Searching for up to 100 curated homologs for HSERO_RS22840 FitnessBrowser__HerbieS:HSERO_RS22840 (306 a.a.)
Found high-coverage hits (≥70%) to 40 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PY2CR_BACCZ / Q63FA5 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Bacillus cereus (strain ZK / E33L) (see paper)
34% identity, 82% coverage of query (136 bits)
6t3eB / H3ZMH3 Structure of thermococcus litoralis delta(1)-pyrroline-2-carboxylate reductase in complex with nadh and l-proline (see paper)
32% identity, 98% coverage of query (135 bits)
4bvaA Crystal structure of the NADPH-t3 form of mouse mu-crystallin.
32% identity, 96% coverage of query (129 bits)
PY2CR_BACHK / Q6HMS8 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Bacillus thuringiensis subsp. konkukian (strain 97-27) (see paper)
34% identity, 81% coverage of query (128 bits)
O54983 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) (EC 1.5.1.21) from Mus musculus (see paper)
31% identity, 96% coverage of query (127 bits)
PY2CR_BACC1 / Q73CR9 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Bacillus cereus (strain ATCC 10987 / NRS 248) (see paper)
33% identity, 82% coverage of query (127 bits)
F1RPC8 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) (EC 1.5.1.21) from Sus scrofa (see paper)
31% identity, 97% coverage of query (127 bits)
4bv9A Crystal structure of the NADPH form of mouse mu-crystallin.
31% identity, 96% coverage of query (127 bits)
PY2CR_BACCR / Q81HB0 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) (see paper)
33% identity, 82% coverage of query (126 bits)
W5PYW4 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) (EC 1.5.1.21) from Ovis aries (see paper)
35% identity, 72% coverage of query (126 bits)
CRYM / Q14894 ketimine reductase monomer (EC 1.5.1.1; EC 1.5.1.25) from Homo sapiens (see 9 papers)
CRYM_HUMAN / Q14894 Ketimine reductase mu-crystallin; NADP-regulated thyroid-hormone-binding protein; EC 1.5.1.25 from Homo sapiens (Human) (see 3 papers)
Q14894 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) (EC 1.5.1.21); thiomorpholine-carboxylate dehydrogenase (EC 1.5.1.25) from Homo sapiens (see 2 papers)
34% identity, 75% coverage of query (125 bits)
2i99A / Q14894 Crystal structure of human mu_crystallin at 2.6 angstrom (see paper)
34% identity, 75% coverage of query (125 bits)
Q9QYU4 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) (EC 1.5.1.21) from Rattus norvegicus (see paper)
31% identity, 96% coverage of query (124 bits)
Build an alignment for HSERO_RS22840 and 13 homologs with ≥ 30% identity
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PY2CR_COLP3 / Q485R8 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) (see 2 papers)
Q485R8 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] (EC 1.5.1.1) from Colwellia psychrerythraea (see paper)
28% identity, 98% coverage of query (103 bits)
SARD4_ARATH / Q9FLY0 Protein SAR DEFICIENT 4; Ornithine cyclodeaminase-like protein; AtOCD from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
30% identity, 74% coverage of query (97.8 bits)
6rqaA / A1B8Z0 Crystal structure of the iminosuccinate reductase of paracoccus denitrificans in complex with NAD+ (see paper)
33% identity, 70% coverage of query (90.9 bits)
6rqaB Crystal structure of the iminosuccinate reductase of paracoccus denitrificans in complex with NAD+
33% identity, 70% coverage of query (90.9 bits)
BHCD_PARDP / A1B8Z0 Iminosuccinate reductase; EC 1.4.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
33% identity, 70% coverage of query (90.5 bits)
ALADH_ARCFU / O28608 Alanine dehydrogenase; AlaDH; EC 1.4.1.1 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see 2 papers)
O28608 alanine dehydrogenase (EC 1.4.1.1) from Archaeoglobus fulgidus (see paper)
28% identity, 98% coverage of query (90.1 bits)
1omoA / O28608 Alanine dehydrogenase dimer w/bound NAD (archaeal) (see paper)
28% identity, 98% coverage of query (89.7 bits)
YK01_SCHPO / Q9HDZ0 Uncharacterized protein P11E10.01 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
27% identity, 97% coverage of query (79.7 bits)
PY2CR_PARDP / A1B196 Delta(1)-pyrroline-2-carboxylate reductase; Pyr2C reductase; Proline ketimine reductase; EC 1.5.1.49 from Paracoccus denitrificans (strain Pd 1222) (see paper)
28% identity, 97% coverage of query (77.4 bits)
B1GT63 Strombine dehydrogenase (EC 1.5.1.22) from Suberites domuncula (see paper)
32% identity, 74% coverage of query (71.2 bits)
tynB / D7F5L7 tyramine oxidase subunit B (EC 1.4.3.4) from Pseudomonas putida (see paper)
29% identity, 78% coverage of query (71.2 bits)
sbnB / Q2G1N2 N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase monomer (EC 1.5.1.51) from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 2 papers)
SBNB_STAA8 / Q2G1N2 N-((2S)-2-amino-2-carboxyethyl)-L-glutamate dehydrogenase; Staphyloferrin B biosynthesis protein SbnB; EC 1.5.1.51 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 3 papers)
A0A0H3K9Y6 N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase (EC 1.5.1.51) from Staphylococcus aureus (see 2 papers)
25% identity, 74% coverage of query (70.1 bits)
4mp6A / A0A0H3K9Y6 Staphyloferrin b precursor biosynthetic enzyme sbnb bound to citrate and NAD+ (see paper)
25% identity, 74% coverage of query (70.1 bits)
lhpI / V5YW53 Δ1-pyrroline-2-carboxylate reductase subunit (EC 1.5.1.49) from Azospirillum brasilense (see paper)
PY2CR_AZOBR / V5YW53 Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase; Pyr2C/Pip2C reductase; EC 1.5.1.1 from Azospirillum brasilense (see paper)
V5YW53 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] (EC 1.5.1.1) from Azospirillum brasilense (see paper)
32% identity, 81% coverage of query (69.3 bits)
4m54A / A0A0H3K9Y6 The structure of the staphyloferrin b precursor biosynthetic enzyme sbnb bound to n-(1-amino-1-carboxyl-2-ethyl)-glutamic acid and nadh (see paper)
24% identity, 74% coverage of query (68.2 bits)
1u7hA / Q88H32 Structure and a proposed mechanism for ornithine cyclodeaminase from pseudomonas putida (see paper)
27% identity, 74% coverage of query (68.2 bits)
OCD_PSEPK / Q88H32 Ornithine cyclodeaminase; OCD; EC 4.3.1.12 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
Q88H32 ornithine cyclodeaminase (EC 4.3.1.12) from Pseudomonas putida (see 2 papers)
28% identity, 74% coverage of query (68.2 bits)
1x7dA Crystal structure analysis of ornithine cyclodeaminase complexed with NAD and ornithine to 1.6 angstroms
27% identity, 74% coverage of query (68.2 bits)
OCD_AGRT4 / Q59701 Ornithine cyclodeaminase; OCD; EC 4.3.1.12 from Agrobacterium tumefaciens (strain Ach5) (see paper)
CAA82989.1 ornithine cyclodeaminase from Agrobacterium tumefaciens (see 2 papers)
31% identity, 71% coverage of query (67.0 bits)
4mpdA Staphyloferrin b precursor biosynthetic enzyme sbnb bound a- ketoglutarate and NAD+
24% identity, 74% coverage of query (65.5 bits)
PYCR1_BURM1 / A9AKH1 Delta(1)-pyrroline-2-carboxylate reductase 1; Pyr2C reductase 1; Proline ketimine reductase 1; EC 1.5.1.49 from Burkholderia multivorans (strain ATCC 17616 / 249) (see paper)
32% identity, 74% coverage of query (63.9 bits)
dauB / Q9HXE4 anabolic L-arginine dehydrogenase (EC 1.4.1.25) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
DAUB_PSEAE / Q9HXE4 NAD(P)H-dependent anabolic L-arginine dehydrogenase DauB; EC 1.4.1.25 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HXE4 L-arginine dehydrogenase (EC 1.4.1.25) from Pseudomonas aeruginosa (see paper)
30% identity, 94% coverage of query (62.0 bits)
fkbL / Q9KIE2 L-lysine cyclodeaminase (EC 4.3.1.28) from Streptomyces hygroscopicus subsp. ascomyceticus (see paper)
31% identity, 77% coverage of query (62.0 bits)
8j1cA Structure of amino acid dehydrogenase in complex with NADP
28% identity, 95% coverage of query (61.2 bits)
8j1gB / A0A7Y0ZV07 Structure of amino acid dehydrogenase in complex with NADPH (see paper)
28% identity, 95% coverage of query (60.5 bits)
PYCR2_BURCM / Q0B953 Delta(1)-pyrroline-2-carboxylate reductase 2; Pyr2C reductase 2; Proline ketimine reductase 2; EC 1.5.1.49 from Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD)) (see paper)
31% identity, 85% coverage of query (59.3 bits)
8j1cB Structure of amino acid dehydrogenase in complex with NADP
28% identity, 95% coverage of query (55.1 bits)
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Lawrence Berkeley National Laboratory