Searching for up to 100 curated homologs for N515DRAFT_4364 FitnessBrowser__Dyella79:N515DRAFT_4364 (362 a.a.)

Found high-coverage hits (≥70%) to 32 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

MetM / b3940 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
metL / P00562 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 9 papers)
    41% identity, 93% coverage of query (239 bits)

AKH1_ARATH / Q9SA18 Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic; AK-HD 1; AK-HSDH 1; Beta-aspartyl phosphate homoserine 1; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    41% identity, 87% coverage of query (235 bits)

AAA16972.1 aspartokinase-homoserine dehydrogenase, partial from Daucus carota (see paper)
    39% identity, 94% coverage of query (234 bits)

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    39% identity, 94% coverage of query (231 bits)

O63067 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max (see paper)
    38% identity, 94% coverage of query (227 bits)

Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    35% identity, 100% coverage of query (214 bits)

thrA1A2 / CAA43212.1 aspartate kinase from Serratia marcescens (see paper)
    39% identity, 86% coverage of query (209 bits)

ThrD / b0002 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
thrA / P00561 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 33 papers)
P00561 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Escherichia coli (see paper)
    38% identity, 86% coverage of query (205 bits)

CA265_RS23475 aspartate kinase; homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Pedobacter sp. GW460-11-11-14-LB5
    33% identity, 93% coverage of query (201 bits)

DHOM_YEAST / P31116 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
    38% identity, 93% coverage of query (196 bits)

1ebfA / P31116 Homoserine dehydrogenase from s. Cerevisiae complex with NAD+ (see paper)
    38% identity, 93% coverage of query (196 bits)

1tveA Homoserine dehydrogenase in complex with 4-(4-hydroxy-3- isopropylphenylthio)-2-isopropylphenol
    38% identity, 93% coverage of query (196 bits)

1q7gA Homoserine dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-oxonorvaline
    38% identity, 93% coverage of query (196 bits)

1ebuD Homoserine dehydrogenase complex with NAD analogue and l-homoserine
    38% identity, 93% coverage of query (196 bits)

BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Bacteroides thetaiotaomicron VPI-5482
    35% identity, 93% coverage of query (191 bits)

DHOM_EMENI / Q5B998 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
AN2882 homoserine dehydrogenase; EC 1.1.1.3 from Emericella nidulans (see paper)
    41% identity, 72% coverage of query (188 bits)

Q5AIA2 homoserine dehydrogenase (EC 1.1.1.3) from Candida albicans (see 2 papers)
    33% identity, 93% coverage of query (186 bits)

O94671 Probable homoserine dehydrogenase; HDH; EC 1.1.1.3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    34% identity, 95% coverage of query (177 bits)

C1G1C3 homoserine dehydrogenase (EC 1.1.1.3) from Paracoccidioides brasiliensis (see 2 papers)
    39% identity, 72% coverage of query (175 bits)

C1GTZ6 homoserine dehydrogenase (EC 1.1.1.3) from Paracoccidioides lutzii (see paper)
    39% identity, 72% coverage of query (174 bits)

Q3S3F6 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max (see paper)
    33% identity, 93% coverage of query (169 bits)

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Build an alignment for N515DRAFT_4364 and 21 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

6a0sA Homoserine dehydrogenase from thermus thermophilus hb8 complexed with hse and NADPH
    29% identity, 83% coverage of query (81.6 bits)

2ejwA Homoserine dehydrogenase from thermus thermophilus hb8
    29% identity, 83% coverage of query (81.6 bits)

Q5SL04 homoserine dehydrogenase (EC 1.1.1.3) from Thermus thermophilus (see paper)
6a0tB / Q5SL04 Homoserine dehydrogenase k99a mutant from thermus thermophilus hb8 complexed with hse and NADP+ (see paper)
    29% identity, 83% coverage of query (81.3 bits)

hom / AAF21129.1 homoserine dehydrogenase from Methylobacillus flagellatus (see paper)
    27% identity, 93% coverage of query (80.9 bits)

D8WXQ2 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
    26% identity, 94% coverage of query (75.1 bits)

F9VNG5 homoserine dehydrogenase (EC 1.1.1.3) from Sulfurisphaera tokodaii (see paper)
    24% identity, 93% coverage of query (75.1 bits)

D8WXQ1 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
    26% identity, 93% coverage of query (74.7 bits)

5x9dA / F9VNG5 Crystal structure of homoserine dehydrogenase in complex with l- cysteine and NAD (see paper)
    24% identity, 93% coverage of query (72.4 bits)

7f4cA The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon sulfurisphaera tokodaii.
    24% identity, 93% coverage of query (72.4 bits)

Q9WZ17 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Thermotoga maritima (see paper)
    24% identity, 92% coverage of query (68.9 bits)

Q56R01 homoserine dehydrogenase (EC 1.1.1.3) from Streptomyces clavuligerus (see paper)
    28% identity, 94% coverage of query (57.8 bits)

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