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Searching for up to 100 curated homologs for HSERO_RS18285 FitnessBrowser__HerbieS:HSERO_RS18285 (426 a.a.)

Found high-coverage hits (≥70%) to 55 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ANDAC_BURCE / Q84BZ3 Anthranilate 1,2-dioxygenase large subunit; EC 1.14.12.1 from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
Q84BZ3 anthranilate 1,2-dioxygenase (deaminating, decarboxylating) (EC 1.14.12.1) from Burkholderia cepacia (see paper)
    80% identity, 95% coverage of query (707 bits)

phnA1b / CAG17582.1 salicylate 1-hydroxylase alpha subunit from Sphingomonas sp. CHY-1 (see paper)
    51% identity, 95% coverage of query (431 bits)

TPDA1_COMSP / Q3C1E3 Terephthalate 1,2-dioxygenase, terminal oxygenase component subunit alpha 1; TPADO terminal oxygenase component; TER dioxygenase system; TERDOS; Terephthalate 1,2-dioxygenase large subunit 1; EC 1.14.12.15 from Comamonas sp. (see 3 papers)
    44% identity, 95% coverage of query (369 bits)

TPDA2_COMSP / Q3C1D5 Terephthalate 1,2-dioxygenase, terminal oxygenase component subunit alpha 2; TPADO terminal oxygenase component; TER dioxygenase system; TERDOS; Terephthalate 1,2-dioxygenase large subunit 2; EC 1.14.12.15 from Comamonas sp. (see 3 papers)
tphA2II / BAE47085.1 oxygenase large subunit of terephthalate 1,2-dioxygenase from Comamonas sp. E6 (see paper)
    44% identity, 95% coverage of query (368 bits)

7q05E / Q3C1D5 Crystal structure of tpado in complex with tpa (see paper)
    42% identity, 95% coverage of query (348 bits)

7q06D Crystal structure of tpado in complex with 2-oh-tpa
    42% identity, 95% coverage of query (348 bits)

picB3 / A0A1X9WE59 6-hydroxypicolinate 3-monooxygenase subunit 3 from Alcaligenes faecalis (see paper)
    41% identity, 92% coverage of query (341 bits)

7vjuA Crystal structure of terephthalate dioxygenase from comamonas testosteroni kf1
    42% identity, 95% coverage of query (335 bits)

7q04D Crystal structure of tpado in a substrate-free state
    41% identity, 95% coverage of query (326 bits)

nagG / O52379 salicylate-5-hydroxylase large subunit (EC 1.14.13.172) from Ralstonia sp. (see 2 papers)
NAGG_RALSP / O52379 Salicylate 5-hydroxylase, large oxygenase component; S5H large oxygenase component; Salicylate 5-hydroxylase, oxygenase component NagG; Salicylate 5-monooxygenase, hydroxylase large subunit; EC 1.14.13.172 from Ralstonia sp. (see 2 papers)
O52379 salicylate 5-hydroxylase (subunit 2/2) (EC 1.14.13.172) from Ralstonia sp. (see 2 papers)
    37% identity, 95% coverage of query (279 bits)

7c8zA / O52379 Crystal structure of salicylate 5-hydroxylase naggh (a rieske non-heme iron-dependent monooxgenase) (see paper)
    35% identity, 95% coverage of query (257 bits)

Build an alignment

Build an alignment for HSERO_RS18285 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

1wqlA / Q51743 Cumene dioxygenase (cuma1a2) from pseudomonas fluorescens ip01 (see paper)
    27% identity, 92% coverage of query (140 bits)

iacC / B0FXI2 2-(3-hydroxy-2-oxo-1H-indol-3-yl)acetate dioxygenase IacC subunit from Pseudomonas putida (see 2 papers)
    27% identity, 92% coverage of query (140 bits)

Q52438 biphenyl 2,3-dioxygenase (EC 1.14.12.18) from Pseudomonas sp. (see paper)
    27% identity, 93% coverage of query (138 bits)

benA / AAC46436.2 BenA from Acinetobacter baylyi (see 8 papers)
    29% identity, 82% coverage of query (138 bits)

ABSAA_ALCSP / Q9RBG5 2-aminobenzenesulfonate 2,3-dioxygenase subunit alpha; 2-aminobenzenesulfonate dioxygenase large subunit; AbsAa; EC 1.14.12.14 from Alcaligenes sp. (see 2 papers)
Q9RBG5 2-aminobenzenesulfonate 2,3-dioxygenase (EC 1.14.12.14) from Alcaligenes sp. O-1 (see paper)
    28% identity, 81% coverage of query (136 bits)

tdnA1 / BAC82526.1 large subunit of terminal dioxygenase in aniline dioxygenase from Frateuria sp. ANA-18 (see 3 papers)
    29% identity, 92% coverage of query (136 bits)

