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Searching for up to 100 curated homologs for HSERO_RS19255 FitnessBrowser__HerbieS:HSERO_RS19255 (315 a.a.)

Found high-coverage hits (≥70%) to 55 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

GASBP_PSEAE / Q9I402 L-glutamate/L-aspartate-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
TC 3.A.1.3.22 / Q9I402 Probable binding protein component of ABC transporter, component of Amino acid transporter, AatJMQP. Probably transports L-glutamic acid, D-glutamine acid, L-glutamine and N-acetyl L-glutamic acid (Johnson et al. 2008). Very similar to 3.A.1.3.19 of P. putida from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    53% identity, 90% coverage of query (300 bits)

AO353_16290 ABC transporter for L-aspartate, L-asparagine, L-glutamate, and L-glutamine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E3
    50% identity, 92% coverage of query (291 bits)

Pf1N1B4_771 ABC transporter for L-asparagine and L-glutamate, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N1B4
    53% identity, 87% coverage of query (291 bits)

PfGW456L13_4770 ABC transporter for L-Asparagine and possibly other L-amino acids, periplasmic substrate-binding component from Pseudomonas fluorescens GW456-L13
    52% identity, 87% coverage of query (281 bits)

TC 3.A.1.3.19 / Q88NY2 PP1071, component of Acidic amino acid uptake porter, AatJMQP from Pseudomonas putida (strain KT2440) (see paper)
    47% identity, 93% coverage of query (268 bits)

2ia4B / A0A0H2UXX1 Crystal structure of novel amino acid binding protein from shigella flexneri
    43% identity, 84% coverage of query (241 bits)

2vhaA Debp
    43% identity, 84% coverage of query (241 bits)

GltI / b0655 glutamate/aspartate ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
GltI / P37902 glutamate/aspartate ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli (strain K12) (see 3 papers)
GLTI_ECOLI / P37902 Glutamate/aspartate import solute-binding protein from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.3.4 / P37902 YBEJ aka GltI aka B0655, component of Glutamate/aspartate porter from Escherichia coli (see 6 papers)
gltI / GB|BAA35307.2 glutamate-aspartate periplasmic-binding protein from Escherichia coli K12 (see 6 papers)
    42% identity, 84% coverage of query (237 bits)

8ovoA / P37902,P42212 X-ray structure of the sf-iglusnfr-s72a in complex with l-aspartate
    43% identity, 77% coverage of query (213 bits)

5eyfB / Q3XZW5 Crystal structure of solute-binding protein from enterococcus faecium with bound glutamate
    30% identity, 78% coverage of query (103 bits)

4zv1A An ancestral arginine-binding protein bound to arginine (see paper)
    31% identity, 73% coverage of query (100 bits)

4zv2A An ancestral arginine-binding protein bound to glutamine
    32% identity, 73% coverage of query (100 bits)

Build an alignment

Build an alignment for HSERO_RS19255 and 12 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

GLNH_BACSU / O34563 ABC transporter glutamine-binding protein GlnH from Bacillus subtilis (strain 168) (see paper)
    26% identity, 84% coverage of query (90.9 bits)

6svfA / Q9WZ62 Crystal structure of the p235gk mutant of argbp from t. Maritima (see paper)
    29% identity, 76% coverage of query (83.6 bits)

5t0wA Crystal structure of the ancestral amino acid-binding protein anccdt- 1, a precursor of cyclohexadienyl dehydratase
    32% identity, 76% coverage of query (82.8 bits)

AAC45332.1 high affinity cystine binding protein from Lactobacillus reuteri (see 4 papers)
    26% identity, 85% coverage of query (76.6 bits)

4ohnA / A0A0H2UKY8 Crystal structure of an abc uptake transporter substrate binding protein from streptococcus pneumoniae with bound histidine
    25% identity, 77% coverage of query (75.1 bits)

TcyJ / b1920 cystine ABC transporter periplasmic binding protein (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
tcyJ / P0AEM9 cystine ABC transporter periplasmic binding protein (EC 7.4.2.12) from Escherichia coli (strain K12) (see 13 papers)
TCYJ_ECOLI / P0AEM9 L-cystine-binding protein TcyJ; CBP; Protein FliY; Sulfate starvation-induced protein 7; SSI7 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.3.10 / P0AEM9 Cystine-binding periplasmic protein FLIY aka CysX aka B1920, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 7 papers)
    26% identity, 84% coverage of query (73.9 bits)

TC 3.A.1.3.16 / Q0P9X8 PEB1A, component of Uptake system for glutamate and aspartate from Campylobacter jejuni (see 2 papers)
peb1A / RF|YP_002344319.1 major cell-binding factor from Campylobacter jejuni (see 3 papers)
peb1 / AAA02919.1 major cell-binding factor from Campylobacter jejuni (see paper)
    28% identity, 83% coverage of query (73.9 bits)

cjaA / CAJ20048.1 glutamine-binding protein from Campylobacter jejuni (see paper)
    29% identity, 70% coverage of query (71.6 bits)

1xt8B / Q0P9S0 Crystal structure of cysteine-binding protein from campylobacter jejuni at 2.0 a resolution (see paper)
    29% identity, 70% coverage of query (70.1 bits)

SMc02118 ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, periplasmic substrate-binding component from Sinorhizobium meliloti 1021
    25% identity, 75% coverage of query (69.3 bits)

AAPJ_RHIJ3 / Q52812 General L-amino acid-binding periplasmic protein AapJ from Rhizobium johnstonii (strain DSM 114642 / LMG 32736 / 3841) (Rhizobium leguminosarum bv. viciae) (see 2 papers)
TC 3.A.1.3.8 / Q52812 AapJ, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
aapJ / CAA57933.1 general amino acid ABC type transporter from Rhizobium leguminosarum (see paper)
    23% identity, 77% coverage of query (68.6 bits)

TC 3.A.1.3.18 / Q8YPM9 NatF, component of Acidic and neutral amino acid uptake transporter NatFGH/BgtA. BgtA is shared with BgtAB (see paper)
    24% identity, 73% coverage of query (65.5 bits)

2v25A / Q0P9X8 Structure of the campylobacter jejuni antigen peb1a, an aspartate and glutamate receptor with bound aspartate (see paper)
    27% identity, 70% coverage of query (63.2 bits)

3k4uE / Q7MAG0 Crystal structure of putative binding component of abc transporter from wolinella succinogenes dsm 1740 complexed with lysine
    28% identity, 73% coverage of query (63.2 bits)

3vvdA / Q72JG5 Crystal structure of ttc0807 complexed with ornithine (see paper)
    24% identity, 79% coverage of query (62.0 bits)

3vvfA Crystal structure of ttc0807 complexed with arginine
    24% identity, 79% coverage of query (62.0 bits)

3vveA Crystal structure of ttc0807 complexed with lysine
    24% identity, 79% coverage of query (62.0 bits)

3vv5A Crystal structure of ttc0807 complexed with (s)-2-aminoethyl-l- cysteine (aec)
    23% identity, 78% coverage of query (61.6 bits)

PHEC_PSEAE / Q01269 Cyclohexadienyl dehydratase; EC 4.2.1.51; EC 4.2.1.91 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q01269 arogenate dehydratase (EC 4.2.1.91) from Pseudomonas aeruginosa (see 3 papers)
    25% identity, 77% coverage of query (58.5 bits)

Pf6N2E2_5402 ABC transporter for D-Alanine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    25% identity, 78% coverage of query (58.5 bits)

AO356_00480 ABC transporter for D-Glucosamine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    23% identity, 88% coverage of query (58.2 bits)

TC 2.A.56.3.1 / P74223 GtrC aka GLNH aka SLL1104, component of Tripartite glutamate:Na+ symporter (see paper)
    23% identity, 75% coverage of query (58.2 bits)

Pf6N2E2_2053 ABC transporter for D-Glucosamine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    23% identity, 80% coverage of query (57.8 bits)

1lafE / P02911 Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
    25% identity, 73% coverage of query (57.0 bits)

1lstA Three-dimensional structures of the periplasmic lysine-, arginine-, ornithine-binding protein with and without a ligand
    25% identity, 73% coverage of query (57.0 bits)

1lahE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein
    25% identity, 73% coverage of query (57.0 bits)

1lagE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein
    25% identity, 73% coverage of query (57.0 bits)

5owfA Structure of a lao-binding protein mutant with glutamine
    25% identity, 73% coverage of query (57.0 bits)

ARGT_SALTY / P02911 Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 6 papers)
argT / RF|NP_461297.1 lysine/arginine/ornithine ABC transporter, periplasmic lysine/arginine/ornithine-binding protein ArgT from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
    25% identity, 73% coverage of query (56.6 bits)

AO353_21710 ABC transporter for D-glucosamine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E3
    22% identity, 80% coverage of query (56.6 bits)

2yjpA / Q5F5B5 Crystal structure of the solute receptors for l-cysteine of neisseria gonorrhoeae (see paper)
    24% identity, 74% coverage of query (55.8 bits)

5lomB / Q7D447 Crystal structure of the pbp soca from agrobacterium tumefaciens c58 in complex with dfg at 1.5 a resolution (see paper)
    23% identity, 76% coverage of query (55.5 bits)

5l9oA Crystal structure of agrobacterium tumefaciens c58 strain pbp soca in complex with glucopine
    23% identity, 76% coverage of query (55.5 bits)

5l9oB Crystal structure of agrobacterium tumefaciens c58 strain pbp soca in complex with glucopine
    23% identity, 76% coverage of query (55.5 bits)

6detA / S3MDF0 The crystal structure of tv2483 bound to l-arginine (see paper)
    22% identity, 76% coverage of query (53.1 bits)

2q2cA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus
    26% identity, 73% coverage of query (49.3 bits)

2q2aA / D0VWX8 Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus (see paper)
    26% identity, 73% coverage of query (49.3 bits)

2pvuA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus
    26% identity, 73% coverage of query (49.3 bits)

6h20A Glnh bound to asn, mycobacterium tuberculosis
    21% identity, 77% coverage of query (47.8 bits)

6h1uA Glnh bound to asp, mycobacterium tuberculosis
    21% identity, 77% coverage of query (47.8 bits)

6h2tA / P96257 Glnh bound to glu, mycobacterium tuberculosis (see paper)
    21% identity, 77% coverage of query (47.8 bits)

4ymxA / Q8RCC4 Crystal structure of the substrate binding protein of an amino acid abc transporter (see paper)
    24% identity, 74% coverage of query (44.7 bits)

2ylnA / Q5F9M1 Crystal structure of the l-cystine solute receptor of neisseria gonorrhoeae in the closed conformation (see paper)
    25% identity, 77% coverage of query (43.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory