Searching for up to 100 curated homologs for HSERO_RS19735 FitnessBrowser__HerbieS:HSERO_RS19735 (518 a.a.)
Found high-coverage hits (≥70%) to 77 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ILVX_MYCTU / O53554 Putative acetolactate synthase large subunit IlvX; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
O53554 acetolactate synthase (EC 2.2.1.6) from Mycobacterium tuberculosis (see paper)
44% identity, 99% coverage of query (345 bits)
Build an alignment for HSERO_RS19735 and 1 homologs with ≥ 30% identity
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dpgB / A3RJV5 benzoylformate decarboxylase monomer (EC 4.1.1.7) from Stutzerimonas stutzeri (see paper)
27% identity, 97% coverage of query (154 bits)
6a50A Structure of benzoylformate decarboxylases in complex with cofactor tpp
27% identity, 97% coverage of query (149 bits)
mdlC / P20906 MdlC (EC 4.1.1.7) from Pseudomonas putida (see 2 papers)
P20906 benzoylformate decarboxylase (EC 4.1.1.7) from Pseudomonas putida (see 16 papers)
27% identity, 97% coverage of query (148 bits)
3fznA Intermediate analogue in benzoylformate decarboxylase
27% identity, 97% coverage of query (147 bits)
1bfdA Benzoylformate decarboxylase from pseudomonas putida
27% identity, 97% coverage of query (147 bits)
5deiA Benzoylformate decarboxylase from pseudomonas putida
27% identity, 97% coverage of query (147 bits)
3fsjX Crystal structure of benzoylformate decarboxylase in complex with the inhibitor mbp
27% identity, 97% coverage of query (147 bits)
1mczA Benzoylformate decarboxylase from pseudomonas putida complexed with an inhibitor, r-mandelate
27% identity, 97% coverage of query (147 bits)
3f6bX Crystal structure of benzoylformate decarboxylase in complex with the pyridyl inhibitor paa
27% identity, 97% coverage of query (147 bits)
1pi3A E28q mutant benzoylformate decarboxylase from pseudomonas putida
27% identity, 97% coverage of query (146 bits)
6qsiA / Q4KB02 Pseudomonas fluorescens pf-5 thiamine diphosphate-dependent 4- hydroxybenzoylformate decarboxylase (see paper)
28% identity, 97% coverage of query (145 bits)
7orxCCC / Q0SCE8 jostii RHA1 thiamine diphosphate-dependent 4-hydroxybenzoylformate decarboxylase
28% identity, 97% coverage of query (143 bits)
bfd / CAK95977.1 benzoylformate decarboxylase from Pseudomonas putida (see paper)
27% identity, 97% coverage of query (134 bits)
bfd / CAK95976.1 benzoylformate decarboxylase from Pseudomonas putida (see paper)
27% identity, 97% coverage of query (132 bits)
4q9dB / A0QSU7 X-ray structure of a putative thiamin diphosphate-dependent enzyme isolated from mycobacterium smegmatis (see paper)
26% identity, 96% coverage of query (127 bits)
Q8U2A4 acetolactate synthase (EC 2.2.1.6) from Pyrococcus furiosus (see paper)
24% identity, 99% coverage of query (105 bits)
4k9qA / A4SXU0 The crystal structure of benzoylformate decarboxylase from polynucleobacter necessarius
24% identity, 96% coverage of query (103 bits)
6vz8D / P17597 Arabidopsis thaliana acetohydroxyacid synthase complex with valine bound (see paper)
25% identity, 99% coverage of query (94.4 bits)
Q8RL88 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Geobacillus stearothermophilus (see paper)
ilvB / AAL99356.1 acetohydroxy acid synthase large subunit from Geobacillus stearothermophilus (see paper)
24% identity, 99% coverage of query (94.4 bits)
P42463 acetolactate synthase (EC 2.2.1.6) from Corynebacterium glutamicum (see paper)
25% identity, 97% coverage of query (90.9 bits)
IlvI / b0077 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
ilvI / P00893 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli (strain K12) (see 7 papers)
P00893 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
24% identity, 98% coverage of query (88.6 bits)
AN4956 acetolactate synthase; EC 2.2.1.6 from Emericella nidulans (see paper)
23% identity, 99% coverage of query (87.0 bits)
6lpiB / P08142 Crystal structure of ahas holo-enzyme (see paper)
24% identity, 100% coverage of query (85.9 bits)
IlvB / b3671 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
ilvB / P08142 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli (strain K12) (see 4 papers)
P08142 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
24% identity, 100% coverage of query (84.3 bits)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl
23% identity, 99% coverage of query (84.0 bits)
Q5M4L0 acetolactate synthase (EC 2.2.1.6) from Streptococcus thermophilus (see paper)
23% identity, 99% coverage of query (80.9 bits)
Q04789 acetolactate synthase (EC 2.2.1.6); branched-chain-2-oxoacid decarboxylase (EC 4.1.1.72) from Bacillus subtilis (see 2 papers)
23% identity, 100% coverage of query (80.1 bits)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl
22% identity, 99% coverage of query (80.1 bits)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam
23% identity, 99% coverage of query (80.1 bits)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
22% identity, 99% coverage of query (80.1 bits)
ILVG_ECOLI / P0DP90 Acetolactate synthase isozyme 2 large subunit; AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit; EC 2.2.1.6 from Escherichia coli (strain K12) (see 2 papers)
ilvG / GB|CAA28573.1 acetolactate synthase isozyme 2 large subunit; EC 2.2.1.6 from Escherichia coli K12 (see 8 papers)
24% identity, 99% coverage of query (79.7 bits)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl
22% identity, 99% coverage of query (79.7 bits)
4rjiC Acetolactate synthase from bacillus subtilis bound to thdp - crystal form i (see paper)
23% identity, 99% coverage of query (79.3 bits)
4rjkG Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii
23% identity, 99% coverage of query (79.3 bits)
4rjkF Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii
23% identity, 99% coverage of query (79.3 bits)
ILVB_YEAST / P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P07342 acetolactate synthase (EC 2.2.1.6) from Saccharomyces cerevisiae (see 5 papers)
22% identity, 99% coverage of query (79.0 bits)
6u9dB / P07342 Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
22% identity, 99% coverage of query (78.6 bits)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl
22% identity, 99% coverage of query (78.6 bits)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl
22% identity, 99% coverage of query (78.6 bits)
5imsA Saccharomyces cerevisiae acetohydroxyacid synthase
22% identity, 99% coverage of query (78.6 bits)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
22% identity, 99% coverage of query (78.6 bits)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl
22% identity, 99% coverage of query (77.4 bits)
6bd9A Saccharomyces cerevisiae acetohydroxyacid synthase
22% identity, 99% coverage of query (76.3 bits)
ILV2 acetolactate synthase; EC 2.2.1.6 from Candida albicans (see paper)
22% identity, 99% coverage of query (75.5 bits)
ilvB / Q0KCU4 acetohydroxyacid synthase subunit B (EC 2.2.1.6) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
23% identity, 97% coverage of query (75.5 bits)
6bd3A Saccharomyces cerevisiae acetohydroxyacid synthase
22% identity, 99% coverage of query (75.5 bits)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl
22% identity, 99% coverage of query (75.5 bits)
6deqA / A0A1D8PJF9 Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
22% identity, 99% coverage of query (75.1 bits)
1t9bA / P07342 Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
23% identity, 99% coverage of query (74.3 bits)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone
22% identity, 99% coverage of query (74.3 bits)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl
22% identity, 99% coverage of query (74.3 bits)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
23% identity, 99% coverage of query (74.3 bits)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam
22% identity, 99% coverage of query (74.3 bits)
6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit
22% identity, 99% coverage of query (73.9 bits)
Q5S3P7 acetolactate synthase (EC 2.2.1.6) from Streptomyces cinnamonensis (see 2 papers)
ilvB / AAV52901.1 acetohydroxy acid synthase large subunit from Streptomyces cinnamonensis (see paper)
25% identity, 97% coverage of query (73.6 bits)
1jscA Crystal structure of the catalytic subunit of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors
22% identity, 99% coverage of query (73.6 bits)
5dx6B / P27696 Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
23% identity, 98% coverage of query (68.6 bits)
4qq8C / Q9F4L3 Crystal structure of the formolase fls in space group p 43 21 2 (see paper)
25% identity, 88% coverage of query (68.6 bits)
ipdC / P23234 indole-3-pyruvate decarboxylase subunit (EC 4.1.1.74) from Enterobacter cloacae (see 2 papers)
DCIP_ENTCL / P23234 Indole-3-pyruvate decarboxylase; Indolepyruvate decarboxylase; EC 4.1.1.74 from Enterobacter cloacae (see paper)
P23234 indolepyruvate decarboxylase (EC 4.1.1.74) from Enterobacter cloacae (see paper)
23% identity, 100% coverage of query (67.4 bits)
1ovmA / P23234 Crystal structure of indolepyruvate decarboxylase from enterobacter cloacae (see paper)
23% identity, 100% coverage of query (65.9 bits)
3d7kA Crystal structure of benzaldehyde lyase in complex with the inhibitor mbp
24% identity, 88% coverage of query (65.5 bits)
budB / P27696 catabolic acetolactate synthase (EC 2.2.1.6) from Klebsiella pneumoniae (see 2 papers)
23% identity, 98% coverage of query (64.3 bits)
1ozgA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
23% identity, 98% coverage of query (64.3 bits)
5d6rB Acetolactate synthase from klebsiella pneumoniae in complex with mechanism-based inhibitor
23% identity, 98% coverage of query (63.9 bits)
ilvB / AAA93098.1 acetolactate synthase from Streptomyces avermitilis (see paper)
25% identity, 86% coverage of query (63.5 bits)
1ozfA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors
23% identity, 98% coverage of query (61.2 bits)
6wo1A / Q96VZ6 Hybrid acetohydroxyacid synthase complex structure with cryptococcus neoformans ahas catalytic subunit and saccharomyces cerevisiae ahas regulatory subunit (see paper)
21% identity, 91% coverage of query (60.5 bits)
5dx6A Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
23% identity, 98% coverage of query (58.5 bits)
5wdgA Acetolactate synthase from klebsiella pneumoniae in complex with a reaction intermediate
23% identity, 98% coverage of query (58.2 bits)
1y9dD / P37063 Pyruvate oxidase variant v265a from lactobacillus plantarum (see paper)
21% identity, 97% coverage of query (56.6 bits)
6xn8A / A0A1H8YFL8 Crystal structure of 2-hydroxyacyl coa lyase (hacl) from rhodospirillales bacterium urhd0017
23% identity, 88% coverage of query (55.5 bits)
Q92345 Probable pyruvate decarboxylase C1F8.07c; EC 4.1.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
21% identity, 97% coverage of query (55.1 bits)
1v5gA Crystal structure of the reaction intermediate between pyruvate oxidase containing fad and tpp, and substrate pyruvate
21% identity, 94% coverage of query (55.1 bits)
1v5fA Crystal structure of pyruvate oxidase complexed with fad and tpp, from aerococcus viridans
21% identity, 94% coverage of query (55.1 bits)
2djiA / A9X9K8 Crystal structure of pyruvate oxidase from aerococcus viridans containing fad (see paper)
21% identity, 94% coverage of query (54.7 bits)
7b2eA / C5AX46 Quadruple mutant of oxalyl-coa decarboxylase from methylorubrum extorquens with bound tpp and adp (see paper)
23% identity, 98% coverage of query (45.4 bits)
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Lawrence Berkeley National Laboratory