1uliC / Q53122 Biphenyl dioxygenase (bpha1a2) derived from rhodococcus sp. Strain rha1 (see paper)
    28% identity, 92% coverage of query (135 bits)

Q52028 biphenyl 2,3-dioxygenase (EC 1.14.12.18) from Pseudomonas oleovorans (see paper)
    26% identity, 92% coverage of query (134 bits)

XYLC1 / AAC44161.1 iron sulfur protein large subunit from Cycloclasticus oligotrophus (see paper)
    27% identity, 82% coverage of query (134 bits)

TECA1_CUPXP / O24676 Chlorobenzene dioxygenase subunit alpha; EC 1.14.12.26 from Cupriavidus sp. (strain PS12) (see 3 papers)
    30% identity, 76% coverage of query (133 bits)

Q588I9 benzene 1,2-dioxygenase (EC 1.14.12.3) from Rhodococcus opacus (see paper)
    28% identity, 92% coverage of query (133 bits)

BPHA1_RHOJR / Q53122 Biphenyl 2,3-dioxygenase subunit alpha; Biphenyl dioxygenase system, oxygenase component subunit alpha; BDO, oxygenase component subunit alpha; Rieske dioxygenase; Terminal oxygenase component of biphenyl dioxygenase, large subunit; EC 1.14.12.18 from Rhodococcus jostii (strain RHA1) (see 4 papers)
bphA1 / BAA06868.1 biphenyl dioxygenase from Rhodococcus jostii RHA1 (see paper)
    26% identity, 92% coverage of query (133 bits)

dbfA1 / BAC75993.1 angular dioxygenase large subunit from Terrabacter sp. DBF63 (see paper)
    28% identity, 89% coverage of query (131 bits)

A8I4E8 benzoate 4-monooxygenase (EC 1.14.14.92) from Chromohalobacter sp. (see paper)
    27% identity, 83% coverage of query (131 bits)

1uljA Biphenyl dioxygenase (bpha1a2) in complex with the substrate
    28% identity, 92% coverage of query (131 bits)

Q46372 biphenyl 2,3-dioxygenase (EC 1.14.12.18) from Comamonas testosteroni (see 2 papers)
bphA / AAC44526.1 biphenyl dioxygenase terminal oxygenase alpha subunit from Pandoraea pnomenusa (see paper)
    26% identity, 94% coverage of query (129 bits)

bedC1 / Q07944 benzene 1,2 dioxygenase terminal oxygenase component α subunit from Pseudomonas putida (see paper)
bedC1 / AAA17758.1 BedC1 from Pseudomonas putida (see 3 papers)
    28% identity, 76% coverage of query (129 bits)

3gzxA / Q46372 Crystal structure of the biphenyl dioxygenase in complex with biphenyl from comamonas testosteroni sp. Strain b-356 (see paper)
    26% identity, 94% coverage of query (129 bits)

arhA1 / BAD34447.1 large subunit of PAH-dioxygenase from Sphingomonas sp. A4 (see paper)
    30% identity, 81% coverage of query (129 bits)

Q52383 chlorobenzene dioxygenase (subunit 4/4) (EC 1.14.12.26) from Pseudomonas sp. P51 (see 2 papers)
tcbAa / AAC43632.1 chlorobenzene dioxygenase, large subunit of terminal oxygenase from Pseudomonas sp (see 3 papers)
    29% identity, 76% coverage of query (128 bits)

DigA / b2538 putative 3-phenylpropionate/cinnamate dioxygenase subunit α (EC 1.14.12.19) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
hcaE / P0ABR5 putative 3-phenylpropionate/cinnamate dioxygenase subunit α (EC 1.14.12.19) from Escherichia coli (strain K12) (see 2 papers)
HCAE_ECOLI / P0ABR5 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha; EC 1.14.12.19 from Escherichia coli (strain K12) (see paper)
hcaE / RF|NP_417033 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha; EC 1.14.12.19 from Escherichia coli K12 (see 5 papers)
    25% identity, 96% coverage of query (127 bits)

ditA1 / AAD21063.1 dioxygenase DitA oxygenase component large subunit from Pseudomonas abietaniphila (see 4 papers)
    28% identity, 80% coverage of query (125 bits)

tftA / Q51592 2,4,5-trichlorophenoxyacetate hydroxylase oxygenase component α subunit from Burkholderia cepacia (see 2 papers)
    26% identity, 94% coverage of query (124 bits)

AO353_05950 Anthranilate 1,2-dioxygenase (deaminating, decarboxylating) (EC 1.14.12.1) from Pseudomonas fluorescens FW300-N2E3
    27% identity, 83% coverage of query (120 bits)

2ckfE / Q65AT1 Crystal structure of the terminal component of the pah- hydroxylating dioxygenase from sphingomonas sp chy-1 (see paper)
    26% identity, 92% coverage of query (119 bits)

PS417_23685 anthranilate 1,2-dioxygenase (deaminating, decarboxylating) large subunit [EC: 1.14.12.1] from Pseudomonas simiae WCS417
    27% identity, 84% coverage of query (118 bits)

cmtAb / Q51974 p-cumate 2,3-dioxygenase system, large oxygenase component (EC 1.14.12.25) from Pseudomonas putida (see paper)
CMTAB_PSEPU / Q51974 p-cumate 2,3-dioxygenase system, large oxygenase component; Large terminal subunit of p-cumate dioxygenase; p-cumate 2,3-dioxygenase large subunit; p-cumate 2,3-dioxygenase subunit alpha; EC 1.14.12.25 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
Q51974 p-cumate 2,3-dioxygenase (subunit 3/4) (EC 1.14.12.25) from Pseudomonas putida (see paper)
cmtAb / AAB62285.1 p-cumate dioxygenase large subunit from Pseudomonas putida (see 3 papers)
    25% identity, 93% coverage of query (115 bits)

phnA1a / CAG17576.1 ring-hydroxylating dioxygenase alpha subunit from Sphingomonas sp. CHY-1 (see paper)
    25% identity, 92% coverage of query (115 bits)

2gbwA / A2TC87 Crystal structure of biphenyl 2,3-dioxygenase from sphingomonas yanoikuyae b1 (see paper)
    25% identity, 92% coverage of query (114 bits)

2gbxA Crystal structure of biphenyl 2,3-dioxygenase from sphingomonas yanoikuyae b1 bound to biphenyl
    25% identity, 92% coverage of query (114 bits)

DNTAC_BURSR / Q45695 2,4-dinitrotoluene dioxygenase system, large oxygenase component; 2,4-dinitrotoluene dioxygenase ISP alpha; 2,4-dinitrotoluene dioxygenase subunit alpha; EC 1.14.12.24 from Burkholderia sp. (strain RASC) (see paper)
    24% identity, 92% coverage of query (112 bits)

msmA / Q9X404 methanesulfonate monooxygenase hydroxylase component α subunit from Methylosulfonomonas methylovora (see paper)
MSMA_METHY / Q9X404 Methanesulfonate monooxygenase hydroxylase subunit alpha; Methanesulfonic acid monooxygenase hydroxylase large subunit; Methanesulfonic acid monooxygenase hydroxylase subunit alpha; MSA monooxygenase hydroxylase subunit alpha; MSAMO hydroxylase subunit alpha; EC 1.14.13.111 from Methylosulfonomonas methylovora (see 4 papers)
Q9X404 methanesulfonate monooxygenase (NADH) (EC 1.14.13.111) from Methylosulfonomonas methylovora (see paper)
    25% identity, 94% coverage of query (111 bits)

ntdAa / P95564 2-nitrotoluene dioxygenase complex ferredoxin reductase component (EC 1.14.12.23) from Pseudomonas sp. (see 3 papers)
    25% identity, 91% coverage of query (111 bits)

2bmoA / Q8RTL4 The crystal structure of nitrobenzene dioxygenase (see paper)
    25% identity, 91% coverage of query (107 bits)

Q8RTL4 nitroarene dioxygenase (subunit 2/4) (EC 1.14.12.23) from Comamonas sp. (see paper)
    25% identity, 91% coverage of query (107 bits)

M9PW10 nitroarene dioxygenase (subunit 3/4) (EC 1.14.12.23) from Diaphorobacter sp. DS2 (see paper)
    24% identity, 91% coverage of query (107 bits)

5xbpA / M9PW10 Oxygenase component of 3-nitrotoluene dioxygenase from diaphorobacter sp. Strain ds2 (see paper)
    24% identity, 91% coverage of query (107 bits)

F4Y9J0 nitroarene dioxygenase (subunit 2/4) (EC 1.14.12.23) from Pseudomonas stutzeri ZWLR2-1 (see paper)
    24% identity, 92% coverage of query (107 bits)

2bmrA The crystal structure of nitrobenzene dioxygenase in complex with 3- nitrotoluene
    25% identity, 91% coverage of query (107 bits)

2bmqA The crystal structure of nitrobenzene dioxygenase in complex with nitrobenzene
    25% identity, 91% coverage of query (107 bits)

A0A0D6JGB8 methanesulfonate monooxygenase (NADH) (EC 1.14.13.111) from Candidatus Filomicrobium marinum (see paper)
    25% identity, 82% coverage of query (102 bits)

Q93XE1 choline monooxygenase (EC 1.14.15.7) from Amaranthus tricolor (see paper)
    21% identity, 85% coverage of query (71.6 bits)

B8B239 choline monooxygenase (EC 1.14.15.7) from Oryza sativa (see paper)
    21% identity, 84% coverage of query (59.7 bits)

put2H / A0A0H3LKV3 putrescine 2-hydroxylase from Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (see paper)
    23% identity, 74% coverage of query (56.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory