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Searching for up to 100 curated homologs for HSERO_RS21030 FitnessBrowser__HerbieS:HSERO_RS21030 (170 a.a.)

Found high-coverage hits (≥70%) to 71 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

P0A1X4 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase; UDP-3-O-(3-OHC14)-GlcN N-acyltransferase; UDP-3-O-(3-hydroxytetradecanoyl)glucosamine N-acyltransferase; EC 2.3.1.191 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    39% identity, 80% coverage of query (86.3 bits)

P95377 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Neisseria meningitidis (see paper)
    33% identity, 96% coverage of query (82.0 bits)

6p8aA E.Coli lpxd in complex with compound 8.1
    38% identity, 76% coverage of query (81.3 bits)

6p89A E.Coli lpxd in complex with compound 7
    38% identity, 76% coverage of query (81.3 bits)

6p88A E.Coli lpxd in complex with compound 6
    38% identity, 76% coverage of query (81.3 bits)

6p87A E.Coli lpxd in complex with compound 5
    38% identity, 76% coverage of query (81.3 bits)

6p86A E.Coli lpxd in complex with compound 4.1
    38% identity, 76% coverage of query (81.3 bits)

6p85A E.Coli lpxd in complex with compound 3
    38% identity, 76% coverage of query (81.3 bits)

6p84A E.Coli lpxd in complex with compound 2o
    38% identity, 76% coverage of query (81.3 bits)

6p83A E.Coli lpxd in complex with compound 1o
    38% identity, 76% coverage of query (81.3 bits)

4ihgE Chasing acyl carrier protein through a catalytic cycle of lipid a production
    38% identity, 76% coverage of query (81.3 bits)

OmsA / b0179 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
lpxD / P21645 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Escherichia coli (strain K12) (see 30 papers)
LPXD_ECOLI / P21645 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase; UDP-3-O-(3-OHC14)-GlcN N-acyltransferase; Protein FirA; Rifampicin resistance protein; UDP-3-O-(3-hydroxytetradecanoyl)glucosamine N-acyltransferase; EC 2.3.1.191 from Escherichia coli (strain K12) (see 3 papers)
P21645 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Escherichia coli (see 2 papers)
Q0P6M7 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Escherichia coli (see paper)
lpxD UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; EC 2.3.1.- from Escherichia coli (see paper)
    38% identity, 76% coverage of query (80.9 bits)

4ihhE / P21645 Chasing acyl carrier protein through a catalytic cycle of lipid a production (see paper)
    38% identity, 76% coverage of query (80.9 bits)

P32203 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Yersinia enterocolitica (see paper)
    38% identity, 78% coverage of query (79.7 bits)

4ihfA Chasing acyl carrier protein through a catalytic cycle of lipid a production
    37% identity, 76% coverage of query (77.4 bits)

B0VMV2 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Acinetobacter baumannii (see paper)
    35% identity, 78% coverage of query (76.3 bits)

LPXD1_ARATH / F4JGP6 Probable UDP-3-O-acylglucosamine N-acyltransferase 1, mitochondrial; Protein LIPID X D1; AtLpxD1; EC 2.3.1.191 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
F4JGP6 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Arabidopsis thaliana (see paper)
    33% identity, 100% coverage of query (73.9 bits)

LPXD2_ARATH / F4JIP6 Probable UDP-3-O-acylglucosamine N-acyltransferase 2, mitochondrial; Protein LIPID X D2; AtLpxD2; EC 2.3.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    34% identity, 96% coverage of query (73.6 bits)

Q9HXY6 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Pseudomonas aeruginosa (see 2 papers)
    38% identity, 88% coverage of query (72.8 bits)

3pmoA / Q9HXY6 The structure of lpxd from pseudomonas aeruginosa at 1.3 a resolution (see paper)
    38% identity, 88% coverage of query (72.8 bits)

6uecA Pseudomonas aeruginosa lpxd complex structure with ligand
    38% identity, 88% coverage of query (72.8 bits)

Q02RB8 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Pseudomonas aeruginosa (see paper)
    38% identity, 88% coverage of query (72.4 bits)

2iu8A / P0CD76 Chlamydia trachomatis lpxd with 25mm udpglcnac (complex i) (see paper)
    34% identity, 84% coverage of query (67.0 bits)

LPXD_CHLTR / P0CD76 UDP-3-O-acylglucosamine N-acyltransferase; EC 2.3.1.191 from Chlamydia trachomatis (strain D/UW-3/Cx) (see paper)
    34% identity, 84% coverage of query (66.6 bits)

Q5ZRD8 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Legionella pneumophila (see paper)
    35% identity, 95% coverage of query (64.7 bits)

lpxD / Q7MXT7 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Porphyromonas gingivalis (strain ATCC BAA-308 / W83) (see 5 papers)
    31% identity, 91% coverage of query (63.9 bits)

A6V1E4 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) from Pseudomonas aeruginosa (see 2 papers)
    31% identity, 100% coverage of query (62.0 bits)

7ojpZ / Q9X6P4 Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 1 (see paper)
    31% identity, 100% coverage of query (62.0 bits)

7okbA Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 45
    31% identity, 100% coverage of query (62.0 bits)

7ok1A Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 3
    31% identity, 100% coverage of query (62.0 bits)

7ojyA Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 6
    31% identity, 100% coverage of query (62.0 bits)

6ueeA Pseudomonas aeruginosa lpxa complex structure with ligand
    31% identity, 100% coverage of query (62.0 bits)

5depA Structure of pseudomonas aeruginosa lpxa in complex with udp-glcnac
    31% identity, 100% coverage of query (62.0 bits)

Q5ZY64 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Legionella pneumophila (see paper)
    36% identity, 70% coverage of query (61.6 bits)

7t61A P. Aeruginosa lpxa in complex with ligand l15
    31% identity, 100% coverage of query (61.6 bits)

7t60A P. Aeruginosa lpxa in complex with ligand l13
    31% identity, 100% coverage of query (61.6 bits)

7t5zA P. Aeruginosa lpxa in complex with ligand l8
    31% identity, 100% coverage of query (61.6 bits)

7t5xA P. Aeruginosa lpxa in complex with ligand l6
    31% identity, 100% coverage of query (61.6 bits)

7t5sA P. Aeruginosa lpxa in complex with ligand h16
    31% identity, 100% coverage of query (61.6 bits)

7t5rA P. Aeruginosa lpxa in complex with ligand h7
    31% identity, 100% coverage of query (61.6 bits)

7okaa Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 14
    31% identity, 100% coverage of query (61.6 bits)

6uegA Pseudomonas aeruginosa lpxa complex structure with ligand
    31% identity, 100% coverage of query (61.6 bits)

5dg3A Structure of pseudomonas aeruginosa lpxa in complex with udp-3-o-(r-3- hydroxydecanoyl)-glcnac
    31% identity, 100% coverage of query (61.6 bits)

7ojwA Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 93
    31% identity, 100% coverage of query (60.5 bits)

7ojqA Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 7
    30% identity, 100% coverage of query (59.7 bits)

Build an alignment

Build an alignment for HSERO_RS21030 and 45 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

LPXA_ARATH / Q9SU91 Probable acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, mitochondrial; UDP-N-acetylglucosamine acyltransferase; Protein LIPID X A; AtLpxA; EC 2.3.1.129 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9SU91 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) from Arabidopsis thaliana (see 2 papers)
    27% identity, 100% coverage of query (56.6 bits)

Q6QHI7 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129); acyl-[acyl-carrier protein]—UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose N-acyltransferase (EC 2.3.1.305) from Acidithiobacillus ferrooxidans (see paper)
    32% identity, 96% coverage of query (56.6 bits)

Q5LH16 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) from Bacteroides fragilis (see paper)
4r37A / Q5LH16 Crystal structure analysis of lpxa, a udp-n-acetylglucosamine acyltransferase from bacteroides fragilis 9343 with udp-glcnac (see paper)
    28% identity, 98% coverage of query (56.6 bits)

qdtC / Q6TFC6 dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose:acetyl-CoA acetyltransferase from Thermoanaerobacterium thermosaccharolyticum (see paper)
    29% identity, 100% coverage of query (52.0 bits)

3fscA Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-fucose
    29% identity, 100% coverage of query (52.0 bits)

3fs8A Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d- glucose n-acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with acetyl-coa
    29% identity, 100% coverage of query (52.0 bits)

3fsbA / Q6TFC6 Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-quinovose (see paper)
    29% identity, 100% coverage of query (51.6 bits)

Q3BDJ0 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) from Moraxella catarrhalis (see paper)
    27% identity, 94% coverage of query (50.8 bits)

ST0452 / Q975F9 multifunctional glucose-1-phosphate thymidylyltransferase/hexosamine-1-phosphate N-acetyltransferase/UDP-N-acetylhexosamine diphosphorylase (EC 2.7.7.24; EC 2.7.7.23; EC 2.7.7.83; EC 2.3.1.157; EC 2.3.1.276) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see 2 papers)
S1PNA_SULTO / Q975F9 Bifunctional sugar-1-phosphate nucleotidylyltransferase/acetyltransferase; EC 2.7.7.24; EC 2.7.7.9; EC 2.7.7.83; EC 2.7.7.23; EC 2.3.1.276; EC 2.3.1.157 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see 5 papers)
Q975F9 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); galactosamine-1-phosphate N-acetyltransferase (EC 2.3.1.276); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23); glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24); aldose-1-phosphate nucleotidyltransferase (EC 2.7.7.37); UDP-N-acetylgalactosamine diphosphorylase (EC 2.7.7.83); UTP-glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) from Sulfurisphaera tokodaii (see 7 papers)
2ggqA / Q975F9 Complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii
    30% identity, 96% coverage of query (49.7 bits)

5z09A St0452(y97n)-utp binding form
    30% identity, 96% coverage of query (49.7 bits)

4eqyG / Q2SWY6 Crystal structure of acyl-[acyl-carrier-protein]--udp-n- acetylglucosamine o-acyltransferase from burkholderia thailandensis (see paper)
    25% identity, 98% coverage of query (46.6 bits)

3mqgC / A9IH93 Crystal structure of the 3-n-acetyl transferase wlbb from bordetella petrii in complex with acetyl-coa (see paper)
    34% identity, 87% coverage of query (45.8 bits)

8e62C / Q1QD55 Structure of pcryo_0615 from psychrobacter cryohalolentis, an n- acetyltransferase required to produce diacetamido-2,3-dideoxy-d- glucuronic acid (see paper)
    29% identity, 96% coverage of query (45.4 bits)

A9IH93 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (EC 2.3.1.201) from Bordetella petrii (see paper)
    34% identity, 84% coverage of query (45.1 bits)

wbpD / G3XD01 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase monomer (EC 2.3.1.201) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
WBPD_PSEAE / G3XD01 UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase; UDP-D-GlcNAc3NA N-acetyltransferase; UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronic acid 3-N-acetyltransferase; EC 2.3.1.201 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
G3XD01 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (EC 2.3.1.201) from Pseudomonas aeruginosa (see paper)
    29% identity, 92% coverage of query (45.1 bits)

3mqhA Crystal structure of the 3-n-acetyl transferase wlbb from bordetella petrii in complex with coa and udp-3-amino-2-acetamido-2,3-dideoxy glucuronic acid
    34% identity, 84% coverage of query (45.1 bits)

2qivX Structural basis for the acyl chain selectivity and mechanism of udp- n-acetylglucosamine acyltransferase
    26% identity, 99% coverage of query (42.0 bits)

2qiaA Structural basis for the acyl chain selectivity and mechanism of udp- n-acetylglucosamine acyltransferase
    26% identity, 99% coverage of query (42.0 bits)

2jf3A Nucleotide substrate binding by udp-n-acetylglucosamine acyltransferase
    26% identity, 99% coverage of query (42.0 bits)

2aq9A Structure of e. Coli lpxa with a bound peptide that is competitive with acyl-acp
    26% identity, 99% coverage of query (42.0 bits)

6p9tA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 8
    26% identity, 99% coverage of query (42.0 bits)

6p9sA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 7
    26% identity, 99% coverage of query (42.0 bits)

6p9rA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 6
    26% identity, 99% coverage of query (42.0 bits)

6p9qA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 2
    26% identity, 99% coverage of query (42.0 bits)

6p9pA E.Coli lpxa in complex with compound 1
    26% identity, 99% coverage of query (42.0 bits)

7okcA / C3TPH2 Crystal structure of escherichia coli lpxa in complex with compound 1 (see paper)
    26% identity, 99% coverage of query (41.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory