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Searching for up to 100 curated homologs for HSERO_RS21495 HSERO_RS21495 acetylglutamate kinase (297 a.a.)

Found high-coverage hits (≥70%) to 61 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

2bufC / Q9HTN2 Arginine feed-back inhibitable acetylglutamate kinase (see paper)
    57% identity, 96% coverage of query (338 bits)

ARGB_PSEAE / Q9HTN2 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HTN2 acetylglutamate kinase (EC 2.7.2.8) from Pseudomonas aeruginosa (see 3 papers)
    57% identity, 96% coverage of query (337 bits)

2bufA Arginine feed-back inhibitable acetylglutamate kinase
    57% identity, 96% coverage of query (334 bits)

2bufK / Q9HTN2 Arginine feed-back inhibitable acetylglutamate kinase (see paper)
    55% identity, 95% coverage of query (311 bits)

O67848 UDP-3-O-acyl-N-acetylglucosamine deacetylase (EC 3.5.1.108) from Aquifex aeolicus (see paper)
    53% identity, 95% coverage of query (302 bits)

ARGB_THEMA / Q9X2A4 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
Q9X2A4 acetylglutamate kinase (EC 2.7.2.8) from Thermotoga maritima (see 2 papers)
2btyA / Q9X2A4 Acetylglutamate kinase from thermotoga maritima complexed with its inhibitor arginine (see paper)
    48% identity, 95% coverage of query (279 bits)

Q6V1L5 acetylglutamate kinase (EC 2.7.2.8) from Synechococcus elongatus (see paper)
    45% identity, 99% coverage of query (264 bits)

2v5hB / Q6V1L5 Controlling the storage of nitrogen as arginine: the complex of pii and acetylglutamate kinase from synechococcus elongatus pcc 7942 (see paper)
    47% identity, 95% coverage of query (263 bits)

A0A1D6E3W6 acetylglutamate kinase (EC 2.7.2.8) from Zea mays (see paper)
    45% identity, 95% coverage of query (249 bits)

NAGK_ARATH / Q9SCL7 Acetylglutamate kinase, chloroplastic; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AtNAGK; EC 2.7.2.8 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q9SCL7 acetylglutamate kinase (EC 2.7.2.8) from Arabidopsis thaliana (see 5 papers)
    45% identity, 96% coverage of query (249 bits)

2rd5B / Q9SCL7 Structural basis for the regulation of n-acetylglutamate kinase by pii in arabidopsis thaliana (see paper)
    45% identity, 96% coverage of query (247 bits)

4usjB N-acetylglutamate kinase from arabidopsis thaliana in complex with pii from chlamydomonas reinhardtii
    45% identity, 95% coverage of query (244 bits)

Q6R6P5 acetylglutamate kinase (EC 2.7.2.8) from Corynebacterium crenatum (see paper)
    43% identity, 99% coverage of query (223 bits)

argB / CAB82481.1 acetylglutamate kinase from Streptomyces clavuligerus (see 3 papers)
    44% identity, 95% coverage of query (219 bits)

7nlyA Crystal structure of mycobacterium tuberculosis argb in complex with 2-chlorobenzimidazole.
    42% identity, 96% coverage of query (210 bits)

7nloA Crystal structure of mycobacterium tuberculosis argb in complex with l-arginine
    42% identity, 96% coverage of query (210 bits)

7nlpA Crystal structure of mycobacterium tuberculosis argb in complex with l-canavanine
    42% identity, 96% coverage of query (210 bits)

7nlwA Crystal structure of mycobacterium tuberculosis argb in complex with 2-(5-methoxy-1h-indol-3-yl)acetonitrile
    42% identity, 96% coverage of query (210 bits)

ARGB_MYCTU / P9WQ01 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    42% identity, 96% coverage of query (209 bits)

7nlxA Crystal structure of mycobacterium tuberculosis argb in complex with 7-(trifluoromethyl)quinolin-4-ol.
    42% identity, 96% coverage of query (209 bits)

7nlnA Crystal structure of mycobacterium tuberculosis argb in complex with n-acetyl-glutamate
    42% identity, 96% coverage of query (209 bits)

7nnbA Crystal structure of mycobacterium tuberculosis argb in complex with 2,8-bis(trifluoromethyl)quinolin-4-ol.
    42% identity, 96% coverage of query (209 bits)

7nn8A Crystal structure of mycobacterium tuberculosis argb in complex with 1h-indole-3-carbonitrile.
    42% identity, 96% coverage of query (209 bits)

7nm0A Crystal structure of mycobacterium tuberculosis argb in complex with 1-(2,6-dihydroxyphenyl)ethan-1-one.
    42% identity, 96% coverage of query (209 bits)

7nlzA Crystal structure of mycobacterium tuberculosis argb in complex with 5-methoxy-6-(trifluoromethyl)indole.
    42% identity, 96% coverage of query (209 bits)

7nltA Crystal structure of mycobacterium tuberculosis argb in complex with 4-(4-methylpiperazin-1-yl)benzoic acid
    42% identity, 96% coverage of query (209 bits)

7nlrA Crystal structure of mycobacterium tuberculosis argb in complex with 2-phenyl-1h-imidazole
    42% identity, 96% coverage of query (209 bits)

2ap9A / P9WQ01 Crystal structure of acetylglutamate kinase from mycobacterium tuberculosis cdc1551
    42% identity, 96% coverage of query (208 bits)

Q59281 acetylglutamate kinase (EC 2.7.2.8) from Corynebacterium glutamicum (see paper)
    44% identity, 91% coverage of query (203 bits)

argB / AAA22198.1 acetylglutamate kinase from Geobacillus stearothermophilus (see paper)
    37% identity, 83% coverage of query (150 bits)

BT3395 N-succinylglutamate kinase (EC 2.7.2.-) from Bacteroides thetaiotaomicron VPI-5482
    32% identity, 81% coverage of query (115 bits)

Build an alignment

Build an alignment for HSERO_RS21495 and 31 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

ArgA / b2818 N-acetylglutamate synthase (EC 2.3.1.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
argA / P0A6C5 N-acetylglutamate synthase (EC 2.3.1.1) from Escherichia coli (strain K12) (see 5 papers)
ARGA_ECOLI / P0A6C5 Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS; NAGS; EC 2.3.1.1 from Escherichia coli (strain K12) (see paper)
argA / RF|NP_417295 amino-acid acetyltransferase from Escherichia coli K12 (see paper)
    28% identity, 93% coverage of query (107 bits)

Q87EL2 amino-acid N-acetyltransferase (EC 2.3.1.1) from Xylella fastidiosa (see paper)
    30% identity, 92% coverage of query (105 bits)

A0A0H2X8L7 acetylglutamate kinase (EC 2.7.2.8) from Xanthomonas campestris (see paper)
    28% identity, 92% coverage of query (102 bits)

Q8P8J6 acetylglutamate kinase (EC 2.7.2.8) from Xanthomonas campestris (see 2 papers)
    28% identity, 92% coverage of query (102 bits)

lysZ / Q5SH27 [LysW]-L-2-aminoadipate 6-kinase monomer (EC 2.7.2.17) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 2 papers)
    28% identity, 89% coverage of query (100 bits)

LYSZ_THET2 / O50147 [LysW]-aminoadipate kinase; EC 2.7.2.17 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
3wwmA / O50147 Crystal structure of lysz from thermus thermophilus with adp (see paper)
    28% identity, 89% coverage of query (97.8 bits)

N515DRAFT_3768 N-acetylglutamate synthase; N-acetylglutamate kinase (EC 2.3.1.1; EC 2.7.2.8) from Dyella japonica UNC79MFTsu3.2
    28% identity, 92% coverage of query (97.8 bits)

3d2pA Crystal structure of n-acetylglutamate synthase from neisseria gonorrhoeae complexed with coenzyme a and l-arginine
    29% identity, 93% coverage of query (95.5 bits)

3t7bB / Q8ZA87 Crystal structure of n-acetyl-l-glutamate kinase from yersinia pestis
    29% identity, 82% coverage of query (95.1 bits)

3b8gA / Q5FAK7 Crysta structure of n-acetylglutamate synthase from neisseria gonorrhoeae complexed with coenzyme a and n-acetyl-glutamate (see paper)
    29% identity, 93% coverage of query (94.7 bits)

ArgB / b3959 acetylglutamate kinase (EC 2.7.2.8) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
argB / P0A6C8 acetylglutamate kinase (EC 2.7.2.8) from Escherichia coli (strain K12) (see 4 papers)
ARGB_ECOLI / P0A6C8 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Escherichia coli (strain K12) (see 4 papers)
A0A140NEG9 acetylglutamate kinase (EC 2.7.2.8) from Escherichia coli (see paper)
1gs5A / P0A6C8 N-acetyl-l-glutamate kinase from escherichia coli complexed with its substrate n-acetylglutamate and its substrate analog amppnp (see paper)
argB / SP|P0A6C8 acetylglutamate kinase; EC 2.7.2.8 from Escherichia coli (see 2 papers)
    28% identity, 82% coverage of query (94.7 bits)

4i49A Structure of ngnags bound with bisubstrate analog coa-NAG
    29% identity, 93% coverage of query (94.7 bits)

3d2mA Crystal structure of n-acetylglutamate synthase from neisseria gonorrhoeae complexed with coenzyme a and l-glutamate
    29% identity, 93% coverage of query (94.7 bits)

2x2wA Acetylglutamate kinase from escherichia coli bound to n-acetyl-l- glutamyl-5-phosphate
    28% identity, 82% coverage of query (94.7 bits)

2r8vA Native structure of n-acetylglutamate synthase from neisseria gonorrhoeae
    29% identity, 93% coverage of query (94.7 bits)

1oh9A Acetylglutamate kinase from escherichia coli complexed with mgadp, n- acetyl-l-glutamate and the transition-state mimic alf4-
    28% identity, 82% coverage of query (94.7 bits)

P22567 amino-acid N-acetyltransferase (EC 2.3.1.1) from Pseudomonas aeruginosa (see 2 papers)
    27% identity, 94% coverage of query (94.4 bits)

ARG5,6 arginine biosynthetic enzyme activities from Candida albicans (see 3 papers)
    29% identity, 89% coverage of query (88.2 bits)

argB / CAB95021.1 n-acetylglutamate 5-phosphotransferase from Moritella abyssi (see paper)
    30% identity, 74% coverage of query (87.8 bits)

ARG56_SCHPO / P31318 Protein arg11, mitochondrial; EC 1.2.1.38; EC 2.7.2.8 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
arg11 / GI|1204210 N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase; EC 1.2.1.38; EC 2.7.2.8 from Schizosaccharomyces pombe (see 2 papers)
    28% identity, 93% coverage of query (87.0 bits)

3l86A / Q8DV44 The crystal structure of smu.665 from streptococcus mutans ua159
    29% identity, 84% coverage of query (87.0 bits)

4kztA Structure mmnags bound with l-arginine
    30% identity, 92% coverage of query (86.7 bits)

lysZ / Q4JAQ2 [LysW}-glutamate/[LysW]-aminoadipate kinase (EC 2.7.2.17; EC 2.7.2.19) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
LYSZ_SULAC / Q4JAQ2 [LysW]-aminoadipate/[LysW]-glutamate kinase; EC 2.7.2.17; EC 2.7.2.19 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4JAQ2 [amino group carrier protein]-L-2-aminoadipate 6-kinase (EC 2.7.2.17) from Sulfolobus acidocaldarius (see paper)
    30% identity, 83% coverage of query (86.3 bits)

Q0ASS9 amino-acid N-acetyltransferase (EC 2.3.1.1); acetylglutamate kinase (EC 2.7.2.8) from Maricaulis maris (see 3 papers)
    29% identity, 92% coverage of query (85.1 bits)

3s6hA / Q0ASS9 Crystal structure of native mmnags/k (see paper)
    29% identity, 92% coverage of query (84.7 bits)

ARG56_YEAST / Q01217 Protein ARG5,6, mitochondrial; EC 1.2.1.38; EC 2.7.2.8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Q01217 acetylglutamate kinase (EC 2.7.2.8) from Saccharomyces cerevisiae (see paper)
ARG5,6 / CAA40336.1 acetylglutamate kinase from Saccharomyces cerevisiae (see paper)
    28% identity, 89% coverage of query (79.7 bits)

3zzhC Crystal structure of the amino acid kinase domain from saccharomyces cerevisiae acetylglutamate kinase in complex with its feed- back inhibitor l-arginine
    26% identity, 98% coverage of query (79.7 bits)

ARGB_THET2 / Q72HA9 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
    29% identity, 76% coverage of query (79.0 bits)

4ab7H / Q01217 Crystal structure of a tetrameric acetylglutamate kinase from saccharomyces cerevisiae complexed with its substrate n- acetylglutamate (see paper)
    28% identity, 89% coverage of query (79.0 bits)

C4NFG1 amino-acid N-acetyltransferase (EC 2.3.1.1) from Solanum lycopersicum (see paper)
    25% identity, 79% coverage of query (57.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory