Searching for up to 100 curated homologs for N515DRAFT_4366 FitnessBrowser__Dyella79:N515DRAFT_4366 (554 a.a.)
Found high-coverage hits (≥70%) to 52 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
BPHYT_RS17540 L-aspartate/L-glutamate/L-glutamine:H+ symporter from Burkholderia phytofirmans PsJN
63% identity, 96% coverage of query (679 bits)
AIMA_BACSU / Q45577 Glutamate/serine transporter AimA; Amino acid importer A from Bacillus subtilis (strain 168) (see 2 papers)
57% identity, 96% coverage of query (634 bits)
ASPP_BACSU / O07002 Aspartate-proton symporter; L-aspartate transporter from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.11.1 / O07002 The aspartate uptake permease, YveA from Bacillus subtilis (see 3 papers)
36% identity, 95% coverage of query (295 bits)
Build an alignment for N515DRAFT_4366 and 3 homologs with ≥ 30% identity
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BCAP_BACSU / O07576 Branched-chain amino acid permease BcaP; BCAA permease from Bacillus subtilis (strain 168) (see 4 papers)
25% identity, 82% coverage of query (108 bits)
MTRTR_BACSU / Q797A7 Methylthioribose transporter from Bacillus subtilis (strain 168) (see paper)
23% identity, 82% coverage of query (105 bits)
6f34A / Q5L1G5 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. (see paper)
23% identity, 77% coverage of query (102 bits)
5oqtA Crystal structure of a bacterial cationic amino acid transporter (cat) homologue
23% identity, 77% coverage of query (102 bits)
6f2wA / A8UCQ5 Bacterial asc transporter crystal structure in open to in conformation (see paper)
26% identity, 81% coverage of query (95.1 bits)
TC 2.A.3.8.2 / O13020 L-type neutral amino acid transporter, ASUR4 (Na+-independent) of 507 aas and 12 TMSs. Pregabalin (PGB), a drug for the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder, may be transported by L-type transporters from Xenopus laevis (African clawed frog) (see 2 papers)
25% identity, 79% coverage of query (93.2 bits)
SLC7A5 / Q01650 large neutral amino acids transporter small subunit 1 from Homo sapiens (see 4 papers)
LAT1_HUMAN / Q01650 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) (see 19 papers)
TC 2.A.3.8.25 / Q01650 Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain; SLC3A2) (Integral membrane protein E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic and neutral amino acid transporter) from Homo sapiens (see 24 papers)
25% identity, 78% coverage of query (90.1 bits)
LAT1_RABIT / Q7YQK4 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; L-type amino acid transporter 1; LAT1; Solute carrier family 7 member 5 from Oryctolagus cuniculus (Rabbit) (see 4 papers)
26% identity, 78% coverage of query (90.1 bits)
6irtB Human lat1-4f2hc complex bound with bch
25% identity, 78% coverage of query (90.1 bits)
7dskB / Q01650 Overall structure of the lat1-4f2hc bound with jx-075 (see paper)
25% identity, 78% coverage of query (89.7 bits)
7dsqB Overall structure of the lat1-4f2hc bound with 3,5-diiodo-l-tyrosine
25% identity, 78% coverage of query (89.7 bits)
7dsnB Overall structure of the lat1-4f2hc bound with jx-119
25% identity, 78% coverage of query (89.7 bits)
7dslB Overall structure of the lat1-4f2hc bound with jx-078
25% identity, 78% coverage of query (89.7 bits)
YhfM / b3370 fructoselysine/psicoselysine transporter from Escherichia coli K-12 substr. MG1655 (see 4 papers)
frlA / P45539 fructoselysine/psicoselysine transporter from Escherichia coli (strain K12) (see 4 papers)
FRLA_ECOLI / P45539 Probable fructoselysine/psicoselysine transporter FrlA from Escherichia coli (strain K12) (see paper)
25% identity, 84% coverage of query (88.6 bits)
N515DRAFT_2924 L-proline transporter from Dyella japonica UNC79MFTsu3.2
25% identity, 76% coverage of query (88.6 bits)
TC 2.A.3.8.9 / Q19834 Heteromeric amino acid transporter #1 (transports most neutral aas with highest rates for Ala and Ser (Km≈100 μM)). They function by obligatory aa:aa exchange (Veljkovic et al., 2004b) (see paper)
25% identity, 79% coverage of query (85.1 bits)
LAT1_RAT / Q63016 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; Integral membrane protein E16; Protein TA1; L-type amino acid transporter 1; LAT-1; Solute carrier family 7 member 5 from Rattus norvegicus (Rat) (see 8 papers)
TC 2.A.3.8.1 / Q63016 L-type neutral amino acid transporter, LAT1 (Na+-independent) (prefers amino acids with branched or aromatic side chains: Phe, Ile, Leu, Val, Trp, His; catalyzes obligatory exchange with μM affinities on the outside and mM affinities on the inside [1000x difference]). Both LAT1 and LAT2 (2.A.3.8.6) catalyze uptake of S-nitroso-L-cysteine. These and other LAT family members are specifically inhibited by 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (Li and Whorton, 2005). Mediates tryptophan:kynurenine exchange (Kaper et al., 2007). Also transports thyroid hormones and their derivatives from Rattus norvegicus (Rat) (see 6 papers)
25% identity, 78% coverage of query (84.7 bits)
LAT2_MOUSE / Q9QXW9 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; mLAT2; Solute carrier family 7 member 8 from Mus musculus (Mouse) (see 6 papers)
26% identity, 83% coverage of query (84.3 bits)
LAT1_MOUSE / Q9Z127 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; L-type amino acid transporter 1; LAT1; Solute carrier family 7 member 5 from Mus musculus (Mouse) (see 4 papers)
24% identity, 78% coverage of query (84.0 bits)
LAT2_RAT / Q9WVR6 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; Solute carrier family 7 member 8 from Rattus norvegicus (Rat) (see 4 papers)
TC 2.A.3.8.6 / Q9WVR6 L-type neutral amino acid transporter, LAT2 (Na+-independent with broad specificity for all L-isomers of neutral amino acids; preferred substrate: Phe, His, Trp, Ile, Val, Leu, Gln, Cys, Ser; catalyzes obligatory exchange with μM affinities on the outside and mM affinities on the inside [1000x difference]). Both LAT2 and LAT1 (2.A.3.8.1) catalyze uptake of S-nitro-L-cysteine (Li and Whorton, 2005). Also transports thyroid hormones from Rattus norvegicus (Rat) (see 3 papers)
26% identity, 83% coverage of query (84.0 bits)
LAT2_RABIT / Q9N1Q4 Large neutral amino acids transporter small subunit 2; 4F2-LC5; L-type amino acid transporter 2; Solute carrier family 7 member 8 from Oryctolagus cuniculus (Rabbit) (see paper)
26% identity, 82% coverage of query (84.0 bits)
SLC7A8 / Q9UHI5 large neutral amino acids transporter small subunit 2 from Homo sapiens (see 4 papers)
LAT2_HUMAN / Q9UHI5 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) (see 14 papers)
TC 2.A.3.8.20 / Q9UHI5 Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8). Certain detergents stabilize and allow purification of the 4F2hc-LAT2 complex, allowing the measurement of substrate binding. In addition, an improved 3D map could be obtained from Homo sapiens (see 12 papers)
26% identity, 82% coverage of query (83.6 bits)
7b00A Human lat2-4f2hc complex in the apo-state
26% identity, 80% coverage of query (82.4 bits)
7cmhB / Q9UHI5 The lat2-4f2hc complex in complex with tryptophan (see paper)
26% identity, 80% coverage of query (82.0 bits)
CAAT9_ARATH / Q9C5D6 Cationic amino acid transporter 9, chloroplastic from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 71% coverage of query (82.0 bits)
7cmiB The lat2-4f2hc complex in complex with leucine
26% identity, 80% coverage of query (82.0 bits)
CAAT1_ARATH / Q84MA5 Cationic amino acid transporter 1; Amino acid transporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
23% identity, 79% coverage of query (79.3 bits)
CAAT5_ARATH / O64759 Cationic amino acid transporter 5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.12 / O64759 Cationic amino acid transporter 5 from Arabidopsis thaliana (see 3 papers)
23% identity, 78% coverage of query (75.5 bits)
PheP / b0576 phenylalanine:H+ symporter PheP from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pheP / P24207 phenylalanine:H+ symporter PheP from Escherichia coli (strain K12) (see 3 papers)
PHEP_ECOLI / P24207 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) (see 6 papers)
TC 2.A.3.1.1 / P24207 Phenylalanine:H+ symporter, PheP of 458 aas and 12 established TMSs from Escherichia coli (see 6 papers)
25% identity, 82% coverage of query (75.1 bits)
BAT1_RABIT / Q9N1R6 b(0,+)-type amino acid transporter 1; b(0,+)AT; 4F2-LC6; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Oryctolagus cuniculus (Rabbit) (see paper)
23% identity, 82% coverage of query (74.7 bits)
AAA1_MOUSE / P63115 Asc-type amino acid transporter 1; Asc-1; D-serine transporter; Solute carrier family 7 member 10 from Mus musculus (Mouse) (see 5 papers)
AAA1_RAT / P63116 Asc-type amino acid transporter 1; Asc-1; D-serine transporter; Solute carrier family 7 member 10 from Rattus norvegicus (Rat) (see paper)
TC 2.A.3.8.13 / P63115 The Asc-type small neutral D- and L-amino acid:H+ symport transporter-1, Asc-1 (Slc7a10). Also transports amino acid related compounds. Heterodimeric; associates with 4F2hc (TC# 8.A.9.2.1) Most highly expressed in brain and lung, but to a lesser degree in placenta and small intestine. from Mus musculus (Mouse) (see 3 papers)
Slc7a10 Asc-type amino acid transporter 1 from Mus musculus (see paper)
24% identity, 73% coverage of query (72.4 bits)
STET_BACSU / O34739 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.8.12 / O34739 The Ser/Thr exchange transporter (SteT) (also transports aromatic amino acids with lower efficiency) (Reig et al., 2007). The substrate-bound state of SteT shows increased conformational flexibility and kinetic stability, enabling transport of substrate across the cell membrane (Bippes et al. 2009). TMS8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT (Bartoccioni et al., 2010). Mutations allow substrate binding but not translocation. Other mutations stabilize the protein and result in higher production levels from Bacillus subtilis (see 2 papers)
24% identity, 81% coverage of query (72.4 bits)
Ga0059261_1577 L-glutamine and L-histidine transporter from Sphingomonas koreensis DSMZ 15582
27% identity, 71% coverage of query (72.4 bits)
TC 2.A.3.8.11 / Q50E62 The aromatic-preferring amino acid transporter (ArpAT or Slc7a15). Functions with rBAT or 4F2hc (8.A.9) and transports preferentially tyr and 3,4-dihydroxyphenylalanine (L-DOPA), but also ala, glu, ser, cys and arg by a Na+-independent mechanism (present in mouse, rat, dog and chicken, but silenced in humans and chimps)(Fernández et al., 2005; Sato et al., 2005) from Mus musculus (Mouse) (see 2 papers)
24% identity, 81% coverage of query (72.4 bits)
AroR / b0112 aromatic amino acid:H+ symporter AroP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
aroP / P15993 aromatic amino acid:H+ symporter AroP from Escherichia coli (strain K12) (see 6 papers)
AROP_ECOLI / P15993 Aromatic amino acid transport protein AroP; Aromatic amino acid:H(+) symporter AroP; General aromatic amino acid permease; General aromatic transport system from Escherichia coli (strain K12) (see 8 papers)
TC 2.A.3.1.3 / P15993 Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan from Escherichia coli (see 6 papers)
26% identity, 71% coverage of query (71.6 bits)
GABP_BACSU / P46349 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) (see 3 papers)
TC 2.A.3.1.5 / P46349 β-alanine/γ-aminobutyrate/proline/3,4-dehydroproline:H+ symporter, GabP from Bacillus subtilis (see 4 papers)
gabP / AAC44641.1 gamma-aminobutyrate permease from Bacillus subtilis (see 2 papers)
25% identity, 72% coverage of query (71.2 bits)
BAT1_MOUSE / Q9QXA6 b(0,+)-type amino acid transporter 1; b(0,+)AT1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Mus musculus (Mouse) (see 2 papers)
23% identity, 82% coverage of query (71.2 bits)
gabP / AAB62306.1 GabP from Bacillus subtilis (see 4 papers)
25% identity, 72% coverage of query (70.9 bits)
LYSP_LACLM / A2RNZ6 Lysine-specific permease LysP; Lysine transporter LysP from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
26% identity, 82% coverage of query (70.9 bits)
BAT1_HUMAN / P82251 b(0,+)-type amino acid transporter 1; b(0,+)AT1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Homo sapiens (Human) (see 16 papers)
TC 2.A.3.8.19 / P82251 B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9) from Homo sapiens (see 9 papers)
22% identity, 82% coverage of query (70.9 bits)
6li9B / P82251 Heteromeric amino acid transporter b0,+at-rbat complex bound with arginine (see paper)
23% identity, 79% coverage of query (69.7 bits)
TC 2.A.3.8.29 / F1R8V8 Cationic amino acid transporter, y+LAT1 from Danio rerio
24% identity, 81% coverage of query (69.3 bits)
XCT_MOUSE / Q9WTR6 Cystine/glutamate transporter; Amino acid transport system xc-; Solute carrier family 7 member 11; Subtle gray protein; xCT from Mus musculus (Mouse) (see 8 papers)
TC 2.A.3.8.5 / Q9WTR6 Cystine/glutamate antiporter, xCT (requires the 4F2hc protein (TC #8.A.9.2.1)). Functions in the generation of glutathione and plays a role in the oxidative stress response from Mus musculus (Mouse) (see 3 papers)
24% identity, 78% coverage of query (68.9 bits)
H281DRAFT_04042 phenylacetate transporter from Paraburkholderia bryophila 376MFSha3.1
24% identity, 71% coverage of query (68.9 bits)
SLC7A11 / Q9UPY5 cystine/glutamate transporter from Homo sapiens (see paper)
XCT_HUMAN / Q9UPY5 Cystine/glutamate transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT from Homo sapiens (Human) (see 9 papers)
TC 2.A.3.8.18 / Q9UPY5 Cystine/glutamate antiporter (Amino acid transport system xCT) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) from Homo sapiens (see 7 papers)
24% identity, 73% coverage of query (68.9 bits)
TC 2.A.3.1.18 / K7VV21 The lysine specific transporter, LysP of 488 aas and 12 TMSs from Lactococcus lactis subsp. cremoris UC509.9
26% identity, 82% coverage of query (67.4 bits)
CTR1_HUMAN / P30825 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor homolog; Ecotropic retrovirus receptor homolog; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Homo sapiens (Human) (see 4 papers)
TC 2.A.3.3.9 / P30825 High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homologue) (Ecotropic retrovirus receptor homologue) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) from Homo sapiens (see 6 papers)
23% identity, 72% coverage of query (66.6 bits)
7nf6B / A0A6P3EL78 Ovine b0,+at-rbat heterodimer (see paper)
22% identity, 81% coverage of query (63.2 bits)
6jmqA / Q01650 Lat1-cd98hc complex bound to mem-108 fab (see paper)
23% identity, 78% coverage of query (58.2 bits)
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Lawrence Berkeley National Laboratory