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Searching for up to 100 curated homologs for N515DRAFT_0577 FitnessBrowser__Dyella79:N515DRAFT_0577 (382 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

O63067 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max (see paper)
    46% identity, 93% coverage of query (306 bits)

AAA16972.1 aspartokinase-homoserine dehydrogenase, partial from Daucus carota (see paper)
    45% identity, 95% coverage of query (305 bits)

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    44% identity, 93% coverage of query (292 bits)

AKH1_ARATH / Q9SA18 Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic; AK-HD 1; AK-HSDH 1; Beta-aspartyl phosphate homoserine 1; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    44% identity, 95% coverage of query (283 bits)

ThrD / b0002 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
thrA / P00561 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 33 papers)
P00561 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Escherichia coli (see paper)
    43% identity, 87% coverage of query (262 bits)

Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    40% identity, 91% coverage of query (261 bits)

thrA1A2 / CAA43212.1 aspartate kinase from Serratia marcescens (see paper)
    42% identity, 87% coverage of query (249 bits)

MetM / b3940 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
metL / P00562 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 9 papers)
    41% identity, 95% coverage of query (245 bits)

CA265_RS23475 aspartate kinase; homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Pedobacter sp. GW460-11-11-14-LB5
    36% identity, 92% coverage of query (234 bits)

BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Bacteroides thetaiotaomicron VPI-5482
    36% identity, 91% coverage of query (218 bits)

DHOM_EMENI / Q5B998 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
AN2882 homoserine dehydrogenase; EC 1.1.1.3 from Emericella nidulans (see paper)
    40% identity, 88% coverage of query (216 bits)

Q5AIA2 homoserine dehydrogenase (EC 1.1.1.3) from Candida albicans (see 2 papers)
    37% identity, 92% coverage of query (214 bits)

O94671 Probable homoserine dehydrogenase; HDH; EC 1.1.1.3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    36% identity, 93% coverage of query (214 bits)

DHOM_YEAST / P31116 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
    37% identity, 92% coverage of query (201 bits)

1ebfA / P31116 Homoserine dehydrogenase from s. Cerevisiae complex with NAD+ (see paper)
    37% identity, 92% coverage of query (201 bits)

1tveA Homoserine dehydrogenase in complex with 4-(4-hydroxy-3- isopropylphenylthio)-2-isopropylphenol
    37% identity, 92% coverage of query (201 bits)

1q7gA Homoserine dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-oxonorvaline
    37% identity, 92% coverage of query (201 bits)

1ebuD Homoserine dehydrogenase complex with NAD analogue and l-homoserine
    37% identity, 92% coverage of query (201 bits)

C1G1C3 homoserine dehydrogenase (EC 1.1.1.3) from Paracoccidioides brasiliensis (see 2 papers)
    42% identity, 75% coverage of query (200 bits)

C1GTZ6 homoserine dehydrogenase (EC 1.1.1.3) from Paracoccidioides lutzii (see paper)
    42% identity, 75% coverage of query (200 bits)

Build an alignment

Build an alignment for N515DRAFT_0577 and 20 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

D8WXQ1 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
    29% identity, 91% coverage of query (109 bits)

DHOM_BACSU / P19582 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Bacillus subtilis (strain 168) (see paper)
P19582 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus subtilis (see paper)
    26% identity, 92% coverage of query (90.9 bits)

O58802 homoserine dehydrogenase (EC 1.1.1.3) from Pyrococcus horikoshii (see paper)
4xb1A / O58802 Hyperthermophilic archaeal homoserine dehydrogenase in complex with NADPH (see paper)
    25% identity, 90% coverage of query (89.7 bits)

D8WXQ2 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
    25% identity, 90% coverage of query (88.6 bits)

4xb2A Hyperthermophilic archaeal homoserine dehydrogenase mutant in complex with NADPH
    25% identity, 90% coverage of query (88.6 bits)

DHOM_LACLC / P52985 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Lactococcus lactis subsp. cremoris (Streptococcus cremoris) (see paper)
    28% identity, 70% coverage of query (79.3 bits)

DvMF_1412 homoserine dehydrogenase (EC 1.1.1.3) from Desulfovibrio vulgaris Miyazaki F
    28% identity, 92% coverage of query (77.0 bits)

hom / AAF21129.1 homoserine dehydrogenase from Methylobacillus flagellatus (see paper)
    26% identity, 91% coverage of query (75.9 bits)

Q56R01 homoserine dehydrogenase (EC 1.1.1.3) from Streptomyces clavuligerus (see paper)
    28% identity, 91% coverage of query (71.2 bits)

A0A0H2WVX4 homoserine dehydrogenase (EC 1.1.1.3) from Staphylococcus aureus (see 2 papers)
    22% identity, 92% coverage of query (64.3 bits)

4pg7A / A0A0M3KKV6 Crystal structure of s. Aureus homoserine dehydrogenase at ph7.5 (see paper)
    21% identity, 92% coverage of query (50.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory