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Searching for up to 100 curated homologs for N515DRAFT_2996 FitnessBrowser__Dyella79:N515DRAFT_2996 (286 a.a.)

Found high-coverage hits (≥70%) to 64 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3w6zA / A3MU08 Crystal structure of NADP bound l-serine 3-dehydrogenase (k170m) from hyperthermophilic archaeon pyrobaculum calidifontis (see paper)
    39% identity, 97% coverage of query (164 bits)

3ws7A The 1.18 a resolution structure of l-serine 3-dehydrogenase complexed with NADP+ and sulfate ion from the hyperthermophilic archaeon pyrobaculum calidifontis
    39% identity, 97% coverage of query (158 bits)

1wp4A Structure of tt368 protein from thermus thermophilus hb8
    39% identity, 98% coverage of query (158 bits)

Q5SLQ6 3-hydroxypropionate dehydrogenase (NADP+) (EC 1.1.1.298) from Thermus thermophilus (see paper)
2cvzC / Q5SLQ6 Structure of hydroxyisobutyrate dehydrogenase from thermus thermophilus hb8 (see paper)
    39% identity, 98% coverage of query (157 bits)

YKWC_BACSU / O34948 Uncharacterized oxidoreductase YkwC; EC 1.1.-.- from Bacillus subtilis (strain 168) (see paper)
    32% identity, 98% coverage of query (145 bits)

Q8ZLV8 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    35% identity, 98% coverage of query (142 bits)

hgd / Q0QLF5 2-(hydroxymethyl)glutarate dehydrogenase subunit (EC 1.1.1.291) from Eubacterium barkeri (see paper)
HMGD_EUBBA / Q0QLF5 2-(hydroxymethyl)glutarate dehydrogenase; EC 1.1.1.291 from Eubacterium barkeri (Clostridium barkeri) (see 2 papers)
    31% identity, 99% coverage of query (134 bits)

YbbQ / b0509 tartronate semialdehyde reductase 2 from Escherichia coli K-12 substr. MG1655 (see 5 papers)
glxR / P77161 tartronate semialdehyde reductase 2 from Escherichia coli (strain K12) (see 3 papers)
    36% identity, 84% coverage of query (133 bits)

YhaE / b3125 tartronate semialdehyde reductase (EC 1.1.1.60) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
garR / P0ABQ2 tartronate semialdehyde reductase (EC 1.1.1.60) from Escherichia coli (strain K12) (see 2 papers)
GARR_ECOLI / P0ABQ2 2-hydroxy-3-oxopropionate reductase; Tartronate semialdehyde reductase; TSAR; EC 1.1.1.60 from Escherichia coli (strain K12) (see 2 papers)
    34% identity, 97% coverage of query (132 bits)

3pefA / Q39R98 Crystal structure of gamma-hydroxybutyrate dehydrogenase from geobacter metallireducens in complex with NADP+ (see paper)
    32% identity, 97% coverage of query (129 bits)

5je8B / Q81DR6 The crystal structure of bacillus cereus 3-hydroxyisobutyrate dehydrogenase in complex with NAD (see paper)
    30% identity, 97% coverage of query (124 bits)

3q3cA Crystal structure of a serine dehydrogenase from pseudomonas aeruginosa pao1 in complex with NAD
    36% identity, 98% coverage of query (123 bits)

SERDH_PSEAE / Q9I5I6 NAD-dependent L-serine dehydrogenase; L-serine 3-dehydrogenase (NAD(+)); EC 1.1.1.387 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I5I6 L-serine 3-dehydrogenase (NAD+) (EC 1.1.1.387) from Pseudomonas aeruginosa (see paper)
    36% identity, 98% coverage of query (122 bits)

3obbA / Q9I5I6 Crystal structure of a possible 3-hydroxyisobutyrate dehydrogenase from pseudomonas aeruginosa pao1 (see paper)
    36% identity, 98% coverage of query (115 bits)

3pduA / Q74DE4 Crystal structure of gamma-hydroxybutyrate dehydrogenase from geobacter sulfurreducens in complex with NADP+ (see paper)
    30% identity, 97% coverage of query (113 bits)

7puaFM / C9ZJW2 7puaFM (see paper)
    32% identity, 78% coverage of query (112 bits)

MMSB_PSEAE / P28811 3-hydroxyisobutyrate dehydrogenase; HIBADH; EC 1.1.1.31 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
mmsB / AAA25892.1 3-hydroxyisobutyrate dehydrogenase from Pseudomonas aeruginosa (see paper)
    35% identity, 83% coverage of query (112 bits)

Build an alignment

Build an alignment for N515DRAFT_2996 and 17 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

GLYR2_ARATH / F4I907 Glyoxylate/succinic semialdehyde reductase 2, chloroplastic; AtGLYR2; AtGR2; SSA reductase 2; EC 1.1.1.79; EC 1.1.1.n11 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
F4I907 glyoxylate reductase (NADP+) (EC 1.1.1.79) from Arabidopsis thaliana (see 2 papers)
    28% identity, 98% coverage of query (110 bits)

mmsB / Q76KL5 3-hydroxyisobutyrate dehydrogenase subunit (EC 1.1.1.31) from Pseudomonas putida (see 5 papers)
Q76KL5 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas putida (see paper)
    32% identity, 99% coverage of query (108 bits)

5y8iA / P9WNY5 Mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase (mthibadh) + (s)-3-hydroxyisobutyrate (s-hiba) (see paper)
    32% identity, 98% coverage of query (107 bits)

GLYR1 / Q9LSV0 succinate semialdehyde reductase (NADPH) from Arabidopsis thaliana (see paper)
GLYR1_ARATH / Q9LSV0 Glyoxylate/succinic semialdehyde reductase 1; AtGLYR1; AtGR1; SSA reductase 1; Gamma-hydroxybutyrate dehydrogenase; AtGHBDH; EC 1.1.1.79; EC 1.1.1.n11 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
Q9LSV0 glyoxylate reductase (EC 1.1.1.26); 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61); glyoxylate reductase (NADP+) (EC 1.1.1.79) from Arabidopsis thaliana (see 5 papers)
    28% identity, 96% coverage of query (106 bits)

5y8hA Mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase (mthibadh) + NAD+
    32% identity, 98% coverage of query (106 bits)

SSR1 / B1Q3F6 NAD-dependent succinate semialdehyde dehydrogenase (EC 1.2.1.24) from Solanum lycopersicum (see paper)
    26% identity, 96% coverage of query (105 bits)

2i9pB / P31937 Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+
    29% identity, 98% coverage of query (104 bits)

3HIDH_HUMAN / P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial; HIBADH; EC 1.1.1.31 from Homo sapiens (Human) (see paper)
    29% identity, 98% coverage of query (104 bits)

5y8lB Mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase (mthibadh) + NAD +(s)-3-hydroxyisobutyrate (s-hiba)
    32% identity, 98% coverage of query (104 bits)

5y8kA Mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase (mthibadh) + l-serine
    32% identity, 98% coverage of query (104 bits)

Psest_2438 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas stutzeri RCH2
    33% identity, 98% coverage of query (103 bits)

D5MU22 aldehyde oxidase (EC 1.2.3.1) from Pseudomonas sp. (see paper)
    33% identity, 99% coverage of query (103 bits)

2uyyA / Q49A26 Structure of the cytokine-like nuclear factor n-pac
    26% identity, 97% coverage of query (102 bits)

P29266 3-hydroxyisobutyrate dehydrogenase, mitochondrial; HIBADH; EC 1.1.1.31 from Rattus norvegicus (Rat)
    28% identity, 98% coverage of query (102 bits)

GLYR1_HUMAN / Q49A26 Cytokine-like nuclear factor N-PAC; NPAC; 3-hydroxyisobutyrate dehydrogenase-like protein; Glyoxylate reductase 1 homolog; Nuclear protein NP60; Nuclear protein of 60 kDa; Nucleosome-destabilizing factor; hNDF; Putative oxidoreductase GLYR1 from Homo sapiens (Human) (see 7 papers)
    28% identity, 97% coverage of query (100 bits)

AO353_05985 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas fluorescens FW300-N2E3
    33% identity, 99% coverage of query (99.0 bits)

GLYR1_MOUSE / Q922P9 Cytokine-like nuclear factor N-PAC; NPAC; Glyoxylate reductase 1 homolog; Nuclear protein NP60; Putative oxidoreductase GLYR1 from Mus musculus (Mouse) (see 2 papers)
    29% identity, 97% coverage of query (94.7 bits)

PfGW456L13_5145 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas fluorescens GW456-L13
    32% identity, 99% coverage of query (93.2 bits)

2w90B Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase with bound 6-phosphogluconate (see paper)
    33% identity, 73% coverage of query (92.0 bits)

gndA / P80859 6-phosphogluconate dehydrogenase (decarboxylating) (EC 1.1.1.44) from Bacillus subtilis (strain 168) (see paper)
6PGD_BACSU / P80859 6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating; GNTZII; EC 1.1.1.44 from Bacillus subtilis (strain 168) (see paper)
P80859 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Bacillus subtilis (see paper)
    30% identity, 73% coverage of query (92.0 bits)

LTND_ECOL6 / A0A0H2VA68 L-threonate dehydrogenase; EC 1.1.1.411 from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see paper)
    30% identity, 98% coverage of query (90.5 bits)

A0A1I9LPQ6 hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see paper)
    29% identity, 70% coverage of query (89.7 bits)

YgbJ / b2736 putative L-threonate dehydrogenase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
    32% identity, 70% coverage of query (86.7 bits)

LTND_CUPNH / Q0KBC7 L-threonate dehydrogenase; EC 1.1.1.411 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
Q0KBC7 L-threonate 2-dehydrogenase (EC 1.1.1.411) from Cupriavidus necator (see paper)
    31% identity, 99% coverage of query (85.9 bits)

6smyA Crystal structure of sla reductase yihu from e. Coli with nadh and product dhps
    27% identity, 98% coverage of query (84.0 bits)

6smzC / P0A9V8 Crystal structure of sla reductase yihu from e. Coli in complex with nadh
    27% identity, 98% coverage of query (83.6 bits)

SquU / b3882 3-sulfolactaldehyde reductase (EC 1.1.1.373; EC 1.1.1.61) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yihU / P0A9V8 3-sulfolactaldehyde reductase (EC 1.1.1.373; EC 1.1.1.61) from Escherichia coli (strain K12) (see 3 papers)
SQUU_ECOLI / P0A9V8 3-sulfolactaldehyde reductase; SLA reductase; 4-hydroxybutyrate dehydrogenase; Gamma-hydroxybutyrate dehydrogenase; GHBDH; Succinic semialdehyde reductase; SSA reductase; EC 1.1.1.373; EC 1.1.1.61 from Escherichia coli (strain K12) (see 2 papers)
P0A9V8 sulfolactaldehyde 3-reductase (EC 1.1.1.373); 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) from Escherichia coli (see 2 papers)
    27% identity, 98% coverage of query (83.6 bits)

7cb2A The 6-phosphogluconate dehydrogenase (NADP-bound) from staphylococcus aureus
    31% identity, 78% coverage of query (83.2 bits)

7cb5B / A0A0H3KGN1 The 6-phosphogluconate dehydrogenase from staphylococcus aureus (6- phosphogluconate bound) (see paper)
    31% identity, 78% coverage of query (82.8 bits)

P96789 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Lactococcus lactis (see paper)
    32% identity, 73% coverage of query (82.0 bits)

P96789 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Lactococcus lactis subsp. cremoris (strain MG1363)
    32% identity, 73% coverage of query (82.0 bits)

2iz1B / P96789 6pdh complexed with pex inhibitor synchrotron data (see paper)
    32% identity, 73% coverage of query (81.6 bits)

2iypA Product rup
    32% identity, 73% coverage of query (81.6 bits)

2iyoA Structural characterization of a bacterial 6pdh reveals aspects of specificity, mechanism and mode of inhibition
    32% identity, 73% coverage of query (81.6 bits)

2iypB Product rup
    32% identity, 73% coverage of query (81.3 bits)

6PGDH_BACSU / P12013 6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating; EC 1.1.1.343 from Bacillus subtilis (strain 168) (see paper)
P12013 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) (EC 1.1.1.343) from Bacillus subtilis (see paper)
    31% identity, 73% coverage of query (77.4 bits)

6PGD2_YEAST / P53319 6-phosphogluconate dehydrogenase, decarboxylating 2; EC 1.1.1.44 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    28% identity, 73% coverage of query (70.5 bits)

GLYR1_DROME / Q8T079 Cytokine-like nuclear factor N-PAC; NPAC; Glyoxylate reductase 1 homolog; Nuclear protein NP60 homolog; Nucleosome-destabilizing factor; Putative oxidoreductase GLYR1 homolog from Drosophila melanogaster (Fruit fly) (see 2 papers)
    25% identity, 97% coverage of query (69.3 bits)

6fqzA Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate
    24% identity, 73% coverage of query (56.6 bits)

6fqyA / Q8IKT2 Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate (see paper)
    24% identity, 73% coverage of query (56.6 bits)

7y8lA Structure of scired-r2-v3 from streptomyces clavuligerus in complex with 5-(2,5-difluorophenyl)-3,4-dihydro-2h-pyrrole
    25% identity, 98% coverage of query (49.7 bits)

7y8lC Structure of scired-r2-v3 from streptomyces clavuligerus in complex with 5-(2,5-difluorophenyl)-3,4-dihydro-2h-pyrrole
    25% identity, 98% coverage of query (49.3 bits)

7y8mB Structure of scired-r2-v3 from streptomyces clavuligerus in complex with 5-(3-fluorophenyl)-3,4-dihydro-2h-pyrrole
    25% identity, 98% coverage of query (49.3 bits)

6smtB / A0R5X0 S-enantioselective imine reductase from mycobacterium smegmatis (see paper)
    27% identity, 70% coverage of query (47.4 bits)

8jytC Ancestral imine reducatase n560
    28% identity, 97% coverage of query (46.6 bits)

3zhbD / Q1EQE0 R-imine reductase from streptomyces kanamyceticus in complex with NADP. (see paper)
    27% identity, 72% coverage of query (45.1 bits)

8a3xA / A0A0L8BGL4 Imine reductase from ensifer adhaerens in complex with NADP+ (see paper)
    24% identity, 100% coverage of query (43.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory