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Searching for up to 100 curated homologs for HSERO_RS12100 FitnessBrowser__HerbieS:HSERO_RS12100 (341 a.a.)

Found high-coverage hits (≥70%) to 68 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4n54A / A0A0J9X1Y7 Crystal structure of scyllo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD(h) and scyllo-inositol
    37% identity, 99% coverage of query (250 bits)

E1U888 inositol 2-dehydrogenase (EC 1.1.1.18) from Lacticaseibacillus casei (see paper)
    37% identity, 99% coverage of query (248 bits)

3ceaA / F9ULF9 Crystal structure of myo-inositol 2-dehydrogenase (np_786804.1) from lactobacillus plantarum at 2.40 a resolution
    36% identity, 96% coverage of query (221 bits)

iolX / P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (strain 168) (see paper)
IOLX_BACSU / P40332 scyllo-inositol 2-dehydrogenase (NAD(+)); EC 1.1.1.370 from Bacillus subtilis (strain 168) (see paper)
P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (see 2 papers)
    37% identity, 98% coverage of query (215 bits)

iolG / Q9WYP5 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
IOLG_THEMA / Q9WYP5 Myo-inositol 2-dehydrogenase; EC 1.1.1.18 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
Q9WYP5 D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Thermotoga maritima (see paper)
    31% identity, 98% coverage of query (180 bits)

HSERO_RS12095 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Herbaspirillum seropedicae SmR1
    33% identity, 98% coverage of query (164 bits)

Q9EZV8 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium fredii (see paper)
    30% identity, 99% coverage of query (129 bits)

SM_b20899 Inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium meliloti 1021
MI2D_RHIME / O68965 Inositol 2-dehydrogenase; Myo-inositol 2-dehydrogenase; MI-dehydrogenase; EC 1.1.1.18 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
O68965 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium meliloti (see paper)
    30% identity, 99% coverage of query (126 bits)

Build an alignment

Build an alignment for HSERO_RS12100 and 8 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

4l8vA / P26935 Crystal structure of a12k/d35s mutant myo-inositol dehydrogenase from bacillus subtilis with bound cofactor NADP (see paper)
    24% identity, 98% coverage of query (119 bits)

E1U887 inositol 2-dehydrogenase (EC 1.1.1.18) from Lacticaseibacillus casei (see paper)
    28% identity, 89% coverage of query (117 bits)

4minA / A0A0J9X1Y2 Crystal structure of myo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD
    28% identity, 89% coverage of query (117 bits)

4mjlD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD and d-chiro-inositol
    28% identity, 89% coverage of query (117 bits)

4mioD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    28% identity, 89% coverage of query (117 bits)

4mioA Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    28% identity, 89% coverage of query (117 bits)

iolG / P26935 inositol 2-dehydrogenase monomer (EC 1.1.1.18; EC 1.1.1.369) from Bacillus subtilis (strain 168) (see 5 papers)
IOLG_BACSU / P26935 Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; MI 2-dehydrogenase/DCI 3-dehydrogenase; EC 1.1.1.18; EC 1.1.1.369 from Bacillus subtilis (strain 168) (see 3 papers)
P26935 inositol 2-dehydrogenase (EC 1.1.1.18); D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Bacillus subtilis (see 7 papers)
    24% identity, 98% coverage of query (116 bits)

AO356_23190 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas fluorescens FW300-N2C3
    27% identity, 89% coverage of query (116 bits)

3nt5A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor and product inosose
    24% identity, 98% coverage of query (116 bits)

3nt4A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor nadh and inositol
    24% identity, 98% coverage of query (116 bits)

3nt2B Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor
    24% identity, 98% coverage of query (116 bits)

3nt2A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor
    24% identity, 98% coverage of query (116 bits)

3ec7A / Q8ZK57 Crystal structure of putative dehydrogenase from salmonella typhimurium lt2
    25% identity, 90% coverage of query (114 bits)

AO353_21365 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas fluorescens FW300-N2E3
    27% identity, 89% coverage of query (113 bits)

PS417_11875 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas simiae WCS417
    29% identity, 89% coverage of query (112 bits)

BWI76_RS03095 Inositol 2-dehydrogenase (EC 1.1.1.18) from Klebsiella michiganensis M5al
    27% identity, 89% coverage of query (111 bits)

iolG / A0A0H3FQ94 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56) (see 2 papers)
    27% identity, 89% coverage of query (110 bits)

gfo / Q07982 glucose-fructose oxidoreductase (EC 1.1.99.28) from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see paper)
Q07982 glucose-fructose oxidoreductase (EC 1.1.99.28) from Zymomonas mobilis (see 4 papers)
    25% identity, 83% coverage of query (100 bits)

1h6dA / Q07982 Oxidized precursor form of glucose-fructose oxidoreductase from zymomonas mobilis complexed with glycerol (see paper)
    25% identity, 83% coverage of query (100 bits)

1rydA Crystal structure of glucose-fructose oxidoreductase from zymomonas mobilis
    25% identity, 83% coverage of query (100 bits)

mocA / GB|CAA55269.1 rhizopine catabolism protein MocA from Sinorhizobium meliloti (see paper)
    28% identity, 96% coverage of query (98.6 bits)

Q8NTY7 inositol 2-dehydrogenase (EC 1.1.1.18) from Corynebacterium glutamicum (see paper)
    28% identity, 90% coverage of query (95.5 bits)

6jw7A / Q6L737 The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin a (see paper)
    33% identity, 75% coverage of query (94.0 bits)

6jw8A The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin b
    33% identity, 75% coverage of query (94.0 bits)

6jw6A The crystal structure of kand2 in complex with NAD
    33% identity, 75% coverage of query (94.0 bits)

7xreC / A0A3Q9WWX8 Crystal structure of dgpa
    26% identity, 80% coverage of query (86.7 bits)

7xr9A Crystal structure of dgpa with glucose
    24% identity, 80% coverage of query (84.7 bits)

UGNO_METMP / Q6M0B9 UDP-N-acetylglucosamine 3-dehydrogenase; UDP-GlcNAc oxidoreductase; UDP-N-acetyl-alpha-D-glucosamine:NAD(+) 3-oxidoreductase; EC 1.1.1.374 from Methanococcus maripaludis (strain S2 / LL) (see paper)
Q6M0B9 UDP-N-acetylglucosamine 3-dehydrogenase (EC 1.1.1.374) from Methanococcus maripaludis (see paper)
    26% identity, 96% coverage of query (84.3 bits)

3q2kC / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    26% identity, 78% coverage of query (83.6 bits)

3q2kK / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    26% identity, 78% coverage of query (83.6 bits)

8qc8D Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ (see paper)
    24% identity, 99% coverage of query (82.8 bits)

dgpA / A0A3Q9WWX8 puerarin 3-dehydrogenase from human intestinal bacterium PUE (see 5 papers)
    25% identity, 83% coverage of query (81.3 bits)

8qc2A Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ and sulfoquinovose (sq)
    24% identity, 99% coverage of query (80.5 bits)

8qc8B Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ (see paper)
    24% identity, 99% coverage of query (80.1 bits)

A0A064C3N0 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Streptococcus pneumoniae (see paper)
    28% identity, 74% coverage of query (79.7 bits)

KIJDR_ACTKI / B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase; 3-ketoreductase; NADPH-dependent C3-ketoreductase; EC 1.1.1.384 from Actinomadura kijaniata (see paper)
B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase (EC 1.1.1.384) from Actinomadura kijaniata (see paper)
    29% identity, 90% coverage of query (79.3 bits)

6a3iA Levoglucosan dehydrogenase, complex with nadh and levoglucosan
    30% identity, 75% coverage of query (78.6 bits)

dfgE / I5AX46 C-glycoside oxidase (EC 1.1.3.50) from [Eubacterium] cellulosolvens 6 (see 2 papers)
    24% identity, 74% coverage of query (78.2 bits)

xacA / D4GP29 D-xylose dehydrogenase subunit (EC 1.1.1.424) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 4 papers)
XDH1_HALVD / D4GP29 D-xylose 1-dehydrogenase [NADP(+)] 1; XDH 1; EC 1.1.1.424 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 3 papers)
D4GP29 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) (EC 1.1.1.179); D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming) (EC 1.1.1.424) from Haloferax volcanii (see 2 papers)
    26% identity, 75% coverage of query (78.2 bits)

3rc1A / B3TMR8 Crystal structure of kijd10, a 3-ketoreductase from actinomadura kijaniata incomplex with NADP and tdp-benzene (see paper)
    28% identity, 88% coverage of query (77.8 bits)

8qc6A / A0A1C9WRL0 Crystal structure of NAD-dependent glycoside hydrolase from arthrobacter sp. U41 in complex with NAD+ and sulfoquinovose (sq) (see paper)
    23% identity, 99% coverage of query (75.9 bits)

6a3jC / F0M433 Levoglucosan dehydrogenase, complex with nadh and l-sorbose (see paper)
    30% identity, 75% coverage of query (75.5 bits)

6z3cAAA / A0A2N5NNS3 6z3cAAA (see paper)
    28% identity, 74% coverage of query (75.1 bits)

slgS4 / CBA11563.1 NDP-hexose-3-ketoreductase from Streptomyces lydicus (see paper)
    31% identity, 75% coverage of query (74.7 bits)

iolW / O32223 scyllo-inositol dehydrogenase (NADP+) (EC 1.1.1.371) from Bacillus subtilis (strain 168) (see paper)
IOLW_BACSU / O32223 scyllo-inositol 2-dehydrogenase (NADP(+)) IolW; NADP(+)-dependent scyllo-inositol dehydrogenase 1; NADP(+)-dependent SI dehydrogenase 1; EC 1.1.1.371 from Bacillus subtilis (strain 168) (see 3 papers)
O32223 scyllo-inositol 2-dehydrogenase (NADP+) (EC 1.1.1.371) from Bacillus subtilis (see 2 papers)
    22% identity, 99% coverage of query (72.8 bits)

Asphe3_10730 / F0M433 levoglucosan dehydrogenase monomer (EC 1.1.1.425) from Pseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) (see 2 papers)
LGDH_PSEPM / F0M433 Levoglucosan dehydrogenase; LGDH; 1,6-anhydro-beta-D-glucose dehydrogenase; PpLGDH; EC 1.1.1.425 from Pseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) (Arthrobacter phenanthrenivorans) (see paper)
F0M433 levoglucosan dehydrogenase (EC 1.1.1.425) from Pseudarthrobacter phenanthrenivorans (see paper)
    29% identity, 75% coverage of query (72.0 bits)

BT2159 predicted 3-ketohexose reductase from Bacteroides thetaiotaomicron VPI-5482
BT_2159 / Q8A5S9 disaccharide 3-dehydrogenase BT2159 (EC 1.1.99.13) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) (see 2 papers)
    25% identity, 82% coverage of query (70.1 bits)

Q5KYQ3 inositol 2-dehydrogenase (EC 1.1.1.18) from Geobacillus kaustophilus (see paper)
    27% identity, 76% coverage of query (68.2 bits)

3q2iA / Q7NQL0 Crystal structure of the wlba dehydrognase from chromobactrium violaceum in complex with nadh and udp-glcnaca at 1.50 a resolution (see paper)
    26% identity, 76% coverage of query (67.0 bits)

Q7NQL0 UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase (EC 1.1.1.335) from Chromobacterium violaceum (see paper)
    26% identity, 76% coverage of query (67.0 bits)

6norA / Q70KD1 Crystal structure of gend2 from gentamicin a biosynthesis in complex with NAD (see paper)
    24% identity, 79% coverage of query (66.6 bits)

YdgJ / b1624 putative oxidoreductase YdgJ from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ydgJ / RF|NP_416141 uncharacterized oxidoreductase ydgJ from Escherichia coli K12 (see 2 papers)
    24% identity, 78% coverage of query (60.1 bits)

gnnA / Q6QHI6 UDP-N-acetylglucosamine 3-dehydrogenase (EC 1.1.1.374) from Acidithiobacillus ferrooxidans (see 12 papers)
7bvjA / B7JA34 Udp-n-acetylglucosamine 3-dehydrogenase gnna from acidithiobacillus ferrooxidans (p21) (see paper)
    26% identity, 95% coverage of query (57.0 bits)

5b3uB / P72782 Crystal structure of biliverdin reductase in complex with NADP+ from synechocystis sp. Pcc 6803 (see paper)
    24% identity, 83% coverage of query (47.0 bits)

5b3vA Crystal structure of biliverdin reductase in complex with biliverdin and NADP+ from synechocystis sp. Pcc 6803
    24% identity, 83% coverage of query (46.6 bits)

apsD / B9JK80 D-apiose dehydrogenase (EC 1.1.1.420) from Agrobacterium radiobacter (strain K84 / ATCC BAA-868) (see paper)
APSD_RHIR8 / B9JK80 D-apiose dehydrogenase; EC 1.1.1.420 from Rhizobium rhizogenes (strain K84 / ATCC BAA-868) (Agrobacterium radiobacter) (see paper)
B9JK80 D-apiose dehydrogenase (EC 1.1.1.420) from Agrobacterium tumefaciens (see paper)
    22% identity, 79% coverage of query (45.1 bits)

5uiaA Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, r-2,3-dihydroxyisovalerate and magnesium
    22% identity, 79% coverage of query (45.1 bits)

5ui9A Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, 2 -hydroxy-2-hydroxymethyl propanoic acid and magnesium
    22% identity, 79% coverage of query (45.1 bits)

5uhzA Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, d-apionate and magnesium
    22% identity, 79% coverage of query (45.1 bits)

5uhwA / B9JK80 Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+ and magnesium
    22% identity, 79% coverage of query (45.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory