Searching for up to 100 curated homologs for N515DRAFT_1248 N515DRAFT_1248 ABC-2 type transport system ATP-binding protein (315 a.a.)
Found high-coverage hits (≥70%) to 70 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YadG / b0127 putative ABC transporter ATP-binding protein YadG from Escherichia coli K-12 substr. MG1655 (see 7 papers)
YADG_ECOLI / P36879 Uncharacterized ABC transporter ATP-binding protein YadG from Escherichia coli (strain K12) (see paper)
yadG / MB|P36879 uncharacterized ABC transporter ATP-binding protein yadG from Escherichia coli K12 (see paper)
43% identity, 96% coverage of query (239 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
39% identity, 82% coverage of query (174 bits)
LNRL_BACSU / P94440 Linearmycin resistance ATP-binding protein LnrL; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 2 papers)
34% identity, 95% coverage of query (169 bits)
TC 3.A.1.105.2 / Q53716 OleC4, component of Oleandomycin (drug resistance) exporter from Streptomyces antibioticus (see paper)
34% identity, 95% coverage of query (162 bits)
nodI / GB|AAB16898.1 nodulation ATP-binding protein I from Rhizobium sp. N33 (see paper)
35% identity, 95% coverage of query (152 bits)
TC 3.A.1.105.8 / Q7UE58 ABC-type multidrug transport system, ATPase component, component of ABC-2 transporter from Rhodopirellula baltica (strain SH1)
37% identity, 75% coverage of query (151 bits)
ABCA7_RAT / Q7TNJ2 ATP-binding cassette sub-family A member 7 from Rattus norvegicus (Rat) (see paper)
39% identity, 71% coverage of query (150 bits)
ABCA7_MOUSE / Q91V24 ATP-binding cassette sub-family A member 7 from Mus musculus (Mouse) (see 10 papers)
39% identity, 71% coverage of query (145 bits)
sagG / GI|23305059 ABC transporter, ATP-binding protein SagG from Streptococcus iniae (see paper)
31% identity, 95% coverage of query (144 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
35% identity, 99% coverage of query (143 bits)
DRRA_STRPE / P32010 Daunorubicin/doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Streptomyces peucetius (see 2 papers)
P32010 ABC-type xenobiotic transporter (EC 7.6.2.2) from Streptomyces peucetius (see paper)
TC 3.A.1.105.1 / P32010 DrrA, component of Daunorubicin, doxorubicin etc. (multidrug resistance) exporter, DrrAB from Streptomyces peucetius (see 2 papers)
35% identity, 77% coverage of query (142 bits)
TC 3.A.1.105.4 / Q4VWC9 PltI, component of The pyoluteorin (a chlorinated polyketide) efflux pump, PltHIJKN (see 2 papers)
35% identity, 74% coverage of query (142 bits)
ABCA7_HUMAN / Q8IZY2 Phospholipid-transporting ATPase ABCA7; ABCA-SSN; ATP-binding cassette sub-family A member 7; Autoantigen SS-N; Macrophage ABC transporter; EC 7.6.2.1 from Homo sapiens (Human) (see 12 papers)
TC 3.A.1.211.10 / Q8IZY2 ABCA7. Regulates cellular efflux of phospholipids but not cholesterol, to apo A-1 from Homo sapiens (see 10 papers)
38% identity, 74% coverage of query (140 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
31% identity, 95% coverage of query (139 bits)
7roqA / O95477 Alternative structure of human abca1
30% identity, 98% coverage of query (138 bits)
ABCA5_HUMAN / Q8WWZ7 Cholesterol transporter ABCA5; ATP-binding cassette sub-family A member 5; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.9 / Q8WWZ7 ABCA5 of 1642 aas and 12 TMSs. It is related to lysosomal diseases and plays important roles, especially in cardiomyocytes and follicular cells (Kubo et al. 2005). It mediates cholesterol efflux to HDL3 (Voloshyna and Reiss, 2011) and functions in autolysosomes from Homo sapiens (see 3 papers)
38% identity, 71% coverage of query (137 bits)
TC 3.A.1.105.3 / Q70J75 CmrA, component of The 4A-4E-O-dideacetyl-chromomycin A3 (biosynthetic precursor of chromomycin) exporter (may also export chromomycin and mithramycin from Streptomyces griseus subsp. griseus
31% identity, 95% coverage of query (137 bits)
ABCA5_MOUSE / Q8K448 Cholesterol transporter ABCA5; ATP-binding cassette sub-family A member 5; EC 7.6.2.- from Mus musculus (Mouse) (see 7 papers)
37% identity, 71% coverage of query (137 bits)
ABCA5_RAT / Q8CF82 Cholesterol transporter ABCA5; ATP-binding cassette sub-family A member 5; EC 7.6.2.- from Rattus norvegicus (Rat) (see 2 papers)
37% identity, 71% coverage of query (135 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
33% identity, 74% coverage of query (135 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
30% identity, 98% coverage of query (134 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
36% identity, 72% coverage of query (134 bits)
TC 3.A.1.211.1 / P41233 The cholesterol/phospholipid flippase, ABC1 (called ABCA1 in humans; Tangier disease proteins; 2261 aas; sp: O95477). An amphipathic helical region of the N-terminal barrel of the phospholipid transfer protein (PLTP) is critical for ABCA1-dependent cholesterol efflux (Oram et al., 2008). PLTP helix 144-163 removes lipid domains formed by ABCA1, stabilizing ABCA1, interacting with phospholipids, and promoting phospholipid transfer by direct interactions with ABCA1. May transport sphingosine-1-phosphate (Kobayashi et al., 2009). May protect from cardiovascular disease and diabetes from Mus musculus (Mouse) (see 7 papers)
Abca1 ATP-binding cassette sub-family A member 1 from Mus musculus (see paper)
33% identity, 74% coverage of query (133 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
33% identity, 74% coverage of query (133 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
31% identity, 77% coverage of query (129 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
33% identity, 79% coverage of query (129 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
31% identity, 74% coverage of query (125 bits)
Build an alignment for N515DRAFT_1248 and 27 homologs with ≥ 30% identity
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ABCAD_MOUSE / Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
28% identity, 97% coverage of query (125 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
31% identity, 74% coverage of query (124 bits)
ECFA2_STRT2 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
31% identity, 83% coverage of query (124 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
32% identity, 71% coverage of query (122 bits)
YbhF / b0794 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
ybhF / P0A9U1 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli (strain K12) (see 6 papers)
YBHF_ECOLI / P0A9U1 Probable multidrug ABC transporter ATP-binding protein YbhF from Escherichia coli (strain K12) (see paper)
ybhF / MB|P0A9U1 uncharacterized ABC transporter ATP-binding protein ybhF from Escherichia coli K12 (see paper)
32% identity, 74% coverage of query (117 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
28% identity, 96% coverage of query (117 bits)
TC 3.A.1.211.3 / Q9BZC7 Multidrug resistance pump, ABCA2 (ABC2) from Homo sapiens (Human) (see 6 papers)
ABCA2 / GI|55962682 ATP-binding cassette sub-family A member 2 from Homo sapiens
28% identity, 96% coverage of query (117 bits)
ABCA2_MOUSE / P41234 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Mus musculus (Mouse) (see 5 papers)
28% identity, 96% coverage of query (117 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
31% identity, 72% coverage of query (116 bits)
ABCA2_RAT / Q9ESR9 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Rattus norvegicus (Rat) (see 6 papers)
28% identity, 96% coverage of query (114 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
31% identity, 71% coverage of query (112 bits)
ABCAC_HUMAN / Q86UK0 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; ATP-binding cassette transporter 12; ATP-binding cassette 12; EC 7.6.2.1 from Homo sapiens (Human) (see 16 papers)
TC 3.A.1.211.13 / Q86UK0 ABCA12 keratinocyte lipid transporter of 2595 aas from Homo sapiens
31% identity, 71% coverage of query (110 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
30% identity, 71% coverage of query (108 bits)
ABCA4_MOUSE / O35600 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Mus musculus (Mouse) (see 4 papers)
