoribosylglycinamide formyltransferase 2 (EC 6.3.1.21) from Escherichia coli (see 5 papers)
    61% identity, 98% coverage of query (451 bits)

E8X9F0 phosphoribosylglycinamide formyltransferase 2 (EC 6.3.1.21) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    61% identity, 98% coverage of query (449 bits)

1eyzA / P33221 Structure of escherichia coli purt-encoded glycinamide ribonucleotide transformylase complexed with mg and amppnp (see paper)
    61% identity, 98% coverage of query (447 bits)

1kjiA Crystal structure of glycinamide ribonucleotide transformylase in complex with mg-amppcp
    61% identity, 98% coverage of query (447 bits)

1ez1A Structure of escherichia coli purt-encoded glycinamide ribonucleotide transformylase complexed with mg, amppnp, and gar
    61% identity, 98% coverage of query (447 bits)

1kjqA Crystal structure of glycinamide ribonucleotide transformylase in complex with mg-adp
    61% identity, 98% coverage of query (440 bits)

1kjjA Crystal structure of glycniamide ribonucleotide transformylase in complex with mg-atp-gamma-s
    61% identity, 98% coverage of query (440 bits)

1kj8A Crystal structure of purt-encoded glycinamide ribonucleotide transformylase in complex with mg-atp and gar
    61% identity, 98% coverage of query (440 bits)

O58056 Formate-dependent phosphoribosylglycinamide formyltransferase; 5'-phosphoribosylglycinamide transformylase 2; Formate-dependent GAR transformylase; GAR transformylase 2; GART 2; Non-folate glycinamide ribonucleotide transformylase; Phosphoribosylglycinamide formyltransferase 2; EC 6.3.1.21 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    49% identity, 97% coverage of query (381 bits)

2dwcB / O58056 Crystal structure of probable phosphoribosylglycinamide formyl transferase from pyrococcus horikoshii ot3 complexed with adp
    47% identity, 97% coverage of query (358 bits)

P95197 phosphoribosylglycinamide formyltransferase 2 (EC 6.3.1.21) from Mycobacterium tuberculosis (see paper)
    41% identity, 95% coverage of query (277 bits)

P15567 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Schizosaccharomyces pombe (see paper)
ade6 / RF|NP_588141.1 phosphoribosylaminoimidazole carboxylase Ade6; EC 4.1.1.21 from Schizosaccharomyces pombe (see paper)
    30% identity, 89% coverage of query (130 bits)

Build an alignment

Build an alignment for HSERO_RS11090 and 13 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

3r5hA Crystal structure of adp-air complex of purk: n5-carboxyaminoimidazole ribonucleotide synthetase (see paper)
    28% identity, 91% coverage of query (122 bits)

3v4sA Crystal structure of adp-atp complex of purk: n5-carboxyaminoimidazole ribonucleotide synthetase
    28% identity, 91% coverage of query (122 bits)

4dlkA Crystal structure of atp-ca++ complex of purk: n5- carboxyaminoimidazole ribonucleotide synthetase
    28% identity, 91% coverage of query (122 bits)

3q2oB Crystal structure of purk: n5-carboxyaminoimidazole ribonucleotide synthetase
    28% identity, 91% coverage of query (122 bits)

3v4sB Crystal structure of adp-atp complex of purk: n5-carboxyaminoimidazole ribonucleotide synthetase
    28% identity, 91% coverage of query (122 bits)

Q2QJL2 5-(carboxyamino)imidazole ribonucleotide mutase (EC 5.4.99.18) from Acetobacter aceti (see paper)
purK / AAZ04484.1 N5-carboxyaminoimidazole ribonucleotide synthetase from Acetobacter aceti (see paper)
    27% identity, 92% coverage of query (114 bits)

Q01930 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Ogataea methanolica (see paper)
    27% identity, 92% coverage of query (113 bits)

3ax6A / Q9WYS8 Crystal structure of n5-carboxyaminoimidazole ribonucleotide synthetase from thermotoga maritima
    27% identity, 91% coverage of query (111 bits)

Q9UVE6 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Zygosaccharomyces rouxii (see paper)
    27% identity, 90% coverage of query (108 bits)

4mamA / Q5NGE8 The crystal structure of phosphoribosylaminoimidazole carboxylase atpase subunit of francisella tularensis subsp. Tularensis schu s4 in complex with an adp analog, amp-cp
    29% identity, 75% coverage of query (106 bits)

5jqwA The crystal structure of phosphoribosylaminoimidazole carboxylase atpase subunit of francisella tularensis subsp. Tularensis schu s4 in complex with adp
    29% identity, 75% coverage of query (106 bits)

4ma0A The crystal structure of phosphoribosylaminoimidazole carboxylase atpase subunit of francisella tularensis subsp. Tularensis schu s4 in complex with partially hydrolysed atp
    29% identity, 75% coverage of query (106 bits)

ADE2 / P21264 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
PUR6_YEAST / P21264 Phosphoribosylaminoimidazole carboxylase; AIR carboxylase; AIRC; EC 4.1.1.21 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P21264 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Saccharomyces cerevisiae (see paper)
    26% identity, 89% coverage of query (104 bits)

ADE2 / AAA96380.1 phosphoribosylaminoimidazole carboxylase from Schwanniomyces occidentalis (see paper)
    25% identity, 89% coverage of query (102 bits)

4ma5A The crystal structure of phosphoribosylaminoimidazole carboxylase atpase subunit of francisella tularensis subsp. Tularensis schu s4 in complex with an atp analog, amp-pnp.
    29% identity, 75% coverage of query (98.2 bits)

Q92210 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Candida albicans (see paper)
ADE2 phosphoribosylaminoimadazole carboxylase from Candida albicans (see 8 papers)
    25% identity, 89% coverage of query (96.7 bits)

3aw8A / Q5SKY0 Crystal structure of n5-carboxyaminoimidazole ribonucleotide synthetase from thermus thermophilus hb8
    30% identity, 70% coverage of query (95.9 bits)

AN3626 phosphoribosyl-aminoimidazole carboxylase (AFU_orthologue; AFUA_4G12600) from Emericella nidulans (see paper)
    27% identity, 87% coverage of query (93.6 bits)

3orqA / A0A0H3KFM7 Crystal structure of n5-carboxyaminoimidazole synthetase from staphylococcus aureus complexed with adp (see paper)
    23% identity, 87% coverage of query (92.4 bits)

A0A0H3KFM7 5-(carboxyamino)imidazole ribonucleotide synthase (EC 6.3.4.18) from Staphylococcus aureus (see paper)
    23% identity, 87% coverage of query (92.4 bits)

A1CII2 5-(carboxyamino)imidazole ribonucleotide synthase (EC 6.3.4.18) from Aspergillus clavatus (see paper)
    27% identity, 91% coverage of query (90.5 bits)

3k5hA / A1CII2 Crystal structure of carboxyaminoimidazole ribonucleotide synthase from asperigillus clavatus complexed with atp (see paper)
    27% identity, 84% coverage of query (88.2 bits)

3k5iA Crystal structure of n5-carboxyaminoimidazole synthase from aspergillus clavatus in complex with adp and 5-aminoimadazole ribonucleotide
    27% identity, 84% coverage of query (88.2 bits)

purK / CAA73603.1 purK from Saccharolobus solfataricus (see paper)
    25% identity, 88% coverage of query (75.1 bits)

PURK_MYCTU / P9WHL9 N5-carboxyaminoimidazole ribonucleotide synthase; N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase; EC 6.3.4.18 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    27% identity, 90% coverage of query (67.8 bits)

O50302 carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5) from Geobacillus stearothermophilus (see paper)
    24% identity, 91% coverage of query (53.1 bits)

CARB_ARATH / Q42601 Carbamoyl phosphate synthase arginine-specific large chain, chloroplastic; CPS; CPSase; Ammonium-dependent carbamoyl phosphate synthetase; Arginine-specific carbamoyl phosphate synthetase, ammonia chain; Glutamine-dependent carbamoyl phosphate synthetase; Protein VENOSA 3; EC 6.3.4.16; EC 6.3.5.5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    24% identity, 76% coverage of query (47.4 bits)

pyrAB / P25994 pyrimidine-specific carbamoyl-phosphate synthetase (large subunit) (EC 6.3.5.5) from Bacillus subtilis (strain 168) (see 4 papers)
CARB_BACSU / P25994 Carbamoyl phosphate synthase pyrimidine-specific large chain; Carbamoyl phosphate synthetase ammonia chain; EC 6.3.4.16; EC 6.3.5.5 from Bacillus subtilis (strain 168) (see paper)
    23% identity, 70% coverage of query (46.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory