Searching for up to 100 curated homologs for HSERO_RS20590 FitnessBrowser__HerbieS:HSERO_RS20590 (686 a.a.)
Found high-coverage hits (≥70%) to 38 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YdbN / b1387 fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase (EC 3.3.2.12; EC 1.2.1.91; EC 4.2.1.55) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
paaZ / P77455 fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase (EC 3.3.2.12; EC 1.2.1.91; EC 4.2.1.55) from Escherichia coli (strain K12) (see 7 papers)
PAAZ_ECOLI / P77455 Bifunctional protein PaaZ; EC 3.3.2.12; EC 1.2.1.91 from Escherichia coli (strain K12) (see 4 papers)
P77455 oxepin-CoA hydrolase (EC 3.3.2.12) from Escherichia coli (see 2 papers)
59% identity, 99% coverage of query (746 bits)
6jqmA / P77455 Structure of paaz with NADPH (see paper)
59% identity, 99% coverage of query (744 bits)
6jqoA Structure of paaz, a bifunctional enzyme in complex with NADP+ and ccoa
59% identity, 99% coverage of query (744 bits)
6jqnA Structure of paaz, a bifunctional enzyme in complex with NADP+ and ocoa
59% identity, 99% coverage of query (744 bits)
N0DT23 4-trimethylammoniobutyraldehyde dehydrogenase (EC 1.2.1.47) from Pseudomonas sp. (see paper)
30% identity, 71% coverage of query (127 bits)
Build an alignment for HSERO_RS20590 and 5 homologs with ≥ 30% identity
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AL2C4_ARATH / Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
24% identity, 73% coverage of query (107 bits)
mpdC / Q3YAT5 2-hydroxy-2-methylpropanal dehydrogenase (EC 1.2.1.98) from Mycolicibacterium austroafricanum (see paper)
MPDC_MYCAO / Q3YAT5 Hydroxyisobutyraldehyde dehydrogenase; EC 1.2.1.98 from Mycolicibacterium austroafricanum (Mycobacterium austroafricanum) (see paper)
Q3YAT5 2-hydroxy-2-methylpropanal dehydrogenase (EC 1.2.1.98) from Mycolicibacterium austroafricanum (see paper)
27% identity, 73% coverage of query (107 bits)
GABD_BACSU / P94428 Succinate-semialdehyde dehydrogenase [NADP(+)]; SSDH; EC 1.2.1.79 from Bacillus subtilis (strain 168) (see 3 papers)
P94428 succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16) from Bacillus subtilis (see paper)
25% identity, 70% coverage of query (100 bits)
6j76A Structure of 3,6-anhydro-l-galactose dehydrogenase in complex with nap (see paper)
24% identity, 72% coverage of query (91.3 bits)
6mvtA Structure of a bacterial aldh16 complexed with nadh
24% identity, 74% coverage of query (88.6 bits)
6mvsA Structure of a bacterial aldh16 complexed with NAD
24% identity, 74% coverage of query (88.6 bits)
5kj5B / Q83V33 Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase n169d in complex with NAD+ (see paper)
24% identity, 71% coverage of query (87.0 bits)
4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens
24% identity, 70% coverage of query (86.7 bits)
4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens
24% identity, 70% coverage of query (86.7 bits)
4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens
24% identity, 70% coverage of query (86.7 bits)
4ou2A A 2.15 angstroms x-ray crystal structure of e268a 2-aminomuconate 6- semialdehyde dehydrogenase catalytic intermediate from pseudomonas fluorescens
24% identity, 70% coverage of query (85.5 bits)
5kllA Crystal structure of 2-hydroxymuconate-6-semialdehyde derived tautomeric intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase n169d
24% identity, 70% coverage of query (85.1 bits)
4pxnA / C0PHD8 Structure of zm aldh7 in complex with NAD (see paper)
25% identity, 72% coverage of query (84.7 bits)
AADH1_SOLLC / Q56R04 Aminoaldehyde dehydrogenase 1; SlAMADH1; 4-trimethylammoniobutyraldehyde dehydrogenase AMADH1; Aminobutyraldehyde dehydrogenase AMADH1; Betaine aldehyde dehydrogenase AMADH1; Gamma-guanidinobutyraldehyde dehydrogenase AMADH1; EC 1.2.1.-; EC 1.2.1.47; EC 1.2.1.19; EC 1.2.1.8; EC 1.2.1.54 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see paper)
24% identity, 71% coverage of query (84.7 bits)
4i9bA / Q56R04 Structure of aminoaldehyde dehydrogenase 1 from solanum lycopersium (slamadh1) with a thiohemiacetal intermediate (see paper)
24% identity, 71% coverage of query (84.7 bits)
6mvuA / A0A0Q3EUQ3 Structure of a bacterial aldh16 active site mutant c295a complexed with p-nitrophenylacetate (see paper)
24% identity, 74% coverage of query (83.6 bits)
5x5uA Crystal structure of alpha-ketoglutarate-semialdehyde dehydrogenase (kgsadh) complexed with NAD
24% identity, 73% coverage of query (77.0 bits)
5x5tA / Q1JUP4 Crystal structure of alpha-ketoglutarate semialdehyde dehydrogenase (kgsadh) from azospirillum brasilense (see paper)
24% identity, 73% coverage of query (77.0 bits)
8c54A Cryo-em structure of nadh bound sla dehydrogenase rlgabd from rhizobium leguminosarum bv. Trifolii srd1565
24% identity, 72% coverage of query (76.3 bits)
AADH1_PEA / Q8VWZ1 Aminoaldehyde dehydrogenase 1, peroxisomal; PsAMADH1; Aminobutyraldehyde dehydrogenase AMADH1; Gamma-guanidinobutyraldehyde dehydrogenase AMADH1; EC 1.2.1.-; EC 1.2.1.19; EC 1.2.1.54 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
Q8VWZ1 aminobutyraldehyde dehydrogenase (EC 1.2.1.19) from Pisum sativum (see 3 papers)
25% identity, 72% coverage of query (75.9 bits)
3iwkH / Q8VWZ1 Crystal structure of aminoaldehyde dehydrogenase 1 from pisum sativum (psamadh1) (see paper)
25% identity, 72% coverage of query (75.9 bits)
2j6lA Structure of aminoadipate-semialdehyde dehydrogenase
23% identity, 72% coverage of query (73.2 bits)
6o4dB / P49419 Structure of aldh7a1 mutant w175a complexed with l-pipecolic acid (see paper)
23% identity, 72% coverage of query (72.8 bits)
ALDH7A1 / P49419 Alpha-aminoadipic semialdehyde dehydrogenase (EC 1.2.1.8; EC 1.2.1.31) from Homo sapiens (see 5 papers)
AL7A1_HUMAN / P49419 Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31; EC 1.2.1.3; EC 1.2.1.8 from Homo sapiens (Human) (see 7 papers)
P49419 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) from Homo sapiens (see 4 papers)
23% identity, 72% coverage of query (72.8 bits)
4zulA Structure aldh7a1 complexed with alpha-aminoadipate
23% identity, 72% coverage of query (72.8 bits)
4x0tA Structure aldh7a1 inactivated by 4-diethylaminobenzaldehyde and complexed with NAD+
23% identity, 72% coverage of query (72.8 bits)
AADH2_PEA / Q93YB2 Aminoaldehyde dehydrogenase 2, peroxisomal; PsAMADH2; Aminobutyraldehyde dehydrogenase AMADH2; Gamma-guanidinobutyraldehyde dehydrogenase AMADH2; EC 1.2.1.-; EC 1.2.1.19; EC 1.2.1.54 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see 2 papers)
Q93YB2 aminobutyraldehyde dehydrogenase (EC 1.2.1.19) from Pisum sativum (see 2 papers)
25% identity, 72% coverage of query (72.4 bits)
3iwjA / Q93YB2 Crystal structure of aminoaldehyde dehydrogenase 2 from pisum sativum (psamadh2) (see paper)
25% identity, 72% coverage of query (72.4 bits)
4x0uD Structure aldh7a1 inactivated by 4-diethylaminobenzaldehyde
23% identity, 72% coverage of query (65.9 bits)
4go2A Crystal structure of thE C-terminal domain of 10'formyltetrahydrofolate dehydrogenase in complex with thio-NADP
22% identity, 73% coverage of query (62.8 bits)
2o2rA Crystal structure of thE C-terminal domain of rat 10'formyltetrahydrofolate dehydrogenase in complex with NADPH
22% identity, 73% coverage of query (62.8 bits)
AL1L1_RAT / P28037 Cytosolic 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; FDH; Aldehyde dehydrogenase family 1 member L1; FBP-CI; EC 1.5.1.6 from Rattus norvegicus (Rat) (see 7 papers)
P28037 formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) from Rattus norvegicus (see 3 papers)
22% identity, 73% coverage of query (62.0 bits)
7rluA / P28037 Structure of aldh1l1 (10-formyltetrahydrofolate dehydrogenase) in complex with NADP (see paper)
22% identity, 73% coverage of query (61.6 bits)
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Lawrence Berkeley National Laboratory