31% identity, 72% coverage of query (104 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
31% identity, 72% coverage of query (103 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
30% identity, 75% coverage of query (103 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
30% identity, 75% coverage of query (102 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
30% identity, 75% coverage of query (101 bits)
7lkzA Structure of atp-bound human abca4
30% identity, 75% coverage of query (100 bits)
7lkpA Structure of atp-free human abca4
31% identity, 74% coverage of query (100 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
30% identity, 72% coverage of query (99.8 bits)
7o12B / P19844 Abc transporter nosdfy, amppnp-bound in gdn (see paper)
29% identity, 95% coverage of query (99.4 bits)
7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc
28% identity, 95% coverage of query (98.6 bits)
ABCBA_MOUSE / Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 9 papers)
32% identity, 76% coverage of query (93.2 bits)
ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
31% identity, 70% coverage of query (90.1 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
30% identity, 70% coverage of query (87.8 bits)
7qkrA / F2QQK6 Cryo-em structure of abc transporter ste6-2p from pichia pastoris with verapamil at 3.2 a resolution (see paper)
26% identity, 74% coverage of query (85.1 bits)
8dncA Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen and adp
26% identity, 73% coverage of query (81.6 bits)
8dkuA / O67181 Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen (see paper)
26% identity, 73% coverage of query (81.6 bits)
7oz1A Cryo-em structure of abcg1 e242q mutant with atp and cholesteryl hemisuccinate bound
28% identity, 70% coverage of query (81.6 bits)
7r89B / Q9H221 The structure of human abcg5/abcg8 purified from yeast (see paper)
26% identity, 92% coverage of query (78.6 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
29% identity, 73% coverage of query (75.9 bits)
ABCB6_MOUSE / Q9DC29 ATP-binding cassette sub-family B member 6; ABC-type heme transporter ABCB6; EC 7.6.2.5 from Mus musculus (Mouse) (see 7 papers)
27% identity, 70% coverage of query (74.7 bits)
3vx4D / Q8DW05 Crystal structure of the nucleotide-binding domain of s. Mutans coma, a bifunctional atp-binding cassette transporter involved in the quorum-sensing pathway (see paper)
26% identity, 70% coverage of query (72.4 bits)
3nh9A Nucleotide binding domain of human abcb6 (atp bound structure)
26% identity, 70% coverage of query (72.0 bits)
ABC3_SCHPO / Q9P5N0 Vacuolar heme ABC transmembrane exporter abc3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 4 papers)
TC 3.A.1.208.28 / Q9P5N0 Vacuolar iron transporter, Abc3(+) of 1465 aas from Schizosaccharomyces pombe (strain 972 / ATCC 24843)
abc3 ABC transporter Abc3, unknown specificity from Schizosaccharomyces pombe (see paper)
25% identity, 73% coverage of query (70.9 bits)
MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
28% identity, 71% coverage of query (69.7 bits)
7dv5U / O95342 Human bile salt exporter abcb11 in complex with taurocholate (see paper)
28% identity, 70% coverage of query (67.4 bits)
8bwrA Cryo-em structure of nanodisc-reconstituted wildtype human mrp4 (in complex with prostaglandin e2)
23% identity, 73% coverage of query (45.1 bits)
8bwqA Cryo-em structure of nanodisc-reconstituted wildtype human mrp4 (in complex with topotecan)
23% identity, 73% coverage of query (45.1 bits)
8bwpA Cryo-em structure of nanodisc-reconstituted wildtype human mrp4 (in complex with methotrexate)
23% identity, 73% coverage of query (45.1 bits)
8bjfA / O15439 Cryo-em structure of nanodisc-reconstituted wildtype human mrp4 (inward-facing conformation) (see paper)
23% identity, 73% coverage of query (45.1 bits)
8bwoA Cryo-em structure of nanodisc-reconstituted human mrp4 with e1202q mutation (outward-facing occluded conformation)
23% identity, 73% coverage of query (43.5 bits)
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Lawrence Berkeley National Laboratory