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Searching for up to 100 curated homologs for PP_0615 FitnessBrowser__Putida:PP_0615 (231 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
    46% identity, 100% coverage of query (216 bits)

TC 3.A.1.4.6 / Q8YT15 NatE, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
    44% identity, 99% coverage of query (197 bits)

HSERO_RS00900 L-proline ABC transporter, ATPase component 2 from Herbaspirillum seropedicae SmR1
    43% identity, 98% coverage of query (194 bits)

Ac3H11_1692 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, ATPase component 2 from Acidovorax sp. GW101-3H11
    39% identity, 99% coverage of query (190 bits)

TC 3.A.1.4.11 / Q6N8W2 Branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    42% identity, 100% coverage of query (188 bits)

TC 3.A.1.4.10 / Q8DQH7 ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    41% identity, 99% coverage of query (187 bits)

AZOBR_RS08250 L-proline and D-alanine ABC transporter, ATPase component 2 from Azospirillum brasilense Sp245
    42% identity, 98% coverage of query (187 bits)

Pf6N2E2_2926 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 2 LivF from Pseudomonas fluorescens FW300-N2E2
    44% identity, 99% coverage of query (187 bits)

TC 3.A.1.4.8 / P21630 High-affinity branched-chain amino acid transport ATP-binding protein BraG, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    44% identity, 99% coverage of query (186 bits)

LivF / b3454 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
LivF / P22731 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.4.1 / P22731 LivF aka B3454, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 4 papers)
livF / GB|AAC76479.2 high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivF from Escherichia coli K12 (see 5 papers)
    42% identity, 99% coverage of query (186 bits)

TC 3.A.1.4.7 / Q92TN4 Putative branched-chain amino acid uptake ABC transporter ATP-binding protein, component of The protocatechuate (3,4-dihydroxybenzoate) uptake porter, PcaMNVWX from Rhizobium meliloti (strain 1021)
    43% identity, 99% coverage of query (178 bits)

braG / CAB75552.1 ATPase from Rhizobium leguminosarum bv. viciae (see 2 papers)
    41% identity, 98% coverage of query (177 bits)

TC 3.A.1.4.2 / P73650 NatE aka LivF aka SLR1881, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
    40% identity, 97% coverage of query (154 bits)

TC 3.A.1.4.9 / Q0S720 ABC branched-chain amino acid transporter, ATP-binding component, component of Uptake transporter, CamABCD of cholate (steroid) metabolites, 1β(2'-propanoate)-3aα-H-4α(3"(R)-hydroxy-3"-propanoate)-7aβ-methylhexahydro-5-indanone and a desaturated analog from Rhodococcus sp. (strain RHA1)
    40% identity, 99% coverage of query (152 bits)

TC 3.A.1.4.5 / Q8NRV7 UrtE, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
    33% identity, 97% coverage of query (143 bits)

TC 3.A.1.4.4 / Q9L3S2 UrtE, component of The high-affinity (<1 μM) urea porter (see paper)
    40% identity, 90% coverage of query (141 bits)

6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
    34% identity, 98% coverage of query (140 bits)

lptB / O25417 lipopolysaccharide transport system ATP-binding protein LptB (EC 7.5.2.5) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
    33% identity, 99% coverage of query (138 bits)

lptB / Q2YP14 lipopolysaccharide transport system ATP-binding protein (EC 7.5.2.5) from Brucella abortus (strain 2308) (see paper)
    34% identity, 94% coverage of query (134 bits)

E6MYT4 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Neisseria meningitidis serogroup B / serotype 15 (see 2 papers)
    31% identity, 98% coverage of query (133 bits)

lptB / Q7CPN9 LPS export ABC transporter ATP-binding protein (EC 7.5.2.5) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 9 papers)
    34% identity, 98% coverage of query (130 bits)

A0A071L2Z5 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Pseudomonas aeruginosa (see paper)
TC 3.A.1.152.1 / Q9HVV6 Probable ATP-binding component of ABC transporter, component of LPS export system, LptF (M), LptG (M) and LptB (C) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
    32% identity, 94% coverage of query (125 bits)

LptB / b3201 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
LptB / P0A9V1 lipopolysaccharide transport system ATP binding protein LptB (EC 7.5.2.5) from Escherichia coli (strain K12) (see 10 papers)
LPTB_ECOLI / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB; EC 7.5.2.- from Escherichia coli (strain K12) (see 5 papers)
P0A9V1 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Escherichia coli (see 3 papers)
TC 1.B.42.1.2 / P0A9V1 Lipopolysaccharide export system ATP-binding protein LptB, component of LPS export porin complex, LptBCFG-A-DE, consists of LptD (Omp; OmpA; 784 aas)-LptE (RlpB; 193 aas; O.M. lipoprotein)-LptA (KdsD; YhbN; OstA small; 185 aas periplasmic chaparone protein)-LptB (KdsC; YhbG; 241 aas cytoplasmic ABC-type ATPase)-LptC (YrbK, 199aas;1 N-terminal TMS)- LptFG, part of the ABC transporter. LptDE (1:1 stoichiometry) comprise a two-protein β-barrel-lipoprotein complex in the outer membrane that assembles and exports LPS from Escherichia coli (strain K12)
lptB lipopolysaccharide ABC transporter, ATP-binding protein LptB; EC 3.6.3.- from Escherichia coli K12 (see 9 papers)
    34% identity, 98% coverage of query (125 bits)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
    34% identity, 98% coverage of query (125 bits)

6b89A E. Coli lptb in complex with adp and novobiocin
    34% identity, 98% coverage of query (125 bits)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
    34% identity, 98% coverage of query (125 bits)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
    34% identity, 98% coverage of query (125 bits)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
    34% identity, 98% coverage of query (125 bits)

6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
    34% identity, 98% coverage of query (124 bits)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
    34% identity, 97% coverage of query (123 bits)

YhdZ / b3271 putative ABC transporter ATP-binding subunit YhdZ from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yhdZ / RF|NP_417737 uncharacterized amino-acid ABC transporter ATP-binding protein yhdZ from Escherichia coli K12 (see 3 papers)
    30% identity, 95% coverage of query (120 bits)

TC 3.A.1.3.8 / Q52815 AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
aapP / CAA57936.1 general amino acid ABC type transporter from Rhizobium leguminosarum (see paper)
    31% identity, 97% coverage of query (120 bits)

TC 3.A.1.4.10 / Q8DQH8 ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    32% identity, 99% coverage of query (119 bits)

SMc02121 ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component from Sinorhizobium meliloti 1021
    30% identity, 99% coverage of query (117 bits)

Build an alignment

Build an alignment for PP_0615 and 34 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
    29% identity, 93% coverage of query (114 bits)

6z4wA / Q8DQH4 Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
    33% identity, 93% coverage of query (108 bits)

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
    33% identity, 93% coverage of query (108 bits)

4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
    27% identity, 96% coverage of query (108 bits)

ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
    29% identity, 100% coverage of query (105 bits)

3c4jA Abc protein artp in complex with atp-gamma-s
    26% identity, 95% coverage of query (100 bits)

3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
    26% identity, 95% coverage of query (100 bits)

2olkA Abc protein artp in complex with adp-beta-s
    26% identity, 95% coverage of query (100 bits)

2oljA Abc protein artp in complex with adp/mg2+
    26% identity, 95% coverage of query (100 bits)

ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
    32% identity, 90% coverage of query (98.6 bits)

1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
    24% identity, 99% coverage of query (98.2 bits)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
    24% identity, 99% coverage of query (97.8 bits)

Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
    32% identity, 95% coverage of query (94.0 bits)

CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
    31% identity, 85% coverage of query (93.6 bits)

ABC1_MYCTU / O65934 ABC transporter ATP-binding/permease protein Rv1747; EC 7.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
    30% identity, 94% coverage of query (93.2 bits)

7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
    30% identity, 100% coverage of query (92.0 bits)

7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
    30% identity, 100% coverage of query (92.0 bits)

7roqA / O95477 Alternative structure of human abca1
    29% identity, 85% coverage of query (91.7 bits)

ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
    29% identity, 85% coverage of query (91.3 bits)

7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
    30% identity, 100% coverage of query (90.9 bits)

ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
    29% identity, 85% coverage of query (89.7 bits)

8tzjA / A0A085R4L6 Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
    32% identity, 85% coverage of query (89.7 bits)

8igqA / O05779 Cryo-em structure of mycobacterium tuberculosis adp bound ftsex/ripc complex in peptidisc (see paper)
    29% identity, 90% coverage of query (89.7 bits)

FTSE_MYCTA / A5U7B7 Cell division ATP-binding protein FtsE from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (see 2 papers)
    29% identity, 90% coverage of query (89.7 bits)

8iddA Cryo-em structure of mycobacterium tuberculosis atp bound ftsex/ripc complex in peptidisc
    29% identity, 90% coverage of query (89.7 bits)

7tbwA / O95477 The structure of atp-bound abca1 (see paper)
    29% identity, 85% coverage of query (89.7 bits)

1b0uA / P02915 Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
    29% identity, 95% coverage of query (89.4 bits)

HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
    29% identity, 95% coverage of query (89.4 bits)

ABCB7_ORYLA / H2LNR5 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial from Oryzias latipes (Japanese rice fish) (Japanese killifish) (see paper)
    30% identity, 94% coverage of query (89.0 bits)

4hluA / Q9WY65 Structure of the ecfa-a' heterodimer bound to adp (see paper)
    31% identity, 88% coverage of query (89.0 bits)

TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
    26% identity, 94% coverage of query (88.6 bits)

AB25B_ARATH / Q9LVM1 ABC transporter B family member 25, mitochondrial; ABC transporter ABCB.25; AtABCB25; ABC transporter of the mitochondrion 3; AtATM3; Iron-sulfur clusters transporter ATM3; Protein STARIK 1 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.210.8 / Q9LVM1 Mitochondrial ABC transporter, ATM3, involved in iron homeostasis (Chen et al. 2007) and heavy metal resistance (Kim et al. 2006). There are three isoforms: ATM1, ATM2 and ATM3 (Chen et al., 2007). ATM3 can replace the yeast iron/sulfur cluster exporter better than ATM1 or ATM2. Atm3 is most similar to the human and yeast homologues, TC# 3.A.1.210.4 and 3.A.1.210.1, 51% and 47% identical, respectively from Arabidopsis thaliana (Mouse-ear cress) (see 11 papers)
GB|AAN13224.1 putative ABC transporter protein from Arabidopsis thaliana (see paper)
    30% identity, 91% coverage of query (88.6 bits)

7chaI / Q9HVW1 Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
    29% identity, 90% coverage of query (88.6 bits)

7n59A / Q9LVM1 Structure of atatm3 in the inward-facing conformation with gssg bound (see paper)
    30% identity, 91% coverage of query (88.2 bits)

7n5aA Structure of atatm3 in the closed conformation
    30% identity, 91% coverage of query (88.2 bits)

7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
    29% identity, 84% coverage of query (87.8 bits)

5xu1B / Q8DQF8 Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
    28% identity, 84% coverage of query (87.4 bits)

8i6rB / Q9I6C0 Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
    30% identity, 90% coverage of query (87.0 bits)

4q4aA / Q9WYC3 Improved model of amp-pnp bound tm287/288 (see paper)
    30% identity, 90% coverage of query (87.0 bits)

6quzA Structure of atpgs-bound outward-facing tm287/288 in complex with sybody sb_tm35
    30% identity, 90% coverage of query (87.0 bits)

6qv0A Structure of atp-bound outward-facing tm287/288 in complex with sybody sb_tm35
    30% identity, 90% coverage of query (87.0 bits)

MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
    28% identity, 88% coverage of query (86.7 bits)

ABCB7_MOUSE / Q61102 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Mus musculus (Mouse) (see 4 papers)
    32% identity, 90% coverage of query (86.7 bits)

RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
    30% identity, 82% coverage of query (86.7 bits)

8w6iD / P0A9R7 Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
    28% identity, 86% coverage of query (86.3 bits)

ABCAD_MOUSE / Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
    27% identity, 90% coverage of query (86.3 bits)

4zirA Crystal structure of ecfaa' heterodimer bound to amppnp
    31% identity, 88% coverage of query (86.3 bits)

FtsE / b3463 cell division protein FtsE from Escherichia coli K-12 substr. MG1655 (see 9 papers)
FTSE_ECOLI / P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see 4 papers)
ftsE cell division ATP-binding protein ftsE from Escherichia coli K12 (see 3 papers)
    28% identity, 86% coverage of query (86.3 bits)

ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
    29% identity, 80% coverage of query (85.9 bits)

8f5bA / P78363 Human abca4 structure in complex with amp-pnp
    29% identity, 81% coverage of query (85.5 bits)

7lkpA Structure of atp-free human abca4
    29% identity, 81% coverage of query (85.5 bits)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
    28% identity, 88% coverage of query (85.5 bits)

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
    28% identity, 88% coverage of query (85.5 bits)

ABCB7_HUMAN / O75027 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Homo sapiens (Human) (see 8 papers)
TC 3.A.1.210.4 / O75027 ABC7 or ABCB7 iron transporter (X-linked sideroblastis anemia protein, XLSA/A (Fujiwara and Harigae 2013)) from Homo sapiens (Human) (see 9 papers)
    30% identity, 94% coverage of query (85.5 bits)

7m1qA / P78363 Human abca4 structure in complex with n-ret-pe (see paper)
    29% identity, 81% coverage of query (85.5 bits)

6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
    28% identity, 88% coverage of query (85.5 bits)

7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
    29% identity, 81% coverage of query (85.5 bits)

8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
    28% identity, 86% coverage of query (85.1 bits)

ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
    32% identity, 84% coverage of query (85.1 bits)

PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
    29% identity, 96% coverage of query (85.1 bits)

P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    34% identity, 73% coverage of query (84.3 bits)

ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
    29% identity, 81% coverage of query (84.3 bits)

7lkzA Structure of atp-bound human abca4
    28% identity, 81% coverage of query (84.3 bits)

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    28% identity, 94% coverage of query (84.3 bits)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    28% identity, 94% coverage of query (84.3 bits)

GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
    28% identity, 94% coverage of query (84.3 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory